Author: Mark J. Adams

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Preprints

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 31,099
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  • Site-wide: 13,608

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 2,865
  • In genomics: 350
• Year to date:
  • Site-wide: 15,609
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  • Site-wide: 18,913

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • Site-wide: 4,591
  • In genetics: 222
• Year to date:
  • Site-wide: 101,261
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  • Site-wide: 68,872

Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts

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  • Site-wide: 6,152
  • In psychiatry and clinical psychology: 16
• Year to date:
  • Site-wide: 1,893
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  • Site-wide: 2,055

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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  • Site-wide: 6,681
  • In genetics: 337
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  • Site-wide: 53,014
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  • Site-wide: 37,452

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 7,298
  • In genetics: 362
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  • Site-wide: 41,389
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  • Site-wide: 56,202

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • Site-wide: 8,666
  • In genetics: 440
• Year to date:
  • Site-wide: 80,330
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  • Site-wide: 63,867

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 12,016
  • In genetics: 616
• Year to date:
  • Site-wide: 100,492
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  • Site-wide: 50,287

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 14,470
  • In genetics: 754
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  • Site-wide: 107,520
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  • Site-wide: 63,940

Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • Site-wide: 15,904
  • In genetic and genomic medicine: 44
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  • Site-wide: 6,993
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  • Site-wide: 5,552

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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  • Site-wide: 23,388
  • In genetics: 1,178
• Year to date:
  • Site-wide: 80,326
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  • Site-wide: 86,163

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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  • Site-wide: 23,412
  • In genetics: 1,180
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  • Site-wide: 90,079
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  • Site-wide: 103,101

Factors associated with sharing email information and mental health survey participation in large population cohorts

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  • Site-wide: 28,896
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  • Site-wide: 65,775
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  • Site-wide: 92,557

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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  • Site-wide: 29,070
  • In genetics: 1,462
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  • Site-wide: 103,108
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  • Site-wide: 93,301

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 29,634
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  • Site-wide: 82,493
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  • Site-wide: 94,347

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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  • Site-wide: 30,495
  • In epidemiology: 1,509
• Year to date:
  • Site-wide: 53,010
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  • Site-wide: 36,246

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

• Downloaded 675 times
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  • Site-wide: 32,308
  • In genetics: 1,621
• Year to date:
  • Site-wide: 9,669
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  • Site-wide: 9,959

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 33,960
  • In genetics: 1,697
• Year to date:
  • Site-wide: 62,607
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  • Site-wide: 100,816

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • Site-wide: 35,365
  • In genomics: 3,086
• Year to date:
  • Site-wide: 103,378
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  • Site-wide: 111,933

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

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  • Site-wide: 37,589
  • In genetics: 1,868
• Year to date:
  • Site-wide: 89,792
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  • Site-wide: 63,974

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

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  • Site-wide: 43,318
  • In genetics: 2,118
• Year to date:
  • Site-wide: 89,222
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  • Site-wide: 103,776

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

• Downloaded 456 times
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  • Site-wide: 52,163
  • In neuroscience: 7,899
• Year to date:
  • Site-wide: 110,324
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  • Site-wide: 100,932

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

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  • Site-wide: 55,950
  • In genetics: 2,694
• Year to date:
  • Site-wide: 48,229
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  • Site-wide: 54,612

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

• Downloaded 404 times
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  • Site-wide: 59,114
  • In genetics: 2,845
• Year to date:
  • Site-wide: 99,272
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  • Site-wide: 117,133

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

• Downloaded 403 times
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  • Site-wide: 59,374
  • In genetics: 2,848
• Year to date:
  • Site-wide: 61,205
• Since beginning of last month:
  • Site-wide: 71,168

Cognitive functioning and lifetime Major Depressive Disorder in UK Biobank

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  • Site-wide: 63,188
  • In psychiatry and clinical psychology: 177
• Year to date:
  • Site-wide: 105,829
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  • Site-wide: 63,409

Mental Health in UK Biobank Revised

• Downloaded 358 times
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  • Site-wide: 66,314
  • In epidemiology: 2,728
• Year to date:
  • Site-wide: 106,509
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  • Site-wide: 64,119

Sex-Stratified Genome-Wide Association Study of Multisite Chronic Pain in UK Biobank

• Downloaded 351 times
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  • Site-wide: 67,652
  • In genetic and genomic medicine: 184
• Year to date:
  • Site-wide: 12,393
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  • Site-wide: 21,883

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

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  • Site-wide: 69,743
  • In genetics: 3,309
• Year to date:
  • Site-wide: 98,356
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  • Site-wide: 109,999

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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  • Site-wide: 71,043
  • In genetics: 3,360
• Year to date:
  • Site-wide: 111,855
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  • Site-wide: 118,529

A genome-wide association study identifies that the GDF5 and COL27A1 genes are associated with knee pain in UK Biobank (N = 171, 516)

• Downloaded 271 times
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  • Site-wide: 82,525
  • In genetics: 3,841
• Year to date:
  • Site-wide: 108,923
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  • Site-wide: 98,441

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 89,331
  • In psychiatry and clinical psychology: 289
• Year to date:
  • Site-wide: 1,539
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  • Site-wide: 3,745

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

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  • Site-wide: 89,972
  • In genomics: 5,605
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  • Site-wide: 107,053

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

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  • Site-wide: 92,084
  • In genetics: 4,257
• Year to date:
  • Site-wide: 30,935
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  • Site-wide: 47,068

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

• Downloaded 216 times
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  • Site-wide: 93,839
  • In neuroscience: 14,837
• Year to date:
  • Site-wide: 121,525
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  • Site-wide: 113,346

Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.

• Downloaded 190 times
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  • Site-wide: 99,626
  • In genetics: 4,524
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 117,215

White matter microstructure and its relation to longitudinal measures of depressive symptoms in mid-late life

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  • Site-wide: 103,175
  • In neuroscience: 16,268
• Year to date:
  • Site-wide: 61,884
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  • Site-wide: 118,391

DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder

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  • Site-wide: 104,538
  • In psychiatry and clinical psychology: 390
• Year to date:
  • Site-wide: 102,432
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  • Site-wide: 63,197

Associations Between Major Psychiatric Disorder Polygenic Risk Scores and Blood-Based Markers in UK Biobank

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  • Site-wide: 113,659
  • In psychiatry and clinical psychology: 464
• Year to date:
  • Site-wide: 63,162
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  • Site-wide: 34,155

The Influence of Phenotyping Method on Neuroimaging Associations with Depression in UK Biobank

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  • Site-wide: 118,428
  • In psychiatry and clinical psychology: 524
• Year to date:
  • Site-wide: 15,852
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  • Site-wide: 9,473