Author: David M Hougaard

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Common risk variants identified in autism spectrum disorder

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  • In genetics: 34
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Genomewide association study identifies 30 loci associated with bipolar disorder

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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 4,120
  • In genetic and genomic medicine: 11
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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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ASD and ADHD have a similar burden of rare protein-truncating variants

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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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Genome-wide association study implicates CHRNA2 in cannabis use disorder

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  • Site-wide: 9,401
  • In genomics: 1,054
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  • Site-wide: 17,176

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • Site-wide: 10,180
  • In psychiatry and clinical psychology: 32
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 11,972
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  • Site-wide: 42,429
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Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

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• Year to date:
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A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

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  • Site-wide: 15,935
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The genetic architecture of sporadic and recurrent miscarriage

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Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

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  • Site-wide: 17,704
  • In genomics: 1,842
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  • Site-wide: 28,646

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

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  • In genomics: 1,870
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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

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  • Site-wide: 23,388
  • In genomics: 2,289
• Year to date:
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The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

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  • In genetics: 1,425
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Untargeted metabolomic study of autism in newborn screening samples: a pilot study

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  • Site-wide: 41,239
  • In psychiatry and clinical psychology: 127
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Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

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  • Site-wide: 43,329
  • In genomics: 3,554
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Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

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Meta-analysis of Scandinavian Schizophrenia Exomes

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Gestational-age-dependent development of the neonatal metabolome

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  • In pediatrics: 55
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Polygenic prediction of school performance in children with and without psychiatric disorders

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  • Site-wide: 40,301

Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders – findings from a Danish population-based study

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  • Site-wide: 87,204
  • In bioinformatics: 7,790
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The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 117,650
  • In epidemiology: 4,761
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  • Site-wide: 19,097

Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

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  • Site-wide: 119,908
  • In genetic and genomic medicine: 545
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Mendelian randomization study of spermine oxidase and cancer risk

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  • In genetic and genomic medicine: 575
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