Author: Yan Wu

Downloads per author, site-wide

Preprints

Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension

• Downloaded 6,598 times
• Download rankings, all-time:
  • Site-wide: 2,181
  • In pathology: 19
• Year to date:
  • Site-wide: 24,761
• Since beginning of last month:
  • Site-wide: 34,646

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

• Downloaded 5,615 times
• Download rankings, all-time:
  • Site-wide: 2,706
  • In microbiology: 207
• Year to date:
  • Site-wide: 22,594
• Since beginning of last month:
  • Site-wide: 24,317

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

• Downloaded 5,327 times
• Download rankings, all-time:
  • Site-wide: 2,920
  • In molecular biology: 54
• Year to date:
  • Site-wide: 6,566
• Since beginning of last month:
  • Site-wide: 8,177

Visualizing and interpreting single-cell gene expression datasets with Similarity Weighted Nonnegative Embedding

• Downloaded 4,740 times
• Download rankings, all-time:
  • Site-wide: 3,403
  • In bioinformatics: 241
• Year to date:
  • Site-wide: 69,587
• Since beginning of last month:
  • Site-wide: 94,097

An atlas of healthy and injured cell states and niches in the human kidney

• Downloaded 3,271 times
• Download rankings, all-time:
  • Site-wide: 5,753
  • In genomics: 844
• Year to date:
  • Site-wide: 1,189
• Since beginning of last month:
  • Site-wide: 996

A non-competing pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

• Downloaded 3,263 times
• Download rankings, all-time:
  • Site-wide: 5,772
  • In infectious diseases: 1,083
• Year to date:
  • Site-wide: 62,977
• Since beginning of last month:
  • Site-wide: 65,965

Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro

• Downloaded 2,238 times
• Download rankings, all-time:
  • Site-wide: 9,987
  • In pharmacology and toxicology: 54
• Year to date:
  • Site-wide: 103,407
• Since beginning of last month:
  • Site-wide: 103,405

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur

• Downloaded 1,786 times
• Download rankings, all-time:
  • Site-wide: 14,011
  • In biochemistry: 271
• Year to date:
  • Site-wide: 78,295
• Since beginning of last month:
  • Site-wide: 70,880

Cryo-EM Structure of the Human Mitochondrial Translocase TIM22 Complex

• Downloaded 1,707 times
• Download rankings, all-time:
  • Site-wide: 14,984
  • In biophysics: 319
• Year to date:
  • Site-wide: 122,710
• Since beginning of last month:
  • Site-wide: 121,054

Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates

• Downloaded 1,090 times
• Download rankings, all-time:
  • Site-wide: 29,898
  • In microbiology: None
• Year to date:
  • Site-wide: 1,475
• Since beginning of last month:
  • Site-wide: 1,391

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

• Downloaded 1,041 times
• Download rankings, all-time:
  • Site-wide: 32,008
  • In microbiology: 1,762
• Year to date:
  • Site-wide: 106,711
• Since beginning of last month:
  • Site-wide: 96,558

Transmission dynamics of SARS-COV-2 in China: impact of public health interventions

• Downloaded 951 times
• Download rankings, all-time:
  • Site-wide: 36,667
  • In epidemiology: 1,865
• Year to date:
  • Site-wide: 145,284
• Since beginning of last month:
  • Site-wide: 138,110

A Polybasic Domain in aPKC Mediates Par-6-Dependent Control of Plasma Membrane Targeting and Kinase Activity

• Downloaded 842 times
• Download rankings, all-time:
  • Site-wide: 43,911
  • In cell biology: 1,607
• Year to date:
  • Site-wide: 121,571
• Since beginning of last month:
  • Site-wide: 144,771

Revealing the transcription factor regulatory context of human specific cortical development using single-cell multi-omics

• Downloaded 784 times
• Download rankings, all-time:
  • Site-wide: 48,717
  • In genomics: 4,012
• Year to date:
  • Site-wide: 31,728
• Since beginning of last month:
  • Site-wide: 13,807

A novel platform of RNA 2-O-methylation high-throughput and site-specific quantification tools revealed its broad distribution

• Downloaded 742 times
• Download rankings, all-time:
  • Site-wide: 52,777
  • In biochemistry: 1,910
• Year to date:
  • Site-wide: 19,821
• Since beginning of last month:
  • Site-wide: 15,179

An rpw8 quadruple mutant of Arabidopsis Col-0 is partially compromised in bacterial and fungal resistance

• Downloaded 660 times
• Download rankings, all-time:
  • Site-wide: 62,092
  • In plant biology: 1,426
• Year to date:
  • Site-wide: 62,986
• Since beginning of last month:
  • Site-wide: 57,244

Modular Thermal Control of Protein Dimerization

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 65,628
  • In synthetic biology: 742
• Year to date:
  • Site-wide: 156,895
• Since beginning of last month:
  • Site-wide: 145,467

Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells

• Downloaded 628 times
• Download rankings, all-time:
  • Site-wide: 66,265
  • In genetics: 2,635
• Year to date:
  • Site-wide: 104,859
• Since beginning of last month:
  • Site-wide: 93,431

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

• Downloaded 621 times
• Download rankings, all-time:
  • Site-wide: 67,291
  • In immunology: 2,477
• Year to date:
  • Site-wide: 26,100
• Since beginning of last month:
  • Site-wide: 8,283

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 92,274
  • In pharmacology and toxicology: 557
• Year to date:
  • Site-wide: 176,589
• Since beginning of last month:
  • Site-wide: 158,585

Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 98,210
  • In systems biology: 2,193
• Year to date:
  • Site-wide: 68,932
• Since beginning of last month:
  • Site-wide: 22,807

Structural insight into the mechanism of neuraminidase inhibitor-resistant mutations in human-infecting H10N8 Influenza A virus

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 99,341
  • In microbiology: 6,249
• Year to date:
  • Site-wide: 137,988
• Since beginning of last month:
  • Site-wide: 104,687

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 100,642
  • In immunology: None
• Year to date:
  • Site-wide: 6,023
• Since beginning of last month:
  • Site-wide: 2,771

Optimization of Spectral Library Size Improves DIA-MS Proteome Coverage

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 104,580
  • In bioinformatics: 8,800
• Year to date:
  • Site-wide: 85,266
• Since beginning of last month:
  • Site-wide: 84,890

Loss of ASH1L in developing brains causes autistic-like behaviors in a mouse model

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 104,615
  • In neuroscience: 14,940
• Year to date:
  • Site-wide: 123,365
• Since beginning of last month:
  • Site-wide: 153,683

Loss of O-GlcNAcylation on MeCP2 Thr 203 Leads to Neurodevelopmental Disorders

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 109,079
  • In neuroscience: 15,146
• Year to date:
  • Site-wide: 115,340
• Since beginning of last month:
  • Site-wide: 152,112

Co-Expression Network-based Analysis associated with potato initial resistance

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 117,895
  • In plant biology: 3,141
• Year to date:
  • Site-wide: 93,998
• Since beginning of last month:
  • Site-wide: 67,103

Investigation of novel functions of three genes in oriental river prawn, Macrobrachium nipponense: Molecular Cloning, Expression, and In situ Hybridization Analysis

• Downloaded 314 times
• Download rankings, all-time:
  • Site-wide: 134,050
  • In zoology: 497
• Year to date:
  • Site-wide: 147,899
• Since beginning of last month:
  • Site-wide: 162,576

A-to-I mRNA editing in a ferric siderophore receptor improves competition for iron in Xanthomonas oryzae

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 135,325
  • In microbiology: 9,627
• Year to date:
  • Site-wide: 97,539
• Since beginning of last month:
  • Site-wide: 75,477

Structure selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 138,503
  • In immunology: 4,066
• Year to date:
  • Site-wide: 80,535
• Since beginning of last month:
  • Site-wide: 90,399

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 144,739
  • In pharmacology and toxicology: 1,201
• Year to date:
  • Site-wide: 12,094
• Since beginning of last month:
  • Site-wide: 47,996

Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 153,639
  • In immunology: None
• Year to date:
  • Site-wide: 14,343
• Since beginning of last month:
  • Site-wide: 38,068

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

• Downloaded 244 times
• Download rankings, all-time:
  • Site-wide: 154,877
  • In immunology: 4,823
• Year to date:
  • Site-wide: 50,703
• Since beginning of last month:
  • Site-wide: 50,216

Rice LEAFY COTYLEDON1 hinders photosynthesis in the embryo development to promote seed dormancy

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 164,591
  • In plant biology: 4,486
• Year to date:
  • Site-wide: 62,788
• Since beginning of last month:
  • Site-wide: 65,096

An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

• Downloaded 206 times
• Download rankings, all-time:
  • Site-wide: 165,183
  • In pharmacology and toxicology: 1,290
• Year to date:
  • Site-wide: 166,265
• Since beginning of last month:
  • Site-wide: 147,183

BMSCs differentiated into neurons, astrocytes and oligodendrocytesalleviatedthe inflammation and demyelination of EAE mice models

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 172,940
  • In neuroscience: 24,177
• Year to date:
  • Site-wide: 135,964
• Since beginning of last month:
  • Site-wide: 182,639

Histone H3K36me2-specific methyltransferase ASH1L is required for the MLL-AF9-induced leukemogenesis

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 176,640
  • In cancer biology: 5,193
• Year to date:
  • Site-wide: 102,609
• Since beginning of last month:
  • Site-wide: 133,392