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Author: Xiuqing Guo

  • ORCiD: http://orcid.org/0000-0002-5264-5068
  • Most recently observed institution: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Rankings

  • All-time downloads: 90,057 (rank: 2,471 )
  • Categories:
    • bioinformatics: 461 (rank: 37,021 (tie) )
    • epidemiology: 2,115 (rank: 8,789 (tie) )
    • gastroenterology: 1,158 (rank: 450 (tie) )
    • genetic and genomic medicine: 10,492 (rank: 163 )
    • genetics: 48,576 (rank: 109 )
    • genomics: 21,850 (rank: 730 )
    • hiv aids: 2,258 (rank: 53 (tie) )
    • physiology: 459 (rank: 6,912 (tie) )

Downloads per author, site-wide

Preprints

Recovery of trait heritability from whole genome sequence data

genetics more details view paper
  • Downloaded 14,790 times
  • Download rankings, all-time:
    • Site-wide: 801
    • In genetics: 14
  • Year to date:
    • Site-wide: 2,871
  • Since beginning of last month:
    • Site-wide: 6,442

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

genomics more details view paper
  • Downloaded 9,167 times
  • Download rankings, all-time:
    • Site-wide: 1,471
    • In genomics: 99
  • Year to date:
    • Site-wide: 12,088
  • Since beginning of last month:
    • Site-wide: 11,255

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

genetics more details view paper
  • Downloaded 5,711 times
  • Download rankings, all-time:
    • Site-wide: 2,775
    • In genetics: 83
  • Year to date:
    • Site-wide: 235
  • Since beginning of last month:
    • Site-wide: 463

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

genomics more details view paper
  • Downloaded 3,469 times
  • Download rankings, all-time:
    • Site-wide: 5,581
    • In genomics: 526
  • Year to date:
    • Site-wide: 32,065
  • Since beginning of last month:
    • Site-wide: 8,353

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,393 times
  • Download rankings, all-time:
    • Site-wide: 5,777
    • In genetics: 194
  • Year to date:
    • Site-wide: 83,453
  • Since beginning of last month:
    • Site-wide: 126,022

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,360 times
  • Download rankings, all-time:
    • Site-wide: 5,858
    • In genomics: 541
  • Year to date:
    • Site-wide: 144,014
  • Since beginning of last month:
    • Site-wide: 128,075

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

genetic and genomic medicine more details view paper
  • Downloaded 3,322 times
  • Download rankings, all-time:
    • Site-wide: 5,961
    • In genetic and genomic medicine: 30
  • Year to date:
    • Site-wide: 4,522
  • Since beginning of last month:
    • Site-wide: None

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 2,397 times
  • Download rankings, all-time:
    • Site-wide: 9,572
    • In genetic and genomic medicine: 55
  • Year to date:
    • Site-wide: 7,359
  • Since beginning of last month:
    • Site-wide: 23,993

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

genetics more details view paper
  • Downloaded 2,397 times
  • Download rankings, all-time:
    • Site-wide: 9,563
    • In genetics: 376
  • Year to date:
    • Site-wide: 32,736
  • Since beginning of last month:
    • Site-wide: 24,769

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

hiv aids more details view paper
  • Downloaded 2,288 times
  • Download rankings, all-time:
    • Site-wide: 10,242
    • In hiv aids: 6
  • Year to date:
    • Site-wide: 15,236
  • Since beginning of last month:
    • Site-wide: 28,768

Clonal hematopoiesis is driven by aberrant activation of TCL1A

genetics more details view paper
  • Downloaded 2,077 times
  • Download rankings, all-time:
    • Site-wide: 11,910
    • In genetics: 502
  • Year to date:
    • Site-wide: 1,563
  • Since beginning of last month:
    • Site-wide: 4,216

Identification of type 2 diabetes loci in 433,540 East Asian individuals

genetics more details view paper
  • Downloaded 2,062 times
  • Download rankings, all-time:
    • Site-wide: 12,038
    • In genetics: 448
  • Year to date:
    • Site-wide: 91,087
  • Since beginning of last month:
    • Site-wide: 158,497

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,950 times
  • Download rankings, all-time:
    • Site-wide: 13,046
    • In genetics: 506
  • Year to date:
    • Site-wide: 151,153
  • Since beginning of last month:
    • Site-wide: 44,356

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,888 times
  • Download rankings, all-time:
    • Site-wide: 13,703
    • In genetics: 549
  • Year to date:
    • Site-wide: 68,822
  • Since beginning of last month:
    • Site-wide: 11,284

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

genetics more details view paper
  • Downloaded 1,669 times
  • Download rankings, all-time:
    • Site-wide: 16,510
    • In genetics: 677
  • Year to date:
    • Site-wide: 67,602
  • Since beginning of last month:
    • Site-wide: 34,422

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 1,536 times
  • Download rankings, all-time:
    • Site-wide: 18,793
    • In genetics: 769
  • Year to date:
    • Site-wide: 42,392
  • Since beginning of last month:
    • Site-wide: 110,091

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

genetic and genomic medicine more details view paper
  • Downloaded 1,459 times
  • Download rankings, all-time:
    • Site-wide: 20,416
    • In genetic and genomic medicine: 122
  • Year to date:
    • Site-wide: 55,624
  • Since beginning of last month:
    • Site-wide: 21,129

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

genetics more details view paper
  • Downloaded 1,361 times
  • Download rankings, all-time:
    • Site-wide: 22,770
    • In genetics: 920
  • Year to date:
    • Site-wide: 117,091
  • Since beginning of last month:
    • Site-wide: 74,507

Genetic architecture of gene expression traits across diverse populations

genomics more details view paper
  • Downloaded 1,359 times
  • Download rankings, all-time:
    • Site-wide: 22,814
    • In genomics: 1,979
  • Year to date:
    • Site-wide: 132,719
  • Since beginning of last month:
    • Site-wide: 70,280

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

genomics more details view paper
  • Downloaded 1,325 times
  • Download rankings, all-time:
    • Site-wide: 23,715
    • In genomics: 2,132
  • Year to date:
    • Site-wide: 8,947
  • Since beginning of last month:
    • Site-wide: 12,703

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

genetics more details view paper
  • Downloaded 1,271 times
  • Download rankings, all-time:
    • Site-wide: 25,368
    • In genetics: 1,018
  • Year to date:
    • Site-wide: 96,939
  • Since beginning of last month:
    • Site-wide: 84,327

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 1,262 times
  • Download rankings, all-time:
    • Site-wide: 25,636
    • In genetics: 1,079
  • Year to date:
    • Site-wide: 46,699
  • Since beginning of last month:
    • Site-wide: 11,305

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

gastroenterology more details view paper
  • Downloaded 1,166 times
  • Download rankings, all-time:
    • Site-wide: 29,022
    • In gastroenterology: 30
  • Year to date:
    • Site-wide: 77,247
  • Since beginning of last month:
    • Site-wide: None

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

genetics more details view paper
  • Downloaded 931 times
  • Download rankings, all-time:
    • Site-wide: 40,946
    • In genetics: 1,636
  • Year to date:
    • Site-wide: 147,232
  • Since beginning of last month:
    • Site-wide: 126,647

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

genetics more details view paper
  • Downloaded 901 times
  • Download rankings, all-time:
    • Site-wide: 42,955
    • In genetics: 1,700
  • Year to date:
    • Site-wide: 198,603
  • Since beginning of last month:
    • Site-wide: None

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

genomics more details view paper
  • Downloaded 881 times
  • Download rankings, all-time:
    • Site-wide: 44,380
    • In genomics: 3,365
  • Year to date:
    • Site-wide: 147,301
  • Since beginning of last month:
    • Site-wide: 117,488

Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

genetic and genomic medicine more details view paper
  • Downloaded 863 times
  • Download rankings, all-time:
    • Site-wide: 45,924
    • In genetic and genomic medicine: 285
  • Year to date:
    • Site-wide: 22,670
  • Since beginning of last month:
    • Site-wide: 9,822

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

genomics more details view paper
  • Downloaded 859 times
  • Download rankings, all-time:
    • Site-wide: 46,206
    • In genomics: 3,491
  • Year to date:
    • Site-wide: 121,731
  • Since beginning of last month:
    • Site-wide: 43,996

The Socioeconomic Gradient in Epigenetic Aging Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

epidemiology more details view paper
  • Downloaded 835 times
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    • Site-wide: 48,134
    • In epidemiology: 2,440
  • Year to date:
    • Site-wide: 17,375
  • Since beginning of last month:
    • Site-wide: 130,334

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

genetics more details view paper
  • Downloaded 797 times
  • Download rankings, all-time:
    • Site-wide: 51,745
    • In genetics: 2,349
  • Year to date:
    • Site-wide: 9,782
  • Since beginning of last month:
    • Site-wide: 3,090

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals

genetic and genomic medicine more details view paper
  • Downloaded 795 times
  • Download rankings, all-time:
    • Site-wide: 51,834
    • In genetic and genomic medicine: None
  • Year to date:
    • Site-wide: 3,999
  • Since beginning of last month:
    • Site-wide: 393

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

genetics more details view paper
  • Downloaded 783 times
  • Download rankings, all-time:
    • Site-wide: 53,106
    • In genetics: 2,091
  • Year to date:
    • Site-wide: 194,941
  • Since beginning of last month:
    • Site-wide: 162,442

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

genetic and genomic medicine more details view paper
  • Downloaded 730 times
  • Download rankings, all-time:
    • Site-wide: 58,630
    • In genetic and genomic medicine: 352
  • Year to date:
    • Site-wide: 68,632
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    • Site-wide: None

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

genomics more details view paper
  • Downloaded 705 times
  • Download rankings, all-time:
    • Site-wide: 61,656
    • In genomics: 4,337
  • Year to date:
    • Site-wide: 37,182
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    • Site-wide: None

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

genetics more details view paper
  • Downloaded 702 times
  • Download rankings, all-time:
    • Site-wide: 62,101
    • In genetics: 2,424
  • Year to date:
    • Site-wide: 172,886
  • Since beginning of last month:
    • Site-wide: 91,807

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

genetics more details view paper
  • Downloaded 698 times
  • Download rankings, all-time:
    • Site-wide: 62,587
    • In genetics: 2,474
  • Year to date:
    • Site-wide: 55,100
  • Since beginning of last month:
    • Site-wide: 132,532

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

genetics more details view paper
  • Downloaded 641 times
  • Download rankings, all-time:
    • Site-wide: 70,374
    • In genetics: 2,837
  • Year to date:
    • Site-wide: 29,880
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    • Site-wide: None

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

genetics more details view paper
  • Downloaded 640 times
  • Download rankings, all-time:
    • Site-wide: 70,481
    • In genetics: 2,748
  • Year to date:
    • Site-wide: 115,432
  • Since beginning of last month:
    • Site-wide: 64,890

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 615 times
  • Download rankings, all-time:
    • Site-wide: 74,369
    • In genomics: 4,932
  • Year to date:
    • Site-wide: 150,456
  • Since beginning of last month:
    • Site-wide: 54,216

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

genetics more details view paper
  • Downloaded 567 times
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    • Site-wide: 82,226
    • In genetics: 3,170
  • Year to date:
    • Site-wide: 180,263
  • Since beginning of last month:
    • Site-wide: 157,534

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

epidemiology more details view paper
  • Downloaded 496 times
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    • Site-wide: 96,192
    • In epidemiology: 4,246
  • Year to date:
    • Site-wide: 109,811
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    • Site-wide: 108,211

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

genetic and genomic medicine more details view paper
  • Downloaded 476 times
  • Download rankings, all-time:
    • Site-wide: 100,884
    • In genetic and genomic medicine: 638
  • Year to date:
    • Site-wide: 77,592
  • Since beginning of last month:
    • Site-wide: 48,987

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

physiology more details view paper
  • Downloaded 468 times
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    • Site-wide: 102,735
    • In physiology: 806
  • Year to date:
    • Site-wide: 161,362
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    • Site-wide: 73,488

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

bioinformatics more details view paper
  • Downloaded 464 times
  • Download rankings, all-time:
    • Site-wide: 103,549
    • In bioinformatics: 8,738
  • Year to date:
    • Site-wide: 136,067
  • Since beginning of last month:
    • Site-wide: None

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

epidemiology more details view paper
  • Downloaded 459 times
  • Download rankings, all-time:
    • Site-wide: 104,841
    • In epidemiology: 4,524
  • Year to date:
    • Site-wide: 157,690
  • Since beginning of last month:
    • Site-wide: 55,849

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

genetic and genomic medicine more details view paper
  • Downloaded 456 times
  • Download rankings, all-time:
    • Site-wide: 105,400
    • In genetic and genomic medicine: 729
  • Year to date:
    • Site-wide: 19,236
  • Since beginning of last month:
    • Site-wide: 15,012

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

genetics more details view paper
  • Downloaded 451 times
  • Download rankings, all-time:
    • Site-wide: 106,703
    • In genetics: 4,057
  • Year to date:
    • Site-wide: 199,671
  • Since beginning of last month:
    • Site-wide: 121,340

The functional impact of rare variation across the regulatory cascade

genomics more details view paper
  • Downloaded 417 times
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    • Site-wide: 114,847
    • In genomics: None
  • Year to date:
    • Site-wide: 11,349
  • Since beginning of last month:
    • Site-wide: 142

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

epidemiology more details view paper
  • Downloaded 361 times
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    • Site-wide: 130,353
    • In epidemiology: 5,431
  • Year to date:
    • Site-wide: 200,851
  • Since beginning of last month:
    • Site-wide: 154,451

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

genetics more details view paper
  • Downloaded 360 times
  • Download rankings, all-time:
    • Site-wide: 130,692
    • In genetics: 4,968
  • Year to date:
    • Site-wide: 164,590
  • Since beginning of last month:
    • Site-wide: 113,018

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

genetic and genomic medicine more details view paper
  • Downloaded 352 times
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    • Site-wide: 132,778
    • In genetic and genomic medicine: 913
  • Year to date:
    • Site-wide: 47,011
  • Since beginning of last month:
    • Site-wide: 31,372

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

genetic and genomic medicine more details view paper
  • Downloaded 351 times
  • Download rankings, all-time:
    • Site-wide: 133,173
    • In genetic and genomic medicine: 892
  • Year to date:
    • Site-wide: 123,778
  • Since beginning of last month:
    • Site-wide: 111,496

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

genetics more details view paper
  • Downloaded 348 times
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    • Site-wide: 133,986
    • In genetics: 5,091
  • Year to date:
    • Site-wide: 185,920
  • Since beginning of last month:
    • Site-wide: 171,253

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

genetics more details view paper
  • Downloaded 344 times
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    • Site-wide: 135,110
    • In genetics: 5,071
  • Year to date:
    • Site-wide: 180,326
  • Since beginning of last month:
    • Site-wide: 163,294

Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

genetic and genomic medicine more details view paper
  • Downloaded 323 times
  • Download rankings, all-time:
    • Site-wide: 141,512
    • In genetic and genomic medicine: 965
  • Year to date:
    • Site-wide: 65,466
  • Since beginning of last month:
    • Site-wide: 77,293

Protein prediction for trait mapping in diverse populations

genomics more details view paper
  • Downloaded 309 times
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    • Site-wide: 145,685
    • In genomics: 7,585
  • Year to date:
    • Site-wide: 113,188
  • Since beginning of last month:
    • Site-wide: 132,337

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