Author: David M Evans

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Preprints

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,532 times
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  • Site-wide: 1,825
  • In bioinformatics: 93
• Year to date:
  • Site-wide: 62,182
• Since beginning of last month:
  • Site-wide: 77,022

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

• Downloaded 4,307 times
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  • Site-wide: 3,863
  • In epidemiology: 394
• Year to date:
  • Site-wide: 55,823
• Since beginning of last month:
  • Site-wide: 49,316

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 3,312 times
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  • Site-wide: 5,655
  • In genetics: 242
• Year to date:
  • Site-wide: 2,716
• Since beginning of last month:
  • Site-wide: 3,170

Collider Scope: When selection bias can substantially influence observed associations

• Downloaded 2,978 times
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  • Site-wide: 6,601
  • In epidemiology: 573
• Year to date:
  • Site-wide: 54,826
• Since beginning of last month:
  • Site-wide: 58,761

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,893 times
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  • Site-wide: 6,876
  • In genetics: 250
• Year to date:
  • Site-wide: 47,869
• Since beginning of last month:
  • Site-wide: 64,787

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,471 times
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  • Site-wide: 8,668
  • In genetics: 340
• Year to date:
  • Site-wide: 50,441
• Since beginning of last month:
  • Site-wide: 62,291

An Atlas of Human and Murine Genetic Influences on Osteoporosis

• Downloaded 1,827 times
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  • Site-wide: 13,569
  • In genomics: 1,253
• Year to date:
  • Site-wide: 68,210
• Since beginning of last month:
  • Site-wide: 58,323

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,726 times
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  • Site-wide: 14,777
  • In genetics: 576
• Year to date:
  • Site-wide: 147,625
• Since beginning of last month:
  • Site-wide: 157,772

Machine Learning to Predict Osteoporotic Fracture Risk from Genotypes

• Downloaded 1,677 times
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  • Site-wide: 15,432
  • In genomics: 1,374
• Year to date:
  • Site-wide: 88,395
• Since beginning of last month:
  • Site-wide: 77,405

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,488 times
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  • Site-wide: 18,517
  • In genetics: 739
• Year to date:
  • Site-wide: 158,748
• Since beginning of last month:
  • Site-wide: 113,465

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

• Downloaded 1,289 times
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  • Site-wide: 23,178
  • In genetics: 916
• Year to date:
  • Site-wide: 140,595
• Since beginning of last month:
  • Site-wide: 152,826

Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

• Downloaded 1,257 times
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  • Site-wide: 24,098
  • In genetics: 964
• Year to date:
  • Site-wide: 105,608
• Since beginning of last month:
  • Site-wide: 101,351

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 1,053 times
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  • Site-wide: 31,554
  • In genomics: 2,529
• Year to date:
  • Site-wide: 144,383
• Since beginning of last month:
  • Site-wide: 137,339

Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs

• Downloaded 1,015 times
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  • Site-wide: 33,361
  • In genetics: 1,341
• Year to date:
  • Site-wide: 124,129
• Since beginning of last month:
  • Site-wide: 116,467

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 883 times
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  • Site-wide: 40,953
  • In genetics: 1,613
• Year to date:
  • Site-wide: 157,878
• Since beginning of last month:
  • Site-wide: 135,293

Using Structural Equation Modeling to Jointly Estimate Maternal and Foetal Effects on Birthweight in the UK Biobank

• Downloaded 586 times
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  • Site-wide: 72,648
  • In genetics: 2,776
• Year to date:
  • Site-wide: 155,367
• Since beginning of last month:
  • Site-wide: 170,815

Direct and indirect effects of maternal, paternal, and offspring genotypes: Trio-GCTA

• Downloaded 531 times
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  • Site-wide: 81,844
  • In genetics: 3,157
• Year to date:
  • Site-wide: 156,544
• Since beginning of last month:
  • Site-wide: 95,086

Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomization using polygenic risk scores

• Downloaded 468 times
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  • Site-wide: 94,702
  • In epidemiology: 4,441
• Year to date:
  • Site-wide: 24,882
• Since beginning of last month:
  • Site-wide: 20,030

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 464 times
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  • Site-wide: 95,478
  • In epidemiology: 3,869
• Year to date:
  • Site-wide: 176,952
• Since beginning of last month:
  • Site-wide: 180,847

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 100,807
  • In epidemiology: 4,093
• Year to date:
  • Site-wide: 155,182
• Since beginning of last month:
  • Site-wide: 143,039

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 429 times
• Download rankings, all-time:
  • Site-wide: 103,611
  • In genetics: 3,841
• Year to date:
  • Site-wide: 187,536
• Since beginning of last month:
  • Site-wide: 166,924

Haplotype-based heritability estimations reveal gestational duration as a maternal trait and fetal size measurements at birth as fetal traits in human pregnancy

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 116,990
  • In genetics: 4,518
• Year to date:
  • Site-wide: 111,376
• Since beginning of last month:
  • Site-wide: 107,747

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 126,984
  • In genetic and genomic medicine: 756
• Year to date:
  • Site-wide: 102,315
• Since beginning of last month:
  • Site-wide: 132,279

Maternal and fetal genetic contribution to gestational weight gain

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 131,499
  • In genetics: 4,798
• Year to date:
  • Site-wide: 190,533
• Since beginning of last month:
  • Site-wide: 180,032

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 284 times
• Download rankings, all-time:
  • Site-wide: 143,260
  • In genetics: 5,209
• Year to date:
  • Site-wide: 187,553
• Since beginning of last month:
  • Site-wide: 153,010

Modeling Parent-Specific Genetic Nurture in Families with Missing Parental Genotypes: Application to Birthweight and BMI

• Downloaded 268 times
• Download rankings, all-time:
  • Site-wide: 148,288
  • In genetics: 5,399
• Year to date:
  • Site-wide: 156,359
• Since beginning of last month:
  • Site-wide: 133,888

Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 152,159
  • In epidemiology: 6,879
• Year to date:
  • Site-wide: 14,119
• Since beginning of last month:
  • Site-wide: 14,095

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 160,765
  • In genetics: 5,798
• Year to date:
  • Site-wide: 156,666
• Since beginning of last month:
  • Site-wide: 178,935

Genome Wide Association Metanalysis Of Skull Bone Mineral Density Identifies Loci Relevant For Osteoporosis And Craniosynostosis

• Downloaded 201 times
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  • Site-wide: 166,802
  • In genetic and genomic medicine: 1,145
• Year to date:
  • Site-wide: 53,184
• Since beginning of last month:
  • Site-wide: 49,634

Using adopted individuals to partition maternal genetic effects into prenatal and postnatal effects on offspring phenotypes

• Downloaded 155 times
• Download rankings, all-time:
  • Site-wide: 177,374
  • In genetics: 6,234
• Year to date:
  • Site-wide: 141,302
• Since beginning of last month:
  • Site-wide: 160,342

HLA-B27 and not variation in MICA is responsible for genotype by sex interaction in risk of Ankylosing Spondylitis

• Downloaded 150 times
• Download rankings, all-time:
  • Site-wide: 178,422
  • In genetic and genomic medicine: 1,209
• Year to date:
  • Site-wide: 56,980
• Since beginning of last month:
  • Site-wide: 74,639

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 184,212
  • In epidemiology: None
• Year to date:
  • Site-wide: 41,510
• Since beginning of last month:
  • Site-wide: 48,377

Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: A Mendelian randomization study

• Downloaded 72 times
• Download rankings, all-time:
  • Site-wide: 188,869
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 66,563
• Since beginning of last month:
  • Site-wide: 90,409