Author: the 23andMe Research Team

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Preprints

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

• Downloaded 8,304 times
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  • Site-wide: 225 out of 76,880
  • In genetics: 21 out of 4,151
• Year to date:
  • Site-wide: 14,647 out of 76,880
• Since beginning of last month:
  • Site-wide: 13,334 out of 76,880

Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

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  • Site-wide: 1,271 out of 76,880
  • In genetics: 104 out of 4,151
• Year to date:
  • Site-wide: 11,848 out of 76,880
• Since beginning of last month:
  • Site-wide: 12,528 out of 76,880

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

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  • Site-wide: 2,799 out of 76,880
  • In genetics: 243 out of 4,151
• Year to date:
  • Site-wide: 19,805 out of 76,880
• Since beginning of last month:
  • Site-wide: 17,377 out of 76,880

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

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  • Site-wide: 2,858 out of 76,880
  • In genetics: 249 out of 4,151
• Year to date:
  • Site-wide: 30,027 out of 76,880
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  • Site-wide: 32,754 out of 76,880

Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa

• Downloaded 1,778 times
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  • Site-wide: 3,540 out of 76,880
  • In genomics: 659 out of 5,050
• Year to date:
  • Site-wide: 13,074 out of 76,880
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  • Site-wide: 9,112 out of 76,880

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

• Downloaded 1,604 times
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  • Site-wide: 4,228 out of 76,880
  • In genomics: 748 out of 5,050
• Year to date:
  • Site-wide: 7,071 out of 76,880
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  • Site-wide: 8,412 out of 76,880

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

• Downloaded 1,122 times
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  • Site-wide: 7,686 out of 76,880
  • In genomics: 1,205 out of 5,050
• Year to date:
  • Site-wide: 5,622 out of 76,880
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  • Site-wide: 6,193 out of 76,880

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

• Downloaded 1,093 times
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  • Site-wide: 8,021 out of 76,880
  • In genetics: 603 out of 4,151
• Year to date:
  • Site-wide: 43,612 out of 76,880
• Since beginning of last month:
  • Site-wide: 43,384 out of 76,880

Genome-wide association studies of impulsive personality traits (BIS-11 and UPPSP) and drug experimentation in up to 22,861 adult research participants

• Downloaded 654 times
• Download rankings, all-time:
  • Site-wide: 17,789 out of 76,880
  • In genetics: 1,179 out of 4,151
• Year to date:
  • Site-wide: 33,282 out of 76,880
• Since beginning of last month:
  • Site-wide: 34,516 out of 76,880

Genome-wide association study of social relationship satisfaction: significant loci and correlations with psychiatric conditions

• Downloaded 616 times
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  • Site-wide: 19,443 out of 76,880
  • In genomics: 2,304 out of 5,050
• Year to date:
  • Site-wide: 42,728 out of 76,880
• Since beginning of last month:
  • Site-wide: 46,415 out of 76,880

Replication and characterization of CADM2 and MSRA genes on human behavior

• Downloaded 589 times
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  • Site-wide: 20,682 out of 76,880
  • In genetics: 1,341 out of 4,151
• Year to date:
  • Site-wide: 71,466 out of 76,880
• Since beginning of last month:
  • Site-wide: 61,862 out of 76,880

Social and non-social autism symptom and trait domains are genetically dissociable

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  • Site-wide: 20,948 out of 76,880
  • In genetics: 1,365 out of 4,151
• Year to date:
  • Site-wide: 25,607 out of 76,880
• Since beginning of last month:
  • Site-wide: 20,738 out of 76,880

Genome-wide association studies on endometriosis and endometriosis-related infertility

• Downloaded 554 times
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  • Site-wide: 22,461 out of 76,880
  • In genetics: 1,462 out of 4,151
• Year to date:
  • Site-wide: 21,565 out of 76,880
• Since beginning of last month:
  • Site-wide: 17,726 out of 76,880

A Comprehensive Genome-wide and Phenome-wide Examination of BMI and Obesity in a Northern Nevadan Cohort

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  • Site-wide: 63,727 out of 76,880
  • In genetics: 3,584 out of 4,151
• Year to date:
  • Site-wide: 47,204 out of 76,880
• Since beginning of last month:
  • Site-wide: 61,440 out of 76,880