Author: Xiuqing Guo

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Preprints

Recovery of trait heritability from whole genome sequence data

• Downloaded 14,790 times
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  • Site-wide: 801
  • In genetics: 14
• Year to date:
  • Site-wide: 2,871
• Since beginning of last month:
  • Site-wide: 6,442

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 9,167 times
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  • Site-wide: 1,471
  • In genomics: 99
• Year to date:
  • Site-wide: 12,088
• Since beginning of last month:
  • Site-wide: 11,255

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

• Downloaded 5,711 times
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  • Site-wide: 2,775
  • In genetics: 83
• Year to date:
  • Site-wide: 235
• Since beginning of last month:
  • Site-wide: 463

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 3,469 times
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  • Site-wide: 5,581
  • In genomics: 526
• Year to date:
  • Site-wide: 32,065
• Since beginning of last month:
  • Site-wide: 8,353

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,393 times
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  • Site-wide: 5,777
  • In genetics: 194
• Year to date:
  • Site-wide: 83,453
• Since beginning of last month:
  • Site-wide: 126,022

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,360 times
• Download rankings, all-time:
  • Site-wide: 5,858
  • In genomics: 541
• Year to date:
  • Site-wide: 144,014
• Since beginning of last month:
  • Site-wide: 128,075

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

• Downloaded 3,322 times
• Download rankings, all-time:
  • Site-wide: 5,961
  • In genetic and genomic medicine: 30
• Year to date:
  • Site-wide: 4,522
• Since beginning of last month:
  • Site-wide: None

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 2,397 times
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  • Site-wide: 9,572
  • In genetic and genomic medicine: 55
• Year to date:
  • Site-wide: 7,359
• Since beginning of last month:
  • Site-wide: 23,993

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

• Downloaded 2,397 times
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  • Site-wide: 9,563
  • In genetics: 376
• Year to date:
  • Site-wide: 32,736
• Since beginning of last month:
  • Site-wide: 24,769

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 2,288 times
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  • Site-wide: 10,242
  • In hiv aids: 6
• Year to date:
  • Site-wide: 15,236
• Since beginning of last month:
  • Site-wide: 28,768

Clonal hematopoiesis is driven by aberrant activation of TCL1A

• Downloaded 2,077 times
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  • Site-wide: 11,910
  • In genetics: 502
• Year to date:
  • Site-wide: 1,563
• Since beginning of last month:
  • Site-wide: 4,216

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 2,062 times
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  • Site-wide: 12,038
  • In genetics: 448
• Year to date:
  • Site-wide: 91,087
• Since beginning of last month:
  • Site-wide: 158,497

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,950 times
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  • Site-wide: 13,046
  • In genetics: 506
• Year to date:
  • Site-wide: 151,153
• Since beginning of last month:
  • Site-wide: 44,356

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,888 times
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  • Site-wide: 13,703
  • In genetics: 549
• Year to date:
  • Site-wide: 68,822
• Since beginning of last month:
  • Site-wide: 11,284

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,669 times
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  • Site-wide: 16,510
  • In genetics: 677
• Year to date:
  • Site-wide: 67,602
• Since beginning of last month:
  • Site-wide: 34,422

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 1,536 times
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  • Site-wide: 18,793
  • In genetics: 769
• Year to date:
  • Site-wide: 42,392
• Since beginning of last month:
  • Site-wide: 110,091

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

• Downloaded 1,459 times
• Download rankings, all-time:
  • Site-wide: 20,416
  • In genetic and genomic medicine: 122
• Year to date:
  • Site-wide: 55,624
• Since beginning of last month:
  • Site-wide: 21,129

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

• Downloaded 1,361 times
• Download rankings, all-time:
  • Site-wide: 22,770
  • In genetics: 920
• Year to date:
  • Site-wide: 117,091
• Since beginning of last month:
  • Site-wide: 74,507

Genetic architecture of gene expression traits across diverse populations

• Downloaded 1,359 times
• Download rankings, all-time:
  • Site-wide: 22,814
  • In genomics: 1,979
• Year to date:
  • Site-wide: 132,719
• Since beginning of last month:
  • Site-wide: 70,280

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

• Downloaded 1,325 times
• Download rankings, all-time:
  • Site-wide: 23,715
  • In genomics: 2,132
• Year to date:
  • Site-wide: 8,947
• Since beginning of last month:
  • Site-wide: 12,703

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,271 times
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  • Site-wide: 25,368
  • In genetics: 1,018
• Year to date:
  • Site-wide: 96,939
• Since beginning of last month:
  • Site-wide: 84,327

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,262 times
• Download rankings, all-time:
  • Site-wide: 25,636
  • In genetics: 1,079
• Year to date:
  • Site-wide: 46,699
• Since beginning of last month:
  • Site-wide: 11,305

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

• Downloaded 1,166 times
• Download rankings, all-time:
  • Site-wide: 29,022
  • In gastroenterology: 30
• Year to date:
  • Site-wide: 77,247
• Since beginning of last month:
  • Site-wide: None

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 931 times
• Download rankings, all-time:
  • Site-wide: 40,946
  • In genetics: 1,636
• Year to date:
  • Site-wide: 147,232
• Since beginning of last month:
  • Site-wide: 126,647

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

• Downloaded 901 times
• Download rankings, all-time:
  • Site-wide: 42,955
  • In genetics: 1,700
• Year to date:
  • Site-wide: 198,603
• Since beginning of last month:
  • Site-wide: None

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 881 times
• Download rankings, all-time:
  • Site-wide: 44,380
  • In genomics: 3,365
• Year to date:
  • Site-wide: 147,301
• Since beginning of last month:
  • Site-wide: 117,488

Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

• Downloaded 863 times
• Download rankings, all-time:
  • Site-wide: 45,924
  • In genetic and genomic medicine: 285
• Year to date:
  • Site-wide: 22,670
• Since beginning of last month:
  • Site-wide: 9,822

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 859 times
• Download rankings, all-time:
  • Site-wide: 46,206
  • In genomics: 3,491
• Year to date:
  • Site-wide: 121,731
• Since beginning of last month:
  • Site-wide: 43,996

The Socioeconomic Gradient in Epigenetic Aging Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

• Downloaded 835 times
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  • Site-wide: 48,134
  • In epidemiology: 2,440
• Year to date:
  • Site-wide: 17,375
• Since beginning of last month:
  • Site-wide: 130,334

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

• Downloaded 797 times
• Download rankings, all-time:
  • Site-wide: 51,745
  • In genetics: 2,349
• Year to date:
  • Site-wide: 9,782
• Since beginning of last month:
  • Site-wide: 3,090

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals

• Downloaded 795 times
• Download rankings, all-time:
  • Site-wide: 51,834
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 3,999
• Since beginning of last month:
  • Site-wide: 393

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 783 times
• Download rankings, all-time:
  • Site-wide: 53,106
  • In genetics: 2,091
• Year to date:
  • Site-wide: 194,941
• Since beginning of last month:
  • Site-wide: 162,442

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 730 times
• Download rankings, all-time:
  • Site-wide: 58,630
  • In genetic and genomic medicine: 352
• Year to date:
  • Site-wide: 68,632
• Since beginning of last month:
  • Site-wide: None

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 705 times
• Download rankings, all-time:
  • Site-wide: 61,656
  • In genomics: 4,337
• Year to date:
  • Site-wide: 37,182
• Since beginning of last month:
  • Site-wide: None

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 702 times
• Download rankings, all-time:
  • Site-wide: 62,101
  • In genetics: 2,424
• Year to date:
  • Site-wide: 172,886
• Since beginning of last month:
  • Site-wide: 91,807

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

• Downloaded 698 times
• Download rankings, all-time:
  • Site-wide: 62,587
  • In genetics: 2,474
• Year to date:
  • Site-wide: 55,100
• Since beginning of last month:
  • Site-wide: 132,532

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

• Downloaded 641 times
• Download rankings, all-time:
  • Site-wide: 70,374
  • In genetics: 2,837
• Year to date:
  • Site-wide: 29,880
• Since beginning of last month:
  • Site-wide: None

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 70,481
  • In genetics: 2,748
• Year to date:
  • Site-wide: 115,432
• Since beginning of last month:
  • Site-wide: 64,890

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 615 times
• Download rankings, all-time:
  • Site-wide: 74,369
  • In genomics: 4,932
• Year to date:
  • Site-wide: 150,456
• Since beginning of last month:
  • Site-wide: 54,216

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 82,226
  • In genetics: 3,170
• Year to date:
  • Site-wide: 180,263
• Since beginning of last month:
  • Site-wide: 157,534

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 496 times
• Download rankings, all-time:
  • Site-wide: 96,192
  • In epidemiology: 4,246
• Year to date:
  • Site-wide: 109,811
• Since beginning of last month:
  • Site-wide: 108,211

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 476 times
• Download rankings, all-time:
  • Site-wide: 100,884
  • In genetic and genomic medicine: 638
• Year to date:
  • Site-wide: 77,592
• Since beginning of last month:
  • Site-wide: 48,987

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 102,735
  • In physiology: 806
• Year to date:
  • Site-wide: 161,362
• Since beginning of last month:
  • Site-wide: 73,488

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 103,549
  • In bioinformatics: 8,738
• Year to date:
  • Site-wide: 136,067
• Since beginning of last month:
  • Site-wide: None

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 459 times
• Download rankings, all-time:
  • Site-wide: 104,841
  • In epidemiology: 4,524
• Year to date:
  • Site-wide: 157,690
• Since beginning of last month:
  • Site-wide: 55,849

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 105,400
  • In genetic and genomic medicine: 729
• Year to date:
  • Site-wide: 19,236
• Since beginning of last month:
  • Site-wide: 15,012

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 106,703
  • In genetics: 4,057
• Year to date:
  • Site-wide: 199,671
• Since beginning of last month:
  • Site-wide: 121,340

The functional impact of rare variation across the regulatory cascade

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 114,847
  • In genomics: None
• Year to date:
  • Site-wide: 11,349
• Since beginning of last month:
  • Site-wide: 142

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

• Downloaded 361 times
• Download rankings, all-time:
  • Site-wide: 130,353
  • In epidemiology: 5,431
• Year to date:
  • Site-wide: 200,851
• Since beginning of last month:
  • Site-wide: 154,451

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 130,692
  • In genetics: 4,968
• Year to date:
  • Site-wide: 164,590
• Since beginning of last month:
  • Site-wide: 113,018

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 132,778
  • In genetic and genomic medicine: 913
• Year to date:
  • Site-wide: 47,011
• Since beginning of last month:
  • Site-wide: 31,372

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 133,173
  • In genetic and genomic medicine: 892
• Year to date:
  • Site-wide: 123,778
• Since beginning of last month:
  • Site-wide: 111,496

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

• Downloaded 348 times
• Download rankings, all-time:
  • Site-wide: 133,986
  • In genetics: 5,091
• Year to date:
  • Site-wide: 185,920
• Since beginning of last month:
  • Site-wide: 171,253

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 344 times
• Download rankings, all-time:
  • Site-wide: 135,110
  • In genetics: 5,071
• Year to date:
  • Site-wide: 180,326
• Since beginning of last month:
  • Site-wide: 163,294

Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 141,512
  • In genetic and genomic medicine: 965
• Year to date:
  • Site-wide: 65,466
• Since beginning of last month:
  • Site-wide: 77,293

Protein prediction for trait mapping in diverse populations

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 145,685
  • In genomics: 7,585
• Year to date:
  • Site-wide: 113,188
• Since beginning of last month:
  • Site-wide: 132,337