Author: Xiuqing Guo

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Preprints

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 662
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  • Site-wide: 3,000
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  • Site-wide: 5,248

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 1,042
  • In genomics: 94
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  • Site-wide: 2,193
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  • Site-wide: 4,808

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 3,697
  • In genomics: 416
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  • Site-wide: 59,019
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  • Site-wide: 42,343

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,082 times
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  • Site-wide: 3,975
  • In genetics: 168
• Year to date:
  • Site-wide: 54,308
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  • Site-wide: 72,291

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,361
  • In genomics: 489
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  • Site-wide: 7,793
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  • Site-wide: 10,076

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 8,388
  • In genetics: 393
• Year to date:
  • Site-wide: 87,764
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  • Site-wide: 88,900

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 1,821 times
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  • Site-wide: 8,603
  • In genetics: 403
• Year to date:
  • Site-wide: 29,929
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  • Site-wide: 25,127

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 9,872
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• Year to date:
  • Site-wide: 64,880
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  • Site-wide: 45,358

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

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  • Site-wide: 11,956
  • In genetics: 583
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  • Site-wide: 6,991
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  • Site-wide: 5,351

Genetic architecture of gene expression traits across diverse populations

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  • Site-wide: 15,627
  • In genomics: 1,611
• Year to date:
  • Site-wide: 79,528
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  • Site-wide: 65,285

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 16,076
  • In genetics: 793
• Year to date:
  • Site-wide: 52,478
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  • Site-wide: 70,758

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 16,765
  • In genetics: 821
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  • Site-wide: 6,231
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  • Site-wide: 6,192

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 1,121 times
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  • Site-wide: 17,732
  • In hiv aids: 8
• Year to date:
  • Site-wide: 7,924
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  • Site-wide: 5,454

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,083 times
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  • Site-wide: 18,670
  • In genetic and genomic medicine: 64
• Year to date:
  • Site-wide: 7,747
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  • Site-wide: 9,283

A genome-wide association study for nonalcoholic fatty liver disease identifies novel genetic loci and trait-relevant candidate genes in the Million Veteran Program.

• Downloaded 1,017 times
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  • Site-wide: 20,455
  • In genetic and genomic medicine: 69
• Year to date:
  • Site-wide: 1,082
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  • Site-wide: 3,927

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,360
  • In genetics: 1,223
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  • Site-wide: 19,255
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  • Site-wide: 10,875

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

• Downloaded 873 times
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  • Site-wide: 25,530
  • In genetic and genomic medicine: 83
• Year to date:
  • Site-wide: 10,889
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  • Site-wide: 16,888

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

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  • Site-wide: 26,897
  • In genetics: 1,302
• Year to date:
  • Site-wide: 93,077
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  • Site-wide: 96,645

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 27,574
  • In genetics: 1,335
• Year to date:
  • Site-wide: 62,638
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  • Site-wide: 71,245

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

• Downloaded 797 times
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  • Site-wide: 28,964
  • In gastroenterology: 22
• Year to date:
  • Site-wide: 31,362
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  • Site-wide: 41,165

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 29,119
  • In genetics: 1,409
• Year to date:
  • Site-wide: 14,029
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  • Site-wide: 10,559

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 751 times
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  • Site-wide: 31,472
  • In genomics: 2,814
• Year to date:
  • Site-wide: 94,111
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  • Site-wide: 108,316

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 747 times
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  • Site-wide: 31,712
  • In genomics: 2,824
• Year to date:
  • Site-wide: 71,386
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  • Site-wide: 85,686

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 713 times
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  • Site-wide: 33,757
  • In genetics: 1,636
• Year to date:
  • Site-wide: 120,047
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  • Site-wide: 109,216

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 617 times
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  • Site-wide: 40,892
  • In genetics: 1,943
• Year to date:
  • Site-wide: 5,002
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  • Site-wide: 15,504

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 613 times
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  • Site-wide: 41,204
  • In genetics: 1,953
• Year to date:
  • Site-wide: 77,047
• Since beginning of last month:
  • Site-wide: 71,094

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 506 times
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  • Site-wide: 52,036
  • In genomics: 4,036
• Year to date:
  • Site-wide: 120,060
• Since beginning of last month:
  • Site-wide: 116,900

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

• Downloaded 437 times
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  • Site-wide: 61,053
  • In genetics: 2,840
• Year to date:
  • Site-wide: 76,917
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  • Site-wide: 78,447

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

• Downloaded 396 times
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  • Site-wide: 67,467
  • In genetics: 3,098
• Year to date:
  • Site-wide: 61,364
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  • Site-wide: 70,581

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 368 times
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  • Site-wide: 72,026
  • In epidemiology: 3,024
• Year to date:
  • Site-wide: 87,560
• Since beginning of last month:
  • Site-wide: 70,561

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

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  • Site-wide: 72,800
  • In physiology: 549
• Year to date:
  • Site-wide: 71,820
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  • Site-wide: 94,394

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

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  • Site-wide: 80,797
  • In bioinformatics: 7,397
• Year to date:
  • Site-wide: 55,841
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  • Site-wide: 39,077

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 81,123
  • In genetic and genomic medicine: 285
• Year to date:
  • Site-wide: 23,642
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  • Site-wide: 20,822

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

• Downloaded 301 times
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  • Site-wide: 84,910
  • In epidemiology: 3,494
• Year to date:
  • Site-wide: 77,391
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  • Site-wide: 79,547

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 293 times
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  • Site-wide: 86,599
  • In epidemiology: 3,556
• Year to date:
  • Site-wide: 39,612
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  • Site-wide: 53,718

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 292 times
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  • Site-wide: 86,914
  • In genetics: 3,933
• Year to date:
  • Site-wide: 49,549
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  • Site-wide: None

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

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  • Site-wide: 90,695
  • In genetics: 4,085
• Year to date:
  • Site-wide: 117,365
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  • Site-wide: 101,039

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 92,035
  • In genetics: 4,141
• Year to date:
  • Site-wide: 123,272
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  • Site-wide: 112,705

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

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  • Site-wide: 93,981
  • In genetics: 4,217
• Year to date:
  • Site-wide: 130,419
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  • Site-wide: 126,762

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 210 times
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  • Site-wide: 104,866
  • In genomics: 6,130
• Year to date:
  • Site-wide: 98,746
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  • Site-wide: 75,307

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

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  • Site-wide: 111,777
  • In genetic and genomic medicine: 497
• Year to date:
  • Site-wide: 12,724
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  • Site-wide: 37,309

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 171 times
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  • Site-wide: 113,402
  • In genetic and genomic medicine: 512
• Year to date:
  • Site-wide: 13,305
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  • Site-wide: 41,735

The Socioeconomic Gradient in Epigenetic Aging Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

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  • Site-wide: 114,651
  • In epidemiology: 4,715
• Year to date:
  • Site-wide: 13,933
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  • Site-wide: 3,981

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

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  • Site-wide: 130,159
  • In genetic and genomic medicine: 639
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  • Site-wide: 32,156
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  • Site-wide: 23,930