Author: Lenore J Launer

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Preprints

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,831
  • In genetics: 181
• Year to date:
  • Site-wide: 43,683
• Since beginning of last month:
  • Site-wide: 63,239

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,941
  • In genomics: 486
• Year to date:
  • Site-wide: 11,889
• Since beginning of last month:
  • Site-wide: 37,150

Large-scale association analyses identify host factors influencing human gut microbiome composition

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  • Site-wide: 6,554
  • In genetics: 264
• Year to date:
  • Site-wide: 5,579
• Since beginning of last month:
  • Site-wide: 11,594

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 8,695
  • In sexual and reproductive health: 12
• Year to date:
  • Site-wide: 1,749
• Since beginning of last month:
  • Site-wide: 2,820

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 10,737
  • In genetics: 455
• Year to date:
  • Site-wide: 131,789
• Since beginning of last month:
  • Site-wide: 158,990

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 11,487
  • In genetics: 485
• Year to date:
  • Site-wide: 90,782
• Since beginning of last month:
  • Site-wide: 84,772

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 11,829
  • In genetics: 503
• Year to date:
  • Site-wide: 109,203
• Since beginning of last month:
  • Site-wide: 110,617

ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19

• Downloaded 1,613 times
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  • Site-wide: 13,757
  • In cardiovascular medicine: 19
• Year to date:
  • Site-wide: 24,625
• Since beginning of last month:
  • Site-wide: 32,971

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 18,760
  • In genomics: 1,759
• Year to date:
  • Site-wide: 111,643
• Since beginning of last month:
  • Site-wide: 115,020

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 21,885
  • In genetics: 956
• Year to date:
  • Site-wide: 13,348
• Since beginning of last month:
  • Site-wide: 80,528

Coding and regulatory variants affect serum protein levels and common disease

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  • Site-wide: 24,941
  • In genetics: 1,089
• Year to date:
  • Site-wide: 12,473
• Since beginning of last month:
  • Site-wide: 19,218

Antihypertensive medication uses and serum ACE2 levels

• Downloaded 1,086 times
• Download rankings, all-time:
  • Site-wide: 25,281
  • In cardiovascular medicine: 39
• Year to date:
  • Site-wide: 74,006
• Since beginning of last month:
  • Site-wide: 103,022

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,079 times
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  • Site-wide: 25,554
  • In genetics: 1,121
• Year to date:
  • Site-wide: 30,207
• Since beginning of last month:
  • Site-wide: 65,273

Harmonization of large multi-site imaging datasets: Application to 10,232 MRIs for the analysis of imaging patterns of structural brain change throughout the lifespan

• Downloaded 1,041 times
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  • Site-wide: 26,958
  • In bioinformatics: 2,992
• Year to date:
  • Site-wide: 37,313
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  • Site-wide: 51,076

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 887 times
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  • Site-wide: 34,122
  • In genetics: 1,492
• Year to date:
  • Site-wide: 114,165
• Since beginning of last month:
  • Site-wide: 141,899

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

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  • Site-wide: 39,369
  • In bioinformatics: 4,199
• Year to date:
  • Site-wide: 119,380
• Since beginning of last month:
  • Site-wide: 93,753

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 39,600
  • In genomics: 3,195
• Year to date:
  • Site-wide: 140,586
• Since beginning of last month:
  • Site-wide: 146,740

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 668 times
• Download rankings, all-time:
  • Site-wide: 51,071
  • In genetics: 2,175
• Year to date:
  • Site-wide: 128,438
• Since beginning of last month:
  • Site-wide: 142,249

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 654 times
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  • Site-wide: 52,562
  • In genetics: 2,233
• Year to date:
  • Site-wide: 146,434
• Since beginning of last month:
  • Site-wide: 141,276

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

• Downloaded 651 times
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  • Site-wide: 52,903
  • In genetics: 2,252
• Year to date:
  • Site-wide: 111,564
• Since beginning of last month:
  • Site-wide: 106,033

Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 53,323
  • In genetics: 2,273
• Year to date:
  • Site-wide: 129,656
• Since beginning of last month:
  • Site-wide: 116,425

Genetic variants for head size share genes and pathways with cancer

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  • Site-wide: 63,881
  • In genomics: 4,542
• Year to date:
  • Site-wide: 42,836
• Since beginning of last month:
  • Site-wide: 49,341

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 463 times
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  • Site-wide: 79,795
  • In genomics: 5,232
• Year to date:
  • Site-wide: 39,125
• Since beginning of last month:
  • Site-wide: 18,268

A Proteogenomic Signature of Age-related Macular Degeneration in Blood

• Downloaded 273 times
• Download rankings, all-time:
  • Site-wide: 123,992
  • In genetic and genomic medicine: 715
• Year to date:
  • Site-wide: 39,452
• Since beginning of last month:
  • Site-wide: 28,986

A genome-wide association study of serum proteins reveals shared loci with common diseases

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 131,850
  • In genomics: 7,110
• Year to date:
  • Site-wide: 46,018
• Since beginning of last month:
  • Site-wide: 74,569

Batch effects removal for microbiome data via conditional quantile regression (ConQuR)

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 154,874
  • In bioinformatics: 11,738
• Year to date:
  • Site-wide: 86,034
• Since beginning of last month:
  • Site-wide: 18,194