Author: Rosalind M Eggo

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Preprints

Estimating the infection and case fatality ratio for COVID-19 using age-adjusted data from the outbreak on the Diamond Princess cruise ship

• Downloaded 56,599 times
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  • Site-wide: 161
  • In epidemiology: 38
• Year to date:
  • Site-wide: 1,031
• Since beginning of last month:
  • Site-wide: 1,183

Early dynamics of transmission and control of 2019-nCoV: a mathematical modelling study

• Downloaded 17,302 times
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  • Site-wide: 639
  • In infectious diseases: 233
• Year to date:
  • Site-wide: 15,023
• Since beginning of last month:
  • Site-wide: 13,219

Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England

• Downloaded 13,343 times
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  • Site-wide: 885
  • In epidemiology: 136
• Year to date:
  • Site-wide: 2,406
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  • Site-wide: 1,340

Association between living with children and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England

• Downloaded 13,240 times
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  • Site-wide: 891
  • In epidemiology: 130
• Year to date:
  • Site-wide: 17,591
• Since beginning of last month:
  • Site-wide: 24,284

Age-dependent effects in the transmission and control of COVID-19 epidemics

• Downloaded 12,798 times
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  • Site-wide: 934
  • In epidemiology: 141
• Year to date:
  • Site-wide: 13,908
• Since beginning of last month:
  • Site-wide: 8,013

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England

• Downloaded 10,942 times
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  • Site-wide: 1,149
  • In infectious diseases: 371
• Year to date:
  • Site-wide: 7,316
• Since beginning of last month:
  • Site-wide: 4,529

Inferring the number of COVID-19 cases from recently reported deaths

• Downloaded 9,319 times
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  • Site-wide: 1,382
  • In epidemiology: 178
• Year to date:
  • Site-wide: 64,691
• Since beginning of last month:
  • Site-wide: 66,522

UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records

• Downloaded 7,681 times
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  • Site-wide: 1,770
  • In epidemiology: 220
• Year to date:
  • Site-wide: 20,919
• Since beginning of last month:
  • Site-wide: 39,906

Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients primary care records in situ using OpenSAFELY.

• Downloaded 6,284 times
• Download rankings, all-time:
  • Site-wide: 2,328
  • In public and global health: 90
• Year to date:
  • Site-wide: 4,064
• Since beginning of last month:
  • Site-wide: 2,970

Strategies to reduce the risk of SARS-CoV-2 re-introduction from international travellers

• Downloaded 5,435 times
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  • Site-wide: 2,831
  • In epidemiology: 313
• Year to date:
  • Site-wide: 20,534
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  • Site-wide: 18,475

The effect of non-pharmaceutical interventions on COVID-19 cases, deaths and demand for hospital services in the UK: a modelling study

• Downloaded 4,184 times
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  • Site-wide: 4,028
  • In infectious diseases: 871
• Year to date:
  • Site-wide: 33,357
• Since beginning of last month:
  • Site-wide: 20,701

Feasibility of controlling 2019-nCoV outbreaks by isolation of cases and contacts

• Downloaded 4,134 times
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  • Site-wide: 4,095
  • In public and global health: 136
• Year to date:
  • Site-wide: 49,445
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  • Site-wide: 63,368

The effect of control strategies that reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China

• Downloaded 4,062 times
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  • Site-wide: 4,198
  • In public and global health: 138
• Year to date:
  • Site-wide: 76,219
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  • Site-wide: 103,345

Transmission dynamics of Zika virus in island populations: a modelling analysis of the 2013-14 French Polynesia outbreak

• Downloaded 3,996 times
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  • Site-wide: 4,291
  • In ecology: 24
• Year to date:
  • Site-wide: 163,952
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  • Site-wide: 164,876

Comparative analysis of dengue and Zika outbreaks reveals differences by setting and virus

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  • Site-wide: 4,576
  • In ecology: 31
• Year to date:
  • Site-wide: 98,999
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  • Site-wide: 65,721

How many are at increased risk of severe COVID-19 disease? Rapid global, regional and national estimates for 2020

• Downloaded 3,153 times
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  • Site-wide: 6,039
  • In epidemiology: 552
• Year to date:
  • Site-wide: 36,751
• Since beginning of last month:
  • Site-wide: 49,360

Response strategies for COVID-19 epidemics in African settings: a mathematical modelling study

• Downloaded 2,610 times
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  • Site-wide: 8,006
  • In epidemiology: 646
• Year to date:
  • Site-wide: 75,720
• Since beginning of last month:
  • Site-wide: 119,098

Effectiveness of airport screening at detecting travellers infected with 2019-nCoV

• Downloaded 2,527 times
• Download rankings, all-time:
  • Site-wide: 8,385
  • In epidemiology: 670
• Year to date:
  • Site-wide: 58,926
• Since beginning of last month:
  • Site-wide: 61,477

Ethnic differences in COVID-19 infection, hospitalisation, and mortality: an OpenSAFELY analysis of 17 million adults in England

• Downloaded 2,481 times
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  • Site-wide: 8,591
  • In epidemiology: 707
• Year to date:
  • Site-wide: 23,906
• Since beginning of last month:
  • Site-wide: 30,056

Projecting contact matrices in 177 geographical regions: an update and comparison with empirical data for the COVID-19 era

• Downloaded 2,297 times
• Download rankings, all-time:
  • Site-wide: 9,625
  • In epidemiology: 753
• Year to date:
  • Site-wide: 55,374
• Since beginning of last month:
  • Site-wide: 58,082

Interventions targeting air travellers early in the pandemic may delay local outbreaks of SARS-CoV-2

• Downloaded 2,131 times
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  • Site-wide: 10,768
  • In epidemiology: 812
• Year to date:
  • Site-wide: 107,236
• Since beginning of last month:
  • Site-wide: 136,171

Reconstructing the global dynamics of under-ascertained COVID-19 cases and infections

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  • Site-wide: 12,408
  • In epidemiology: 905
• Year to date:
  • Site-wide: 90,577
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  • Site-wide: 57,896

COVID-19 vaccination in Sindh Province, Pakistan: a modelling study of health impact and cost-effectiveness

• Downloaded 1,920 times
• Download rankings, all-time:
  • Site-wide: 12,596
  • In health economics: 24
• Year to date:
  • Site-wide: 19,244
• Since beginning of last month:
  • Site-wide: 16,158

Comparative effectiveness of ChAdOx1 versus BNT162b2 COVID-19 vaccines in Health and Social Care workers in England: a cohort study using OpenSAFELY

• Downloaded 1,805 times
• Download rankings, all-time:
  • Site-wide: 13,763
  • In epidemiology: 1,021
• Year to date:
  • Site-wide: 17,975
• Since beginning of last month:
  • Site-wide: 41,936

Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in non-hospitalised patients: an observational cohort study using the OpenSAFELY platform

• Downloaded 1,553 times
• Download rankings, all-time:
  • Site-wide: 17,328
  • In epidemiology: None
• Year to date:
  • Site-wide: 890
• Since beginning of last month:
  • Site-wide: 125

Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19: a descriptive cohort study within the OpenSAFELY platform

• Downloaded 1,488 times
• Download rankings, all-time:
  • Site-wide: 18,457
  • In epidemiology: 1,344
• Year to date:
  • Site-wide: 10,368
• Since beginning of last month:
  • Site-wide: 9,986

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

• Downloaded 1,479 times
• Download rankings, all-time:
  • Site-wide: 18,619
  • In infectious diseases: 2,149
• Year to date:
  • Site-wide: 22,879
• Since beginning of last month:
  • Site-wide: 42,079

The impact of Coronavirus disease 2019 (COVID-19) on health systems and household resources in Africa and South Asia

• Downloaded 1,421 times
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  • Site-wide: 19,826
  • In health economics: 39
• Year to date:
  • Site-wide: 51,878
• Since beginning of last month:
  • Site-wide: 53,798

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: A cohort study from OpenSAFELY

• Downloaded 1,356 times
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  • Site-wide: 21,345
  • In epidemiology: 1,607
• Year to date:
  • Site-wide: 4,197
• Since beginning of last month:
  • Site-wide: 16,019

Assessing the performance of real-time epidemic forecasts: A case study of Ebola in the Western Area Region of Sierra Leone, 2014-15

• Downloaded 1,314 times
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  • Site-wide: 22,413
  • In epidemiology: 1,353
• Year to date:
  • Site-wide: 139,736
• Since beginning of last month:
  • Site-wide: 115,875

OpenSAFELY NHS Service Restoration Observatory 1: describing trends and variation in primary care clinical activity for 23.3 million patients in England during the first wave of COVID-19

• Downloaded 1,246 times
• Download rankings, all-time:
  • Site-wide: 24,356
  • In health systems and quality improvement: 41
• Year to date:
  • Site-wide: 53,410
• Since beginning of last month:
  • Site-wide: 69,884

Short-term forecasts to inform the response to the COVID-19 epidemic in the UK

• Downloaded 1,231 times
• Download rankings, all-time:
  • Site-wide: 24,831
  • In epidemiology: 1,576
• Year to date:
  • Site-wide: 19,591
• Since beginning of last month:
  • Site-wide: 14,914

HIV infection and COVID-19 death: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

• Downloaded 1,225 times
• Download rankings, all-time:
  • Site-wide: 25,021
  • In infectious diseases: 2,441
• Year to date:
  • Site-wide: 65,439
• Since beginning of last month:
  • Site-wide: 46,264

Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY

• Downloaded 1,175 times
• Download rankings, all-time:
  • Site-wide: 26,639
  • In epidemiology: 1,592
• Year to date:
  • Site-wide: 34,982
• Since beginning of last month:
  • Site-wide: 27,425

The contribution of asymptomatic SARS-CoV-2 infections to transmission - a model-based analysis of the Diamond Princess outbreak

• Downloaded 1,154 times
• Download rankings, all-time:
  • Site-wide: 27,405
  • In infectious diseases: 2,546
• Year to date:
  • Site-wide: 79,279
• Since beginning of last month:
  • Site-wide: 95,644

Behavioural change towards reduced intensity physical activity is disproportionately prevalent among adults with serious health issues or self-perception of high risk during the UK COVID-19 lockdown.

• Downloaded 1,090 times
• Download rankings, all-time:
  • Site-wide: 29,853
  • In infectious diseases: 2,635
• Year to date:
  • Site-wide: 124,008
• Since beginning of last month:
  • Site-wide: 126,555

The effect of inter-city travel restrictions on geographical spread of COVID-19: Evidence from Wuhan, China

• Downloaded 952 times
• Download rankings, all-time:
  • Site-wide: 36,575
  • In epidemiology: 1,924
• Year to date:
  • Site-wide: 71,600
• Since beginning of last month:
  • Site-wide: 48,917

Trust and Transparency in times of Crisis: Results from an Online Survey During the First Wave (April 2020) of the COVID-19 Epidemic in the UK

• Downloaded 949 times
• Download rankings, all-time:
  • Site-wide: 36,735
  • In public and global health: 675
• Year to date:
  • Site-wide: 75,379
• Since beginning of last month:
  • Site-wide: 63,837

Effect of vaccinating health care workers to control Ebola virus disease: a modelling analysis of outbreak data

• Downloaded 871 times
• Download rankings, all-time:
  • Site-wide: 41,670
  • In epidemiology: 2,077
• Year to date:
  • Site-wide: 129,834
• Since beginning of last month:
  • Site-wide: 144,177

Real-time monitoring of COVID-19 dynamics using automated trend fitting and anomaly detection

• Downloaded 843 times
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  • Site-wide: 43,753
  • In health informatics: 181
• Year to date:
  • Site-wide: 84,427
• Since beginning of last month:
  • Site-wide: 80,678

Optimising social mixing strategies achieving COVID-19 herd immunity while minimising mortality in six European countries

• Downloaded 824 times
• Download rankings, all-time:
  • Site-wide: 45,215
  • In infectious diseases: 3,333
• Year to date:
  • Site-wide: 58,925
• Since beginning of last month:
  • Site-wide: 106,888

Detecting behavioural changes in human movement to inform the spatial scale of interventions against COVID-19

• Downloaded 765 times
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  • Site-wide: 50,378
  • In epidemiology: 2,727
• Year to date:
  • Site-wide: 34,973
• Since beginning of last month:
  • Site-wide: 8,663

Projecting the end of the Zika virus epidemic in Latin America: a modelling analysis

• Downloaded 746 times
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  • Site-wide: 52,316
  • In epidemiology: 2,431
• Year to date:
  • Site-wide: 180,023
• Since beginning of last month:
  • Site-wide: 175,961

Potential Test-Negative Design Study Bias in Outbreak Settings: Application to Ebola vaccination in Democratic Republic of Congo

• Downloaded 743 times
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  • Site-wide: 52,555
  • In epidemiology: 2,537
• Year to date:
  • Site-wide: 79,214
• Since beginning of last month:
  • Site-wide: 78,330

OpenSAFELY: impact of national guidance on switching from warfarin to direct oral anticoagulants (DOACs) in early phase of COVID-19 pandemic in England

• Downloaded 740 times
• Download rankings, all-time:
  • Site-wide: 52,895
  • In cardiovascular medicine: 95
• Year to date:
  • Site-wide: 65,862
• Since beginning of last month:
  • Site-wide: 74,430

Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune modifying therapies: a nationwide cohort study in the OpenSAFELY platform

• Downloaded 728 times
• Download rankings, all-time:
  • Site-wide: 54,101
  • In infectious diseases: 4,495
• Year to date:
  • Site-wide: 8,741
• Since beginning of last month:
  • Site-wide: 3,756

Guiding Vaccine Efficacy Trial Design During Public Health Emergencies: An interactive web-based decision support tool

• Downloaded 708 times
• Download rankings, all-time:
  • Site-wide: 56,245
  • In epidemiology: 2,579
• Year to date:
  • Site-wide: 159,632
• Since beginning of last month:
  • Site-wide: 144,208

Extremely high SARS-CoV-2 seroprevalence in a strictly-Orthodox Jewish community in the UK

• Downloaded 687 times
• Download rankings, all-time:
  • Site-wide: 58,654
  • In infectious diseases: 3,922
• Year to date:
  • Site-wide: 56,022
• Since beginning of last month:
  • Site-wide: 22,318

Short report: Ethnicity and COVID-19 death in the early part of the COVID-19 second wave in England: an analysis of OpenSAFELY data from 1st September to 9th November 2020

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 58,864
  • In infectious diseases: 4,131
• Year to date:
  • Site-wide: 25,022
• Since beginning of last month:
  • Site-wide: 6,946

Changing travel patterns in China during the early stages of the COVID-19 pandemic

• Downloaded 666 times
• Download rankings, all-time:
  • Site-wide: 61,269
  • In public and global health: 949
• Year to date:
  • Site-wide: 109,727
• Since beginning of last month:
  • Site-wide: 107,210

OpenSAFELY: Risks of COVID-19 hospital admission and death for people with learning disabilities - a cohort study.

• Downloaded 590 times
• Download rankings, all-time:
  • Site-wide: 71,756
  • In infectious diseases: 4,311
• Year to date:
  • Site-wide: 50,796
• Since beginning of last month:
  • Site-wide: 31,301

How immunity from and interaction with seasonal coronaviruses can shape SARS-CoV-2 epidemiology

• Downloaded 586 times
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  • Site-wide: 72,351
  • In infectious diseases: 4,244
• Year to date:
  • Site-wide: 66,885
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  • Site-wide: 34,825

Influenza Interaction with Cocirculating Pathogens, and Its Impact on Surveillance, Pathogenesis and Epidemic Profile: A Key Role for Mathematical Modeling

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 83,314
  • In epidemiology: 3,513
• Year to date:
  • Site-wide: 159,681
• Since beginning of last month:
  • Site-wide: 117,647

Association between oral anticoagulants and COVID-19 related outcomes: two cohort studies

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 85,481
  • In epidemiology: 3,699
• Year to date:
  • Site-wide: 59,274
• Since beginning of last month:
  • Site-wide: 64,066

Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 98,259
  • In epidemiology: 4,551
• Year to date:
  • Site-wide: 44,183
• Since beginning of last month:
  • Site-wide: 18,695

Accident and emergency (AE) attendance in England following infection with SARS-CoV-2 Omicron or Delta

• Downloaded 440 times
• Download rankings, all-time:
  • Site-wide: 100,687
  • In infectious diseases: None
• Year to date:
  • Site-wide: 5,974
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  • Site-wide: 730

Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 106,310
  • In public and global health: 1,504
• Year to date:
  • Site-wide: 73,836
• Since beginning of last month:
  • Site-wide: 60,198

Potentially inappropriate prescribing of DOACs to patients with mechanical heart valves: a federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 108,539
  • In primary care research: 95
• Year to date:
  • Site-wide: 50,643
• Since beginning of last month:
  • Site-wide: 64,831

Association between mobility, non-pharmaceutical interventions, and COVID-19 transmission in Ghana: a modelling study using mobile phone data

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 109,588
  • In epidemiology: 5,171
• Year to date:
  • Site-wide: 28,610
• Since beginning of last month:
  • Site-wide: 28,535

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: cohort study in OpenSAFELY using linked primary care, secondary care and death registration data

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 111,051
  • In infectious diseases: 5,619
• Year to date:
  • Site-wide: 41,548
• Since beginning of last month:
  • Site-wide: 58,794

Localising Vaccination Services: Qualitative Insights on an Orthodox Jewish Collaboration with Public health during the UK coronavirus Vaccine Programme

• Downloaded 391 times
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  • Site-wide: 112,552
  • In public and global health: 1,655
• Year to date:
  • Site-wide: 29,711
• Since beginning of last month:
  • Site-wide: 52,075

CpG-creating Mutations are Costly in Many Human Viruses

• Downloaded 378 times
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  • Site-wide: 115,970
  • In evolutionary biology: 5,257
• Year to date:
  • Site-wide: 181,235
• Since beginning of last month:
  • Site-wide: 161,684

Population disruption: estimating changes in population distribution in the UK during the COVID-19 pandemic

• Downloaded 347 times
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  • Site-wide: 124,502
  • In public and global health: 1,753
• Year to date:
  • Site-wide: 72,338
• Since beginning of last month:
  • Site-wide: 46,304

Models of COVID-19 vaccine prioritisation: a systematic literature search and narrative review

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 124,901
  • In infectious diseases: 5,605
• Year to date:
  • Site-wide: 97,700
• Since beginning of last month:
  • Site-wide: 109,520

Predicting COVID-19 related death using the OpenSAFELY platform

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 129,879
  • In infectious diseases: 5,943
• Year to date:
  • Site-wide: 71,234
• Since beginning of last month:
  • Site-wide: 40,326

Long-term health-related quality of life in non-hospitalised COVID-19 cases with confirmed SARS-CoV-2 infection in England: Longitudinal analysis and cross-sectional comparison with controls

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 129,839
  • In epidemiology: 5,704
• Year to date:
  • Site-wide: 42,352
• Since beginning of last month:
  • Site-wide: 60,527

The impact of co-circulating pathogens on SARS-CoV-2/COVID-19 surveillance. How concurrent epidemics may decrease true SARS-CoV-2 percent positivity.

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 136,075
  • In epidemiology: 5,472
• Year to date:
  • Site-wide: 131,342
• Since beginning of last month:
  • Site-wide: 138,015

Time use and social mixing during and around festive periods: Potential changes in the age distribution of COVID-19 cases from increased intergenerational interactions

• Downloaded 283 times
• Download rankings, all-time:
  • Site-wide: 143,232
  • In public and global health: 1,909
• Year to date:
  • Site-wide: 123,154
• Since beginning of last month:
  • Site-wide: 125,233

Recording of 'COVID-19 vaccine declined' among vaccination priority groups: a cohort study on 57.9 million NHS patients' primary care records in situ using OpenSAFELY

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 144,276
  • In public and global health: 1,952
• Year to date:
  • Site-wide: 80,007
• Since beginning of last month:
  • Site-wide: 99,129

Transmission dynamics of SARS-CoV-2 in a strictly-Orthodox Jewish community in the UK

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 155,348
  • In infectious diseases: 6,540
• Year to date:
  • Site-wide: 74,115
• Since beginning of last month:
  • Site-wide: 80,449

Social contacts and other risk factors for respiratory infections among internally displaced people in Somaliland

• Downloaded 213 times
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  • Site-wide: 163,211
  • In epidemiology: 6,828
• Year to date:
  • Site-wide: 41,544
• Since beginning of last month:
  • Site-wide: 34,015

Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an analysis of 4.3 million adults over the age of 65

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 174,233
  • In epidemiology: 6,867
• Year to date:
  • Site-wide: 109,003
• Since beginning of last month:
  • Site-wide: 80,661

Evidence for Influenza and RSV interaction from 10 years of enhanced surveillance in Nha Trang, Vietnam, a modelling study.

• Downloaded 163 times
• Download rankings, all-time:
  • Site-wide: 175,415
  • In infectious diseases: 7,152
• Year to date:
  • Site-wide: 60,548
• Since beginning of last month:
  • Site-wide: 58,776

Association between household composition and severe COVID-19 outcomes in older people by ethnicity: an observational cohort study using the OpenSAFELY platform

• Downloaded 163 times
• Download rankings, all-time:
  • Site-wide: 175,320
  • In epidemiology: None
• Year to date:
  • Site-wide: 25,707
• Since beginning of last month:
  • Site-wide: 8,809

Assessing the impacts of timing on the health benefits, cost-effectiveness and relative affordability of COVID-19 vaccination programmes in 27 African Countries

• Downloaded 116 times
• Download rankings, all-time:
  • Site-wide: 183,653
  • In health economics: None
• Year to date:
  • Site-wide: 39,082
• Since beginning of last month:
  • Site-wide: 6,273