Author: Ludmil B Alexandrov

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Preprints

The Repertoire of Mutational Signatures in Human Cancer

• Downloaded 20,560 times
• Download rankings, all-time:
  • Site-wide: 521
  • In cancer biology: 2
• Year to date:
  • Site-wide: 17,704
• Since beginning of last month:
  • Site-wide: 29,901

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

• Downloaded 5,665 times
• Download rankings, all-time:
  • Site-wide: 2,683
  • In genomics: 207
• Year to date:
  • Site-wide: 43,518
• Since beginning of last month:
  • Site-wide: 96,177

Mutational signatures associated with tobacco smoking in human cancer

• Downloaded 3,677 times
• Download rankings, all-time:
  • Site-wide: 4,886
  • In cancer biology: 60
• Year to date:
  • Site-wide: 90,241
• Since beginning of last month:
  • Site-wide: 139,707

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

• Downloaded 2,903 times
• Download rankings, all-time:
  • Site-wide: 6,890
  • In bioinformatics: 1,144
• Year to date:
  • Site-wide: 1,439
• Since beginning of last month:
  • Site-wide: 776

Signatures of copy number alterations in human cancer

• Downloaded 2,213 times
• Download rankings, all-time:
  • Site-wide: 10,239
  • In cancer biology: 424
• Year to date:
  • Site-wide: 1,573
• Since beginning of last month:
  • Site-wide: 349

The APOBEC3A deaminase drives episodic mutagenesis in cancer cells

• Downloaded 1,399 times
• Download rankings, all-time:
  • Site-wide: 20,569
  • In cancer biology: 611
• Year to date:
  • Site-wide: 10,279
• Since beginning of last month:
  • Site-wide: 3,747

Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidence

• Downloaded 1,384 times
• Download rankings, all-time:
  • Site-wide: 20,913
  • In epidemiology: 1,646
• Year to date:
  • Site-wide: 6,868
• Since beginning of last month:
  • Site-wide: 4,770

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

• Downloaded 1,294 times
• Download rankings, all-time:
  • Site-wide: 23,203
  • In genomics: 1,966
• Year to date:
  • Site-wide: 84,445
• Since beginning of last month:
  • Site-wide: 81,542

Somatic mutational profiles and germline polygenic risk scores in human cancer

• Downloaded 1,048 times
• Download rankings, all-time:
  • Site-wide: 32,077
  • In genomics: 2,572
• Year to date:
  • Site-wide: 62,083
• Since beginning of last month:
  • Site-wide: 189,830

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

• Downloaded 991 times
• Download rankings, all-time:
  • Site-wide: 34,879
  • In cancer biology: 829
• Year to date:
  • Site-wide: 151,075
• Since beginning of last month:
  • Site-wide: 108,373

Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA

• Downloaded 843 times
• Download rankings, all-time:
  • Site-wide: 44,420
  • In cancer biology: 1,204
• Year to date:
  • Site-wide: 27,732
• Since beginning of last month:
  • Site-wide: 47,705

Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4

• Downloaded 810 times
• Download rankings, all-time:
  • Site-wide: 47,015
  • In cancer biology: 1,201
• Year to date:
  • Site-wide: 142,604
• Since beginning of last month:
  • Site-wide: 114,412

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events

• Downloaded 786 times
• Download rankings, all-time:
  • Site-wide: 49,175
  • In bioinformatics: 4,669
• Year to date:
  • Site-wide: 157,779
• Since beginning of last month:
  • Site-wide: 166,285

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

• Downloaded 763 times
• Download rankings, all-time:
  • Site-wide: 51,374
  • In cancer biology: 2,139
• Year to date:
  • Site-wide: 9,317
• Since beginning of last month:
  • Site-wide: 30,949

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses

• Downloaded 710 times
• Download rankings, all-time:
  • Site-wide: 56,754
  • In cancer biology: 1,913
• Year to date:
  • Site-wide: 14,309
• Since beginning of last month:
  • Site-wide: 26,933

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

• Downloaded 662 times
• Download rankings, all-time:
  • Site-wide: 62,723
  • In genomics: 4,166
• Year to date:
  • Site-wide: 176,855
• Since beginning of last month:
  • Site-wide: 165,749

Generating realistic null hypothesis of cancer mutational landscapes using SigProfilerSimulator

• Downloaded 550 times
• Download rankings, all-time:
  • Site-wide: 79,354
  • In genomics: 5,078
• Year to date:
  • Site-wide: 90,760
• Since beginning of last month:
  • Site-wide: 128,045

Examining clustered somatic mutations with SigProfilerClusters

• Downloaded 523 times
• Download rankings, all-time:
  • Site-wide: 84,356
  • In bioinformatics: None
• Year to date:
  • Site-wide: 5,018
• Since beginning of last month:
  • Site-wide: 30,309

Topography of mutational signatures in human cancer

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 94,174
  • In cancer biology: None
• Year to date:
  • Site-wide: 5,856
• Since beginning of last month:
  • Site-wide: 769

AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 162,281
  • In cancer biology: 5,313
• Year to date:
  • Site-wide: 18,583
• Since beginning of last month:
  • Site-wide: 30,219

A Genetic Model for Central Chondrosarcoma Evolution Correlates with Patient Outcome

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 176,784
  • In genetic and genomic medicine: 1,201
• Year to date:
  • Site-wide: 79,139
• Since beginning of last month:
  • Site-wide: 62,534