Author: Yi Liu

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Preprints

Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China

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  • Site-wide: 638
  • In pathology: 5
• Year to date:
  • Site-wide: 2,158
• Since beginning of last month:
  • Site-wide: 6,396

Ultra-fast and onsite interrogation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in environmental specimens via surface enhanced Raman scattering (SERS)

• Downloaded 4,301 times
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  • Site-wide: 3,312
  • In infectious diseases: 739
• Year to date:
  • Site-wide: 3,747
• Since beginning of last month:
  • Site-wide: 15,055

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 4,139 times
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  • Site-wide: 3,470
  • In genetics: 108
• Year to date:
  • Site-wide: 14,605
• Since beginning of last month:
  • Site-wide: 54,574

Direct preparation of Cas9 ribonucleoprotein from E. coli for PCR-free seamless DNA assembly

• Downloaded 3,488 times
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  • Site-wide: 4,417
  • In synthetic biology: 40
• Year to date:
  • Site-wide: 17,125
• Since beginning of last month:
  • Site-wide: 15,125

Mitochondrial dysfunction is signaled to the integrated stress response by OMA1, DELE1 and HRI

• Downloaded 2,203 times
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  • Site-wide: 8,672
  • In cell biology: 185
• Year to date:
  • Site-wide: 32,695
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  • Site-wide: 25,920

Direct purification of CRISPR/Cas ribonucleoprotein from E. coli in a single step

• Downloaded 1,965 times
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  • Site-wide: 10,272
  • In synthetic biology: 106
• Year to date:
  • Site-wide: 18,394
• Since beginning of last month:
  • Site-wide: 18,439

Systematic quantification of health parameters from UK Biobank abdominal MRI using deep learning

• Downloaded 1,865 times
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  • Site-wide: 11,110
  • In genetics: 470
• Year to date:
  • Site-wide: 7,147
• Since beginning of last month:
  • Site-wide: 16,586

Distributions and risks of SARS-CoV-2 in hospital outdoor environment

• Downloaded 1,502 times
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  • Site-wide: 15,431
  • In infectious diseases: 1,803
• Year to date:
  • Site-wide: 16,703
• Since beginning of last month:
  • Site-wide: 25,710

Multi-omics study revealing putative drug targets of COVID-19 severity and other viral infection diseases

• Downloaded 1,469 times
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  • Site-wide: 15,995
  • In genetic and genomic medicine: 78
• Year to date:
  • Site-wide: 26,504
• Since beginning of last month:
  • Site-wide: 27,295

Fully Interpretable Deep Learning Model of Transcriptional Control

• Downloaded 1,462 times
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  • Site-wide: 16,116
  • In systems biology: 281
• Year to date:
  • Site-wide: 87,481
• Since beginning of last month:
  • Site-wide: 39,211

Potential spreading risks and disinfection challenges of medical wastewater by the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral RNA in septic tanks of fangcang hospital

• Downloaded 1,415 times
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  • Site-wide: 16,938
  • In public and global health: 368
• Year to date:
  • Site-wide: 35,312
• Since beginning of last month:
  • Site-wide: 51,114

Differential Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern

• Downloaded 1,163 times
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  • Site-wide: 22,756
  • In biophysics: 597
• Year to date:
  • Site-wide: 4,315
• Since beginning of last month:
  • Site-wide: 4,775

Pleotropic effects of PPARD accelerate colorectal tumor progression and invasion

• Downloaded 1,121 times
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  • Site-wide: 24,099
  • In cancer biology: 593
• Year to date:
  • Site-wide: 57,024
• Since beginning of last month:
  • Site-wide: 114,089

The MRC IEU OpenGWAS data infrastructure

• Downloaded 1,109 times
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  • Site-wide: 24,497
  • In genetics: 1,065
• Year to date:
  • Site-wide: 8,378
• Since beginning of last month:
  • Site-wide: 6,795

A NOVEL MECHANISM FOR NF-κB-ACTIVATION VIA IκB-AGGREGATION: IMPLICATIONS FOR HEPATIC MALLORY-DENK-BODY INDUCED INFLAMMATION

• Downloaded 671 times
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  • Site-wide: 50,721
  • In cell biology: 2,151
• Year to date:
  • Site-wide: 54,173
• Since beginning of last month:
  • Site-wide: 52,468

Suppression of membranous LRP5 recycling, WNT/β-catenin signaling, and colorectal tumorigenesis by 15-LOX-1 peroxidation of PI3P_linoleic acid

• Downloaded 487 times
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  • Site-wide: 75,516
  • In cancer biology: 2,205
• Year to date:
  • Site-wide: 77,135
• Since beginning of last month:
  • Site-wide: 69,366

H+- and Na+- elicited swift changes of the microtubule system in the biflagellated green alga Chlamydomonas

• Downloaded 467 times
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  • Site-wide: 79,004
  • In cell biology: 3,596
• Year to date:
  • Site-wide: 123,228
• Since beginning of last month:
  • Site-wide: 100,037

Robust bidirectional communication between electronics and an engineered multi-functional microbial community

• Downloaded 434 times
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  • Site-wide: 85,507
  • In synthetic biology: 951
• Year to date:
  • Site-wide: 79,928
• Since beginning of last month:
  • Site-wide: 112,383

Identification and physiological significance of temporal NFκB signaling codewords deployed by macrophages to classify immune threats

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 87,024
  • In immunology: 2,642
• Year to date:
  • Site-wide: 68,420
• Since beginning of last month:
  • Site-wide: 98,165

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

• Downloaded 408 times
• Download rankings, all-time:
  • Site-wide: 90,792
  • In immunology: 2,745
• Year to date:
  • Site-wide: 54,555
• Since beginning of last month:
  • Site-wide: 90,629

Assessment of the aging of the brown adipose tissue by 18F-FDG PET/CT imaging in the progeria mouse model LmnaG609G/G609G

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 93,158
  • In cell biology: 4,291
• Year to date:
  • Site-wide: 157,338
• Since beginning of last month:
  • Site-wide: 153,666

Clinical Course And Risk Factors For In-hospital Death In Critical COVID-19 In Wuhan, China

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 95,050
  • In public and global health: 1,305
• Year to date:
  • Site-wide: 50,009
• Since beginning of last month:
  • Site-wide: 55,034

Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila

• Downloaded 388 times
• Download rankings, all-time:
  • Site-wide: 95,196
  • In developmental biology: 2,560
• Year to date:
  • Site-wide: 127,418
• Since beginning of last month:
  • Site-wide: 81,116

Modulation of the cAMP levels with a conserved actinobacteria phosphodiesterase enzyme reduces antimicrobial tolerance in mycobacteria

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 95,917
  • In microbiology: 6,593
• Year to date:
  • Site-wide: 63,093
• Since beginning of last month:
  • Site-wide: 68,583

Effects of Diabetes and Blood Glucose on COVID-19 Mortality: A Retrospective Observational Study

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 97,821
  • In public and global health: 1,348
• Year to date:
  • Site-wide: 25,022
• Since beginning of last month:
  • Site-wide: 71,086

Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/ Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.

• Downloaded 348 times
• Download rankings, all-time:
  • Site-wide: 104,632
  • In pharmacology and toxicology: 749
• Year to date:
  • Site-wide: 142,579
• Since beginning of last month:
  • Site-wide: 157,898

Deficiency of gluconeogenic enzyme PCK1 promotes murine NASH progression and fibrosis by activation PI3K/AKT/PDGF axis

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 112,558
  • In molecular biology: 3,353
• Year to date:
  • Site-wide: 32,214
• Since beginning of last month:
  • Site-wide: 16,033

Sequencing uracil in DNA at single-nucleotide resolution

• Downloaded 294 times
• Download rankings, all-time:
  • Site-wide: 118,300
  • In biochemistry: 3,494
• Year to date:
  • Site-wide: 35,606
• Since beginning of last month:
  • Site-wide: 58,166

Development of rice conidiation media for Ustilaginoidea virens

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 118,830
  • In microbiology: 8,494
• Year to date:
  • Site-wide: 142,179
• Since beginning of last month:
  • Site-wide: 120,368

Ppard is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant Kras Mice

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 123,256
  • In cancer biology: 3,743
• Year to date:
  • Site-wide: 72,629
• Since beginning of last month:
  • Site-wide: 50,292

Human hepatic tryptophan 2,3-dioxygenase ubiquitin-dependent protein degradation: The critical role of its exosite as the molecular lynchpin of its substrate-mediated protein stabilization

• Downloaded 273 times
• Download rankings, all-time:
  • Site-wide: 123,912
  • In biochemistry: 3,697
• Year to date:
  • Site-wide: 122,184
• Since beginning of last month:
  • Site-wide: 99,160

EpiGraphDB: a database and data mining platform for health data science

• Downloaded 269 times
• Download rankings, all-time:
  • Site-wide: 124,955
  • In bioinformatics: 10,059
• Year to date:
  • Site-wide: 154,124
• Since beginning of last month:
  • Site-wide: 162,579

Reengineering the Specificity of the Highly Selective Clostridium botulinum Protease via Directed Evolution

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 126,295
  • In biochemistry: 3,783
• Year to date:
  • Site-wide: 73,681
• Since beginning of last month:
  • Site-wide: 72,917

Phagocytosis by stroma confounds co-culture studies

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 128,184
  • In cancer biology: 3,891
• Year to date:
  • Site-wide: 74,771
• Since beginning of last month:
  • Site-wide: 91,590

PPARD regulation in gastric progenitor cells drives gastric tumorigenesis in mice

• Downloaded 244 times
• Download rankings, all-time:
  • Site-wide: 131,586
  • In cancer biology: 4,031
• Year to date:
  • Site-wide: 155,101
• Since beginning of last month:
  • Site-wide: 113,950

Methylomic alteration in peripheral blood lymphocytes of prodromal stage and first-episode Chinese Han schizophrenia patients

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 131,922
  • In genetics: 5,282
• Year to date:
  • Site-wide: 45,940
• Since beginning of last month:
  • Site-wide: 101,874

Unbalanced dietary patterns contribute to the pathogenesis of precocious puberty by affecting gut microbiota and host metabolites

• Downloaded 216 times
• Download rankings, all-time:
  • Site-wide: 138,738
  • In microbiology: 10,269
• Year to date:
  • Site-wide: 53,417
• Since beginning of last month:
  • Site-wide: 19,536

Requirement and functional redundancy of two large ribonucleotide reductase subunit genes for cell cycle, chloroplast biogenesis in tomato

• Downloaded 203 times
• Download rankings, all-time:
  • Site-wide: 141,794
  • In developmental biology: 3,804
• Year to date:
  • Site-wide: 127,898
• Since beginning of last month:
  • Site-wide: 112,957

Intracellular pH dynamics regulates intestinal stem cell fate

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 144,152
  • In cell biology: 6,619
• Year to date:
  • Site-wide: 60,656
• Since beginning of last month:
  • Site-wide: 5,942

Two years later - changes in abdominal organs: First observations from the UK Biobank longitudinal imaging study

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 146,887
  • In radiology and imaging: 344
• Year to date:
  • Site-wide: 65,302
• Since beginning of last month:
  • Site-wide: 22,069

Non-optimal codon usage is critical for protein structure and function of the master general amino acid control regulator CPC-1

• Downloaded 180 times
• Download rankings, all-time:
  • Site-wide: 147,245
  • In molecular biology: 4,420
• Year to date:
  • Site-wide: 125,284
• Since beginning of last month:
  • Site-wide: 62,480

Is there a need for preoperative α-blocker in patients missed preoperative diagnosis of extra-adrenal retroperitoneal paraganglioma undergoing paraganglioma resection? A retrospective study of 167 cases at a single center

• Downloaded 165 times
• Download rankings, all-time:
  • Site-wide: 150,371
  • In physiology: 1,770
• Year to date:
  • Site-wide: 133,032
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  • Site-wide: 119,147

Inoculum origin, incubation temperature and mild hydrostatic pressure modulate growth and activity of anaerobic saline communities

• Downloaded 140 times
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  • Site-wide: 154,991
  • In microbiology: 11,818
• Year to date:
  • Site-wide: 86,159
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  • Site-wide: 111,937

Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron recycling and erythrocyte morphology

• Downloaded 93 times
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  • Site-wide: 161,248
  • In hematology: 126
• Year to date:
  • Site-wide: 121,488
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  • Site-wide: 20,269

Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for IFT of radial spokes

• Downloaded 80 times
• Download rankings, all-time:
  • Site-wide: 162,565
  • In cell biology: 7,395
• Year to date:
  • Site-wide: 132,360
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  • Site-wide: 26,001