Author: Luke Wiseman

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Preprints

Distinct Structural Features of the Lon Protease Drive Conserved Hand-over-Hand Substrate Translocation

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A surface morphometrics toolkit to quantify organellar membrane ultrastructure using cryo-electron tomography

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  • In cell biology: 988
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Unique structural features of the mitochondrial AAA+ protease AFG3L2 reveal the molecular basis for activity in health and disease

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Atomic structure of the mitochondrial inner membrane AAA+ protease YME1 reveals the mechanism of substrate processing

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Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation

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Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

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Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity

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  • In physiology: 178
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Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

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Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

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Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration

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Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing

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The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development

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  • In developmental biology: 2,826
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ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

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  • In biochemistry: 3,061
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Cryo-EM structure of hexameric yeast Lon (PIM1) highlights importance of conserved structural elements

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PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

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PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

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Metabolically Activated Proteostasis Regulators Protect Against Glutamate Toxicity by Activating NRF2

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Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer

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ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

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