Author: Najaf Amin

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Preprints

New insights on the genetic etiology of Alzheimer and related dementia

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  • Site-wide: 2,715
  • In neurology: 7
• Year to date:
  • Site-wide: 758
• Since beginning of last month:
  • Site-wide: 1,308

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,321 times
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  • Site-wide: 4,081
  • In genetics: 155
• Year to date:
  • Site-wide: 45,639
• Since beginning of last month:
  • Site-wide: 49,262

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,209 times
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  • Site-wide: 4,293
  • In genetics: 168
• Year to date:
  • Site-wide: 31,535
• Since beginning of last month:
  • Site-wide: 7,653

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,874 times
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  • Site-wide: 9,397
  • In genetics: 416
• Year to date:
  • Site-wide: 99,379
• Since beginning of last month:
  • Site-wide: 115,521

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 10,395
  • In genetics: 468
• Year to date:
  • Site-wide: 85,740
• Since beginning of last month:
  • Site-wide: 72,842

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,506 times
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  • Site-wide: 12,884
  • In genetics: 593
• Year to date:
  • Site-wide: 37,828
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  • Site-wide: 66,116

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

• Downloaded 1,320 times
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  • Site-wide: 15,778
  • In genetics: 734
• Year to date:
  • Site-wide: 80,175
• Since beginning of last month:
  • Site-wide: 56,783

Exome sequencing identifies novel AD-associated genes.

• Downloaded 1,242 times
• Download rankings, all-time:
  • Site-wide: 17,283
  • In genetic and genomic medicine: 70
• Year to date:
  • Site-wide: 12,080
• Since beginning of last month:
  • Site-wide: 19,863

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 21,302
  • In genomics: 2,058
• Year to date:
  • Site-wide: 14,287
• Since beginning of last month:
  • Site-wide: 14,085

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,064 times
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  • Site-wide: 21,718
  • In genetics: 1,000
• Year to date:
  • Site-wide: 9,204
• Since beginning of last month:
  • Site-wide: 9,221

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 983 times
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  • Site-wide: 24,367
  • In genetics: 1,132
• Year to date:
  • Site-wide: 21,730
• Since beginning of last month:
  • Site-wide: 29,517

Quality Control and Integration of Genotypes from Two Calling Pipelines for Whole Genome Sequence Data in the Alzheimer's Disease Sequencing Project

• Downloaded 866 times
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  • Site-wide: 29,219
  • In genetics: 1,357
• Year to date:
  • Site-wide: 53,976
• Since beginning of last month:
  • Site-wide: None

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

• Downloaded 847 times
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  • Site-wide: 30,114
  • In genetics: 1,402
• Year to date:
  • Site-wide: 29,700
• Since beginning of last month:
  • Site-wide: 52,965

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

• Downloaded 810 times
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  • Site-wide: 32,062
  • In genetics: 1,496
• Year to date:
  • Site-wide: 135,311
• Since beginning of last month:
  • Site-wide: 130,373

Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors

• Downloaded 774 times
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  • Site-wide: 34,151
  • In epidemiology: 1,746
• Year to date:
  • Site-wide: 53,222
• Since beginning of last month:
  • Site-wide: 49,931

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 769 times
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  • Site-wide: 34,429
  • In genomics: 2,943
• Year to date:
  • Site-wide: 109,376
• Since beginning of last month:
  • Site-wide: 77,649

Relationship between gut microbiota and circulating metabolites in population-based cohorts

• Downloaded 706 times
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  • Site-wide: 38,722
  • In epidemiology: 1,926
• Year to date:
  • Site-wide: 134,791
• Since beginning of last month:
  • Site-wide: 132,755

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 52,172
  • In genetics: 2,337
• Year to date:
  • Site-wide: 6,340
• Since beginning of last month:
  • Site-wide: 12,739

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 514 times
• Download rankings, all-time:
  • Site-wide: 57,624
  • In genomics: 4,276
• Year to date:
  • Site-wide: 139,028
• Since beginning of last month:
  • Site-wide: 141,373

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

• Downloaded 456 times
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  • Site-wide: 65,754
  • In neuroscience: 9,700
• Year to date:
  • Site-wide: 111,940
• Since beginning of last month:
  • Site-wide: 102,904

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

• Downloaded 356 times
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  • Site-wide: 83,227
  • In genomics: 5,429
• Year to date:
  • Site-wide: 145,856
• Since beginning of last month:
  • Site-wide: 135,100

Effect of inbreeding on type 2 diabetes-related metabolites in a Dutch genetic isolate

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 103,780
  • In genetics: 4,465
• Year to date:
  • Site-wide: 141,430
• Since beginning of last month:
  • Site-wide: 101,523

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 105,129
  • In genomics: 6,200
• Year to date:
  • Site-wide: 77,553
• Since beginning of last month:
  • Site-wide: 39,787

Recessive genetic effects on type 2 diabetes-related metabolites in a consanguineous population

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 111,457
  • In genetics: 4,742
• Year to date:
  • Site-wide: 146,092
• Since beginning of last month:
  • Site-wide: 132,735