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Author: Luke Wiseman

Rankings

  • All-time downloads: 13,948 (rank: 22,319 (tie) )
  • Categories:
    • biochemistry: 936 (rank: 8,405 (tie) )
    • cell biology: 3,352 (rank: 2,067 )
    • developmental biology: 378 (rank: 17,399 (tie) )
    • molecular biology: 5,265 (rank: 799 )
    • neuroscience: 1,503 (rank: 21,640 (tie) )
    • physiology: 835 (rank: 2,106 (tie) )

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Preprints

Distinct Structural Features of the Lon Protease Drive Conserved Hand-over-Hand Substrate Translocation

molecular biology more details view paper
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    • Site-wide: 15,337
    • In molecular biology: 362
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    • Site-wide: 129,393
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    • Site-wide: 162,846

A surface morphometrics toolkit to quantify organellar membrane ultrastructure using cryo-electron tomography

cell biology more details view paper
  • Downloaded 1,605 times
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    • Site-wide: 17,071
    • In cell biology: 988
  • Year to date:
    • Site-wide: 1,092
  • Since beginning of last month:
    • Site-wide: 4,972

Unique structural features of the mitochondrial AAA+ protease AFG3L2 reveal the molecular basis for activity in health and disease

molecular biology more details view paper
  • Downloaded 1,158 times
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    • Site-wide: 28,396
    • In molecular biology: 665
  • Year to date:
    • Site-wide: 165,788
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Atomic structure of the mitochondrial inner membrane AAA+ protease YME1 reveals the mechanism of substrate processing

molecular biology more details view paper
  • Downloaded 1,092 times
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    • Site-wide: 31,115
    • In molecular biology: 734
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    • Site-wide: 163,772
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    • Site-wide: 187,573

Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation

molecular biology more details view paper
  • Downloaded 1,092 times
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    • Site-wide: 31,086
    • In molecular biology: 786
  • Year to date:
    • Site-wide: 74,110
  • Since beginning of last month:
    • Site-wide: 133,281

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

neuroscience more details view paper
  • Downloaded 933 times
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    • Site-wide: 39,399
    • In neuroscience: 4,782
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    • Site-wide: 115,802
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    • Site-wide: 67,478

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity

physiology more details view paper
  • Downloaded 883 times
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    • Site-wide: 42,715
    • In physiology: 178
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    • Site-wide: 82,473

Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

cell biology more details view paper
  • Downloaded 777 times
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    • Site-wide: 51,821
    • In cell biology: 1,948
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Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

cell biology more details view paper
  • Downloaded 762 times
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    • Site-wide: 53,263
    • In cell biology: 1,961
  • Year to date:
    • Site-wide: 175,090
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    • Site-wide: 149,788

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration

neuroscience more details view paper
  • Downloaded 676 times
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    • Site-wide: 63,079
    • In neuroscience: 8,819
  • Year to date:
    • Site-wide: 74,835
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    • Site-wide: 56,148

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing

cell biology more details view paper
  • Downloaded 633 times
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    • Site-wide: 68,899
    • In cell biology: 2,689
  • Year to date:
    • Site-wide: 161,405
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    • Site-wide: 159,917

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development

developmental biology more details view paper
  • Downloaded 432 times
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    • Site-wide: 107,625
    • In developmental biology: 2,826
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    • Site-wide: 86,518
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ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

biochemistry more details view paper
  • Downloaded 415 times
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    • Site-wide: 111,769
    • In biochemistry: 3,061
  • Year to date:
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    • Site-wide: 129,657

Cryo-EM structure of hexameric yeast Lon (PIM1) highlights importance of conserved structural elements

molecular biology more details view paper
  • Downloaded 361 times
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    • Site-wide: 126,064
    • In molecular biology: 3,460
  • Year to date:
    • Site-wide: 45,324
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    • Site-wide: None

PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

cell biology more details view paper
  • Downloaded 346 times
  • Download rankings, all-time:
    • Site-wide: 130,238
    • In cell biology: None
  • Year to date:
    • Site-wide: 12,278
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PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

biochemistry more details view paper
  • Downloaded 332 times
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    • Site-wide: 134,458
    • In biochemistry: 3,532
  • Year to date:
    • Site-wide: 192,171
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    • Site-wide: 182,296

Metabolically Activated Proteostasis Regulators Protect Against Glutamate Toxicity by Activating NRF2

biochemistry more details view paper
  • Downloaded 294 times
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    • Site-wide: 145,546
    • In biochemistry: 4,360
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    • Site-wide: 79,853
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    • Site-wide: 96,433

Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer

cell biology more details view paper
  • Downloaded 256 times
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    • Site-wide: 156,480
    • In cell biology: 7,418
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    • Site-wide: 20,271
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ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

cell biology more details view paper
  • Downloaded 181 times
  • Download rankings, all-time:
    • Site-wide: 175,818
    • In cell biology: None
  • Year to date:
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