Author: Najaf Amin

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Preprints

New insights on the genetic etiology of Alzheimer and related dementia

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  • Site-wide: 1,998
  • In neurology: 6
• Year to date:
  • Site-wide: 5,605
• Since beginning of last month:
  • Site-wide: 7,465

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,545 times
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  • Site-wide: 5,724
  • In genetics: 185
• Year to date:
  • Site-wide: 70,949
• Since beginning of last month:
  • Site-wide: 51,440

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,432 times
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  • Site-wide: 6,004
  • In genetics: 198
• Year to date:
  • Site-wide: 40,539
• Since beginning of last month:
  • Site-wide: 117,184

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimers Disease

• Downloaded 2,813 times
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  • Site-wide: 7,996
  • In genetic and genomic medicine: 46
• Year to date:
  • Site-wide: 14,632
• Since beginning of last month:
  • Site-wide: 13,940

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,966 times
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  • Site-wide: 13,792
  • In genetics: 531
• Year to date:
  • Site-wide: 192,585
• Since beginning of last month:
  • Site-wide: 175,129

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,910 times
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  • Site-wide: 14,406
  • In genetics: 565
• Year to date:
  • Site-wide: 132,608
• Since beginning of last month:
  • Site-wide: 198,388

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,795 times
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  • Site-wide: 15,892
  • In genetics: 642
• Year to date:
  • Site-wide: 35,460
• Since beginning of last month:
  • Site-wide: 60,493

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

• Downloaded 1,699 times
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  • Site-wide: 17,264
  • In genetics: 858
• Year to date:
  • Site-wide: 2,662
• Since beginning of last month:
  • Site-wide: 1,113

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 1,423 times
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  • Site-wide: 22,943
  • In genomics: 2,000
• Year to date:
  • Site-wide: 50,605
• Since beginning of last month:
  • Site-wide: 120,850

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,377 times
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  • Site-wide: 24,172
  • In genetics: 976
• Year to date:
  • Site-wide: 13,863
• Since beginning of last month:
  • Site-wide: 27,043

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 26,327
  • In genetics: 1,064
• Year to date:
  • Site-wide: 28,798
• Since beginning of last month:
  • Site-wide: 65,558

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

• Downloaded 1,136 times
• Download rankings, all-time:
  • Site-wide: 32,806
  • In genetics: 1,303
• Year to date:
  • Site-wide: 118,879
• Since beginning of last month:
  • Site-wide: 140,894

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

• Downloaded 1,128 times
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  • Site-wide: 33,137
  • In genetics: 1,334
• Year to date:
  • Site-wide: 18,704
• Since beginning of last month:
  • Site-wide: 112,944

Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors

• Downloaded 1,000 times
• Download rankings, all-time:
  • Site-wide: 39,867
  • In epidemiology: 2,113
• Year to date:
  • Site-wide: 30,130
• Since beginning of last month:
  • Site-wide: 150,499

Quality Control and Integration of Genotypes from Two Calling Pipelines for Whole Genome Sequence Data in the Alzheimer's Disease Sequencing Project

• Downloaded 999 times
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  • Site-wide: 39,958
  • In genetics: 1,571
• Year to date:
  • Site-wide: 132,503
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  • Site-wide: 209,699

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 883 times
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  • Site-wide: 48,383
  • In genomics: 3,575
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 91,803

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

• Downloaded 876 times
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  • Site-wide: 48,977
  • In genetics: 1,898
• Year to date:
  • Site-wide: 187,745
• Since beginning of last month:
  • Site-wide: 180,016

Relationship between gut microbiota and circulating metabolites in population-based cohorts

• Downloaded 790 times
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  • Site-wide: 57,101
  • In epidemiology: 2,761
• Year to date:
  • Site-wide: 193,512
• Since beginning of last month:
  • Site-wide: 151,339

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 737 times
• Download rankings, all-time:
  • Site-wide: 63,354
  • In genomics: 4,383
• Year to date:
  • Site-wide: 85,802
• Since beginning of last month:
  • Site-wide: 130,997

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 78,052
  • In genomics: 5,105
• Year to date:
  • Site-wide: 111,660
• Since beginning of last month:
  • Site-wide: 205,460

Longitudinal analysis of UK Biobank participants suggests age and APOE-dependent alterations of energy metabolism in development of dementia

• Downloaded 618 times
• Download rankings, all-time:
  • Site-wide: 80,456
  • In neurology: 337
• Year to date:
  • Site-wide: 18,780
• Since beginning of last month:
  • Site-wide: 22,348

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

• Downloaded 578 times
• Download rankings, all-time:
  • Site-wide: 87,658
  • In neuroscience: 12,457
• Year to date:
  • Site-wide: 171,904
• Since beginning of last month:
  • Site-wide: 144,569

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

• Downloaded 435 times
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  • Site-wide: 120,339
  • In genomics: 6,774
• Year to date:
  • Site-wide: 188,775
• Since beginning of last month:
  • Site-wide: 200,859

Effect of inbreeding on type 2 diabetes-related metabolites in a Dutch genetic isolate

• Downloaded 386 times
• Download rankings, all-time:
  • Site-wide: 133,998
  • In genetics: 5,022
• Year to date:
  • Site-wide: 138,441
• Since beginning of last month:
  • Site-wide: 151,419

Recessive genetic effects on type 2 diabetes-related metabolites in a consanguineous population

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 144,651
  • In genetics: 5,450
• Year to date:
  • Site-wide: 113,117
• Since beginning of last month:
  • Site-wide: 151,408

Challenges at the APOE locus: A robust quality control approach for accurate APOE genotyping

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 181,737
  • In neurology: 1,185
• Year to date:
  • Site-wide: 143,404
• Since beginning of last month:
  • Site-wide: 159,281

Interplay of Human Metabolome and Gut Microbiome in Major Depression

• Downloaded 189 times
• Download rankings, all-time:
  • Site-wide: 190,125
  • In epidemiology: 7,607
• Year to date:
  • Site-wide: 13,355
• Since beginning of last month:
  • Site-wide: 106,761