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Author: Costas A Lyssiotis

Rankings

  • All-time downloads: 25,656 (rank: 11,462 )
  • Categories:
    • biochemistry: 305 (rank: 27,211 (tie) )
    • bioinformatics: 1,581 (rank: 13,536 (tie) )
    • cancer biology: 17,082 (rank: 109 )
    • immunology: 1,632 (rank: 10,918 (tie) )
    • microbiology: 242 (rank: 69,330 (tie) )
    • molecular biology: 1,750 (rank: 4,587 (tie) )
    • neuroscience: 431 (rank: 74,497 (tie) )
    • oncology: 148 (rank: 8,327 (tie) )
    • pathology: 336 (rank: 6,906 (tie) )

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Preprints

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

immunology more details view paper

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Meta-analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics

bioinformatics more details view paper
  • Downloaded 1,663 times
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    • Site-wide: 17,261
    • In bioinformatics: 1,923
  • Year to date:
    • Site-wide: 41,643
  • Since beginning of last month:
    • Site-wide: 31,698

Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1

cancer biology more details view paper
  • Downloaded 1,543 times
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    • Site-wide: 19,419
    • In cancer biology: 514
  • Year to date:
    • Site-wide: 7,423
  • Since beginning of last month:
    • Site-wide: 6,841

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

cancer biology more details view paper
  • Downloaded 1,499 times
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    • Site-wide: 20,371
    • In cancer biology: 470
  • Year to date:
    • Site-wide: 19,027
  • Since beginning of last month:
    • Site-wide: 43,001

Integration of high-content fluorescence imaging into the metabolic flux assay reveals insights into mitochondrial properties and functions

molecular biology more details view paper
  • Downloaded 1,452 times
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    • Site-wide: 21,391
    • In molecular biology: 580
  • Year to date:
    • Site-wide: 35,298
  • Since beginning of last month:
    • Site-wide: 14,423

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

cancer biology more details view paper
  • Downloaded 1,278 times
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    • Site-wide: 26,247
    • In cancer biology: 622
  • Year to date:
    • Site-wide: 143,346
  • Since beginning of last month:
    • Site-wide: 106,897

GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron

cancer biology more details view paper
  • Downloaded 1,265 times
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    • Site-wide: 26,697
    • In cancer biology: 685
  • Year to date:
    • Site-wide: 35,886
  • Since beginning of last month:
    • Site-wide: 23,890

Clonal Heterogeneity Supports Mitochondrial Metabolism in Pancreatic Cancer

cancer biology more details view paper
  • Downloaded 1,243 times
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    • Site-wide: 27,413
    • In cancer biology: 677
  • Year to date:
    • Site-wide: 71,368
  • Since beginning of last month:
    • Site-wide: 36,757

Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

cancer biology more details view paper
  • Downloaded 1,182 times
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    • Site-wide: 29,637
    • In cancer biology: 743
  • Year to date:
    • Site-wide: 82,903
  • Since beginning of last month:
    • Site-wide: 64,245

Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated Immunopathology

immunology more details view paper
  • Downloaded 1,140 times
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    • Site-wide: 31,428
    • In immunology: 1,169
  • Year to date:
    • Site-wide: 10,809
  • Since beginning of last month:
    • Site-wide: 20,428

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

cancer biology more details view paper
  • Downloaded 1,082 times
  • Download rankings, all-time:
    • Site-wide: 34,044
    • In cancer biology: 895
  • Year to date:
    • Site-wide: 68,430
  • Since beginning of last month:
    • Site-wide: 42,866

Multi-dimensional analyses identify genes of high priority for pancreatic cancer research

cancer biology more details view paper
  • Downloaded 1,012 times
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    • Site-wide: 37,672
    • In cancer biology: 1,153
  • Year to date:
    • Site-wide: 26,846
  • Since beginning of last month:
    • Site-wide: 16,047

Hypoxia inducible factor-2α increases sensitivity of colon cancer cells towards oxidative cell death

cancer biology more details view paper
  • Downloaded 990 times
  • Download rankings, all-time:
    • Site-wide: 38,990
    • In cancer biology: 1,068
  • Year to date:
    • Site-wide: 65,731
  • Since beginning of last month:
    • Site-wide: 47,260

IDH1R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response

cancer biology more details view paper
  • Downloaded 943 times
  • Download rankings, all-time:
    • Site-wide: 42,012
    • In cancer biology: 1,135
  • Year to date:
    • Site-wide: 146,342
  • Since beginning of last month:
    • Site-wide: 70,570

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

cancer biology more details view paper
  • Downloaded 857 times
  • Download rankings, all-time:
    • Site-wide: 48,606
    • In cancer biology: 1,431
  • Year to date:
    • Site-wide: 24,565
  • Since beginning of last month:
    • Site-wide: 48,349

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

cancer biology more details view paper
  • Downloaded 719 times
  • Download rankings, all-time:
    • Site-wide: 62,931
    • In cancer biology: 1,767
  • Year to date:
    • Site-wide: 49,199
  • Since beginning of last month:
    • Site-wide: 108,752

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

cancer biology more details view paper
  • Downloaded 715 times
  • Download rankings, all-time:
    • Site-wide: 63,388
    • In cancer biology: 2,284
  • Year to date:
    • Site-wide: 5,923
  • Since beginning of last month:
    • Site-wide: 11,558

Hyaluronic Acid Fuels Pancreatic Cancer Growth

cancer biology more details view paper
  • Downloaded 715 times
  • Download rankings, all-time:
    • Site-wide: 63,393
    • In cancer biology: 1,791
  • Year to date:
    • Site-wide: 103,099
  • Since beginning of last month:
    • Site-wide: 129,153

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

cancer biology more details view paper
  • Downloaded 590 times
  • Download rankings, all-time:
    • Site-wide: 82,025
    • In cancer biology: 2,321
  • Year to date:
    • Site-wide: 174,115
  • Since beginning of last month:
    • Site-wide: 126,220

Multi-omic Characterization of Pancreatic Cancer-Associated Macrophage Polarization Reveals Deregulated Metabolic Programs Driven by the GMCSF-PI3K Pathway

cancer biology more details view paper
  • Downloaded 530 times
  • Download rankings, all-time:
    • Site-wide: 93,702
    • In cancer biology: 2,806
  • Year to date:
    • Site-wide: 51,190
  • Since beginning of last month:
    • Site-wide: 76,232

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

neuroscience more details view paper
  • Downloaded 449 times
  • Download rankings, all-time:
    • Site-wide: 112,084
    • In neuroscience: 15,980
  • Year to date:
    • Site-wide: 196,785
  • Since beginning of last month:
    • Site-wide: 167,723

Arginase 1 is a key driver of immune suppression in pancreatic cancer

cancer biology more details view paper
  • Downloaded 440 times
  • Download rankings, all-time:
    • Site-wide: 114,516
    • In cancer biology: 4,898
  • Year to date:
    • Site-wide: 13,349
  • Since beginning of last month:
    • Site-wide: 6,267

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

cancer biology more details view paper
  • Downloaded 417 times
  • Download rankings, all-time:
    • Site-wide: 120,366
    • In cancer biology: 3,943
  • Year to date:
    • Site-wide: 14,599
  • Since beginning of last month:
    • Site-wide: 19,463

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection

molecular biology more details view paper
  • Downloaded 396 times
  • Download rankings, all-time:
    • Site-wide: 126,115
    • In molecular biology: 3,531
  • Year to date:
    • Site-wide: 169,535
  • Since beginning of last month:
    • Site-wide: 182,610

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiforme

cancer biology more details view paper
  • Downloaded 393 times
  • Download rankings, all-time:
    • Site-wide: 126,966
    • In cancer biology: 3,783
  • Year to date:
    • Site-wide: 121,216
  • Since beginning of last month:
    • Site-wide: 96,368

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

immunology more details view paper
  • Downloaded 388 times
  • Download rankings, all-time:
    • Site-wide: 128,562
    • In immunology: 4,527
  • Year to date:
    • Site-wide: 39,160
  • Since beginning of last month:
    • Site-wide: 20,892

Microbiota metabolic exchange is critical for colorectal cancer redox homeostasis and growth

cancer biology more details view paper
  • Downloaded 386 times
  • Download rankings, all-time:
    • Site-wide: 129,136
    • In cancer biology: 3,779
  • Year to date:
    • Site-wide: 145,950
  • Since beginning of last month:
    • Site-wide: 171,626

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

pathology more details view paper
  • Downloaded 372 times
  • Download rankings, all-time:
    • Site-wide: 132,948
    • In pathology: 740
  • Year to date:
    • Site-wide: 66,355
  • Since beginning of last month:
    • Site-wide: 35,361

NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress

cancer biology more details view paper
  • Downloaded 342 times
  • Download rankings, all-time:
    • Site-wide: 141,712
    • In cancer biology: 4,358
  • Year to date:
    • Site-wide: 45,767
  • Since beginning of last month:
    • Site-wide: 117,304

A redox cycle with complex II promotes sulfide quinone oxidoreductase dependent H2S oxidation

biochemistry more details view paper
  • Downloaded 324 times
  • Download rankings, all-time:
    • Site-wide: 147,146
    • In biochemistry: 4,320
  • Year to date:
    • Site-wide: 106,965
  • Since beginning of last month:
    • Site-wide: 189,814

Human norovirus infection of primary B cells triggers immune activation in vitro

microbiology more details view paper
  • Downloaded 266 times
  • Download rankings, all-time:
    • Site-wide: 164,462
    • In microbiology: 11,859
  • Year to date:
    • Site-wide: 89,630
  • Since beginning of last month:
    • Site-wide: 174,046

Metabolomic profiles of human glioma inform patient survival

oncology more details view paper
  • Downloaded 258 times
  • Download rankings, all-time:
    • Site-wide: 166,788
    • In oncology: 699
  • Year to date:
    • Site-wide: 31,266
  • Since beginning of last month:
    • Site-wide: 22,679

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

cancer biology more details view paper
  • Downloaded 251 times
  • Download rankings, all-time:
    • Site-wide: 168,820
    • In cancer biology: 5,258
  • Year to date:
    • Site-wide: 32,408
  • Since beginning of last month:
    • Site-wide: 44,062

Glutamine metabolism enables NKT cell homeostasis and function through the AMPK-mTORC1 signaling axis

immunology more details view paper
  • Downloaded 241 times
  • Download rankings, all-time:
    • Site-wide: 171,562
    • In immunology: 5,423
  • Year to date:
    • Site-wide: 82,700
  • Since beginning of last month:
    • Site-wide: 67,312

PINK1 supports colorectal cancer growth by regulating the labile iron pool.

cancer biology more details view paper
  • Downloaded 165 times
  • Download rankings, all-time:
    • Site-wide: 189,488
    • In cancer biology: None
  • Year to date:
    • Site-wide: 58,281
  • Since beginning of last month:
    • Site-wide: 7,691

Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II assembly and stability

immunology more details view paper
  • Downloaded 150 times
  • Download rankings, all-time:
    • Site-wide: 192,559
    • In immunology: 6,184
  • Year to date:
    • Site-wide: 64,812
  • Since beginning of last month:
    • Site-wide: 41,898

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