Author: Tamar Sofer

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Preprints

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 2,538 times
• Download rankings, all-time:
  • Site-wide: 9,359
  • In genetic and genomic medicine: 55
• Year to date:
  • Site-wide: 22,074
• Since beginning of last month:
  • Site-wide: 16,701

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,306 times
• Download rankings, all-time:
  • Site-wide: 26,393
  • In genetics: 1,064
• Year to date:
  • Site-wide: 38,930
• Since beginning of last month:
  • Site-wide: 64,203

A Fully-Adjusted Two-Stage Procedure for Rank Normalization in Genetic Association Studies

• Downloaded 1,087 times
• Download rankings, all-time:
  • Site-wide: 35,092
  • In genetics: 1,397
• Year to date:
  • Site-wide: 99,375
• Since beginning of last month:
  • Site-wide: 75,198

Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 38,300
  • In genetics: 1,673
• Year to date:
  • Site-wide: 3,716
• Since beginning of last month:
  • Site-wide: 4,476

Generalizing Genetic Risk Scores from Europeans to Hispanics/Latinos

• Downloaded 993 times
• Download rankings, all-time:
  • Site-wide: 40,438
  • In genetics: 1,598
• Year to date:
  • Site-wide: 138,472
• Since beginning of last month:
  • Site-wide: 209,536

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

• Downloaded 923 times
• Download rankings, all-time:
  • Site-wide: 45,176
  • In genetics: 1,759
• Year to date:
  • Site-wide: 196,975
• Since beginning of last month:
  • Site-wide: 177,674

Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

• Downloaded 916 times
• Download rankings, all-time:
  • Site-wide: 45,780
  • In genetic and genomic medicine: 291
• Year to date:
  • Site-wide: 27,891
• Since beginning of last month:
  • Site-wide: 42,236

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

• Downloaded 778 times
• Download rankings, all-time:
  • Site-wide: 58,613
  • In genetic and genomic medicine: 394
• Year to date:
  • Site-wide: 8,469
• Since beginning of last month:
  • Site-wide: 7,973

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 62,761
  • In genomics: 4,383
• Year to date:
  • Site-wide: 38,957
• Since beginning of last month:
  • Site-wide: 129,092

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

• Downloaded 739 times
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  • Site-wide: 63,319
  • In genetics: 2,449
• Year to date:
  • Site-wide: 119,895
• Since beginning of last month:
  • Site-wide: 42,443

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 717 times
• Download rankings, all-time:
  • Site-wide: 66,059
  • In genetics: 2,533
• Year to date:
  • Site-wide: 195,233
• Since beginning of last month:
  • Site-wide: 92,353

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

• Downloaded 668 times
• Download rankings, all-time:
  • Site-wide: 72,840
  • In genomics: 4,865
• Year to date:
  • Site-wide: 139,400
• Since beginning of last month:
  • Site-wide: 148,111

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

• Downloaded 661 times
• Download rankings, all-time:
  • Site-wide: 73,914
  • In genetics: 2,904
• Year to date:
  • Site-wide: 37,846
• Since beginning of last month:
  • Site-wide: 24,446

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 78,155
  • In genomics: 5,105
• Year to date:
  • Site-wide: 139,600
• Since beginning of last month:
  • Site-wide: 205,712

Pathway-specific Polygenic Risk Scores (PRS) identify OSA-related pathways differentially moderating genetic susceptibility to CAD

• Downloaded 612 times
• Download rankings, all-time:
  • Site-wide: 81,684
  • In cardiovascular medicine: 178
• Year to date:
  • Site-wide: 116,008
• Since beginning of last month:
  • Site-wide: 28,379

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 86,035
  • In genetics: 3,273
• Year to date:
  • Site-wide: 178,007
• Since beginning of last month:
  • Site-wide: 182,421

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 98,187
  • In epidemiology: 4,200
• Year to date:
  • Site-wide: 155,363
• Since beginning of last month:
  • Site-wide: 98,990

Polygenic Risk Scores for Alzheimer's Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos - Investigation ofNeurocognitive Aging

• Downloaded 485 times
• Download rankings, all-time:
  • Site-wide: 108,004
  • In genetic and genomic medicine: 707
• Year to date:
  • Site-wide: 117,647
• Since beginning of last month:
  • Site-wide: 89,124

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 109,754
  • In genetic and genomic medicine: 720
• Year to date:
  • Site-wide: 86,819
• Since beginning of last month:
  • Site-wide: 88,330

Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American specific associations

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 126,494
  • In genomics: 6,977
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 207,715

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 137,654
  • In genetics: 5,111
• Year to date:
  • Site-wide: 174,396
• Since beginning of last month:
  • Site-wide: 205,229

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 137,992
  • In genetic and genomic medicine: 962
• Year to date:
  • Site-wide: 144,696
• Since beginning of last month:
  • Site-wide: 109,457

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 138,475
  • In genetic and genomic medicine: 968
• Year to date:
  • Site-wide: 120,424
• Since beginning of last month:
  • Site-wide: 105,789

Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 139,694
  • In genetic and genomic medicine: 991
• Year to date:
  • Site-wide: 67,148
• Since beginning of last month:
  • Site-wide: 86,647

Benchmarking Association Analyses of Continuous Exposures with RNA-seq in Observational Studies

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 140,988
  • In bioinformatics: 11,684
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 103,782

Rare variants association testing for a binary outcome when pooling individual level data from heterogeneous studies

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 144,296
  • In genetics: 5,422
• Year to date:
  • Site-wide: 52,936
• Since beginning of last month:
  • Site-wide: 159,779

Transcriptional survey of peripheral blood links lower oxygen saturation during sleep with reduced expressions of CD1D and RAB20 that is reversed by CPAP therapy

• Downloaded 347 times
• Download rankings, all-time:
  • Site-wide: 146,176
  • In genetic and genomic medicine: 1,028
• Year to date:
  • Site-wide: 93,604
• Since beginning of last month:
  • Site-wide: 191,143

Integrated Computing And Tracking System For Centralized High-Throughput Genetic Analysis: A Case Study

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 147,576
  • In bioinformatics: 11,588
• Year to date:
  • Site-wide: 162,092
• Since beginning of last month:
  • Site-wide: 202,221

The impact of Mendelian sleep and circadian genetic variants in a population setting

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 151,419
  • In genetic and genomic medicine: 1,083
• Year to date:
  • Site-wide: 48,742
• Since beginning of last month:
  • Site-wide: 134,368

Population Stratification at the Phenotypic Variance level and Implication for the Analysis of Whole Genome Sequencing Data from Multiple Studies

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 151,707
  • In genetics: 5,607
• Year to date:
  • Site-wide: 158,669
• Since beginning of last month:
  • Site-wide: 187,579

Uncovering Cross-Cohort Molecular Features with Multi-Omics Integration Analysis

• Downloaded 311 times
• Download rankings, all-time:
  • Site-wide: 156,804
  • In genomics: 8,457
• Year to date:
  • Site-wide: 7,320
• Since beginning of last month:
  • Site-wide: 5,225

AFA: Computationally efficient Ancestral Frequency estimation in Admixed populations: the Hispanic Community Health Study/Study of Latinos

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 164,653
  • In genomics: 8,297
• Year to date:
  • Site-wide: 52,574
• Since beginning of last month:
  • Site-wide: 165,800

Blood metabolites predicting Mild Cognitive Impairment in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL)

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 178,284
  • In epidemiology: 7,106
• Year to date:
  • Site-wide: 150,600
• Since beginning of last month:
  • Site-wide: 137,237

Genetics of Latin American Diversity (GLAD) Project: insights into population genetics and association studies in recently admixed groups in the Americas

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 181,102
  • In genetics: None
• Year to date:
  • Site-wide: 344
• Since beginning of last month:
  • Site-wide: None

Multi-ancestry genome-wide analysis identifies common genetic variants for self-reported sleep duration and shared genetic effects

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 182,542
  • In genomics: 8,778
• Year to date:
  • Site-wide: 187,254
• Since beginning of last month:
  • Site-wide: 96,912

Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 185,327
  • In epidemiology: 7,388
• Year to date:
  • Site-wide: 84,293
• Since beginning of last month:
  • Site-wide: 83,829

An integrated multi-omics analysis of sleep-disordered breathing traits across multiple blood cell types

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 200,299
  • In genetic and genomic medicine: 1,565
• Year to date:
  • Site-wide: 56,175
• Since beginning of last month:
  • Site-wide: 62,319

Development and Validation of a Metabolite Index for Obstructive Sleep Apnea across Race/Ethnicities

• Downloaded 133 times
• Download rankings, all-time:
  • Site-wide: 201,768
  • In respiratory medicine: 465
• Year to date:
  • Site-wide: 21,062
• Since beginning of last month:
  • Site-wide: 56,383

Associations between evening shift work, irregular sleep timing, and gestational diabetes in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b)

• Downloaded 115 times
• Download rankings, all-time:
  • Site-wide: 205,043
  • In public and global health: 3,186
• Year to date:
  • Site-wide: 68,474
• Since beginning of last month:
  • Site-wide: 37,648

Genome-wide association study of obstructive sleep apnea in the Million Veteran Program uncovers genetic heterogeneity by sex

• Downloaded 108 times
• Download rankings, all-time:
  • Site-wide: 206,390
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 4,123
• Since beginning of last month:
  • Site-wide: 5,265