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Author: Michael V Holmes

Rankings

  • All-time downloads: 28,269 (rank: 7,751 )
  • Categories:
    • cardiovascular medicine: 1,912 (rank: 240 )
    • endocrinology: 257 (rank: 1,304 (tie) )
    • epidemiology: 10,044 (rank: 1,767 )
    • genetic and genomic medicine: 1,177 (rank: 3,819 (tie) )
    • genetics: 12,468 (rank: 1,319 )
    • genomics: 966 (rank: 26,616 (tie) )
    • infectious diseases: 566 (rank: 39,493 (tie) )
    • pharmacology and therapeutics: 565 (rank: 684 (tie) )
    • rheumatology: 314 (rank: 1,143 (tie) )

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Preprints

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
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    • Site-wide: 3,470
    • In genetics: 108
  • Year to date:
    • Site-wide: 14,605
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    • Site-wide: 54,574

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

genetics more details view paper
  • Downloaded 2,702 times
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    • Site-wide: 6,406
    • In genetics: 258
  • Year to date:
    • Site-wide: 10,240
  • Since beginning of last month:
    • Site-wide: 14,736

Cannabis use and risk of schizophrenia: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 2,524 times
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    • Site-wide: 7,112
    • In epidemiology: 601
  • Year to date:
    • Site-wide: 66,771
  • Since beginning of last month:
    • Site-wide: 63,436

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

genetics more details view paper
  • Downloaded 1,557 times
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    • Site-wide: 14,550
    • In genetics: 637
  • Year to date:
    • Site-wide: 106,175
  • Since beginning of last month:
    • Site-wide: 90,081

Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

genetics more details view paper
  • Downloaded 1,339 times
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    • Site-wide: 18,394
    • In genetics: 821
  • Year to date:
    • Site-wide: 76,460
  • Since beginning of last month:
    • Site-wide: 94,338

Causal relationships between obesity and the leading causes of death in women and men

epidemiology more details view paper
  • Downloaded 1,050 times
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    • Site-wide: 26,657
    • In epidemiology: 1,553
  • Year to date:
    • Site-wide: 111,637
  • Since beginning of last month:
    • Site-wide: 129,432

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

cardiovascular medicine more details view paper
  • Downloaded 995 times
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    • Site-wide: 28,816
    • In cardiovascular medicine: 46
  • Year to date:
    • Site-wide: 98,574
  • Since beginning of last month:
    • Site-wide: 130,951

GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

genomics more details view paper
  • Downloaded 966 times
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    • Site-wide: 30,114
    • In genomics: 2,587
  • Year to date:
    • Site-wide: 141,847
  • Since beginning of last month:
    • Site-wide: 129,977

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

epidemiology more details view paper
  • Downloaded 713 times
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    • Site-wide: 46,662
    • In epidemiology: 2,307
  • Year to date:
    • Site-wide: 138,333
  • Since beginning of last month:
    • Site-wide: 114,758

Education and coronary heart disease: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 673 times
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    • Site-wide: 50,523
    • In epidemiology: 2,447
  • Year to date:
    • Site-wide: 160,081
  • Since beginning of last month:
    • Site-wide: 161,758

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

genetics more details view paper
  • Downloaded 640 times
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    • Site-wide: 54,116
    • In genetics: 2,303
  • Year to date:
    • Site-wide: 98,740
  • Since beginning of last month:
    • Site-wide: 138,557

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

epidemiology more details view paper
  • Downloaded 617 times
  • Download rankings, all-time:
    • Site-wide: 56,757
    • In epidemiology: 2,654
  • Year to date:
    • Site-wide: 144,975
  • Since beginning of last month:
    • Site-wide: 123,800

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

genetics more details view paper
  • Downloaded 614 times
  • Download rankings, all-time:
    • Site-wide: 57,154
    • In genetics: 2,417
  • Year to date:
    • Site-wide: 137,992
  • Since beginning of last month:
    • Site-wide: 158,034

Genetic inhibition of interleukin-6 receptor signaling and Covid-19

infectious diseases more details view paper
  • Downloaded 566 times
  • Download rankings, all-time:
    • Site-wide: 63,274
    • In infectious diseases: 3,717
  • Year to date:
    • Site-wide: 98,246
  • Since beginning of last month:
    • Site-wide: 69,170

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

pharmacology and therapeutics more details view paper
  • Downloaded 565 times
  • Download rankings, all-time:
    • Site-wide: 63,352
    • In pharmacology and therapeutics: 75
  • Year to date:
    • Site-wide: 13,317
  • Since beginning of last month:
    • Site-wide: 56,020

Colocalization highlights genes in hypothalamic–pituitary–gonadal axis as potentially mediating polycystic ovary syndrome risk

genetics more details view paper
  • Downloaded 560 times
  • Download rankings, all-time:
    • Site-wide: 64,097
    • In genetics: 2,706
  • Year to date:
    • Site-wide: 72,236
  • Since beginning of last month:
    • Site-wide: 71,673

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

epidemiology more details view paper
  • Downloaded 550 times
  • Download rankings, all-time:
    • Site-wide: 65,515
    • In epidemiology: 2,959
  • Year to date:
    • Site-wide: 149,776
  • Since beginning of last month:
    • Site-wide: 129,680

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

epidemiology more details view paper
  • Downloaded 543 times
  • Download rankings, all-time:
    • Site-wide: 66,552
    • In epidemiology: 2,998
  • Year to date:
    • Site-wide: 93,043
  • Since beginning of last month:
    • Site-wide: 85,433

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

genetics more details view paper
  • Downloaded 520 times
  • Download rankings, all-time:
    • Site-wide: 70,020
    • In genetics: 2,963
  • Year to date:
    • Site-wide: 94,025
  • Since beginning of last month:
    • Site-wide: 99,707

Direct estimation of HDL-mediated cholesterol efflux capacity from serum

epidemiology more details view paper
  • Downloaded 503 times
  • Download rankings, all-time:
    • Site-wide: 72,760
    • In epidemiology: 3,232
  • Year to date:
    • Site-wide: 154,676
  • Since beginning of last month:
    • Site-wide: 155,837

An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkers

genetic and genomic medicine more details view paper
  • Downloaded 493 times
  • Download rankings, all-time:
    • Site-wide: 74,421
    • In genetic and genomic medicine: 365
  • Year to date:
    • Site-wide: 16,419
  • Since beginning of last month:
    • Site-wide: 1,214

Assessing the efficacy and safety of angiotensinogen inhibition using human genetics

cardiovascular medicine more details view paper
  • Downloaded 492 times
  • Download rankings, all-time:
    • Site-wide: 74,611
    • In cardiovascular medicine: 143
  • Year to date:
    • Site-wide: 45,350
  • Since beginning of last month:
    • Site-wide: 60,932

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

epidemiology more details view paper
  • Downloaded 475 times
  • Download rankings, all-time:
    • Site-wide: 77,567
    • In epidemiology: 3,403
  • Year to date:
    • Site-wide: 64,151
  • Since beginning of last month:
    • Site-wide: 133,974

Metabolic biomarkers for peripheral artery disease compared with coronary artery disease: Lipoprotein and metabolite profiling of 31,657 individuals from five prospective cohorts

epidemiology more details view paper
  • Downloaded 467 times
  • Download rankings, all-time:
    • Site-wide: 79,033
    • In epidemiology: 3,465
  • Year to date:
    • Site-wide: 42,105
  • Since beginning of last month:
    • Site-wide: 34,046

Body mass index and heart failure risk: a cohort study in 1.5 million individuals and Mendelian randomisation analysis

cardiovascular medicine more details view paper
  • Downloaded 425 times
  • Download rankings, all-time:
    • Site-wide: 87,351
    • In cardiovascular medicine: 185
  • Year to date:
    • Site-wide: 73,216
  • Since beginning of last month:
    • Site-wide: 61,174

The role of obesity in female reproductive conditions: A Mendelian Randomisation Study

genetic and genomic medicine more details view paper
  • Downloaded 412 times
  • Download rankings, all-time:
    • Site-wide: 89,817
    • In genetic and genomic medicine: 457
  • Year to date:
    • Site-wide: 21,729
  • Since beginning of last month:
    • Site-wide: 24,864

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

genetics more details view paper
  • Downloaded 397 times
  • Download rankings, all-time:
    • Site-wide: 93,138
    • In genetics: 3,870
  • Year to date:
    • Site-wide: 156,163
  • Since beginning of last month:
    • Site-wide: 158,636

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

epidemiology more details view paper
  • Downloaded 372 times
  • Download rankings, all-time:
    • Site-wide: 98,985
    • In epidemiology: 4,216
  • Year to date:
    • Site-wide: 147,291
  • Since beginning of last month:
    • Site-wide: 120,182

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

epidemiology more details view paper
  • Downloaded 372 times
  • Download rankings, all-time:
    • Site-wide: 98,914
    • In epidemiology: 4,214
  • Year to date:
    • Site-wide: 52,731
  • Since beginning of last month:
    • Site-wide: 116,805

Dominant role of abdominal adiposity in circulating lipoprotein, lipid, and metabolite levels in UK Biobank: Mendelian randomization study

epidemiology more details view paper
  • Downloaded 342 times
  • Download rankings, all-time:
    • Site-wide: 106,059
    • In epidemiology: 4,506
  • Year to date:
    • Site-wide: 28,747
  • Since beginning of last month:
    • Site-wide: 42,074

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

epidemiology more details view paper
  • Downloaded 331 times
  • Download rankings, all-time:
    • Site-wide: 108,730
    • In epidemiology: 4,613
  • Year to date:
    • Site-wide: 73,383
  • Since beginning of last month:
    • Site-wide: 91,554

The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: mendelian randomization study

rheumatology more details view paper
  • Downloaded 314 times
  • Download rankings, all-time:
    • Site-wide: 113,257
    • In rheumatology: 111
  • Year to date:
    • Site-wide: 32,467
  • Since beginning of last month:
    • Site-wide: 70,589

Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomization

genetic and genomic medicine more details view paper
  • Downloaded 272 times
  • Download rankings, all-time:
    • Site-wide: 124,331
    • In genetic and genomic medicine: 718
  • Year to date:
    • Site-wide: 39,544
  • Since beginning of last month:
    • Site-wide: 29,219

Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200,000 men in UK Biobank

epidemiology more details view paper
  • Downloaded 267 times
  • Download rankings, all-time:
    • Site-wide: 125,467
    • In epidemiology: 5,293
  • Year to date:
    • Site-wide: 130,511
  • Since beginning of last month:
    • Site-wide: 142,866

Obesity as a cause of kidney disease - insights from Mendelian randomisation studies

endocrinology more details view paper
  • Downloaded 257 times
  • Download rankings, all-time:
    • Site-wide: 128,220
    • In endocrinology: 132
  • Year to date:
    • Site-wide: 75,581
  • Since beginning of last month:
    • Site-wide: 82,306

Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

epidemiology more details view paper
  • Downloaded 245 times
  • Download rankings, all-time:
    • Site-wide: 131,216
    • In epidemiology: 5,497
  • Year to date:
    • Site-wide: 99,623
  • Since beginning of last month:
    • Site-wide: 72,641

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