Author: Chia-Yen Chen

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Preprints

Improving Polygenic Prediction in Ancestrally Diverse Populations

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Phenome-wide Heritability Analysis of the UK Biobank

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  • Site-wide: 4,475
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • In genetics: 160
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Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases

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  • Site-wide: 6,370
  • In genomics: 617
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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 7,455
  • In genetics: 275
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The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology

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  • Site-wide: 9,011
  • In genetics: 344
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FinnGen: Unique genetic insights from combining isolated population and national health register data

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  • In genetic and genomic medicine: 59
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Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traits

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  • Site-wide: 9,056
  • In genetic and genomic medicine: 54
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Comparative genetic architectures of schizophrenia in East Asian and European populations

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  • In genetics: 356
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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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Widespread pleiotropy confounds causal relationships between complex traits and diseases inferred from Mendelian randomization

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  • In genomics: 1,396
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Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

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  • Site-wide: 17,330
  • In genetic and genomic medicine: 109
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Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systems

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  • Site-wide: 18,354
  • In genetics: 733
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  • Site-wide: 107,911
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Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

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Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

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  • In genetics: 896
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Genetic associations of protein-coding variants in human disease

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  • In genetic and genomic medicine: 150
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The genetic architecture of sporadic and recurrent miscarriage

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  • Site-wide: 25,704
  • In genetics: 1,029
• Year to date:
  • Site-wide: 58,810
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  • Site-wide: 117,095

Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major depressive disorder

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  • Site-wide: 27,518
  • In genetic and genomic medicine: 166
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Testing Causal Bidirectional Influences between Physical Activity and Depression using Mendelian Randomization

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  • Site-wide: 28,487
  • In genetics: 1,128
• Year to date:
  • Site-wide: 174,399
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  • Site-wide: 205,206

The burden of rare protein-truncating genetic variants on human lifespan

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  • Site-wide: 29,772
  • In genetics: 1,177
• Year to date:
  • Site-wide: 114,536
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  • Site-wide: 125,899

GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

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  • Site-wide: 29,848
  • In genomics: 2,493
• Year to date:
  • Site-wide: 162,445
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  • Site-wide: 119,943

Taiwan Biobank: a rich biomedical research database of the Taiwanese population

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  • Site-wide: 32,649
  • In genetic and genomic medicine: 209
• Year to date:
  • Site-wide: 8,163
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The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization study

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  • Site-wide: 33,934
  • In genetics: 1,347
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  • Site-wide: 178,997
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  • Site-wide: 94,619

The impact of rare protein coding genetic variation on adult cognitive function

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  • Site-wide: 39,182
  • In genetic and genomic medicine: 246
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  • Site-wide: 29,023
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Prospective Study of Polygenic Risk, Protective Factors, and Incident Depression Following Combat Deployment in US Army Soldiers

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  • Site-wide: 48,992
  • In genetics: 1,903
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  • Site-wide: 138,725
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A two-stage approach to identifying and validating modifiable factors for the prevention of depression

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  • Site-wide: 51,788
  • In genetics: 2,012
• Year to date:
  • Site-wide: 136,372
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  • Site-wide: 188,601

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

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  • Site-wide: 56,441
  • In biochemistry: 1,474
• Year to date:
  • Site-wide: 104,778
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  • Site-wide: 187,574

GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

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  • Site-wide: 60,074
  • In genetics: 2,325
• Year to date:
  • Site-wide: 138,657
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  • Site-wide: 152,093

Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

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  • Site-wide: 62,315
  • In genetics: 2,422
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  • Site-wide: 181,123

Validation of a Trans-Ancestry Polygenic Risk Score for Type 2 Diabetes in Diverse Populations

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  • Site-wide: 68,661
  • In genetic and genomic medicine: 441
• Year to date:
  • Site-wide: 66,148
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  • Site-wide: 37,008

Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

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  • Site-wide: 73,163
  • In genetics: 2,810
• Year to date:
  • Site-wide: 79,044
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  • Site-wide: 174,744

Causal influence of dietary habits on the risk of major depressive disorder: a diet-wide Mendelian randomization analysis

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  • Site-wide: 74,760
  • In psychiatry and clinical psychology: 354
• Year to date:
  • Site-wide: 55,219
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  • Site-wide: 124,122

Genomewide Analyses of Psychological Resilience in US Army Soldiers

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  • Site-wide: 76,925
  • In genetics: 2,951
• Year to date:
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  • Site-wide: 210,142

Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases

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  • Site-wide: 85,638
  • In genetics: 3,275
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  • Site-wide: 178,070

Elucidating the Joint Genetic Architecture of Mood Disorder and Schizophrenia

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  • Site-wide: 85,941
  • In genetic and genomic medicine: 555
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  • Site-wide: 158,515
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  • Site-wide: 59,094

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases

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  • Site-wide: 111,556
  • In genetic and genomic medicine: None
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  • Site-wide: 110
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Genomic Influences on Self-Reported Childhood Maltreatment

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  • Site-wide: 115,792
  • In genomics: 6,665
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  • Site-wide: 141,375
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  • Site-wide: 203,097

Rare genetic variants impact muscle strength

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  • Site-wide: 116,781
  • In genetic and genomic medicine: 783
• Year to date:
  • Site-wide: 96,865
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  • Site-wide: 45,134

Dissecting Biological Pathways of Psychopathology using Cognitive Genomics

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  • Site-wide: 120,458
  • In psychiatry and clinical psychology: 667
• Year to date:
  • Site-wide: 147,141
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  • Site-wide: 106,107

Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records

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  • Site-wide: 128,748
  • In genetics: 4,800
• Year to date:
  • Site-wide: 195,194
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  • Site-wide: 197,752

Pairwise genetic interactions modulate lipid plasma levels and cellular uptake

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  • Site-wide: 130,161
  • In genetics: 4,888
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  • Site-wide: 109,029
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  • Site-wide: 131,408

An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo)

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  • Site-wide: 136,011
  • In bioinformatics: 11,502
• Year to date:
  • Site-wide: 125,180
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  • Site-wide: 10,630

Evaluating the potential benefits and pitfalls of combining protein and expression quantitative trait loci in evidencing drug targets

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  • Site-wide: 162,333
  • In genetics: 6,068
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  • Site-wide: 74,534

Causality of Abdominal Obesity on Cognition: a Trans-ethnic Mendelian Randomization study

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  • Site-wide: 183,969
  • In public and global health: 2,719
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Evaluation of the Causal Relationship Between Smoking and Schizophrenia in Asia

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  • Site-wide: 196,752
  • In epidemiology: 7,742
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Independent effect and joint effect of polygenic liabilities for schizophrenia and bipolar disorder on cognitive aging and education attainment

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  • In epidemiology: 7,964
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