Author: Ralph S Baric

Downloads per author, site-wide

Preprints

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

No download data for this paper yet.

Severe acute respiratory syndrome-related coronavirus – The species and its viruses, a statement of the Coronavirus Study Group

• Downloaded 124,773 times
• Download rankings, all-time:
  • Site-wide: 49
  • In microbiology: 3
• Year to date:
  • Site-wide: 201
• Since beginning of last month:
  • Site-wide: 244

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

• Downloaded 37,218 times
• Download rankings, all-time:
  • Site-wide: 263
  • In immunology: 12
• Year to date:
  • Site-wide: 1,113
• Since beginning of last month:
  • Site-wide: 1,652

Molnupiravir, an Oral Antiviral Treatment for COVID-19

• Downloaded 31,067 times
• Download rankings, all-time:
  • Site-wide: 320
  • In infectious diseases: 127
• Year to date:
  • Site-wide: 224
• Since beginning of last month:
  • Site-wide: 376

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

• Downloaded 20,142 times
• Download rankings, all-time:
  • Site-wide: 539
  • In microbiology: 53
• Year to date:
  • Site-wide: 18,440
• Since beginning of last month:
  • Site-wide: 24,343

Homologous and Heterologous Vaccine Boost Strategies for Humoral and Cellular Immunologic Coverage of the SARS-CoV-2 Omicron Variant

• Downloaded 18,839 times
• Download rankings, all-time:
  • Site-wide: 572
  • In infectious diseases: 220
• Year to date:
  • Site-wide: 280
• Since beginning of last month:
  • Site-wide: 2,052

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

• Downloaded 9,809 times
• Download rankings, all-time:
  • Site-wide: 1,309
  • In microbiology: 117
• Year to date:
  • Site-wide: 17,801
• Since beginning of last month:
  • Site-wide: 22,473

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

• Downloaded 8,315 times
• Download rankings, all-time:
  • Site-wide: 1,605
  • In immunology: 56
• Year to date:
  • Site-wide: 4,471
• Since beginning of last month:
  • Site-wide: 4,037

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

• Downloaded 5,422 times
• Download rankings, all-time:
  • Site-wide: 2,842
  • In cell biology: 42
• Year to date:
  • Site-wide: 9,860
• Since beginning of last month:
  • Site-wide: 7,496

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

• Downloaded 5,404 times
• Download rankings, all-time:
  • Site-wide: 2,851
  • In microbiology: 213
• Year to date:
  • Site-wide: 29,841
• Since beginning of last month:
  • Site-wide: 43,893

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as vaccine candidate

• Downloaded 5,091 times
• Download rankings, all-time:
  • Site-wide: 3,112
  • In microbiology: 224
• Year to date:
  • Site-wide: 32,365
• Since beginning of last month:
  • Site-wide: 27,123

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

• Downloaded 5,055 times
• Download rankings, all-time:
  • Site-wide: 3,122
  • In immunology: 120
• Year to date:
  • Site-wide: 43,221
• Since beginning of last month:
  • Site-wide: 41,457

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

• Downloaded 4,715 times
• Download rankings, all-time:
  • Site-wide: 3,422
  • In biochemistry: 53
• Year to date:
  • Site-wide: 18,433
• Since beginning of last month:
  • Site-wide: 14,729

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

• Downloaded 4,301 times
• Download rankings, all-time:
  • Site-wide: 3,866
  • In microbiology: 262
• Year to date:
  • Site-wide: 33,266
• Since beginning of last month:
  • Site-wide: 28,375

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

• Downloaded 4,300 times
• Download rankings, all-time:
  • Site-wide: 3,867
  • In immunology: 150
• Year to date:
  • Site-wide: 22,423
• Since beginning of last month:
  • Site-wide: 25,027

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

• Downloaded 4,074 times
• Download rankings, all-time:
  • Site-wide: 4,188
  • In immunology: 156
• Year to date:
  • Site-wide: 52,647
• Since beginning of last month:
  • Site-wide: 54,205

Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome

• Downloaded 3,982 times
• Download rankings, all-time:
  • Site-wide: 4,326
  • In biochemistry: 64
• Year to date:
  • Site-wide: 11,581
• Since beginning of last month:
  • Site-wide: 12,855

Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models

• Downloaded 3,543 times
• Download rankings, all-time:
  • Site-wide: 5,104
  • In microbiology: 332
• Year to date:
  • Site-wide: 38,854
• Since beginning of last month:
  • Site-wide: 34,788

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

• Downloaded 3,413 times
• Download rankings, all-time:
  • Site-wide: 5,408
  • In microbiology: 359
• Year to date:
  • Site-wide: 14,436
• Since beginning of last month:
  • Site-wide: 39,393

The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies

• Downloaded 3,151 times
• Download rankings, all-time:
  • Site-wide: 6,057
  • In infectious diseases: 1,137
• Year to date:
  • Site-wide: 28,345
• Since beginning of last month:
  • Site-wide: 38,777

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

• Downloaded 2,720 times
• Download rankings, all-time:
  • Site-wide: 7,506
  • In microbiology: 477
• Year to date:
  • Site-wide: 6,141
• Since beginning of last month:
  • Site-wide: 10,512

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

• Downloaded 2,648 times
• Download rankings, all-time:
  • Site-wide: 7,819
  • In immunology: 278
• Year to date:
  • Site-wide: 58,596
• Since beginning of last month:
  • Site-wide: 84,604

Mucin 4 Protects Female Mice from Coronavirus Pathogenesis

• Downloaded 2,478 times
• Download rankings, all-time:
  • Site-wide: 8,620
  • In microbiology: 498
• Year to date:
  • Site-wide: 54,413
• Since beginning of last month:
  • Site-wide: 29,814

Combination attenuation offers strategy for live-attenuated coronavirus vaccines

• Downloaded 2,429 times
• Download rankings, all-time:
  • Site-wide: 8,880
  • In microbiology: 501
• Year to date:
  • Site-wide: 106,923
• Since beginning of last month:
  • Site-wide: 117,133

Evaluation of SARS-CoV-2 neutralization assays for antibody monitoring in natural infection and vaccine trials

• Downloaded 2,265 times
• Download rankings, all-time:
  • Site-wide: 9,833
  • In infectious diseases: 1,569
• Year to date:
  • Site-wide: 11,857
• Since beginning of last month:
  • Site-wide: 17,744

Trypsin treatment unlocks barrier for zoonotic coronaviruses infection

• Downloaded 2,167 times
• Download rankings, all-time:
  • Site-wide: 10,494
  • In microbiology: 593
• Year to date:
  • Site-wide: 34,196
• Since beginning of last month:
  • Site-wide: 48,759

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

• Downloaded 2,140 times
• Download rankings, all-time:
  • Site-wide: 10,696
  • In immunology: 387
• Year to date:
  • Site-wide: 24,174
• Since beginning of last month:
  • Site-wide: 19,853

A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine

• Downloaded 2,111 times
• Download rankings, all-time:
  • Site-wide: 10,940
  • In microbiology: 623
• Year to date:
  • Site-wide: 59,290
• Since beginning of last month:
  • Site-wide: 67,846

High-density amplicon sequencing identifies community spread and ongoing evolution of SARS-CoV-2 in the Southern United States

• Downloaded 1,958 times
• Download rankings, all-time:
  • Site-wide: 12,263
  • In microbiology: 697
• Year to date:
  • Site-wide: 54,416
• Since beginning of last month:
  • Site-wide: 33,470

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

• Downloaded 1,883 times
• Download rankings, all-time:
  • Site-wide: 12,982
  • In microbiology: 802
• Year to date:
  • Site-wide: 13,350
• Since beginning of last month:
  • Site-wide: 12,958

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma

• Downloaded 1,830 times
• Download rankings, all-time:
  • Site-wide: 13,506
  • In immunology: 467
• Year to date:
  • Site-wide: 33,526
• Since beginning of last month:
  • Site-wide: 52,728

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

• Downloaded 1,820 times
• Download rankings, all-time:
  • Site-wide: 13,615
  • In immunology: 500
• Year to date:
  • Site-wide: 21,775
• Since beginning of last month:
  • Site-wide: 44,299

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

• Downloaded 1,795 times
• Download rankings, all-time:
  • Site-wide: 13,911
  • In microbiology: 772
• Year to date:
  • Site-wide: 74,163
• Since beginning of last month:
  • Site-wide: 65,114

Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection in vivo

• Downloaded 1,733 times
• Download rankings, all-time:
  • Site-wide: 14,662
  • In microbiology: 820
• Year to date:
  • Site-wide: 64,009
• Since beginning of last month:
  • Site-wide: 57,254

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

• Downloaded 1,619 times
• Download rankings, all-time:
  • Site-wide: 16,207
  • In immunology: 584
• Year to date:
  • Site-wide: 29,594
• Since beginning of last month:
  • Site-wide: 47,694

Comparative analysis of coronavirus genomic RNA structure reveals conservation in SARS-like coronaviruses

• Downloaded 1,475 times
• Download rankings, all-time:
  • Site-wide: 18,734
  • In microbiology: 1,087
• Year to date:
  • Site-wide: 37,714
• Since beginning of last month:
  • Site-wide: 29,316

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

• Downloaded 1,204 times
• Download rankings, all-time:
  • Site-wide: 25,719
  • In immunology: 1,497
• Year to date:
  • Site-wide: 1,276
• Since beginning of last month:
  • Site-wide: 6,368

SARS-CoV-2 mRNA Vaccine Induces Robust Specific and Cross-reactive IgG and Unequal Strain-specific Neutralizing Antibodies in Naïve and Previously Infected Recipients

• Downloaded 1,113 times
• Download rankings, all-time:
  • Site-wide: 29,000
  • In immunology: 958
• Year to date:
  • Site-wide: 72,812
• Since beginning of last month:
  • Site-wide: 87,029

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

• Downloaded 1,106 times
• Download rankings, all-time:
  • Site-wide: 29,254
  • In immunology: None
• Year to date:
  • Site-wide: 1,442
• Since beginning of last month:
  • Site-wide: 3,162

Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

• Downloaded 1,084 times
• Download rankings, all-time:
  • Site-wide: 30,195
  • In immunology: 1,249
• Year to date:
  • Site-wide: 4,859
• Since beginning of last month:
  • Site-wide: 13,906

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

• Downloaded 1,016 times
• Download rankings, all-time:
  • Site-wide: 33,206
  • In microbiology: None
• Year to date:
  • Site-wide: 1,647
• Since beginning of last month:
  • Site-wide: 2,627

Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species

• Downloaded 1,012 times
• Download rankings, all-time:
  • Site-wide: 33,429
  • In microbiology: 2,139
• Year to date:
  • Site-wide: 28,251
• Since beginning of last month:
  • Site-wide: 26,653

Sex disparities and neutralizing antibody durability to SARS-CoV-2 infection in convalescent individuals

• Downloaded 849 times
• Download rankings, all-time:
  • Site-wide: 43,329
  • In allergy and immunology: 126
• Year to date:
  • Site-wide: 27,490
• Since beginning of last month:
  • Site-wide: 8,088

Infectious SARS-CoV-2 Virus in Symptomatic COVID-19 Outpatients: Host, Disease, and Viral Correlates

• Downloaded 844 times
• Download rankings, all-time:
  • Site-wide: 43,793
  • In infectious diseases: 3,456
• Year to date:
  • Site-wide: 30,884
• Since beginning of last month:
  • Site-wide: 40,787

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

• Downloaded 816 times
• Download rankings, all-time:
  • Site-wide: 45,941
  • In microbiology: 2,574
• Year to date:
  • Site-wide: 121,126
• Since beginning of last month:
  • Site-wide: 148,832

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 46,935
  • In pharmacology and toxicology: 270
• Year to date:
  • Site-wide: 75,546
• Since beginning of last month:
  • Site-wide: 64,139

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection

• Downloaded 763 times
• Download rankings, all-time:
  • Site-wide: 50,697
  • In immunology: 1,541
• Year to date:
  • Site-wide: 131,987
• Since beginning of last month:
  • Site-wide: 119,732

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

• Downloaded 726 times
• Download rankings, all-time:
  • Site-wide: 54,352
  • In microbiology: 4,873
• Year to date:
  • Site-wide: 2,814
• Since beginning of last month:
  • Site-wide: 22,364

Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

• Downloaded 641 times
• Download rankings, all-time:
  • Site-wide: 64,574
  • In microbiology: 4,382
• Year to date:
  • Site-wide: 44,162
• Since beginning of last month:
  • Site-wide: 32,830

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 69,008
  • In cell biology: 4,098
• Year to date:
  • Site-wide: 3,705
• Since beginning of last month:
  • Site-wide: 18,355

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 74,374
  • In microbiology: 4,590
• Year to date:
  • Site-wide: 97,939
• Since beginning of last month:
  • Site-wide: 77,049

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

• Downloaded 560 times
• Download rankings, all-time:
  • Site-wide: 76,541
  • In immunology: 3,236
• Year to date:
  • Site-wide: 4,205
• Since beginning of last month:
  • Site-wide: 20,060

Predicted Norovirus Resurgence in 2021-2022 Due to the Relaxation of Nonpharmaceutical Interventions Associated with COVID-19 Restrictions in England: A Mathematical Modelling Study

• Downloaded 547 times
• Download rankings, all-time:
  • Site-wide: 78,728
  • In epidemiology: 3,649
• Year to date:
  • Site-wide: 44,801
• Since beginning of last month:
  • Site-wide: 37,777

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

• Downloaded 504 times
• Download rankings, all-time:
  • Site-wide: 86,981
  • In immunology: 3,558
• Year to date:
  • Site-wide: 7,141
• Since beginning of last month:
  • Site-wide: 16,003

Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein

• Downloaded 484 times
• Download rankings, all-time:
  • Site-wide: 90,779
  • In microbiology: 6,401
• Year to date:
  • Site-wide: 52,459
• Since beginning of last month:
  • Site-wide: 55,623

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 97,640
  • In genetics: 3,687
• Year to date:
  • Site-wide: 151,302
• Since beginning of last month:
  • Site-wide: 154,179

Preadaptation of pandemic GII.4 noroviruses in hidden virus reservoirs years before emergence

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 109,578
  • In evolutionary biology: 4,995
• Year to date:
  • Site-wide: 159,491
• Since beginning of last month:
  • Site-wide: 129,428

Zika virus infection in Collaborative Cross mice

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 109,879
  • In microbiology: 7,079
• Year to date:
  • Site-wide: 167,681
• Since beginning of last month:
  • Site-wide: 116,830

Diallel analysis reveals Mx1-dependent and Mx1-independent effects on response to influenza A virus in mice

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 133,789
  • In genetics: 4,894
• Year to date:
  • Site-wide: 184,920
• Since beginning of last month:
  • Site-wide: 160,532

Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 142,358
  • In genetics: 5,585
• Year to date:
  • Site-wide: 64,976
• Since beginning of last month:
  • Site-wide: 49,578

STAT5: A Target of Antagonism by Neurotropic Flaviviruses

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 147,246
  • In microbiology: 9,900
• Year to date:
  • Site-wide: 178,272
• Since beginning of last month:
  • Site-wide: 187,686

Genetically Engineered DENV Produces Antigenically Distinct Mature Particles

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 153,059
  • In microbiology: 10,911
• Year to date:
  • Site-wide: 97,354
• Since beginning of last month:
  • Site-wide: 109,967

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding

• Downloaded 213 times
• Download rankings, all-time:
  • Site-wide: 163,462
  • In microbiology: 12,480
• Year to date:
  • Site-wide: 37,981
• Since beginning of last month:
  • Site-wide: 60,584

Defining levels of dengue virus serotype-specific neutralizing antibodies induced by a live attenuated tetravalent dengue vaccine (TAK-003)

• Downloaded 196 times
• Download rankings, all-time:
  • Site-wide: 167,907
  • In immunology: 4,910
• Year to date:
  • Site-wide: 150,522
• Since beginning of last month:
  • Site-wide: 101,732

Outcomes of convalescent plasma with defined high- versus lower-neutralizing antibody titers against SARS-CoV-2 among hospitalized patients: CoronaVirus Inactivating Plasma (CoVIP), double-blind phase 2 study.

• Downloaded 188 times
• Download rankings, all-time:
  • Site-wide: 169,781
  • In infectious diseases: None
• Year to date:
  • Site-wide: 21,580
• Since beginning of last month:
  • Site-wide: 3,020