Author: Mark J Adams

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Preprints

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,635
  • In genetics: 86
• Year to date:
  • Site-wide: 39,443
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  • Site-wide: 81,529

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 3,683
  • In genomics: 384
• Year to date:
  • Site-wide: 45,561
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  • Site-wide: 57,510

Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts

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  • Site-wide: 4,528
  • In psychiatry and clinical psychology: 17
• Year to date:
  • Site-wide: 2,534
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  • Site-wide: 27,061

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,625 times
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  • Site-wide: 5,841
  • In genetics: 248
• Year to date:
  • Site-wide: 74,542
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  • Site-wide: 73,195

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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  • Site-wide: 8,084
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  • Site-wide: 43,113
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  • Site-wide: 60,137

Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • Site-wide: 9,340
  • In genetic and genomic medicine: 39
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  • Site-wide: 10,399

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 9,334
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  • Site-wide: 87,378
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  • Site-wide: 73,059

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • Site-wide: 10,537
  • In genetics: 468
• Year to date:
  • Site-wide: 59,523
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  • Site-wide: 71,130

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 13,821
  • In genetics: 632
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  • Site-wide: 47,755
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  • Site-wide: 32,603

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 15,843
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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 17,737
  • In genetics: 825
• Year to date:
  • Site-wide: 90,069
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  • Site-wide: 73,236

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 887 times
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  • Site-wide: 28,982
  • In genetics: 1,323
• Year to date:
  • Site-wide: 121,693
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  • Site-wide: None

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

• Downloaded 877 times
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  • Site-wide: 29,417
  • In genetics: 1,348
• Year to date:
  • Site-wide: 136,444
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  • Site-wide: 85,339

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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  • Site-wide: 32,805
  • In epidemiology: 1,706
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  • Site-wide: 55,208
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Factors associated with sharing email information and mental health survey participation in large population cohorts

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  • Site-wide: 35,664
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• Year to date:
  • Site-wide: 123,005
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Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 758 times
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  • Site-wide: 36,099
  • In genetics: 1,646
• Year to date:
  • Site-wide: 133,100
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  • Site-wide: 73,278

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 37,311
  • In genetics: 1,693
• Year to date:
  • Site-wide: 141,583
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  • Site-wide: 73,241

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 39,422
  • In genetics: 1,775
• Year to date:
  • Site-wide: 87,614
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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 656 times
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  • Site-wide: 43,828
  • In genomics: 3,510
• Year to date:
  • Site-wide: 137,649
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  • Site-wide: 72,768

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

• Downloaded 652 times
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  • Site-wide: 44,160
  • In genetics: 1,979
• Year to date:
  • Site-wide: 100,347
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  • Site-wide: None

Sex-Stratified Genome-Wide Association Study of Multisite Chronic Pain in UK Biobank

• Downloaded 582 times
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  • Site-wide: 50,916
  • In genetic and genomic medicine: 202
• Year to date:
  • Site-wide: 22,133
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CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

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  • Site-wide: 52,180
  • In genetics: 2,317
• Year to date:
  • Site-wide: 121,304
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  • Site-wide: 84,291

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

• Downloaded 496 times
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  • Site-wide: 61,675
  • In genetics: 2,726
• Year to date:
  • Site-wide: 79,785
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  • Site-wide: 62,822

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

• Downloaded 478 times
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  • Site-wide: 64,099
  • In neuroscience: 9,481
• Year to date:
  • Site-wide: 144,056
• Since beginning of last month:
  • Site-wide: 74,955

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

• Downloaded 478 times
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  • Site-wide: 64,130
  • In psychiatry and clinical psychology: 225
• Year to date:
  • Site-wide: 14,605
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  • Site-wide: 39,503

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

• Downloaded 473 times
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  • Site-wide: 64,929
  • In genetics: 2,863
• Year to date:
  • Site-wide: 79,328
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  • Site-wide: 31,708

Cognitive functioning and lifetime Major Depressive Disorder in UK Biobank

• Downloaded 468 times
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  • Site-wide: 65,627
  • In psychiatry and clinical psychology: 232
• Year to date:
  • Site-wide: 67,926
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  • Site-wide: 104,133

Mental Health in UK Biobank Revised

• Downloaded 463 times
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  • Site-wide: 66,525
  • In epidemiology: 2,906
• Year to date:
  • Site-wide: 59,187
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  • Site-wide: None

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

• Downloaded 429 times
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  • Site-wide: 71,985
  • In genetics: 3,163
• Year to date:
  • Site-wide: 139,339
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  • Site-wide: None

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 358 times
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  • Site-wide: 84,938
  • In genetics: 3,712
• Year to date:
  • Site-wide: 145,558
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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 351 times
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  • Site-wide: 86,424
  • In genetics: 3,761
• Year to date:
  • Site-wide: 146,274
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A genome-wide association study identifies that the GDF5 and COL27A1 genes are associated with knee pain in UK Biobank (N = 171, 516)

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  • Site-wide: 97,669
  • In genetics: 4,194
• Year to date:
  • Site-wide: 132,458
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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

• Downloaded 267 times
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  • Site-wide: 105,280
  • In genetics: 4,487
• Year to date:
  • Site-wide: 102,435
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  • Site-wide: 55,192

DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder

• Downloaded 260 times
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  • Site-wide: 106,919
  • In psychiatry and clinical psychology: 459
• Year to date:
  • Site-wide: 64,326
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  • Site-wide: 36,245

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

• Downloaded 250 times
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  • Site-wide: 109,418
  • In genomics: 6,342
• Year to date:
  • Site-wide: 147,745
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  • Site-wide: None

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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  • Site-wide: 114,254
  • In neuroscience: 17,488
• Year to date:
  • Site-wide: 150,875
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  • Site-wide: None

Characterization of Age and Polarity at Onset in Bipolar Disorder

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  • Site-wide: 114,703
  • In psychiatry and clinical psychology: 498
• Year to date:
  • Site-wide: 25,485
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  • Site-wide: 112,685

Associations Between Major Psychiatric Disorder Polygenic Risk Scores and Blood-Based Markers in UK Biobank

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  • Site-wide: 118,047
  • In psychiatry and clinical psychology: 524
• Year to date:
  • Site-wide: 58,730
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  • Site-wide: 107,259

Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.

• Downloaded 210 times
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  • Site-wide: 119,478
  • In genetics: 4,979
• Year to date:
  • Site-wide: 147,482
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  • Site-wide: 82,803

Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity

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  • Site-wide: 120,250
  • In genetic and genomic medicine: 621
• Year to date:
  • Site-wide: 28,874
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  • Site-wide: 53,948

White matter microstructure and its relation to longitudinal measures of depressive symptoms in mid-late life

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  • Site-wide: 127,139
  • In neuroscience: 19,326
• Year to date:
  • Site-wide: 151,392
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  • Site-wide: None

The Influence of Phenotyping Method on Neuroimaging Associations with Depression in UK Biobank

• Downloaded 175 times
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  • Site-wide: 127,931
  • In psychiatry and clinical psychology: 612
• Year to date:
  • Site-wide: 58,712
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  • Site-wide: 28,118

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

• Downloaded 143 times
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  • Site-wide: 135,132
  • In genetic and genomic medicine: 736
• Year to date:
  • Site-wide: 44,445
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  • Site-wide: 28,993

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

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  • Site-wide: 148,028
  • In psychiatry and clinical psychology: 901
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  • Site-wide: 83,990
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  • Site-wide: 115,258

Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

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  • Site-wide: 151,065
  • In genetics: 5,867
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  • Site-wide: 16,281