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Author: Xiuqing Guo

Rankings

  • All-time downloads: 64,198 (rank: 2,531 )
  • Categories:
    • bioinformatics: 369 (rank: 32,235 (tie) )
    • epidemiology: 1,385 (rank: 8,551 (tie) )
    • gastroenterology: 908 (rank: 414 (tie) )
    • genetic and genomic medicine: 6,165 (rank: 158 (tie) )
    • genetics: 34,900 (rank: 161 )
    • genomics: 18,495 (rank: 751 )
    • hiv aids: 1,578 (rank: 70 (tie) )
    • physiology: 398 (rank: 4,943 (tie) )

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Preprints

Recovery of trait heritability from whole genome sequence data

genetics more details view paper
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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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    • In genomics: 97
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
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    • Site-wide: 4,331
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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

genomics more details view paper
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A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

genetic and genomic medicine more details view paper
  • Downloaded 2,015 times
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    • Site-wide: 8,767
    • In genetic and genomic medicine: 39
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Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

genetics more details view paper
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    • Site-wide: 9,032
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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
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Identification of type 2 diabetes loci in 433,540 East Asian individuals

genetics more details view paper
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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
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    • Site-wide: 10,799
    • In genetics: 476
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A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

hiv aids more details view paper
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    • In hiv aids: 7
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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 1,478 times
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    • Site-wide: 13,829
    • In genetic and genomic medicine: 62
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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

genetics more details view paper
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    • Site-wide: 14,370
    • In genetics: 657
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Genetic architecture of gene expression traits across diverse populations

genomics more details view paper
  • Downloaded 1,281 times
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    • Site-wide: 17,200
    • In genomics: 1,679
  • Year to date:
    • Site-wide: 75,859
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

genetics more details view paper
  • Downloaded 1,256 times
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    • Site-wide: 17,691
    • In genetics: 820
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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

genetics more details view paper
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    • Site-wide: 20,491
    • In genetics: 943
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Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

genetic and genomic medicine more details view paper
  • Downloaded 1,103 times
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    • Site-wide: 21,447
    • In genetic and genomic medicine: 86
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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 993 times
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    • Site-wide: 24,994
    • In genetics: 1,139
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rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

gastroenterology more details view paper
  • Downloaded 908 times
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    • Site-wide: 28,454
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Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

genetics more details view paper
  • Downloaded 861 times
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    • Site-wide: 30,709
    • In genetics: 1,410
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    • Site-wide: 85,714
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Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

genetics more details view paper
  • Downloaded 858 times
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    • Site-wide: 30,853
    • In genetics: 1,414
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    • Site-wide: 125,148
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Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 848 times
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    • Site-wide: 31,348
    • In genetics: 1,443
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Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

genomics more details view paper
  • Downloaded 786 times
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    • Site-wide: 34,895
    • In genomics: 2,946
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    • Site-wide: 88,347
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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

genomics more details view paper
  • Downloaded 776 times
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    • Site-wide: 35,472
    • In genomics: 2,992
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    • Site-wide: 116,739
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Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

genetics more details view paper
  • Downloaded 724 times
  • Download rankings, all-time:
    • Site-wide: 39,099
    • In genetics: 1,761
  • Year to date:
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    • Site-wide: 106,179

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

genetics more details view paper
  • Downloaded 651 times
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    • Site-wide: 44,959
    • In genetics: 2,011
  • Year to date:
    • Site-wide: 92,476
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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 518 times
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    • Site-wide: 59,607
    • In genomics: 4,368
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A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

genetics more details view paper
  • Downloaded 499 times
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    • Site-wide: 62,277
    • In genetics: 2,751
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Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

genetics more details view paper
  • Downloaded 485 times
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    • Site-wide: 64,179
    • In genetics: 2,833
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Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

genetic and genomic medicine more details view paper
  • Downloaded 460 times
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    • In genetic and genomic medicine: 279
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Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

genetics more details view paper
  • Downloaded 412 times
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    • Site-wide: 75,971
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Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

epidemiology more details view paper
  • Downloaded 406 times
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    • Site-wide: 77,147
    • In epidemiology: 3,319
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Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

physiology more details view paper
  • Downloaded 398 times
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    • In physiology: 602
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Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

genetic and genomic medicine more details view paper
  • Downloaded 370 times
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    • Site-wide: 83,908
    • In genetic and genomic medicine: 366
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Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

bioinformatics more details view paper
  • Downloaded 369 times
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    • Site-wide: 84,130
    • In bioinformatics: 7,572
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    • Site-wide: 72,207
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    • Site-wide: 128,711

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

epidemiology more details view paper
  • Downloaded 334 times
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    • Site-wide: 91,520
    • In epidemiology: 3,850
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Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

epidemiology more details view paper
  • Downloaded 332 times
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Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

genetics more details view paper
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The Socioeconomic Gradient in Epigenetic Aging Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

epidemiology more details view paper
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Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

genetics more details view paper
  • Downloaded 310 times
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Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

genetic and genomic medicine more details view paper
  • Downloaded 290 times
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    • Site-wide: 101,550
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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

genomics more details view paper
  • Downloaded 289 times
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    • Site-wide: 101,731
    • In genomics: 6,105
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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

genetics more details view paper
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    • In genetics: 4,465
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GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

genetics more details view paper
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    • Site-wide: 107,098
    • In genetics: 4,540
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BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

genetic and genomic medicine more details view paper
  • Downloaded 227 times
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    • Site-wide: 117,084
    • In genetic and genomic medicine: 614
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Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

genetic and genomic medicine more details view paper
  • Downloaded 118 times
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    • Site-wide: 142,196
    • In genetic and genomic medicine: 812
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Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

genetic and genomic medicine more details view paper
  • Downloaded 104 times
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Protein prediction for trait mapping in diverse populations

genomics more details view paper
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