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Author: Lei Chen

  • ORCiD: http://orcid.org/0000-0002-5459-863X
  • Most recently observed institution: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China

Rankings

  • All-time downloads: 68,508 (rank: 2,602 )
  • Categories:
    • biochemistry: 2,094 (rank: 2,264 (tie) )
    • bioengineering: 205 (rank: 15,719 (tie) )
    • bioinformatics: 3,280 (rank: 4,693 (tie) )
    • biophysics: 3,209 (rank: 1,199 (tie) )
    • cancer biology: 3,586 (rank: 1,409 (tie) )
    • cell biology: 3,699 (rank: 1,429 )
    • developmental biology: 2,234 (rank: 1,529 )
    • ecology: 677 (rank: 7,439 (tie) )
    • endocrinology: 285 (rank: 925 (tie) )
    • evolutionary biology: 684 (rank: 11,827 (tie) )
    • genetic and genomic medicine: 269 (rank: 10,577 (tie) )
    • genetics: 1,365 (rank: 13,710 (tie) )
    • genomics: 6,523 (rank: 3,659 )
    • immunology: 1,877 (rank: 6,896 (tie) )
    • infectious diseases: 36,797 (rank: 1,562 )
    • microbiology: 600 (rank: 28,427 (tie) )
    • neuroscience: 259 (rank: 74,376 (tie) )
    • plant biology: 664 (rank: 7,881 (tie) )
    • radiology and imaging: 201 (rank: 2,313 (tie) )

Downloads per author, site-wide

Preprints

Features of C-reactive protein in COVID-19 patients with different ages, clinical types and outcomes: a cohort study

infectious diseases more details view paper
  • Downloaded 24,376 times
  • Download rankings, all-time:
    • Site-wide: 353
    • In infectious diseases: 127
  • Year to date:
    • Site-wide: 101
  • Since beginning of last month:
    • Site-wide: 309

Features of C-reactive protein in COVID-19 patients within various period: a cohort study

infectious diseases more details view paper
  • Downloaded 6,787 times
  • Download rankings, all-time:
    • Site-wide: 1,684
    • In infectious diseases: 465
  • Year to date:
    • Site-wide: 415
  • Since beginning of last month:
    • Site-wide: 13,019

Bisulfite-free, Base-resolution, and Quantitative Sequencing of Cytosine Modifications

genomics more details view paper
  • Downloaded 3,562 times
  • Download rankings, all-time:
    • Site-wide: 4,067
    • In genomics: 405
  • Year to date:
    • Site-wide: 11,021
  • Since beginning of last month:
    • Site-wide: 7,010

Epidemiologic and Clinical Characteristics of 91 Hospitalized Patients with COVID-19 in Zhejiang, China: A retrospective, multi-centre case series

infectious diseases more details view paper
  • Downloaded 3,435 times
  • Download rankings, all-time:
    • Site-wide: 4,280
    • In infectious diseases: 846
  • Year to date:
    • Site-wide: 60,399
  • Since beginning of last month:
    • Site-wide: 88,783

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

cell biology more details view paper
  • Downloaded 2,370 times
  • Download rankings, all-time:
    • Site-wide: 7,335
    • In cell biology: 154
  • Year to date:
    • Site-wide: 15,195
  • Since beginning of last month:
    • Site-wide: 12,801

Transcriptional Difference between SARS-COV-2 and other Human Coronaviruses Revealed by Sub-genomic RNA Profiling

bioinformatics more details view paper
  • Downloaded 1,706 times
  • Download rankings, all-time:
    • Site-wide: 11,861
    • In bioinformatics: 1,346
  • Year to date:
    • Site-wide: 27,584
  • Since beginning of last month:
    • Site-wide: 90,707

Structure of the receptor-activated human TRPC6 ion channel

biophysics more details view paper
  • Downloaded 1,561 times
  • Download rankings, all-time:
    • Site-wide: 13,464
    • In biophysics: 312
  • Year to date:
    • Site-wide: 98,649
  • Since beginning of last month:
    • Site-wide: 135,301

The Trans-omics Landscape of COVID-19

infectious diseases more details view paper
  • Downloaded 1,427 times
  • Download rankings, all-time:
    • Site-wide: 15,515
    • In infectious diseases: 1,766
  • Year to date:
    • Site-wide: 23,577
  • Since beginning of last month:
    • Site-wide: 72,878

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

cancer biology more details view paper
  • Downloaded 1,264 times
  • Download rankings, all-time:
    • Site-wide: 18,617
    • In cancer biology: 417
  • Year to date:
    • Site-wide: 3,054
  • Since beginning of last month:
    • Site-wide: 1,823

The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic

immunology more details view paper
  • Downloaded 1,176 times
  • Download rankings, all-time:
    • Site-wide: 20,727
    • In immunology: 715
  • Year to date:
    • Site-wide: 27,433
  • Since beginning of last month:
    • Site-wide: 28,434

EPIP: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles

bioinformatics more details view paper
  • Downloaded 1,174 times
  • Download rankings, all-time:
    • Site-wide: 20,790
    • In bioinformatics: 2,378
  • Year to date:
    • Site-wide: 55,299
  • Since beginning of last month:
    • Site-wide: 82,679

The origin of domestication genes in goats

genomics more details view paper
  • Downloaded 1,084 times
  • Download rankings, all-time:
    • Site-wide: 23,340
    • In genomics: 2,194
  • Year to date:
    • Site-wide: 61,937
  • Since beginning of last month:
    • Site-wide: 62,505

Selective targeting of an oncogenic KRAS mutant allele by CRISPR/Cas9 induces efficient tumor regression

genetics more details view paper
  • Downloaded 957 times
  • Download rankings, all-time:
    • Site-wide: 28,064
    • In genetics: 1,265
  • Year to date:
    • Site-wide: 41,099
  • Since beginning of last month:
    • Site-wide: 51,652

Structural insights into the mechanism of the human soluble guanylate cyclase

biochemistry more details view paper
  • Downloaded 869 times
  • Download rankings, all-time:
    • Site-wide: 32,252
    • In biochemistry: 770
  • Year to date:
    • Site-wide: 47,780
  • Since beginning of last month:
    • Site-wide: 24,793

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

biochemistry more details view paper
  • Downloaded 864 times
  • Download rankings, all-time:
    • Site-wide: 32,493
    • In biochemistry: 779
  • Year to date:
    • Site-wide: 72,914
  • Since beginning of last month:
    • Site-wide: 45,340

Draft genome of the Reindeer (Rangifer tarandus)

genomics more details view paper
  • Downloaded 859 times
  • Download rankings, all-time:
    • Site-wide: 32,805
    • In genomics: 2,809
  • Year to date:
    • Site-wide: 122,287
  • Since beginning of last month:
    • Site-wide: 156,474

Map3k2-Regulated Intestinal Stromal Cells (MRISC) Define a Distinct Sub-cryptic Stem Cell Niche for Damage Induced Wnt Agonist R-spondin1 Production

cell biology more details view paper
  • Downloaded 833 times
  • Download rankings, all-time:
    • Site-wide: 34,134
    • In cell biology: 1,304
  • Year to date:
    • Site-wide: 21,955
  • Since beginning of last month:
    • Site-wide: 83,125

The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine Development

developmental biology more details view paper
  • Downloaded 791 times
  • Download rankings, all-time:
    • Site-wide: 36,836
    • In developmental biology: 743
  • Year to date:
    • Site-wide: 84,503
  • Since beginning of last month:
    • Site-wide: 93,402

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

genomics more details view paper
  • Downloaded 782 times
  • Download rankings, all-time:
    • Site-wide: 37,390
    • In genomics: 3,094
  • Year to date:
    • Site-wide: 146,453
  • Since beginning of last month:
    • Site-wide: 157,342

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

biophysics more details view paper
  • Downloaded 727 times
  • Download rankings, all-time:
    • Site-wide: 41,384
    • In biophysics: 1,327
  • Year to date:
    • Site-wide: 48,636
  • Since beginning of last month:
    • Site-wide: 48,742

SCT promoter methylation is a highly discriminative biomarker for lung and many other cancers

cancer biology more details view paper
  • Downloaded 721 times
  • Download rankings, all-time:
    • Site-wide: 41,828
    • In cancer biology: 1,139
  • Year to date:
    • Site-wide: 130,085
  • Since beginning of last month:
    • Site-wide: 100,994

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

evolutionary biology more details view paper
  • Downloaded 684 times
  • Download rankings, all-time:
    • Site-wide: 44,886
    • In evolutionary biology: 2,128
  • Year to date:
    • Site-wide: 56,782
  • Since beginning of last month:
    • Site-wide: 39,543

Chemical composition of essential oil from Folium nelumbinis and its antioxidant activity

plant biology more details view paper
  • Downloaded 591 times
  • Download rankings, all-time:
    • Site-wide: 54,278
    • In plant biology: 1,261
  • Year to date:
    • Site-wide: 76,012
  • Since beginning of last month:
    • Site-wide: 70,454

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

cancer biology more details view paper
  • Downloaded 586 times
  • Download rankings, all-time:
    • Site-wide: 54,845
    • In cancer biology: 1,569
  • Year to date:
    • Site-wide: 110,356
  • Since beginning of last month:
    • Site-wide: 134,674

Comparative transcriptome analysis by deep RNA sequencing at early stage of skin pigmentation in goats (Capra hircus)

developmental biology more details view paper
  • Downloaded 576 times
  • Download rankings, all-time:
    • Site-wide: 56,112
    • In developmental biology: 1,303
  • Year to date:
    • Site-wide: 135,737
  • Since beginning of last month:
    • Site-wide: 100,084

HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine

developmental biology more details view paper
  • Downloaded 542 times
  • Download rankings, all-time:
    • Site-wide: 60,342
    • In developmental biology: 1,429
  • Year to date:
    • Site-wide: 115,005
  • Since beginning of last month:
    • Site-wide: 114,557

Forward-reverse mutation cycles between stages of cancer development

cancer biology more details view paper
  • Downloaded 531 times
  • Download rankings, all-time:
    • Site-wide: 61,822
    • In cancer biology: 1,769
  • Year to date:
    • Site-wide: 143,925
  • Since beginning of last month:
    • Site-wide: 84,549

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

cancer biology more details view paper
  • Downloaded 484 times
  • Download rankings, all-time:
    • Site-wide: 68,651
    • In cancer biology: 1,996
  • Year to date:
    • Site-wide: 111,830
  • Since beginning of last month:
    • Site-wide: 70,496

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

biophysics more details view paper
  • Downloaded 480 times
  • Download rankings, all-time:
    • Site-wide: 69,227
    • In biophysics: 2,460
  • Year to date:
    • Site-wide: 117,750
  • Since beginning of last month:
    • Site-wide: 91,337

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

biophysics more details view paper
  • Downloaded 441 times
  • Download rankings, all-time:
    • Site-wide: 75,830
    • In biophysics: 2,751
  • Year to date:
    • Site-wide: 133,377
  • Since beginning of last month:
    • Site-wide: 142,078

Transient high glucose causes delayed wound healing by the DNMT1-mediated Ang-1/NF-κB pathway

cell biology more details view paper
  • Downloaded 413 times
  • Download rankings, all-time:
    • Site-wide: 81,002
    • In cell biology: 3,706
  • Year to date:
    • Site-wide: 30,924
  • Since beginning of last month:
    • Site-wide: 27,727

Association of Structural Variation with Cardiometabolic Traits in Finns

genetics more details view paper
  • Downloaded 408 times
  • Download rankings, all-time:
    • Site-wide: 82,032
    • In genetics: 3,523
  • Year to date:
    • Site-wide: 31,128
  • Since beginning of last month:
    • Site-wide: 50,490

Predicting protein subcellular location using learned distributed representations from a protein-protein network

bioinformatics more details view paper
  • Downloaded 400 times
  • Download rankings, all-time:
    • Site-wide: 83,622
    • In bioinformatics: 7,547
  • Year to date:
    • Site-wide: 88,652
  • Since beginning of last month:
    • Site-wide: 68,310

Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in macrophage RAW264.7 cells

immunology more details view paper
  • Downloaded 393 times
  • Download rankings, all-time:
    • Site-wide: 84,912
    • In immunology: 2,538
  • Year to date:
    • Site-wide: 98,803
  • Since beginning of last month:
    • Site-wide: 64,013

Structure and mechanism of human dual oxidase 1 complex

biochemistry more details view paper
  • Downloaded 361 times
  • Download rankings, all-time:
    • Site-wide: 91,654
    • In biochemistry: 2,628
  • Year to date:
    • Site-wide: 72,285
  • Since beginning of last month:
    • Site-wide: 92,121

Species packing and the latitudinal gradient in local beta-diversity

ecology more details view paper
  • Downloaded 358 times
  • Download rankings, all-time:
    • Site-wide: 92,299
    • In ecology: 2,646
  • Year to date:
    • Site-wide: 66,130
  • Since beginning of last month:
    • Site-wide: 73,018

An emerging role of Prevotella histicola on estrogen-deficiency induced bone loss through the gut microbiota-bone axis

microbiology more details view paper
  • Downloaded 330 times
  • Download rankings, all-time:
    • Site-wide: 98,629
    • In microbiology: 6,889
  • Year to date:
    • Site-wide: 63,130
  • Since beginning of last month:
    • Site-wide: 105,920

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

developmental biology more details view paper
  • Downloaded 325 times
  • Download rankings, all-time:
    • Site-wide: 99,793
    • In developmental biology: 2,680
  • Year to date:
    • Site-wide: 113,729
  • Since beginning of last month:
    • Site-wide: 85,948

The expression of PDCD1 and CD274 in T cells and macrophages correlated positively with COVID-19 severity

immunology more details view paper
  • Downloaded 308 times
  • Download rankings, all-time:
    • Site-wide: 103,909
    • In immunology: 3,128
  • Year to date:
    • Site-wide: 74,016
  • Since beginning of last month:
    • Site-wide: 68,051

Early prediction of high risk gestational diabetes mellitus via machine learning models.

endocrinology more details view paper
  • Downloaded 285 times
  • Download rankings, all-time:
    • Site-wide: 109,534
    • In endocrinology: 90
  • Year to date:
    • Site-wide: 83,260
  • Since beginning of last month:
    • Site-wide: 88,633

Elucidation of the determinant for orchestration of solo unisexual cycle in an important human fungal pathogen

microbiology more details view paper
  • Downloaded 270 times
  • Download rankings, all-time:
    • Site-wide: 113,381
    • In microbiology: 8,118
  • Year to date:
    • Site-wide: 149,042
  • Since beginning of last month:
    • Site-wide: 136,128

Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

genetic and genomic medicine more details view paper
  • Downloaded 269 times
  • Download rankings, all-time:
    • Site-wide: 113,662
    • In genetic and genomic medicine: 600
  • Year to date:
    • Site-wide: 51,296
  • Since beginning of last month:
    • Site-wide: 96,334

Dendritic GABAergic inhibition controlled by Shh signaling-dependent stellate cell pool is critical for motor learning

neuroscience more details view paper
  • Downloaded 259 times
  • Download rankings, all-time:
    • Site-wide: 116,331
    • In neuroscience: 17,503
  • Year to date:
    • Site-wide: 30,832
  • Since beginning of last month:
    • Site-wide: 5,895

A Whole-Genome Association Approach for Large-scaled Inter-species Trait

genomics more details view paper
  • Downloaded 236 times
  • Download rankings, all-time:
    • Site-wide: 122,482
    • In genomics: 6,805
  • Year to date:
    • Site-wide: 151,294
  • Since beginning of last month:
    • Site-wide: 123,775

A quantitative exploration of symptoms in COVID-19 patients: an observational cohort study

infectious diseases more details view paper
  • Downloaded 208 times
  • Download rankings, all-time:
    • Site-wide: 129,634
    • In infectious diseases: 5,366
  • Year to date:
    • Site-wide: 95,611
  • Since beginning of last month:
    • Site-wide: 105,368

Benchtop Carbon Fiber Microelectrode Array Fabrication Toolkit

bioengineering more details view paper
  • Downloaded 205 times
  • Download rankings, all-time:
    • Site-wide: 130,346
    • In bioengineering: 2,625
  • Year to date:
    • Site-wide: 41,283
  • Since beginning of last month:
    • Site-wide: 32,715

Staging and typing of chest CT images: A quantitative analysis based on an ambispective observational cohort study of 125 patients with COVID-19 in Xiangyang, China

radiology and imaging more details view paper
  • Downloaded 201 times
  • Download rankings, all-time:
    • Site-wide: 131,518
    • In radiology and imaging: 287
  • Year to date:
    • Site-wide: 109,242
  • Since beginning of last month:
    • Site-wide: 126,235

Shifts in leaf senescence across the Northern Hemisphere in response to seasonal warming

ecology more details view paper
  • Downloaded 187 times
  • Download rankings, all-time:
    • Site-wide: 134,744
    • In ecology: 4,566
  • Year to date:
    • Site-wide: 46,100
  • Since beginning of last month:
    • Site-wide: 23,899

Features of creatine-kinase in COVID-19 patients within various specific periods: A cohort study

infectious diseases more details view paper
  • Downloaded 184 times
  • Download rankings, all-time:
    • Site-wide: 135,470
    • In infectious diseases: 5,541
  • Year to date:
    • Site-wide: 68,017
  • Since beginning of last month:
    • Site-wide: 36,373

Features of creatine-kinase in COVID-19 patients with different ages, clinical types and outcomes: A cohort study

infectious diseases more details view paper
  • Downloaded 136 times
  • Download rankings, all-time:
    • Site-wide: 146,430
    • In infectious diseases: 5,885
  • Year to date:
    • Site-wide: 91,802
  • Since beginning of last month:
    • Site-wide: 96,397

Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study

infectious diseases more details view paper
  • Downloaded 134 times
  • Download rankings, all-time:
    • Site-wide: 146,878
    • In infectious diseases: 5,909
  • Year to date:
    • Site-wide: 106,308
  • Since beginning of last month:
    • Site-wide: 71,140

A warmer growing season triggers earlier following spring phenology

ecology more details view paper
  • Downloaded 132 times
  • Download rankings, all-time:
    • Site-wide: 147,210
    • In ecology: 5,217
  • Year to date:
    • Site-wide: 66,662
  • Since beginning of last month:
    • Site-wide: 55,491

Features of α-Hydroxybutyrate Dehydrogenase during various specific periods in COVID-19 patients within Xiangyang, China: a cohort study

infectious diseases more details view paper
  • Downloaded 110 times
  • Download rankings, all-time:
    • Site-wide: 151,296
    • In infectious diseases: 6,043
  • Year to date:
    • Site-wide: 102,144
  • Since beginning of last month:
    • Site-wide: 56,065

Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasis

cell biology more details view paper
  • Downloaded 83 times
  • Download rankings, all-time:
    • Site-wide: 155,163
    • In cell biology: 7,076
  • Year to date:
    • Site-wide: 99,459
  • Since beginning of last month:
    • Site-wide: 30,464

Transcriptome and metabolome analyses reveal pathways associated with fruit color in plum (Prunus salicina Lindl.)

plant biology more details view paper
  • Downloaded 73 times
  • Download rankings, all-time:
    • Site-wide: 156,151
    • In plant biology: 4,387
  • Year to date:
    • Site-wide: 109,146
  • Since beginning of last month:
    • Site-wide: 95,605

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