Author: Rodolfo G Goya

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Preprints

YOUNG PLASMA REJUVENATES BLOOD DNA METHYLATION PROFILE, PROLONGS MEAN LIFESPAN AND IMPROVES HEALTH IN OLD RATS

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Reversing age: dual species measurement of epigenetic age with a single clock

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Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

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Phenotypic Age: a novel signature of mortality and morbidity risk

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Universal DNA methylation age across mammalian tissues

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An epigenetic biomarker of aging for lifespan and healthspan

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Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells

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Global changes in patterning, splicing and primate specific lncRNAs in autism brain

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Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

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Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation

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Epigenetic predictors of maximum lifespan and other life history traits in mammals

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A mammalian methylation array for profiling methylation levels at conserved sequences

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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

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Small extracellular vesicles from young mice prevent frailty, improve healthspan and decrease epigenetic age in old mice.

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A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

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Rapamycin treatment during development extends lifespan and healthspan

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Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons

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Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts

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Genome Methylation Predicts Age and Longevity of Bats

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DNA Methylation Networks Underlying Mammalian Traits

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Biological age is increased by stress and restored upon recovery

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Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

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An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 33,375
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PRC2 clock: a universal biomarker of aging and rejuvenation

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  • Site-wide: 41,688
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  • Site-wide: 4,317

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

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  • Site-wide: 43,170
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GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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Hibernation slows epigenetic aging in yellow-bellied marmots

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Epigenetic clock and methylation studies in dogs

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  • Site-wide: 47,725
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Causal Epigenetic Age Uncouples Damage and Adaptation

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Divergent age-related methylation patterns in long and short-lived mammals

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Genetic Loci and Metabolic States Associated With Murine Epigenetic Aging

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DNA methylation clocks show slower progression of aging in naked mole-rat queens

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Epigenetic clock and methylation studies in cats

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  • Site-wide: 114,688

Aging the Brain: Multi-Region Methylation Principal Component Based Clock in the Context of Alzheimer's Disease

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A meta-analysis of genome-wide association studies of epigenetic age acceleration

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  • Site-wide: 71,060
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Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscle

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  • Site-wide: 74,908
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Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)

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  • Site-wide: 76,154
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Pan-primate DNA methylation clocks

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Castration delays epigenetic aging and feminises DNA methylation at androgen-regulated loci

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A systematic evaluation of 41 DNA methylation predictors across 101 data preprocessing and normalization strategies highlights considerable variation in algorithm performance

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Chronic Glucocorticoid Stress Reveals Increased Energy Expenditure and Accelerated Aging as Cellular Features of Allostatic Load

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Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging

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  • Site-wide: 100,292
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  • Site-wide: 171,639
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  • Site-wide: 142,254

Epigenetic age provides insight into tissue origin in endometriosis

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  • Site-wide: 101,694
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DNAmFitAge: Biological Age Indicator Incorporating Physical Fitness

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Epigenetic clock and methylation studies in the rhesus macaque

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Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing

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The analysis of epigenomic evolution

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An epigenetic predictor of death captures multi-modal measures of brain health

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  • Site-wide: 112,691
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Development of epigenetic clocks for New Zealand livestock

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Epigenetic clock and DNA methylation studies of roe deer in the wild

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Epigenetic clock and methylation studies in vervet monkeys

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Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

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DNA methylation age analysis of rapamycin in common marmosets

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Refining epigenetic prediction of chronological and biological age

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  • Site-wide: 140,441
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  • Site-wide: 19,822
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Epigenetic models predict age and aging in plains zebras and other equids

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An epigenetic clock to estimate the age of living beluga whales

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Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity

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  • Site-wide: 147,790
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Multi-tissue methylation clocks for age estimation in the common bottlenose dolphin

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The influence of biological and statistical properties of CpGs on epigenetic predictions of eighteen traits

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Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy

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  • Site-wide: 150,326

Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes

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Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in Xenopus laevis

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DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic ageing

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Epigenetics and island-mainland divergence in an insectivorous small mammal

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Epigenetic clock and methylation studies in gray short-tailed opossums

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  • Site-wide: 181,240
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  • Site-wide: 172,823

HIV, Pathology and epigenetic age acceleration in different human tissues

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  • Site-wide: 187,354
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DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation

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  • Site-wide: 93,917

Epigenome-wide meta-analysis of BMI in nine population-based cohorts: examining the utility of methylation as a biomarker of BMI

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DNA methylation age studies of humpback whales

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