Author: Paul M Ridker

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Preprints

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,073 times
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  • Site-wide: 3,750
  • In genetics: 166
• Year to date:
  • Site-wide: 36,147
• Since beginning of last month:
  • Site-wide: 37,530

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,502 times
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  • Site-wide: 5,040
  • In genetics: 232
• Year to date:
  • Site-wide: 72,032
• Since beginning of last month:
  • Site-wide: 74,314

Efficient Bayesian mixed model analysis increases association power in large cohorts

• Downloaded 2,263 times
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  • Site-wide: 5,846
  • In genetics: 282
• Year to date:
  • Site-wide: 59,584
• Since beginning of last month:
  • Site-wide: 74,262

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,826 times
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  • Site-wide: 7,982
  • In genetics: 387
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,637 times
• Download rankings, all-time:
  • Site-wide: 9,471
  • In genetics: 467
• Year to date:
  • Site-wide: 79,816
• Since beginning of last month:
  • Site-wide: 81,654

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,466 times
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  • Site-wide: 11,093
  • In genetics: 549
• Year to date:
  • Site-wide: 62,826
• Since beginning of last month:
  • Site-wide: 62,852

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,240 times
• Download rankings, all-time:
  • Site-wide: 14,299
  • In genomics: 1,516
• Year to date:
  • Site-wide: 58,774
• Since beginning of last month:
  • Site-wide: 50,516

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 814 times
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  • Site-wide: 26,437
  • In genetics: 1,315
• Year to date:
  • Site-wide: 47,462
• Since beginning of last month:
  • Site-wide: 61,543

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 798 times
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  • Site-wide: 27,152
  • In genetics: 1,351
• Year to date:
  • Site-wide: 26,919
• Since beginning of last month:
  • Site-wide: 49,485

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 747 times
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  • Site-wide: 29,839
  • In genomics: 2,729
• Year to date:
  • Site-wide: 70,929
• Since beginning of last month:
  • Site-wide: 62,897

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
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  • Site-wide: 31,917
  • In genetics: 1,591
• Year to date:
  • Site-wide: 15,571
• Since beginning of last month:
  • Site-wide: 12,392

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 41,033
  • In epidemiology: 1,938
• Year to date:
  • Site-wide: 50,499
• Since beginning of last month:
  • Site-wide: 39,671

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 561 times
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  • Site-wide: 43,371
  • In genetics: 2,091
• Year to date:
  • Site-wide: 62,021
• Since beginning of last month:
  • Site-wide: None

A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians

• Downloaded 522 times
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  • Site-wide: 47,327
  • In genetics: 2,258
• Year to date:
  • Site-wide: 69,804
• Since beginning of last month:
  • Site-wide: 37,541

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 53,356
  • In sexual and reproductive health: 20
• Year to date:
  • Site-wide: 1,431
• Since beginning of last month:
  • Site-wide: 1,725

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

• Downloaded 355 times
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  • Site-wide: 70,536
  • In genetics: 3,287
• Year to date:
  • Site-wide: 45,033
• Since beginning of last month:
  • Site-wide: 44,613

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

• Downloaded 290 times
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  • Site-wide: 82,758
  • In epidemiology: 3,381
• Year to date:
  • Site-wide: 67,021
• Since beginning of last month:
  • Site-wide: 54,205

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 88,150
  • In genetics: 4,052
• Year to date:
  • Site-wide: 109,493
• Since beginning of last month:
  • Site-wide: 82,881

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 91,140
  • In genetic and genomic medicine: 318
• Year to date:
  • Site-wide: 3,469
• Since beginning of last month:
  • Site-wide: 6,387