Author: Chia-Yen Chen

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Preprints

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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Phenome-wide Heritability Analysis of the UK Biobank

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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Comparative genetic architectures of schizophrenia in East Asian and European populations

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The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology

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Widespread pleiotropy confounds causal relationships between complex traits and diseases inferred from Mendelian randomization

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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systems

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Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

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Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

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Testing Causal Bidirectional Influences between Physical Activity and Depression using Mendelian Randomization

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The genetic architecture of sporadic and recurrent miscarriage

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GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

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The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization study

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The burden of rare protein-truncating genetic variants on human lifespan

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A two-stage approach to identifying and validating modifiable factors for the prevention of depression

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The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

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Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

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GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

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Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

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Genomewide Analyses of Psychological Resilience in US Army Soldiers

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Prospective Study of Polygenic Risk, Protective Factors, and Incident Depression Following Combat Deployment in US Army Soldiers

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Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases

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Genomic Influences on Self-Reported Childhood Maltreatment

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Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records

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