Author: Chia-Yen Chen

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Preprints

Impact of Glycosylation on SARS-CoV-2 Infection and Broadly Protective Vaccine Design

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Phenome-wide Heritability Analysis of the UK Biobank

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  • Site-wide: 122,557
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • Site-wide: 3,497
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Comparative genetic architectures of schizophrenia in East Asian and European populations

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The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology

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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,452
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Widespread pleiotropy confounds causal relationships between complex traits and diseases inferred from Mendelian randomization

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Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systems

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  • Site-wide: 12,392
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Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

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Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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The genetic architecture of sporadic and recurrent miscarriage

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Testing Causal Bidirectional Influences between Physical Activity and Depression using Mendelian Randomization

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  • Site-wide: 18,954
  • In genetics: 907
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  • Site-wide: 81,651
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Improving Polygenic Prediction in Ancestrally Diverse Populations

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  • Site-wide: 22,064
  • In genetic and genomic medicine: 78
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  • Site-wide: 4,657

Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases

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  • In genomics: 2,164
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The burden of rare protein-truncating genetic variants on human lifespan

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The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization study

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  • Site-wide: 24,450
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GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

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  • Site-wide: 25,692
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A two-stage approach to identifying and validating modifiable factors for the prevention of depression

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  • Site-wide: 36,303
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The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

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  • Site-wide: 38,768
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Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

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  • Site-wide: 43,634
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Prospective Study of Polygenic Risk, Protective Factors, and Incident Depression Following Combat Deployment in US Army Soldiers

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  • Site-wide: 43,967
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GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

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  • Site-wide: 45,315
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Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

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  • Site-wide: 48,728
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  • Site-wide: 111,972

Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

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  • Site-wide: 50,318
  • In genetic and genomic medicine: 179
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Genomewide Analyses of Psychological Resilience in US Army Soldiers

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  • Site-wide: 51,657
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Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases

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  • Site-wide: 52,593
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• Year to date:
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  • Site-wide: 110,235

Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traits

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  • Site-wide: 58,412
  • In genetic and genomic medicine: 214
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  • Site-wide: 5,706
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Genomic Influences on Self-Reported Childhood Maltreatment

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  • Site-wide: 72,832
  • In genomics: 4,986
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  • Site-wide: 111,672
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  • Site-wide: 100,841

Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records

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  • Site-wide: 78,917
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  • Site-wide: 140,303
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  • Site-wide: 126,910

Elucidating the Joint Genetic Architecture of Mood Disorder and Schizophrenia

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  • Site-wide: 85,016
  • In genetic and genomic medicine: 332
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  • Site-wide: 44,430
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  • Site-wide: 95,257

Causal influence of dietary habits on the risk of major depressive disorder: a diet-wide Mendelian randomization analysis

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  • Site-wide: 88,370
  • In psychiatry and clinical psychology: 314
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  • Site-wide: 45,092
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  • Site-wide: 116,640

Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major depressive disorder

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  • Site-wide: 100,569
  • In genetic and genomic medicine: 432
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Pairwise genetic interactions modulate lipid plasma levels and cellular uptake

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