Author: Xiuqing Guo

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Preprints

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 1,511
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  • Site-wide: 27,107

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 1,195
  • In genomics: 97
• Year to date:
  • Site-wide: 3,884
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  • Site-wide: 47,534

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 4,331
  • In genomics: 443
• Year to date:
  • Site-wide: 88,355
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  • Site-wide: 95,300

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,216 times
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  • Site-wide: 4,464
  • In genetics: 171
• Year to date:
  • Site-wide: 36,491
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  • Site-wide: 94,447

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,703
  • In genomics: 488
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  • Site-wide: 10,121
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A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

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  • Site-wide: 8,767
  • In genetic and genomic medicine: 39
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  • Site-wide: 1,285
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  • Site-wide: 536

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

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  • Site-wide: 9,032
  • In genetics: 386
• Year to date:
  • Site-wide: 4,588
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  • Site-wide: 1,589

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 9,609
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• Year to date:
  • Site-wide: 90,726
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  • Site-wide: 27,200

Identification of type 2 diabetes loci in 433,540 East Asian individuals

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  • Site-wide: 9,681
  • In genetics: 422
• Year to date:
  • Site-wide: 45,007
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  • Site-wide: 110,388

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 10,799
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  • Site-wide: 53,350
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  • Site-wide: 16,453

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

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  • Site-wide: 12,548
  • In hiv aids: 7
• Year to date:
  • Site-wide: 5,473
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  • Site-wide: 21,210

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 13,829
  • In genetic and genomic medicine: 62
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  • Site-wide: 6,173
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  • Site-wide: 8,085

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 14,370
  • In genetics: 657
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  • Site-wide: 7,397
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  • Site-wide: 128,312

Genetic architecture of gene expression traits across diverse populations

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  • Site-wide: 17,200
  • In genomics: 1,679
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  • Site-wide: 75,859
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  • Site-wide: 18,836

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 17,691
  • In genetics: 820
• Year to date:
  • Site-wide: 64,311
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  • Site-wide: 19,392

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 20,491
  • In genetics: 943
• Year to date:
  • Site-wide: 8,890
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  • Site-wide: 5,096

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

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  • Site-wide: 21,447
  • In genetic and genomic medicine: 86
• Year to date:
  • Site-wide: 11,357
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  • Site-wide: 38,728

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 24,994
  • In genetics: 1,139
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  • Site-wide: 25,121
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  • Site-wide: 112,628

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

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  • Site-wide: 28,454
  • In gastroenterology: 26
• Year to date:
  • Site-wide: 33,485
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  • Site-wide: 18,173

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 30,709
  • In genetics: 1,410
• Year to date:
  • Site-wide: 85,714
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  • Site-wide: 77,240

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

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  • Site-wide: 30,853
  • In genetics: 1,414
• Year to date:
  • Site-wide: 125,148
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  • Site-wide: 105,507

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 31,348
  • In genetics: 1,443
• Year to date:
  • Site-wide: 7,354
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  • Site-wide: 3,714

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 786 times
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  • Site-wide: 34,895
  • In genomics: 2,946
• Year to date:
  • Site-wide: 88,347
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  • Site-wide: 108,780

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 776 times
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  • Site-wide: 35,472
  • In genomics: 2,992
• Year to date:
  • Site-wide: 116,739
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  • Site-wide: 99,245

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 724 times
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  • Site-wide: 39,099
  • In genetics: 1,761
• Year to date:
  • Site-wide: 146,746
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  • Site-wide: 106,179

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 651 times
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  • Site-wide: 44,959
  • In genetics: 2,011
• Year to date:
  • Site-wide: 92,476
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  • Site-wide: 30,014

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 518 times
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  • Site-wide: 59,607
  • In genomics: 4,368
• Year to date:
  • Site-wide: 145,703
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  • Site-wide: None

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 62,277
  • In genetics: 2,751
• Year to date:
  • Site-wide: 23,176
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  • Site-wide: 38,602

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

• Downloaded 485 times
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  • Site-wide: 64,179
  • In genetics: 2,833
• Year to date:
  • Site-wide: 83,287
• Since beginning of last month:
  • Site-wide: 109,775

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 460 times
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  • Site-wide: 67,947
  • In genetic and genomic medicine: 279
• Year to date:
  • Site-wide: 24,610
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  • Site-wide: 35,649

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

• Downloaded 412 times
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  • Site-wide: 75,971
  • In genetics: 3,312
• Year to date:
  • Site-wide: 105,799
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  • Site-wide: 92,710

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 406 times
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  • Site-wide: 77,147
  • In epidemiology: 3,319
• Year to date:
  • Site-wide: 97,390
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  • Site-wide: 33,933

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

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  • Site-wide: 78,490
  • In physiology: 602
• Year to date:
  • Site-wide: 93,933
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  • Site-wide: 34,513

Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

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  • Site-wide: 83,908
  • In genetic and genomic medicine: 366
• Year to date:
  • Site-wide: 14,056
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  • Site-wide: 1,672

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

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  • Site-wide: 84,130
  • In bioinformatics: 7,572
• Year to date:
  • Site-wide: 72,207
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  • Site-wide: 128,711

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 334 times
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  • Site-wide: 91,520
  • In epidemiology: 3,850
• Year to date:
  • Site-wide: 63,568
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  • Site-wide: 129,814

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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  • Site-wide: 91,899
  • In epidemiology: 3,867
• Year to date:
  • Site-wide: 100,340
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  • Site-wide: 48,531

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

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  • Site-wide: 93,329
  • In genetics: 4,024
• Year to date:
  • Site-wide: 16,926
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  • Site-wide: 8,615

The Socioeconomic Gradient in Epigenetic Aging Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

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  • Site-wide: 96,125
  • In epidemiology: 4,052
• Year to date:
  • Site-wide: 17,905
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  • Site-wide: 88,892

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

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  • Site-wide: 96,982
  • In genetics: 4,155
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  • Site-wide: 112,605
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  • Site-wide: 19,438

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

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  • Site-wide: 101,550
  • In genetic and genomic medicine: 488
• Year to date:
  • Site-wide: 19,967
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  • Site-wide: 44,972

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 101,731
  • In genomics: 6,105
• Year to date:
  • Site-wide: 67,647
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  • Site-wide: 74,194

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 104,951
  • In genetics: 4,465
• Year to date:
  • Site-wide: 151,131
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  • Site-wide: None

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

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  • Site-wide: 107,098
  • In genetics: 4,540
• Year to date:
  • Site-wide: 151,934
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  • Site-wide: 101,380

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 227 times
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  • Site-wide: 117,084
  • In genetic and genomic medicine: 614
• Year to date:
  • Site-wide: 27,681
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  • Site-wide: 52,721

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

• Downloaded 118 times
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  • Site-wide: 142,196
  • In genetic and genomic medicine: 812
• Year to date:
  • Site-wide: 57,813
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Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

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  • Site-wide: 144,943
  • In genetic and genomic medicine: 838
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  • Site-wide: 2,652

Protein prediction for trait mapping in diverse populations

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  • Site-wide: 153,946
  • In genomics: 7,668
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  • Site-wide: 153,829
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  • Site-wide: 46,064