Author: James F Wilson

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Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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The genetic structure of the world's first farmers

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Genetic mechanisms of critical illness in Covid-19

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A reference panel of 64,976 haplotypes for genotype imputation

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Beyond power: Multivariate discovery, replication, and interpretation of pleiotropic loci using summary association statistics

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Genomic underpinnings of lifespan allow prediction and reveal basis in modern risks

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Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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Using genetic variation to disentangle the complex relationship between food intake and health outcomes.

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits

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Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

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Within-sibship GWAS improve estimates of direct genetic effects

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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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Genetic insights into the biological mechanisms governing human ovarian ageing

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Discovering patterns of pleiotropy in genome-wide association studies

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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

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Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

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Global variability of the human IgG glycome

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Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

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Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

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A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

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Associations of ‘Relative corticosterone deficiency’ with genetic variation in CYP17A1 and metabolic syndrome features

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Improvements in the incidence and survival of cancer and cardiovascular but not infectious disease have driven recent mortality improvements in Scotland: nationwide cohort study of linked hospital admission and death records 2001-2016

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Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

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Omics versus Questionnaires: Using methylation data to assess the environmental impact of smoking on obesity-related traits

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A multi-omics study of circulating phospholipid markers of blood pressure

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