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Author: Lei Chen

Rankings

  • All-time downloads: 85,583 (rank: 2,781 )
  • Categories:
    • biochemistry: 3,454 (rank: 1,574 (tie) )
    • bioengineering: 472 (rank: 13,662 (tie) )
    • bioinformatics: 3,702 (rank: 5,101 )
    • biophysics: 4,756 (rank: 932 )
    • cancer biology: 4,958 (rank: 1,259 )
    • cell biology: 4,796 (rank: 1,428 )
    • developmental biology: 2,472 (rank: 1,878 )
    • ecology: 1,164 (rank: 5,164 (tie) )
    • endocrinology: 374 (rank: 1,469 (tie) )
    • evolutionary biology: 790 (rank: 13,139 (tie) )
    • genetic and genomic medicine: 468 (rank: 12,388 (tie) )
    • genetics: 1,533 (rank: 14,520 (tie) )
    • genomics: 7,442 (rank: 3,866 )
    • immunology: 2,943 (rank: 5,948 )
    • infectious diseases: 40,340 (rank: 1,847 )
    • microbiology: 760 (rank: 30,563 (tie) )
    • neuroscience: 546 (rank: 63,123 (tie) )
    • physiology: 39 (rank: 17,118 (tie) )
    • plant biology: 823 (rank: 8,500 (tie) )
    • radiology and imaging: 295 (rank: 2,947 (tie) )
    • systems biology: 376 (rank: 14,154 (tie) )

Downloads per author, site-wide

Preprints

3D Printed Skull Cap and Benchtop Fabricated Microwire-based Microelectrode Array for Custom Rat Brain Recordings

neuroscience more details view paper

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Features of C-reactive protein in COVID-19 patients with different ages, clinical types and outcomes: a cohort study

infectious diseases more details view paper
  • Downloaded 26,984 times
  • Download rankings, all-time:
    • Site-wide: 402
    • In infectious diseases: 148
  • Year to date:
    • Site-wide: 1,568
  • Since beginning of last month:
    • Site-wide: 63,842

Features of C-reactive protein in COVID-19 patients within various period: a cohort study

infectious diseases more details view paper
  • Downloaded 7,175 times
  • Download rankings, all-time:
    • Site-wide: 2,089
    • In infectious diseases: 580
  • Year to date:
    • Site-wide: 32,376
  • Since beginning of last month:
    • Site-wide: 30,490

Bisulfite-free, Base-resolution, and Quantitative Sequencing of Cytosine Modifications

genomics more details view paper
  • Downloaded 4,414 times
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    • Site-wide: 4,024
    • In genomics: 382
  • Year to date:
    • Site-wide: 7,328
  • Since beginning of last month:
    • Site-wide: 6,269

Epidemiologic and Clinical Characteristics of 91 Hospitalized Patients with COVID-19 in Zhejiang, China: A retrospective, multi-centre case series

infectious diseases more details view paper
  • Downloaded 3,575 times
  • Download rankings, all-time:
    • Site-wide: 5,483
    • In infectious diseases: 1,084
  • Year to date:
    • Site-wide: 119,080
  • Since beginning of last month:
    • Site-wide: 121,449

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

cell biology more details view paper
  • Downloaded 2,778 times
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    • Site-wide: 7,905
    • In cell biology: 162
  • Year to date:
    • Site-wide: 27,952
  • Since beginning of last month:
    • Site-wide: 24,289

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

cancer biology more details view paper
  • Downloaded 2,124 times
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    • Site-wide: 11,889
    • In cancer biology: 221
  • Year to date:
    • Site-wide: 15,658
  • Since beginning of last month:
    • Site-wide: 28,562

The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic

immunology more details view paper
  • Downloaded 1,976 times
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    • Site-wide: 13,236
    • In immunology: 528
  • Year to date:
    • Site-wide: 7,692
  • Since beginning of last month:
    • Site-wide: 7,020

Meta-transcriptomic analysis reveals the gene expression and novel conserved sub-genomic RNAs in SARS-CoV-2 and MERS-CoV.

bioinformatics more details view paper
  • Downloaded 1,935 times
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    • Site-wide: 13,658
    • In bioinformatics: 1,419
  • Year to date:
    • Site-wide: 67,602
  • Since beginning of last month:
    • Site-wide: 99,573

Structure of the receptor-activated human TRPC6 ion channel

biophysics more details view paper
  • Downloaded 1,650 times
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    • Site-wide: 17,442
    • In biophysics: 398
  • Year to date:
    • Site-wide: 142,532
  • Since beginning of last month:
    • Site-wide: 70,141

The Trans-omics Landscape of COVID-19

infectious diseases more details view paper
  • Downloaded 1,571 times
  • Download rankings, all-time:
    • Site-wide: 18,837
    • In infectious diseases: 2,191
  • Year to date:
    • Site-wide: 106,377
  • Since beginning of last month:
    • Site-wide: 99,284

EPIP: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles

bioinformatics more details view paper
  • Downloaded 1,378 times
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    • Site-wide: 23,226
    • In bioinformatics: 2,526
  • Year to date:
    • Site-wide: 70,232
  • Since beginning of last month:
    • Site-wide: 150,406

The origin of domestication genes in goats

genomics more details view paper
  • Downloaded 1,252 times
  • Download rankings, all-time:
    • Site-wide: 27,076
    • In genomics: 2,294
  • Year to date:
    • Site-wide: 71,401
  • Since beginning of last month:
    • Site-wide: 102,463

Selective targeting of an oncogenic KRAS mutant allele by CRISPR/Cas9 induces efficient tumor regression

genetics more details view paper
  • Downloaded 1,092 times
  • Download rankings, all-time:
    • Site-wide: 33,491
    • In genetics: 1,335
  • Year to date:
    • Site-wide: 97,576
  • Since beginning of last month:
    • Site-wide: 101,725

Structural insights into the mechanism of the human soluble guanylate cyclase

biochemistry more details view paper
  • Downloaded 1,090 times
  • Download rankings, all-time:
    • Site-wide: 33,590
    • In biochemistry: 803
  • Year to date:
    • Site-wide: 67,427
  • Since beginning of last month:
    • Site-wide: 61,267

An improved vector for baculovirus-mediated protein production in mammalian cells

biochemistry more details view paper
  • Downloaded 1,075 times
  • Download rankings, all-time:
    • Site-wide: 34,264
    • In biochemistry: 938
  • Year to date:
    • Site-wide: 10,223
  • Since beginning of last month:
    • Site-wide: 11,985

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

biochemistry more details view paper
  • Downloaded 988 times
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    • Site-wide: 38,976
    • In biochemistry: 965
  • Year to date:
    • Site-wide: 97,618
  • Since beginning of last month:
    • Site-wide: 139,602

Map3k2-Regulated Intestinal Stromal Cells (MRISC) Define a Distinct Sub-cryptic Stem Cell Niche for Damage Induced Wnt Agonist R-spondin1 Production

cell biology more details view paper
  • Downloaded 964 times
  • Download rankings, all-time:
    • Site-wide: 40,538
    • In cell biology: 1,548
  • Year to date:
    • Site-wide: 104,027
  • Since beginning of last month:
    • Site-wide: 88,581

Draft genome of the Reindeer (Rangifer tarandus)

genomics more details view paper
  • Downloaded 922 times
  • Download rankings, all-time:
    • Site-wide: 43,384
    • In genomics: 3,263
  • Year to date:
    • Site-wide: 169,430
  • Since beginning of last month:
    • Site-wide: 107,787

The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine Development

developmental biology more details view paper
  • Downloaded 870 times
  • Download rankings, all-time:
    • Site-wide: 47,397
    • In developmental biology: 980
  • Year to date:
    • Site-wide: 165,302
  • Since beginning of last month:
    • Site-wide: 128,005

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

biophysics more details view paper
  • Downloaded 855 times
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    • Site-wide: 48,616
    • In biophysics: 1,547
  • Year to date:
    • Site-wide: 108,205
  • Since beginning of last month:
    • Site-wide: 58,053

SCT promoter methylation is a highly discriminative biomarker for lung and many other cancers

cancer biology more details view paper
  • Downloaded 828 times
  • Download rankings, all-time:
    • Site-wide: 51,132
    • In cancer biology: 1,420
  • Year to date:
    • Site-wide: 160,228
  • Since beginning of last month:
    • Site-wide: 91,490

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex

biophysics more details view paper
  • Downloaded 826 times
  • Download rankings, all-time:
    • Site-wide: 51,280
    • In biophysics: 1,675
  • Year to date:
    • Site-wide: 18,205
  • Since beginning of last month:
    • Site-wide: 49,806

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

genomics more details view paper
  • Downloaded 825 times
  • Download rankings, all-time:
    • Site-wide: 51,418
    • In genomics: 3,669
  • Year to date:
    • Site-wide: 204,128
  • Since beginning of last month:
    • Site-wide: 186,559

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

evolutionary biology more details view paper
  • Downloaded 810 times
  • Download rankings, all-time:
    • Site-wide: 52,764
    • In evolutionary biology: 2,186
  • Year to date:
    • Site-wide: 104,790
  • Since beginning of last month:
    • Site-wide: 177,459

Chemical composition of essential oil from Folium nelumbinis and its antioxidant activity

plant biology more details view paper
  • Downloaded 705 times
  • Download rankings, all-time:
    • Site-wide: 64,627
    • In plant biology: 1,437
  • Year to date:
    • Site-wide: 109,087
  • Since beginning of last month:
    • Site-wide: 67,760

Transient high glucose causes delayed wound healing by the DNMT1-mediated Ang-1/NF-κB pathway

cell biology more details view paper
  • Downloaded 688 times
  • Download rankings, all-time:
    • Site-wide: 66,942
    • In cell biology: 2,917
  • Year to date:
    • Site-wide: 49,947
  • Since beginning of last month:
    • Site-wide: 88,388

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

cancer biology more details view paper
  • Downloaded 652 times
  • Download rankings, all-time:
    • Site-wide: 71,988
    • In cancer biology: 2,014
  • Year to date:
    • Site-wide: 190,168
  • Since beginning of last month:
    • Site-wide: 166,775

Comparative transcriptome analysis by deep RNA sequencing at early stage of skin pigmentation in goats (Capra hircus)

developmental biology more details view paper
  • Downloaded 651 times
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    • Site-wide: 72,233
    • In developmental biology: 1,744
  • Year to date:
    • Site-wide: 165,530
  • Since beginning of last month:
    • Site-wide: 68,553

HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine

developmental biology more details view paper
  • Downloaded 608 times
  • Download rankings, all-time:
    • Site-wide: 78,854
    • In developmental biology: 1,913
  • Year to date:
    • Site-wide: 169,550
  • Since beginning of last month:
    • Site-wide: 148,633

Forward-reverse mutation cycles between stages of cancer development

cancer biology more details view paper
  • Downloaded 598 times
  • Download rankings, all-time:
    • Site-wide: 80,485
    • In cancer biology: 2,263
  • Year to date:
    • Site-wide: 187,247
  • Since beginning of last month:
    • Site-wide: 148,966

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

cancer biology more details view paper
  • Downloaded 584 times
  • Download rankings, all-time:
    • Site-wide: 83,069
    • In cancer biology: 2,396
  • Year to date:
    • Site-wide: 162,456
  • Since beginning of last month:
    • Site-wide: 123,375

Dendritic GABAergic inhibition controlled by Shh signaling-dependent stellate cell pool is critical for motor learning

neuroscience more details view paper
  • Downloaded 562 times
  • Download rankings, all-time:
    • Site-wide: 87,095
    • In neuroscience: 12,086
  • Year to date:
    • Site-wide: 105,361
  • Since beginning of last month:
    • Site-wide: 190,488

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

biophysics more details view paper
  • Downloaded 556 times
  • Download rankings, all-time:
    • Site-wide: 88,226
    • In biophysics: 3,055
  • Year to date:
    • Site-wide: 178,259
  • Since beginning of last month:
    • Site-wide: 178,530

Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in macrophage RAW264.7 cells

immunology more details view paper
  • Downloaded 510 times
  • Download rankings, all-time:
    • Site-wide: 97,780
    • In immunology: 3,105
  • Year to date:
    • Site-wide: 104,056
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    • Site-wide: 122,655

Benchtop Carbon Fiber Microelectrode Array Fabrication Toolkit

bioengineering more details view paper
  • Downloaded 498 times
  • Download rankings, all-time:
    • Site-wide: 100,254
    • In bioengineering: 1,973
  • Year to date:
    • Site-wide: 40,736
  • Since beginning of last month:
    • Site-wide: None

Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

genetic and genomic medicine more details view paper
  • Downloaded 493 times
  • Download rankings, all-time:
    • Site-wide: 101,624
    • In genetic and genomic medicine: 626
  • Year to date:
    • Site-wide: 48,644
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    • Site-wide: 158,406

Association of Structural Variation with Cardiometabolic Traits in Finns

genetics more details view paper
  • Downloaded 491 times
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    • Site-wide: 102,055
    • In genetics: 3,799
  • Year to date:
    • Site-wide: 175,406
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    • Site-wide: 190,858

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

biophysics more details view paper
  • Downloaded 491 times
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    • Site-wide: 102,098
    • In biophysics: 3,620
  • Year to date:
    • Site-wide: 183,955
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    • Site-wide: 127,608

Species packing and the latitudinal gradient in beta-diversity

ecology more details view paper
  • Downloaded 482 times
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    • Site-wide: 104,105
    • In ecology: 2,714
  • Year to date:
    • Site-wide: 111,578
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    • Site-wide: 139,476

Predicting protein subcellular location using learned distributed representations from a protein-protein network

bioinformatics more details view paper
  • Downloaded 480 times
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    • Site-wide: 104,579
    • In bioinformatics: 8,660
  • Year to date:
    • Site-wide: 174,572
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    • Site-wide: 179,693

Spatial Meta-transcriptomes of human and murine intestines

systems biology more details view paper
  • Downloaded 456 times
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    • Site-wide: 110,179
    • In systems biology: 2,542
  • Year to date:
    • Site-wide: 21,231
  • Since beginning of last month:
    • Site-wide: 23,726

Structure and mechanism of human dual oxidase 1 complex

biochemistry more details view paper
  • Downloaded 450 times
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    • Site-wide: 111,634
    • In biochemistry: 3,079
  • Year to date:
    • Site-wide: 161,238
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    • Site-wide: 143,523

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

developmental biology more details view paper
  • Downloaded 441 times
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    • Site-wide: 113,970
    • In developmental biology: 2,985
  • Year to date:
    • Site-wide: 116,559
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    • Site-wide: 88,737

An emerging role of Prevotella histicola on estrogen-deficiency induced bone loss through the gut microbiota-bone axis

microbiology more details view paper
  • Downloaded 438 times
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    • Site-wide: 114,694
    • In microbiology: 7,088
  • Year to date:
    • Site-wide: 145,109
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    • Site-wide: None

Shifts in leaf senescence across the Northern Hemisphere in response to seasonal warming

ecology more details view paper
  • Downloaded 431 times
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    • Site-wide: 116,447
    • In ecology: 3,303
  • Year to date:
    • Site-wide: 53,108
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    • Site-wide: 83,539

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

cancer biology more details view paper
  • Downloaded 426 times
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    • Site-wide: 117,845
    • In cancer biology: 4,256
  • Year to date:
    • Site-wide: 13,941
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    • Site-wide: 18,669

The expression of PDCD1 and CD274 in T cells and macrophages correlated positively with COVID-19 severity

immunology more details view paper
  • Downloaded 401 times
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    • Site-wide: 124,388
    • In immunology: 3,781
  • Year to date:
    • Site-wide: 157,332
  • Since beginning of last month:
    • Site-wide: 195,111

Early prediction of high risk gestational diabetes mellitus via machine learning models.

endocrinology more details view paper
  • Downloaded 394 times
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    • Site-wide: 126,389
    • In endocrinology: 136
  • Year to date:
    • Site-wide: 139,738
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    • Site-wide: 139,929

Structural insights into the mechanism of nucleotide regulation of pancreatic KATP channel

biophysics more details view paper
  • Downloaded 366 times
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    • Site-wide: 134,431
    • In biophysics: 4,878
  • Year to date:
    • Site-wide: 84,087
  • Since beginning of last month:
    • Site-wide: 156,626

A warmer growing season triggers earlier following spring phenology

ecology more details view paper
  • Downloaded 341 times
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    • Site-wide: 141,958
    • In ecology: 4,331
  • Year to date:
    • Site-wide: 56,162
  • Since beginning of last month:
    • Site-wide: 63,330

Features of creatine-kinase in COVID-19 patients within various specific periods: A cohort study

infectious diseases more details view paper
  • Downloaded 341 times
  • Download rankings, all-time:
    • Site-wide: 141,947
    • In infectious diseases: 6,531
  • Year to date:
    • Site-wide: 110,268
  • Since beginning of last month:
    • Site-wide: 187,796

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan

immunology more details view paper
  • Downloaded 330 times
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    • Site-wide: 145,409
    • In immunology: 4,959
  • Year to date:
    • Site-wide: 21,123
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    • Site-wide: 24,224

Elucidation of the determinant for orchestration of solo unisexual cycle in an important human fungal pathogen

microbiology more details view paper
  • Downloaded 329 times
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    • Site-wide: 145,506
    • In microbiology: 9,753
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    • Site-wide: 195,925

A quantitative exploration of symptoms in COVID-19 patients: an observational cohort study

infectious diseases more details view paper
  • Downloaded 319 times
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    • Site-wide: 148,620
    • In infectious diseases: 6,708
  • Year to date:
    • Site-wide: 135,851
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    • Site-wide: 153,192

Staging and typing of chest CT images: A quantitative analysis based on an ambispective observational cohort study of 125 patients with COVID-19 in Xiangyang, China

radiology and imaging more details view paper
  • Downloaded 316 times
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    • Site-wide: 149,577
    • In radiology and imaging: 348
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    • Site-wide: 138,444
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    • Site-wide: 173,667

A Whole-Genome Association Approach for Large-scaled Inter-species Trait

genomics more details view paper
  • Downloaded 302 times
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    • Site-wide: 153,689
    • In genomics: 7,772
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    • Site-wide: 190,487
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    • Site-wide: 168,531

Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells

cell biology more details view paper
  • Downloaded 273 times
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    • Site-wide: 162,041
    • In cell biology: 7,497
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    • Site-wide: 83,773

Features of creatine-kinase in COVID-19 patients with different ages, clinical types and outcomes: A cohort study

infectious diseases more details view paper
  • Downloaded 222 times
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    • Site-wide: 176,084
    • In infectious diseases: 7,422
  • Year to date:
    • Site-wide: 155,194
  • Since beginning of last month:
    • Site-wide: 152,895

Structure of human phagocyte NADPH oxidase in the resting state

biochemistry more details view paper
  • Downloaded 220 times
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    • Site-wide: 176,631
    • In biochemistry: None
  • Year to date:
    • Site-wide: 38,893
  • Since beginning of last month:
    • Site-wide: 1,468

Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study

infectious diseases more details view paper
  • Downloaded 215 times
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    • Site-wide: 178,058
    • In infectious diseases: 7,445
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    • Site-wide: 175,534
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    • Site-wide: 176,026

Features of α-Hydroxybutyrate Dehydrogenase during various specific periods in COVID-19 patients within Xiangyang, China: a cohort study

infectious diseases more details view paper
  • Downloaded 203 times
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    • Site-wide: 180,947
    • In infectious diseases: 7,562
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    • Site-wide: 146,557
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    • Site-wide: 133,034

Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety

immunology more details view paper
  • Downloaded 188 times
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    • Site-wide: 184,364
    • In immunology: None
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    • Site-wide: 7,816

Transcriptome and metabolome analyses reveal pathways associated with fruit color in plum (Prunus salicina Lindl.)

plant biology more details view paper
  • Downloaded 180 times
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    • Site-wide: 186,072
    • In plant biology: 5,162
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    • Site-wide: 124,173
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    • Site-wide: 63,607

Structural insights into the high selectivity of the anti-diabetic drug mitiglinide

biophysics more details view paper
  • Downloaded 177 times
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    • Site-wide: 186,786
    • In biophysics: 7,041
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    • Site-wide: 52,665
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    • Site-wide: 105,852

Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasis

cell biology more details view paper
  • Downloaded 172 times
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    • Site-wide: 187,891
    • In cell biology: 8,377
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    • Site-wide: 171,923
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    • Site-wide: 191,174

Maf Family Transcription Factors are Required for Nutrient Uptake in the Neonatal Gut

physiology more details view paper
  • Downloaded 169 times
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    • Site-wide: 188,396
    • In physiology: 2,546
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    • Site-wide: 55,723
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    • Site-wide: 17,166

Simultaneous Profiling of Host Expression and Microbial Abundance by Spatial Meta-Transcriptome Sequencing

genomics more details view paper
  • Downloaded 162 times
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    • Site-wide: 189,911
    • In genomics: None
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    • Site-wide: 58,878
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    • Site-wide: 18,165

Identification of ASPDH as a novel NAADP-binding protein

biochemistry more details view paper
  • Downloaded 131 times
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    • Site-wide: 195,585
    • In biochemistry: 5,974
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    • Site-wide: 73,114
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    • Site-wide: 39,818

MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FoxO1 protein complex

cell biology more details view paper
  • Downloaded 115 times
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    • Site-wide: 198,231
    • In cell biology: 8,791
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Automated assembly of high-density carbon fiber electrode arrays for single unit electrophysiological recordings

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