Author: Lawrence F Bielak

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Preprints

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 991
  • In genomics: 98
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  • Site-wide: 2,609
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  • Site-wide: 2,237

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,206 times
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  • Site-wide: 3,307
  • In genomics: 391
• Year to date:
  • Site-wide: 113,110
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  • Site-wide: 93,791

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,254
  • In genomics: 507
• Year to date:
  • Site-wide: 4,521
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  • Site-wide: 8,499

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 7,434
  • In genetics: 368
• Year to date:
  • Site-wide: 50,726
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  • Site-wide: 100,594

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 8,945
  • In genetics: 456
• Year to date:
  • Site-wide: 65,994
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  • Site-wide: 38,011

Population sequencing data reveal a compendium of mutational processes in human germline

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  • Site-wide: 14,395
  • In genetics: 748
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  • Site-wide: 29,376
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  • Site-wide: 34,140

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 853 times
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  • Site-wide: 23,324
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 10,059
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  • Site-wide: 5,795

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

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  • Site-wide: 24,518
  • In genetics: 1,234
• Year to date:
  • Site-wide: 50,526
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  • Site-wide: 101,035

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 27,227
  • In genetics: 1,372
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  • Site-wide: 21,377
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  • Site-wide: 24,317

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

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  • Site-wide: 29,390
  • In genomics: 2,710
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  • Site-wide: 44,822

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 34,277
  • In genetics: 1,717
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  • Site-wide: 20,686
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  • Site-wide: 11,192

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 462 times
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  • Site-wide: 51,521
  • In genetics: 2,496
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  • Site-wide: 655
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  • Site-wide: 1,390

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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  • Site-wide: 81,248
  • In epidemiology: 3,282
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  • Site-wide: 62,449
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  • Site-wide: 109,539

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 84,749
  • In genetics: 3,939
• Year to date:
  • Site-wide: 14,820
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  • Site-wide: 24,855

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 85,019
  • In genetics: 3,945
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  • Site-wide: 90,859
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  • Site-wide: 108,039

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 92,791
  • In genetic and genomic medicine: 305
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  • Site-wide: 37,518
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  • Site-wide: 8,978

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

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  • Site-wide: 119,295
  • In genetic and genomic medicine: 516
• Year to date:
  • Site-wide: 2,235
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  • Site-wide: None