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Author: Lei Chen

  • ORCiD: http://orcid.org/0000-0002-7619-8311
  • Most recently observed institution: The Ministry of Education Key Laboratory of Clinical Diagnostics, School of Laboratory Medicine, Chongqing Medical University, China

Rankings

  • All-time downloads: 52,863 (rank: 2,783 )
  • Categories:
    • biochemistry: 1,834 (rank: 2,202 (tie) )
    • bioengineering: 73 (rank: 15,869 (tie) )
    • bioinformatics: 3,013 (rank: 4,472 (tie) )
    • biophysics: 3,048 (rank: 1,050 (tie) )
    • cancer biology: 2,203 (rank: 2,485 )
    • cell biology: 3,197 (rank: 1,495 (tie) )
    • developmental biology: 2,062 (rank: 1,436 )
    • ecology: 306 (rank: 13,426 (tie) )
    • endocrinology: 222 (rank: 799 (tie) )
    • evolutionary biology: 589 (rank: 11,816 (tie) )
    • genetic and genomic medicine: 189 (rank: 8,402 (tie) )
    • genetics: 1,209 (rank: 13,773 (tie) )
    • genomics: 6,104 (rank: 3,556 )
    • immunology: 1,635 (rank: 6,079 (tie) )
    • infectious diseases: 25,868 (rank: 2,030 )
    • microbiology: 516 (rank: 27,020 (tie) )
    • neuroscience: 113 (rank: 79,847 (tie) )
    • plant biology: 524 (rank: 8,701 (tie) )
    • radiology and imaging: 158 (rank: 2,009 (tie) )

Downloads per author, site-wide

Preprints

Features of C-reactive protein in COVID-19 patients with different ages, clinical types and outcomes: a cohort study

infectious diseases more details view paper
  • Downloaded 15,539 times
  • Download rankings, all-time:
    • Site-wide: 453
    • In infectious diseases: 162
  • Year to date:
    • Site-wide: 60
  • Since beginning of last month:
    • Site-wide: 13

Features of C-reactive protein in COVID-19 patients within various period: a cohort study

infectious diseases more details view paper
  • Downloaded 5,175 times
  • Download rankings, all-time:
    • Site-wide: 1,977
    • In infectious diseases: 474
  • Year to date:
    • Site-wide: 218
  • Since beginning of last month:
    • Site-wide: 59

Epidemiologic and Clinical Characteristics of 91 Hospitalized Patients with COVID-19 in Zhejiang, China: A retrospective, multi-centre case series

infectious diseases more details view paper
  • Downloaded 3,360 times
  • Download rankings, all-time:
    • Site-wide: 3,668
    • In infectious diseases: 681
  • Year to date:
    • Site-wide: 49,060
  • Since beginning of last month:
    • Site-wide: 41,035

Bisulfite-free, Base-resolution, and Quantitative Sequencing of Cytosine Modifications

genomics more details view paper
  • Downloaded 3,271 times
  • Download rankings, all-time:
    • Site-wide: 3,815
    • In genomics: 420
  • Year to date:
    • Site-wide: 12,463
  • Since beginning of last month:
    • Site-wide: 11,943

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

cell biology more details view paper
  • Downloaded 2,151 times
  • Download rankings, all-time:
    • Site-wide: 7,007
    • In cell biology: 154
  • Year to date:
    • Site-wide: 14,894
  • Since beginning of last month:
    • Site-wide: 15,970

Transcriptional Difference between SARS-COV-2 and other Human Coronaviruses Revealed by Sub-genomic RNA Profiling

bioinformatics more details view paper
  • Downloaded 1,581 times
  • Download rankings, all-time:
    • Site-wide: 11,053
    • In bioinformatics: 1,346
  • Year to date:
    • Site-wide: 21,273
  • Since beginning of last month:
    • Site-wide: 27,196

Structure of the receptor-activated human TRPC6 ion channel

biophysics more details view paper
  • Downloaded 1,516 times
  • Download rankings, all-time:
    • Site-wide: 11,693
    • In biophysics: 271
  • Year to date:
    • Site-wide: 80,328
  • Since beginning of last month:
    • Site-wide: 71,219

The Trans-omics Landscape of COVID-19

infectious diseases more details view paper
  • Downloaded 1,283 times
  • Download rankings, all-time:
    • Site-wide: 15,093
    • In infectious diseases: 1,525
  • Year to date:
    • Site-wide: 18,911
  • Since beginning of last month:
    • Site-wide: 18,169

EPIP: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles

bioinformatics more details view paper
  • Downloaded 1,093 times
  • Download rankings, all-time:
    • Site-wide: 19,154
    • In bioinformatics: 2,273
  • Year to date:
    • Site-wide: 45,104
  • Since beginning of last month:
    • Site-wide: 46,048

The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic

immunology more details view paper
  • Downloaded 1,034 times
  • Download rankings, all-time:
    • Site-wide: 20,780
    • In immunology: 616
  • Year to date:
    • Site-wide: 24,215
  • Since beginning of last month:
    • Site-wide: 30,831

The origin of domestication genes in goats

genomics more details view paper
  • Downloaded 1,021 times
  • Download rankings, all-time:
    • Site-wide: 21,195
    • In genomics: 2,094
  • Year to date:
    • Site-wide: 44,449
  • Since beginning of last month:
    • Site-wide: 41,890

Selective targeting of an oncogenic KRAS mutant allele by CRISPR/Cas9 induces efficient tumor regression

genetics more details view paper
  • Downloaded 869 times
  • Download rankings, all-time:
    • Site-wide: 26,712
    • In genetics: 1,273
  • Year to date:
    • Site-wide: 29,600
  • Since beginning of last month:
    • Site-wide: 27,061

Draft genome of the Reindeer (Rangifer tarandus)

genomics more details view paper
  • Downloaded 829 times
  • Download rankings, all-time:
    • Site-wide: 28,497
    • In genomics: 2,616
  • Year to date:
    • Site-wide: 94,990
  • Since beginning of last month:
    • Site-wide: 133,706

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

biochemistry more details view paper
  • Downloaded 798 times
  • Download rankings, all-time:
    • Site-wide: 30,087
    • In biochemistry: 694
  • Year to date:
    • Site-wide: 61,584
  • Since beginning of last month:
    • Site-wide: 55,541

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

genomics more details view paper
  • Downloaded 767 times
  • Download rankings, all-time:
    • Site-wide: 31,786
    • In genomics: 2,829
  • Year to date:
    • Site-wide: 107,944
  • Since beginning of last month:
    • Site-wide: 108,198

Map3k2-Regulated Intestinal Stromal Cells (MRISC) Define a Distinct Sub-cryptic Stem Cell Niche for Damage Induced Wnt Agonist R-spondin1 Production

cell biology more details view paper
  • Downloaded 765 times
  • Download rankings, all-time:
    • Site-wide: 31,927
    • In cell biology: 1,230
  • Year to date:
    • Site-wide: 10,687
  • Since beginning of last month:
    • Site-wide: 21,542

Structural insights into the mechanism of the human soluble guanylate cyclase

biochemistry more details view paper
  • Downloaded 744 times
  • Download rankings, all-time:
    • Site-wide: 33,124
    • In biochemistry: 804
  • Year to date:
    • Site-wide: 59,670
  • Since beginning of last month:
    • Site-wide: 58,395

The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine Development

developmental biology more details view paper
  • Downloaded 736 times
  • Download rankings, all-time:
    • Site-wide: 33,662
    • In developmental biology: 688
  • Year to date:
    • Site-wide: 68,842
  • Since beginning of last month:
    • Site-wide: 53,952

SCT promoter methylation is a highly discriminative biomarker for lung and many other cancers

cancer biology more details view paper
  • Downloaded 694 times
  • Download rankings, all-time:
    • Site-wide: 36,457
    • In cancer biology: 979
  • Year to date:
    • Site-wide: 102,106
  • Since beginning of last month:
    • Site-wide: 132,329

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

biophysics more details view paper
  • Downloaded 668 times
  • Download rankings, all-time:
    • Site-wide: 38,339
    • In biophysics: 1,237
  • Year to date:
    • Site-wide: 29,229
  • Since beginning of last month:
    • Site-wide: 33,018

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

evolutionary biology more details view paper
  • Downloaded 589 times
  • Download rankings, all-time:
    • Site-wide: 44,949
    • In evolutionary biology: 2,319
  • Year to date:
    • Site-wide: 56,283
  • Since beginning of last month:
    • Site-wide: 79,883

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

cancer biology more details view paper
  • Downloaded 555 times
  • Download rankings, all-time:
    • Site-wide: 48,352
    • In cancer biology: 1,361
  • Year to date:
    • Site-wide: 78,228
  • Since beginning of last month:
    • Site-wide: 43,412

Comparative transcriptome analysis by deep RNA sequencing at early stage of skin pigmentation in goats (Capra hircus)

developmental biology more details view paper
  • Downloaded 540 times
  • Download rankings, all-time:
    • Site-wide: 50,005
    • In developmental biology: 1,175
  • Year to date:
    • Site-wide: 134,259
  • Since beginning of last month:
    • Site-wide: 137,094

Chemical composition of essential oil from Folium nelumbinis and its antioxidant activity

plant biology more details view paper
  • Downloaded 524 times
  • Download rankings, all-time:
    • Site-wide: 51,842
    • In plant biology: 1,240
  • Year to date:
    • Site-wide: 68,313
  • Since beginning of last month:
    • Site-wide: 69,979

HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine

developmental biology more details view paper
  • Downloaded 507 times
  • Download rankings, all-time:
    • Site-wide: 53,941
    • In developmental biology: 1,294
  • Year to date:
    • Site-wide: 90,621
  • Since beginning of last month:
    • Site-wide: 111,264

Forward-reverse mutation cycles between stages of cancer development

cancer biology more details view paper
  • Downloaded 503 times
  • Download rankings, all-time:
    • Site-wide: 54,480
    • In cancer biology: 1,529
  • Year to date:
    • Site-wide: 131,854
  • Since beginning of last month:
    • Site-wide: 127,663

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

cancer biology more details view paper
  • Downloaded 451 times
  • Download rankings, all-time:
    • Site-wide: 61,337
    • In cancer biology: 1,756
  • Year to date:
    • Site-wide: 82,135
  • Since beginning of last month:
    • Site-wide: 85,294

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

biophysics more details view paper
  • Downloaded 449 times
  • Download rankings, all-time:
    • Site-wide: 61,515
    • In biophysics: 2,164
  • Year to date:
    • Site-wide: 88,497
  • Since beginning of last month:
    • Site-wide: 115,649

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

biophysics more details view paper
  • Downloaded 415 times
  • Download rankings, all-time:
    • Site-wide: 66,789
    • In biophysics: 2,406
  • Year to date:
    • Site-wide: 108,456
  • Since beginning of last month:
    • Site-wide: 113,163

Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in macrophage RAW264.7 cells

immunology more details view paper
  • Downloaded 346 times
  • Download rankings, all-time:
    • Site-wide: 78,967
    • In immunology: 2,242
  • Year to date:
    • Site-wide: 82,432
  • Since beginning of last month:
    • Site-wide: 83,946

Association of Structural Variation with Cardiometabolic Traits in Finns

genetics more details view paper
  • Downloaded 340 times
  • Download rankings, all-time:
    • Site-wide: 79,990
    • In genetics: 3,623
  • Year to date:
    • Site-wide: 16,628
  • Since beginning of last month:
    • Site-wide: 13,566

Predicting protein subcellular location using learned distributed representations from a protein-protein network

bioinformatics more details view paper
  • Downloaded 339 times
  • Download rankings, all-time:
    • Site-wide: 80,274
    • In bioinformatics: 7,344
  • Year to date:
    • Site-wide: 86,151
  • Since beginning of last month:
    • Site-wide: 73,072

Species packing and the latitudinal gradient in local beta-diversity

ecology more details view paper
  • Downloaded 306 times
  • Download rankings, all-time:
    • Site-wide: 87,044
    • In ecology: 2,655
  • Year to date:
    • Site-wide: 43,245
  • Since beginning of last month:
    • Site-wide: 24,664

Structure and mechanism of human dual oxidase 1 complex

biochemistry more details view paper
  • Downloaded 292 times
  • Download rankings, all-time:
    • Site-wide: 89,926
    • In biochemistry: 2,608
  • Year to date:
    • Site-wide: 64,036
  • Since beginning of last month:
    • Site-wide: 82,404

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

developmental biology more details view paper
  • Downloaded 279 times
  • Download rankings, all-time:
    • Site-wide: 92,702
    • In developmental biology: 2,500
  • Year to date:
    • Site-wide: 112,376
  • Since beginning of last month:
    • Site-wide: 76,560

An emerging role of Prevotella histicola on estrogen-deficiency induced bone loss through the gut microbiota-bone axis

microbiology more details view paper
  • Downloaded 261 times
  • Download rankings, all-time:
    • Site-wide: 96,849
    • In microbiology: 6,974
  • Year to date:
    • Site-wide: 49,084
  • Since beginning of last month:
    • Site-wide: 38,783

Elucidation of the determinant for orchestration of solo unisexual cycle in an important human fungal pathogen

microbiology more details view paper
  • Downloaded 255 times
  • Download rankings, all-time:
    • Site-wide: 98,173
    • In microbiology: 7,086
  • Year to date:
    • Site-wide: 113,465
  • Since beginning of last month:
    • Site-wide: 91,548

The expression of PDCD1 and CD274 in T cells and macrophages correlated positively with COVID-19 severity

immunology more details view paper
  • Downloaded 255 times
  • Download rankings, all-time:
    • Site-wide: 98,094
    • In immunology: 2,822
  • Year to date:
    • Site-wide: 52,939
  • Since beginning of last month:
    • Site-wide: 60,252

Transient high glucose causes delayed wound healing by the DNMT1-mediated Ang-1/NF-κB pathway

cell biology more details view paper
  • Downloaded 254 times
  • Download rankings, all-time:
    • Site-wide: 98,304
    • In cell biology: 4,568
  • Year to date:
    • Site-wide: 35,552
  • Since beginning of last month:
    • Site-wide: 39,288

Early prediction of high risk gestational diabetes mellitus via machine learning models.

endocrinology more details view paper
  • Downloaded 222 times
  • Download rankings, all-time:
    • Site-wide: 105,679
    • In endocrinology: 79
  • Year to date:
    • Site-wide: 77,020
  • Since beginning of last month:
    • Site-wide: 67,090

A Whole-Genome Association Approach for Large-scaled Inter-species Trait

genomics more details view paper
  • Downloaded 216 times
  • Download rankings, all-time:
    • Site-wide: 106,954
    • In genomics: 6,207
  • Year to date:
    • Site-wide: 130,830
  • Since beginning of last month:
    • Site-wide: 134,244

Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

genetic and genomic medicine more details view paper
  • Downloaded 189 times
  • Download rankings, all-time:
    • Site-wide: 113,115
    • In genetic and genomic medicine: 524
  • Year to date:
    • Site-wide: 39,196
  • Since beginning of last month:
    • Site-wide: 45,006

A quantitative exploration of symptoms in COVID-19 patients: an observational cohort study

infectious diseases more details view paper
  • Downloaded 161 times
  • Download rankings, all-time:
    • Site-wide: 119,410
    • In infectious diseases: 4,435
  • Year to date:
    • Site-wide: 77,533
  • Since beginning of last month:
    • Site-wide: 93,057

Staging and typing of chest CT images: A quantitative analysis based on an ambispective observational cohort study of 125 patients with COVID-19 in Xiangyang, China

radiology and imaging more details view paper
  • Downloaded 158 times
  • Download rankings, all-time:
    • Site-wide: 120,076
    • In radiology and imaging: 244
  • Year to date:
    • Site-wide: 97,704
  • Since beginning of last month:
    • Site-wide: 116,483

Features of creatine-kinase in COVID-19 patients within various specific periods: A cohort study

infectious diseases more details view paper
  • Downloaded 115 times
  • Download rankings, all-time:
    • Site-wide: 128,737
    • In infectious diseases: 4,700
  • Year to date:
    • Site-wide: 55,557
  • Since beginning of last month:
    • Site-wide: 45,572

Dendritic GABAergic inhibition controlled by Shh signaling-dependent stellate cell pool is critical for motor learning

neuroscience more details view paper
  • Downloaded 113 times
  • Download rankings, all-time:
    • Site-wide: 129,064
    • In neuroscience: 19,743
  • Year to date:
    • Site-wide: 31,151
  • Since beginning of last month:
    • Site-wide: 6,097

Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study

infectious diseases more details view paper
  • Downloaded 91 times
  • Download rankings, all-time:
    • Site-wide: 132,958
    • In infectious diseases: 4,844
  • Year to date:
    • Site-wide: 91,853
  • Since beginning of last month:
    • Site-wide: 92,810

Features of creatine-kinase in COVID-19 patients with different ages, clinical types and outcomes: A cohort study

infectious diseases more details view paper
  • Downloaded 86 times
  • Download rankings, all-time:
    • Site-wide: 133,790
    • In infectious diseases: 4,864
  • Year to date:
    • Site-wide: 75,339
  • Since beginning of last month:
    • Site-wide: 83,094

Benchtop Carbon Fiber Microelectrode Array Fabrication Toolkit

bioengineering more details view paper
  • Downloaded 73 times
  • Download rankings, all-time:
    • Site-wide: 135,551
    • In bioengineering: 2,795
  • Year to date:
    • Site-wide: 47,519
  • Since beginning of last month:
    • Site-wide: 28,480

Features of α-Hydroxybutyrate Dehydrogenase during various specific periods in COVID-19 patients within Xiangyang, China: a cohort study

infectious diseases more details view paper
  • Downloaded 58 times
  • Download rankings, all-time:
    • Site-wide: 137,095
    • In infectious diseases: 5,000
  • Year to date:
    • Site-wide: 97,794
  • Since beginning of last month:
    • Site-wide: 92,862

Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasis

cell biology more details view paper
  • Downloaded 27 times
  • Download rankings, all-time:
    • Site-wide: 138,699
    • In cell biology: 6,306
  • Year to date:
    • Site-wide: 100,518
  • Since beginning of last month:
    • Site-wide: 31,900

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