Author: James B Meigs

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Preprints

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 3,108
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 4,018
  • In genomics: 434
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  • Site-wide: 80,014

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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  • Site-wide: 10,643
  • In genetics: 489
• Year to date:
  • Site-wide: 78,783
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Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

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  • Site-wide: 11,096
  • In genetic and genomic medicine: 43
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Cardiometabolic Risk Factors for COVID-19 Susceptibility and Severity: A Mendelian Randomization Analysis

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  • In epidemiology: 968
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A genome-wide association study for nonalcoholic fatty liver disease identifies novel genetic loci and trait-relevant candidate genes in the Million Veteran Program.

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  • Site-wide: 14,919
  • In genetic and genomic medicine: 59
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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 15,763
  • In genetic and genomic medicine: 61
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  • Site-wide: 7,110

COVID-19 Outpatient Screening: a Prediction Score for Adverse Events

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  • Site-wide: 21,288

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 4,538

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

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Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 36,847
  • In genetics: 1,720
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  • Site-wide: 7,231
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Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

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  • Site-wide: 71,451
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Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 71,655
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Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

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Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification

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  • Site-wide: 86,366
  • In genetic and genomic medicine: 347
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Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

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  • Site-wide: 106,270
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Massachusetts General Hospital Covid-19 Registry reveals two distinct populations of hospitalized patients by race and ethnicity

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  • Site-wide: 109,842
  • In infectious diseases: 4,352
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  • Site-wide: 110,457

A long noncoding RNA, LOC157273, is the effector transcript at the chromosome 8p23.1-PPP1R3B metabolic traits and type 2 diabetes risk locus

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  • In genomics: 6,714
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