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Author: James A Wells

Rankings

  • All-time downloads: 24,112 (rank: 10,073 (tie) )
  • Categories:
    • biochemistry: 7,129 (rank: 397 )
    • bioengineering: 5,278 (rank: 291 )
    • biophysics: 919 (rank: 7,764 (tie) )
    • cancer biology: 3,930 (rank: 1,409 (tie) )
    • cell biology: 1,641 (rank: 6,116 (tie) )
    • immunology: 1,075 (rank: 13,682 (tie) )
    • infectious diseases: 4,140 (rank: 12,988 (tie) )

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Preprints

MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas

cancer biology more details view paper

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Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity

biochemistry more details view paper
  • Downloaded 2,871 times
  • Download rankings, all-time:
    • Site-wide: 6,141
    • In biochemistry: 104
  • Year to date:
    • Site-wide: 16,822
  • Since beginning of last month:
    • Site-wide: 9,845

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

bioengineering more details view paper
  • Downloaded 2,264 times
  • Download rankings, all-time:
    • Site-wide: 8,708
    • In bioengineering: 138
  • Year to date:
    • Site-wide: 94,126
  • Since beginning of last month:
    • Site-wide: 43,913

A SARS-CoV-2 serological assay to determine the presence of blocking antibodies that compete for human ACE2 binding

infectious diseases more details view paper
  • Downloaded 1,721 times
  • Download rankings, all-time:
    • Site-wide: 13,040
    • In infectious diseases: 1,737
  • Year to date:
    • Site-wide: 69,922
  • Since beginning of last month:
    • Site-wide: 34,973

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

cell biology more details view paper
  • Downloaded 1,641 times
  • Download rankings, all-time:
    • Site-wide: 13,961
    • In cell biology: 392
  • Year to date:
    • Site-wide: 1,668
  • Since beginning of last month:
    • Site-wide: 19,150

Cell-surface tethered promiscuous biotinylators enable small-scale surface proteomics of human exosomes

biochemistry more details view paper
  • Downloaded 1,353 times
  • Download rankings, all-time:
    • Site-wide: 18,808
    • In biochemistry: 397
  • Year to date:
    • Site-wide: 5,233
  • Since beginning of last month:
    • Site-wide: 7,148

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection

infectious diseases more details view paper
  • Downloaded 1,324 times
  • Download rankings, all-time:
    • Site-wide: 19,438
    • In infectious diseases: 2,130
  • Year to date:
    • Site-wide: 16,810
  • Since beginning of last month:
    • Site-wide: 28,547

Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance

cancer biology more details view paper
  • Downloaded 1,150 times
  • Download rankings, all-time:
    • Site-wide: 24,075
    • In cancer biology: 583
  • Year to date:
    • Site-wide: 9,778
  • Since beginning of last month:
    • Site-wide: 17,396

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28

bioengineering more details view paper
  • Downloaded 1,141 times
  • Download rankings, all-time:
    • Site-wide: 24,352
    • In bioengineering: 429
  • Year to date:
    • Site-wide: 40,712
  • Since beginning of last month:
    • Site-wide: 55,882

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

bioengineering more details view paper
  • Downloaded 1,135 times
  • Download rankings, all-time:
    • Site-wide: 24,570
    • In bioengineering: 434
  • Year to date:
    • Site-wide: 18,236
  • Since beginning of last month:
    • Site-wide: 63,115

SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay

infectious diseases more details view paper
  • Downloaded 1,095 times
  • Download rankings, all-time:
    • Site-wide: 25,919
    • In infectious diseases: 2,472
  • Year to date:
    • Site-wide: 10,213
  • Since beginning of last month:
    • Site-wide: 21,240

Time-resolved proteomics vs. ribosome profiling reveals translation dynamics under stress

cancer biology more details view paper
  • Downloaded 990 times
  • Download rankings, all-time:
    • Site-wide: 30,128
    • In cancer biology: 762
  • Year to date:
    • Site-wide: 121,912
  • Since beginning of last month:
    • Site-wide: 143,294

Multi-omics analysis of AML cells treated with azacitidine reveals highly variable cell surface proteome remodeling

cancer biology more details view paper
  • Downloaded 976 times
  • Download rankings, all-time:
    • Site-wide: 30,748
    • In cancer biology: 782
  • Year to date:
    • Site-wide: 44,983
  • Since beginning of last month:
    • Site-wide: 144,605

Mapping proteolytic neo-N termini at the surface of living cells

biochemistry more details view paper
  • Downloaded 929 times
  • Download rankings, all-time:
    • Site-wide: 33,094
    • In biochemistry: 799
  • Year to date:
    • Site-wide: 16,656
  • Since beginning of last month:
    • Site-wide: 50,397

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

biophysics more details view paper
  • Downloaded 919 times
  • Download rankings, all-time:
    • Site-wide: 33,641
    • In biophysics: 1,007
  • Year to date:
    • Site-wide: 15,160
  • Since beginning of last month:
    • Site-wide: 82,994

Broad and thematic remodeling of the surface glycoproteome on isogenic cells transformed with driving proliferative oncogenes

biochemistry more details view paper
  • Downloaded 772 times
  • Download rankings, all-time:
    • Site-wide: 43,244
    • In biochemistry: 1,086
  • Year to date:
    • Site-wide: 81,649
  • Since beginning of last month:
    • Site-wide: 54,995

Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries

biochemistry more details view paper
  • Downloaded 751 times
  • Download rankings, all-time:
    • Site-wide: 45,081
    • In biochemistry: 1,144
  • Year to date:
    • Site-wide: 137,103
  • Since beginning of last month:
    • Site-wide: 128,022

Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation

bioengineering more details view paper
  • Downloaded 738 times
  • Download rankings, all-time:
    • Site-wide: 46,188
    • In bioengineering: 871
  • Year to date:
    • Site-wide: 105,465
  • Since beginning of last month:
    • Site-wide: 126,598

Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling

cancer biology more details view paper
  • Downloaded 583 times
  • Download rankings, all-time:
    • Site-wide: 63,196
    • In cancer biology: 1,820
  • Year to date:
    • Site-wide: 80,055
  • Since beginning of last month:
    • Site-wide: 144,678

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance

immunology more details view paper
  • Downloaded 572 times
  • Download rankings, all-time:
    • Site-wide: 64,761
    • In immunology: 2,022
  • Year to date:
    • Site-wide: 21,068
  • Since beginning of last month:
    • Site-wide: 77,098

Hypoxia is a dominant remodeler of the CD8+ T cell surface proteome relative to activation and regulatory T cell-mediated suppression

immunology more details view paper
  • Downloaded 503 times
  • Download rankings, all-time:
    • Site-wide: 75,415
    • In immunology: 2,333
  • Year to date:
    • Site-wide: 11,521
  • Since beginning of last month:
    • Site-wide: 20,550

Targeting a proteolytic neo-epitope of CUB-domain containing protein 1 in RAS-driven cancer

biochemistry more details view paper
  • Downloaded 453 times
  • Download rankings, all-time:
    • Site-wide: 84,719
    • In biochemistry: 2,392
  • Year to date:
    • Site-wide: 47,825
  • Since beginning of last month:
    • Site-wide: 21,028

CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

cancer biology more details view paper
  • Downloaded 231 times
  • Download rankings, all-time:
    • Site-wide: 139,357
    • In cancer biology: 4,259
  • Year to date:
    • Site-wide: 37,208
  • Since beginning of last month:
    • Site-wide: 78,240

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