Author: Paul M Ridker

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Preprints

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,831
  • In genetics: 181
• Year to date:
  • Site-wide: 43,683
• Since beginning of last month:
  • Site-wide: 63,239

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 7,018
  • In genetics: 287
• Year to date:
  • Site-wide: 148,965
• Since beginning of last month:
  • Site-wide: 160,470

Efficient Bayesian mixed model analysis increases association power in large cohorts

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  • Site-wide: 7,962
  • In genetics: 336
• Year to date:
  • Site-wide: 120,544
• Since beginning of last month:
  • Site-wide: 136,734

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 8,695
  • In sexual and reproductive health: 12
• Year to date:
  • Site-wide: 1,749
• Since beginning of last month:
  • Site-wide: 2,820

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 10,737
  • In genetics: 455
• Year to date:
  • Site-wide: 131,789
• Since beginning of last month:
  • Site-wide: 158,990

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 11,958
  • In genetics: 509
• Year to date:
  • Site-wide: 79,631
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  • Site-wide: 132,578

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,557 times
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  • Site-wide: 14,550
  • In genetics: 637
• Year to date:
  • Site-wide: 106,175
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  • Site-wide: 90,081

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,322 times
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  • Site-wide: 18,760
  • In genomics: 1,759
• Year to date:
  • Site-wide: 111,643
• Since beginning of last month:
  • Site-wide: 115,020

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 21,885
  • In genetics: 956
• Year to date:
  • Site-wide: 13,348
• Since beginning of last month:
  • Site-wide: 80,528

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,554
  • In genetics: 1,121
• Year to date:
  • Site-wide: 30,207
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  • Site-wide: 65,273

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 34,122
  • In genetics: 1,492
• Year to date:
  • Site-wide: 114,165
• Since beginning of last month:
  • Site-wide: 141,899

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

• Downloaded 826 times
• Download rankings, all-time:
  • Site-wide: 37,834
  • In genetic and genomic medicine: 176
• Year to date:
  • Site-wide: 7,324
• Since beginning of last month:
  • Site-wide: 9,508

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 39,600
  • In genomics: 3,195
• Year to date:
  • Site-wide: 140,586
• Since beginning of last month:
  • Site-wide: 146,740

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries

• Downloaded 777 times
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  • Site-wide: 41,270
  • In epidemiology: 2,089
• Year to date:
  • Site-wide: 53,024
• Since beginning of last month:
  • Site-wide: 56,647

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

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  • Site-wide: 57,154
  • In genetics: 2,417
• Year to date:
  • Site-wide: 137,992
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  • Site-wide: 158,034

A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians

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  • Site-wide: 65,956
  • In genetics: 2,796
• Year to date:
  • Site-wide: 159,453
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  • Site-wide: 164,968

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

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  • Site-wide: 86,233
  • In genetics: 3,610
• Year to date:
  • Site-wide: 111,846
• Since beginning of last month:
  • Site-wide: 123,255

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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  • Site-wide: 105,481
  • In epidemiology: 4,473
• Year to date:
  • Site-wide: 139,227
• Since beginning of last month:
  • Site-wide: 148,801

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 314 times
• Download rankings, all-time:
  • Site-wide: 113,037
  • In genetics: 4,633
• Year to date:
  • Site-wide: 150,900
• Since beginning of last month:
  • Site-wide: 122,931