Author: Caroline L. Relton

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Preprints

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

• Downloaded 2,131 times
• Download rankings, all-time:
  • Site-wide: 11,875
  • In epidemiology: 900
• Year to date:
  • Site-wide: 109,400
• Since beginning of last month:
  • Site-wide: 82,106

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,720 times
• Download rankings, all-time:
  • Site-wide: 16,387
  • In genetics: 644
• Year to date:
  • Site-wide: 159,903
• Since beginning of last month:
  • Site-wide: 101,921

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,520 times
• Download rankings, all-time:
  • Site-wide: 19,900
  • In genetics: 795
• Year to date:
  • Site-wide: 161,822
• Since beginning of last month:
  • Site-wide: 132,481

High COVID-19 transmission potential associated with re-opening universities can be mitigated with layered interventions

• Downloaded 1,505 times
• Download rankings, all-time:
  • Site-wide: 20,227
  • In infectious diseases: 2,266
• Year to date:
  • Site-wide: 112,152
• Since beginning of last month:
  • Site-wide: None

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,488 times
• Download rankings, all-time:
  • Site-wide: 20,625
  • In bioinformatics: 2,170
• Year to date:
  • Site-wide: 105,921
• Since beginning of last month:
  • Site-wide: None

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,487 times
• Download rankings, all-time:
  • Site-wide: 20,656
  • In epidemiology: 1,328
• Year to date:
  • Site-wide: 75,611
• Since beginning of last month:
  • Site-wide: 31,364

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 1,459 times
• Download rankings, all-time:
  • Site-wide: 21,275
  • In genetic and genomic medicine: 121
• Year to date:
  • Site-wide: 55,185
• Since beginning of last month:
  • Site-wide: 156,693

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,293 times
• Download rankings, all-time:
  • Site-wide: 25,797
  • In epidemiology: 1,517
• Year to date:
  • Site-wide: 180,451
• Since beginning of last month:
  • Site-wide: 75,897

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

• Downloaded 1,265 times
• Download rankings, all-time:
  • Site-wide: 26,743
  • In epidemiology: 1,546
• Year to date:
  • Site-wide: 186,672
• Since beginning of last month:
  • Site-wide: 173,944

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 1,098 times
• Download rankings, all-time:
  • Site-wide: 33,375
  • In genetics: 1,303
• Year to date:
  • Site-wide: 177,022
• Since beginning of last month:
  • Site-wide: 100,848

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 1,086 times
• Download rankings, all-time:
  • Site-wide: 33,893
  • In genomics: 2,697
• Year to date:
  • Site-wide: 150,869
• Since beginning of last month:
  • Site-wide: None

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

• Downloaded 1,085 times
• Download rankings, all-time:
  • Site-wide: 33,965
  • In epidemiology: 1,830
• Year to date:
  • Site-wide: 169,170
• Since beginning of last month:
  • Site-wide: 126,126

University students and staff able to maintain low daily contact numbers during various COVID-19 guideline periods

• Downloaded 1,065 times
• Download rankings, all-time:
  • Site-wide: 34,898
  • In epidemiology: 2,143
• Year to date:
  • Site-wide: 9,517
• Since beginning of last month:
  • Site-wide: 107,977

Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study

• Downloaded 914 times
• Download rankings, all-time:
  • Site-wide: 44,085
  • In genetics: 1,747
• Year to date:
  • Site-wide: 131,596
• Since beginning of last month:
  • Site-wide: 100,289

Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

• Downloaded 834 times
• Download rankings, all-time:
  • Site-wide: 50,795
  • In epidemiology: 2,520
• Year to date:
  • Site-wide: 118,744
• Since beginning of last month:
  • Site-wide: 31,409

Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis

• Downloaded 823 times
• Download rankings, all-time:
  • Site-wide: 51,776
  • In genetics: 2,025
• Year to date:
  • Site-wide: 107,550
• Since beginning of last month:
  • Site-wide: 59,902

Alternative Covid-19 mitigation measures in school classrooms: analysis using an agent-based model of SARS-CoV-2 transmission

• Downloaded 820 times
• Download rankings, all-time:
  • Site-wide: 52,034
  • In health policy: 137
• Year to date:
  • Site-wide: 23,366
• Since beginning of last month:
  • Site-wide: 133,467

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 808 times
• Download rankings, all-time:
  • Site-wide: 53,217
  • In genetics: 2,058
• Year to date:
  • Site-wide: 153,369
• Since beginning of last month:
  • Site-wide: 79,403

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 762 times
• Download rankings, all-time:
  • Site-wide: 57,990
  • In epidemiology: 2,759
• Year to date:
  • Site-wide: 122,829
• Since beginning of last month:
  • Site-wide: 39,590

Epigenome-wide change and variation in DNA methylation from birth to late adolescence

• Downloaded 646 times
• Download rankings, all-time:
  • Site-wide: 73,225
  • In genomics: 4,821
• Year to date:
  • Site-wide: 174,158
• Since beginning of last month:
  • Site-wide: 111,553

DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 82,734
  • In epidemiology: 3,609
• Year to date:
  • Site-wide: 190,534
• Since beginning of last month:
  • Site-wide: 99,642

Epigenome-Wide Association Study Of Asthma And Wheeze In Childhood And Adolescence

• Downloaded 582 times
• Download rankings, all-time:
  • Site-wide: 83,619
  • In epidemiology: 3,665
• Year to date:
  • Site-wide: 189,421
• Since beginning of last month:
  • Site-wide: 80,121

Predicting cellular aging following exposure to adversity: Does accumulation, recency, or developmental timing of exposure matter?

• Downloaded 553 times
• Download rankings, all-time:
  • Site-wide: 89,208
  • In genetics: 3,397
• Year to date:
  • Site-wide: 173,356
• Since beginning of last month:
  • Site-wide: 123,555

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 491 times
• Download rankings, all-time:
  • Site-wide: 102,357
  • In epidemiology: 4,319
• Year to date:
  • Site-wide: 167,571
• Since beginning of last month:
  • Site-wide: 162,482

Investigating the added value of biomarkers compared with self-reported smoking in predicting future e-cigarette use: Evidence from a longitudinal UK cohort study

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 104,282
  • In epidemiology: 4,416
• Year to date:
  • Site-wide: 143,614
• Since beginning of last month:
  • Site-wide: 187,470

Impacts of vaccination and asymptomatic testing on SARS-CoV-2 transmission dynamics in a university setting

• Downloaded 466 times
• Download rankings, all-time:
  • Site-wide: 108,210
  • In infectious diseases: 5,583
• Year to date:
  • Site-wide: 54,328
• Since beginning of last month:
  • Site-wide: 88,767

Contacts and behaviours of university students during the COVID-19 pandemic at the start of the 2020/21 academic year

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 110,708
  • In public and global health: 1,626
• Year to date:
  • Site-wide: 123,645
• Since beginning of last month:
  • Site-wide: 166,040

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 111,895
  • In genetics: 4,230
• Year to date:
  • Site-wide: 166,567
• Since beginning of last month:
  • Site-wide: 79,448

Modelling pooling strategies for SARS-CoV-2 testing in a university setting

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 117,746
  • In infectious diseases: 5,796
• Year to date:
  • Site-wide: 157,307
• Since beginning of last month:
  • Site-wide: 167,359

Epigenome-wide association study of seizures in childhood and adolescence

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 135,042
  • In epidemiology: 5,507
• Year to date:
  • Site-wide: 184,654
• Since beginning of last month:
  • Site-wide: 168,105

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 139,482
  • In epidemiology: 5,910
• Year to date:
  • Site-wide: 43,623
• Since beginning of last month:
  • Site-wide: 120,667

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 142,066
  • In genetics: 5,171
• Year to date:
  • Site-wide: 177,713
• Since beginning of last month:
  • Site-wide: None

A prospective study of time-dependent exposures to childhood adversity and DNA methylation in childhood and adolescence

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 152,398
  • In genetic and genomic medicine: 1,160
• Year to date:
  • Site-wide: 58,983
• Since beginning of last month:
  • Site-wide: 18,866

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 154,194
  • In psychiatry and clinical psychology: 934
• Year to date:
  • Site-wide: 92,776
• Since beginning of last month:
  • Site-wide: 133,651

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 297 times
• Download rankings, all-time:
  • Site-wide: 155,505
  • In genetics: 5,692
• Year to date:
  • Site-wide: 198,155
• Since beginning of last month:
  • Site-wide: 128,147

Validation and characterization of a DNA methylation alcohol biomarker across the life course

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 156,367
  • In epidemiology: 6,320
• Year to date:
  • Site-wide: 189,901
• Since beginning of last month:
  • Site-wide: 105,501

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 158,888
  • In cancer biology: 4,699
• Year to date:
  • Site-wide: 194,050
• Since beginning of last month:
  • Site-wide: 187,798

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 161,736
  • In genetics: 5,850
• Year to date:
  • Site-wide: 191,996
• Since beginning of last month:
  • Site-wide: 162,074

Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 172,645
  • In epidemiology: 7,022
• Year to date:
  • Site-wide: 35,503
• Since beginning of last month:
  • Site-wide: 137,839

The impact of low input DNA on the reliability of DNA methylation as measured by the Illumina Infinium MethylationEPIC BeadChip

• Downloaded 233 times
• Download rankings, all-time:
  • Site-wide: 173,717
  • In bioinformatics: 12,928
• Year to date:
  • Site-wide: 62,122
• Since beginning of last month:
  • Site-wide: 180,123

Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 186,156
  • In genetics: 6,574
• Year to date:
  • Site-wide: 194,360
• Since beginning of last month:
  • Site-wide: 162,882

Sex steroid hormones and risk of breast cancer incidence and survival: A two-sample Mendelian randomization study

• Downloaded 135 times
• Download rankings, all-time:
  • Site-wide: 195,523
  • In epidemiology: 7,640
• Year to date:
  • Site-wide: 115,775
• Since beginning of last month:
  • Site-wide: 177,475

Salicylic acid and risk of colorectal cancer: a two sample Mendelian randomization study

• Downloaded 130 times
• Download rankings, all-time:
  • Site-wide: 196,272
  • In epidemiology: 7,634
• Year to date:
  • Site-wide: 157,277
• Since beginning of last month:
  • Site-wide: None

Epigenetic markers of adverse lifestyle identified among night shift workers

• Downloaded 102 times
• Download rankings, all-time:
  • Site-wide: 201,011
  • In genetics: 6,893
• Year to date:
  • Site-wide: 94,062
• Since beginning of last month:
  • Site-wide: 72,293

Investigating causality in the association between DNA methylation and prevalent T2D using a bidirectional two-sample Mendelian Randomization

• Downloaded 70 times
• Download rankings, all-time:
  • Site-wide: 205,789
  • In epidemiology: 7,900
• Year to date:
  • Site-wide: 130,092
• Since beginning of last month:
  • Site-wide: 173,298