Author: Yan Wu

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Preprints

Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension

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  • Site-wide: 1,692
  • In pathology: 15
• Year to date:
  • Site-wide: 7,491
• Since beginning of last month:
  • Site-wide: 18,866

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

• Downloaded 5,267 times
• Download rankings, all-time:
  • Site-wide: 2,123
  • In microbiology: 173
• Year to date:
  • Site-wide: 12,311
• Since beginning of last month:
  • Site-wide: 17,372

Visualizing and interpreting single-cell gene expression datasets with Similarity Weighted Nonnegative Embedding

• Downloaded 4,591 times
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  • Site-wide: 2,575
  • In bioinformatics: 214
• Year to date:
  • Site-wide: 27,192
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  • Site-wide: 28,833

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

• Downloaded 4,349 times
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  • Site-wide: 2,779
  • In molecular biology: 56
• Year to date:
  • Site-wide: 3,452
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  • Site-wide: 5,219

A non-competing pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

• Downloaded 3,046 times
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  • Site-wide: 4,615
  • In infectious diseases: 847
• Year to date:
  • Site-wide: 28,919
• Since beginning of last month:
  • Site-wide: 30,766

Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro

• Downloaded 2,100 times
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  • Site-wide: 7,942
  • In pharmacology and toxicology: 44
• Year to date:
  • Site-wide: 25,446
• Since beginning of last month:
  • Site-wide: 39,086

Cryo-EM Structure of the Human Mitochondrial Translocase TIM22 Complex

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  • Site-wide: 11,707
  • In biophysics: 255
• Year to date:
  • Site-wide: 78,082
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  • Site-wide: 89,104

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur

• Downloaded 1,594 times
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  • Site-wide: 11,937
  • In biochemistry: 235
• Year to date:
  • Site-wide: 33,327
• Since beginning of last month:
  • Site-wide: 21,349

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

• Downloaded 906 times
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  • Site-wide: 27,441
  • In microbiology: 1,625
• Year to date:
  • Site-wide: 27,316
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  • Site-wide: 26,137

Transmission dynamics of SARS-COV-2 in China: impact of public health interventions

• Downloaded 856 times
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  • Site-wide: 29,770
  • In epidemiology: 1,588
• Year to date:
  • Site-wide: 86,054
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  • Site-wide: 52,200

A Polybasic Domain in aPKC Mediates Par-6-Dependent Control of Plasma Membrane Targeting and Kinase Activity

• Downloaded 779 times
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  • Site-wide: 33,873
  • In cell biology: 1,310
• Year to date:
  • Site-wide: 82,074
• Since beginning of last month:
  • Site-wide: 112,879

Modular Thermal Control of Protein Dimerization

• Downloaded 584 times
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  • Site-wide: 49,465
  • In synthetic biology: 606
• Year to date:
  • Site-wide: 94,939
• Since beginning of last month:
  • Site-wide: 125,792

Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells

• Downloaded 528 times
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  • Site-wide: 55,974
  • In genetics: 2,499
• Year to date:
  • Site-wide: 105,202
• Since beginning of last month:
  • Site-wide: 113,026

An rpw8 quadruple mutant of Arabidopsis Col-0 is partially compromised in bacterial and fungal resistance

• Downloaded 505 times
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  • Site-wide: 58,990
  • In plant biology: 1,440
• Year to date:
  • Site-wide: 79,272
• Since beginning of last month:
  • Site-wide: 82,424

Revealing the transcription factor regulatory context of human specific cortical development using single-cell multi-omics

• Downloaded 463 times
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  • Site-wide: 64,716
  • In genomics: 4,629
• Year to date:
  • Site-wide: 8,496
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  • Site-wide: 32,952

Identification and exploration of 2'-O-methylation sites in rRNA and mRNA with a novel RNase based platform

• Downloaded 450 times
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  • Site-wide: 66,788
  • In biochemistry: 1,797
• Year to date:
  • Site-wide: 45,102
• Since beginning of last month:
  • Site-wide: 46,673

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

• Downloaded 424 times
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  • Site-wide: 71,085
  • In pharmacology and toxicology: 453
• Year to date:
  • Site-wide: 100,595
• Since beginning of last month:
  • Site-wide: 114,359

Structural insight into the mechanism of neuraminidase inhibitor-resistant mutations in human-infecting H10N8 Influenza A virus

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 83,867
  • In microbiology: 5,787
• Year to date:
  • Site-wide: 112,042
• Since beginning of last month:
  • Site-wide: 72,923

Loss of ASH1L in developing brains causes autistic-like behaviors in a mouse model

• Downloaded 304 times
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  • Site-wide: 94,662
  • In neuroscience: 14,344
• Year to date:
  • Site-wide: 36,631
• Since beginning of last month:
  • Site-wide: 83,655

Loss of O-GlcNAcylation on MeCP2 Thr 203 Leads to Neurodevelopmental Disorders

• Downloaded 298 times
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  • Site-wide: 95,914
  • In neuroscience: 14,553
• Year to date:
  • Site-wide: 52,550
• Since beginning of last month:
  • Site-wide: 70,519

Co-Expression Network-based Analysis associated with potato initial resistance

• Downloaded 268 times
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  • Site-wide: 102,718
  • In plant biology: 2,767
• Year to date:
  • Site-wide: 133,014
• Since beginning of last month:
  • Site-wide: 103,001

Optimization of Spectral Library Size Improves DIA-MS Proteome Coverage

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 103,260
  • In bioinformatics: 8,807
• Year to date:
  • Site-wide: 47,916
• Since beginning of last month:
  • Site-wide: 48,881

Investigation of novel functions of three genes in oriental river prawn, Macrobrachium nipponense: Molecular Cloning, Expression, and In situ Hybridization Analysis

• Downloaded 243 times
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  • Site-wide: 108,876
  • In zoology: 455
• Year to date:
  • Site-wide: 146,248
• Since beginning of last month:
  • Site-wide: 126,851

Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas

• Downloaded 212 times
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  • Site-wide: 116,503
  • In systems biology: 2,585
• Year to date:
  • Site-wide: 25,069
• Since beginning of last month:
  • Site-wide: 73,293

An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

• Downloaded 161 times
• Download rankings, all-time:
  • Site-wide: 128,445
  • In pharmacology and toxicology: 1,049
• Year to date:
  • Site-wide: 144,885
• Since beginning of last month:
  • Site-wide: 122,371

New insight into bacterial iron competition: A-to-I editing in ferric enterobactin uptake

• Downloaded 134 times
• Download rankings, all-time:
  • Site-wide: 134,416
  • In microbiology: 10,211
• Year to date:
  • Site-wide: 77,427
• Since beginning of last month:
  • Site-wide: 95,211

BMSCs differentiated into neurons, astrocytes and oligodendrocytesalleviatedthe inflammation and demyelination of EAE mice models

• Downloaded 94 times
• Download rankings, all-time:
  • Site-wide: 142,208
  • In neuroscience: 21,399
• Year to date:
  • Site-wide: 102,258
• Since beginning of last month:
  • Site-wide: 124,212