Author: André G. Uitterlinden

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 983
  • In genetics: 26
• Year to date:
  • Site-wide: 43,752
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  • Site-wide: 62,817

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,283
  • In genetics: 168
• Year to date:
  • Site-wide: 30,787
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  • Site-wide: 7,397

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,660 times
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  • Site-wide: 5,598
  • In genetics: 241
• Year to date:
  • Site-wide: 25,658
• Since beginning of last month:
  • Site-wide: 28,062

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 8,431
  • In genetics: 368
• Year to date:
  • Site-wide: 128,985
• Since beginning of last month:
  • Site-wide: 132,349

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 9,407
  • In genetics: 416
• Year to date:
  • Site-wide: 99,308
• Since beginning of last month:
  • Site-wide: 116,365

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 10,409
  • In genetics: 470
• Year to date:
  • Site-wide: 86,125
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  • Site-wide: 73,178

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 10,469
  • In genetics: 473
• Year to date:
  • Site-wide: 86,302
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  • Site-wide: 59,163

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 10,678
  • In genetics: 482
• Year to date:
  • Site-wide: 59,622
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  • Site-wide: 51,600

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,506 times
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  • Site-wide: 12,897
  • In genetics: 593
• Year to date:
  • Site-wide: 38,037
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  • Site-wide: 67,795

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 13,922
  • In genetics: 643
• Year to date:
  • Site-wide: 97,881
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  • Site-wide: 132,192

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 14,044
  • In genomics: 1,444
• Year to date:
  • Site-wide: 23,976
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  • Site-wide: 52,194

A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population

• Downloaded 1,305 times
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  • Site-wide: 16,094
  • In genetics: 754
• Year to date:
  • Site-wide: 96,398
• Since beginning of last month:
  • Site-wide: 123,777

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,258 times
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  • Site-wide: 16,978
  • In genomics: 1,682
• Year to date:
  • Site-wide: 110,362
• Since beginning of last month:
  • Site-wide: 137,213

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

• Downloaded 1,096 times
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  • Site-wide: 20,790
  • In genetics: 964
• Year to date:
  • Site-wide: 85,687
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  • Site-wide: 69,376

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 1,077 times
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  • Site-wide: 21,328
  • In genomics: 2,058
• Year to date:
  • Site-wide: 14,384
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  • Site-wide: 14,603

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 1,008 times
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  • Site-wide: 23,525
  • In genetics: 1,093
• Year to date:
  • Site-wide: 96,058
• Since beginning of last month:
  • Site-wide: 112,127

Meta-GWAS Accuracy and Power (MetaGAP) calculator shows that hiding heritability is partially due to imperfect genetic correlations across studies

• Downloaded 995 times
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  • Site-wide: 23,978
  • In genetics: 1,116
• Year to date:
  • Site-wide: 92,920
• Since beginning of last month:
  • Site-wide: 97,148

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 922 times
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  • Site-wide: 26,813
  • In genetic and genomic medicine: 102
• Year to date:
  • Site-wide: 8,766
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  • Site-wide: 13,154

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 809 times
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  • Site-wide: 32,139
  • In genetics: 1,500
• Year to date:
  • Site-wide: 83,258
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  • Site-wide: 67,354

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 769 times
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  • Site-wide: 34,472
  • In genomics: 2,943
• Year to date:
  • Site-wide: 109,682
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  • Site-wide: 80,620

Novel genetic loci affecting facial shape variation in humans

• Downloaded 708 times
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  • Site-wide: 38,683
  • In genomics: 3,208
• Year to date:
  • Site-wide: 92,451
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  • Site-wide: 95,523

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 621 times
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  • Site-wide: 45,827
  • In genetics: 2,079
• Year to date:
  • Site-wide: 123,880
• Since beginning of last month:
  • Site-wide: 143,891

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 514 times
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  • Site-wide: 57,685
  • In genomics: 4,287
• Year to date:
  • Site-wide: 140,389
• Since beginning of last month:
  • Site-wide: 141,958

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 483 times
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  • Site-wide: 61,854
  • In genetics: 2,766
• Year to date:
  • Site-wide: 139,292
• Since beginning of last month:
  • Site-wide: 142,830

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

• Downloaded 356 times
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  • Site-wide: 83,247
  • In genomics: 5,434
• Year to date:
  • Site-wide: 145,903
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  • Site-wide: 137,282

Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification

• Downloaded 356 times
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  • Site-wide: 83,336
  • In genetic and genomic medicine: 350
• Year to date:
  • Site-wide: 12,262
• Since beginning of last month:
  • Site-wide: 17,191

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 101,190
  • In genetics: 4,362
• Year to date:
  • Site-wide: 143,545
• Since beginning of last month:
  • Site-wide: 143,642

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 105,319
  • In genomics: 6,204
• Year to date:
  • Site-wide: 78,298
• Since beginning of last month:
  • Site-wide: 41,096