Author: Lu Chen

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Preprints

A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

• Downloaded 3,328 times
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  • Site-wide: 5,598
  • In cell biology: 97
• Year to date:
  • Site-wide: 57,771
• Since beginning of last month:
  • Site-wide: 73,577

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

• Downloaded 2,974 times
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  • Site-wide: 6,593
  • In microbiology: 402
• Year to date:
  • Site-wide: 40,061
• Since beginning of last month:
  • Site-wide: 57,861

Comparative analysis of neutrophil and monocyte epigenomes

• Downloaded 1,770 times
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  • Site-wide: 14,214
  • In genomics: 1,284
• Year to date:
  • Site-wide: 91,886
• Since beginning of last month:
  • Site-wide: 75,982

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,667 times
• Download rankings, all-time:
  • Site-wide: 15,523
  • In microbiology: 936
• Year to date:
  • Site-wide: 20,554
• Since beginning of last month:
  • Site-wide: 16,967

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 1,538 times
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  • Site-wide: 17,582
  • In cell biology: 530
• Year to date:
  • Site-wide: 34,660
• Since beginning of last month:
  • Site-wide: 27,853

Interpretable Artificial Intelligence for COVID-19 Diagnosis from Chest CT Reveals Specificity of Ground-Glass Opacities

• Downloaded 1,498 times
• Download rankings, all-time:
  • Site-wide: 18,264
  • In health informatics: 89
• Year to date:
  • Site-wide: 47,749
• Since beginning of last month:
  • Site-wide: 84,981

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis

• Downloaded 1,262 times
• Download rankings, all-time:
  • Site-wide: 23,881
  • In microbiology: 1,426
• Year to date:
  • Site-wide: 30,259
• Since beginning of last month:
  • Site-wide: 48,925

Genome-wide Analysis of Differential Transcriptional and Epigenetic Variability Across Human Immune Cell Types

• Downloaded 1,160 times
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  • Site-wide: 27,177
  • In genomics: 2,229
• Year to date:
  • Site-wide: 170,859
• Since beginning of last month:
  • Site-wide: 147,080

Transposons modulate transcriptomic and phenotypic variation via the formation of circular RNAs in maize

• Downloaded 1,107 times
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  • Site-wide: 29,172
  • In genomics: 2,371
• Year to date:
  • Site-wide: 182,068
• Since beginning of last month:
  • Site-wide: 183,188

Robust Antibacterial Activity of Tungsten Oxide (WO3-X) Nanodots

• Downloaded 1,069 times
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  • Site-wide: 30,762
  • In pharmacology and toxicology: 177
• Year to date:
  • Site-wide: 42,732
• Since beginning of last month:
  • Site-wide: 40,469

Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility

• Downloaded 990 times
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  • Site-wide: 34,474
  • In genetics: 1,399
• Year to date:
  • Site-wide: 104,224
• Since beginning of last month:
  • Site-wide: 104,288

Portrait of a genus: the genetic diversity of Zea

• Downloaded 940 times
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  • Site-wide: 37,299
  • In evolutionary biology: 1,909
• Year to date:
  • Site-wide: 19,632
• Since beginning of last month:
  • Site-wide: 9,988

The Ocular Glymphatic Clearance System

• Downloaded 866 times
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  • Site-wide: 42,032
  • In physiology: 196
• Year to date:
  • Site-wide: 67,253
• Since beginning of last month:
  • Site-wide: 128,512

Human Identical Sequences of SARS-CoV-2 Promote Clinical Progression of COVID-19 by Upregulating Hyaluronan via NamiRNA-Enhancer Network

• Downloaded 863 times
• Download rankings, all-time:
  • Site-wide: 42,266
  • In molecular biology: 1,150
• Year to date:
  • Site-wide: 42,487
• Since beginning of last month:
  • Site-wide: 57,672

ZEAMAP, a comprehensive database adapted to the maize multi-omics era

• Downloaded 790 times
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  • Site-wide: 48,160
  • In bioinformatics: 4,716
• Year to date:
  • Site-wide: 98,724
• Since beginning of last month:
  • Site-wide: 87,390

Clonal inactivation of telomerase promotes accelerated stem cell differentiation

• Downloaded 682 times
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  • Site-wide: 59,321
  • In developmental biology: 1,547
• Year to date:
  • Site-wide: 31,433
• Since beginning of last month:
  • Site-wide: 17,608

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 64,534
  • In pharmacology and toxicology: 385
• Year to date:
  • Site-wide: 111,289
• Since beginning of last month:
  • Site-wide: 105,744

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus

• Downloaded 546 times
• Download rankings, all-time:
  • Site-wide: 78,744
  • In bioengineering: 1,549
• Year to date:
  • Site-wide: 59,363
• Since beginning of last month:
  • Site-wide: 31,524

TGS1 controls snRNA 3' end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

• Downloaded 543 times
• Download rankings, all-time:
  • Site-wide: 79,340
  • In genetics: 3,387
• Year to date:
  • Site-wide: 42,524
• Since beginning of last month:
  • Site-wide: 33,445

Spinal cord homeostatic plasticity gates mechanical allodynia in chronic pain

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 84,670
  • In neuroscience: 18,685
• Year to date:
  • Site-wide: 4,706
• Since beginning of last month:
  • Site-wide: 12,899

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

• Downloaded 404 times
• Download rankings, all-time:
  • Site-wide: 109,163
  • In plant biology: 2,731
• Year to date:
  • Site-wide: 113,754
• Since beginning of last month:
  • Site-wide: 84,762

Enriched G-quadruplexes on the Drosophila Male X Chromosome Function as Insulators of Dosage Compensation Complex

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 112,816
  • In evolutionary biology: 5,032
• Year to date:
  • Site-wide: 163,416
• Since beginning of last month:
  • Site-wide: 176,659

Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 114,567
  • In microbiology: 7,478
• Year to date:
  • Site-wide: 141,706
• Since beginning of last month:
  • Site-wide: 107,976

Association of Egg Consumption, Metabolic Markers, and Risk of Cardiovascular Diseases: A Nested Case-control Study

• Downloaded 283 times
• Download rankings, all-time:
  • Site-wide: 143,298
  • In nutrition: 170
• Year to date:
  • Site-wide: 19,571
• Since beginning of last month:
  • Site-wide: 8,241

Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating PPARγ-UCP2 cascade

• Downloaded 278 times
• Download rankings, all-time:
  • Site-wide: 144,587
  • In pathology: 791
• Year to date:
  • Site-wide: 120,291
• Since beginning of last month:
  • Site-wide: 102,450

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

• Downloaded 262 times
• Download rankings, all-time:
  • Site-wide: 149,395
  • In biochemistry: 4,339
• Year to date:
  • Site-wide: 112,931
• Since beginning of last month:
  • Site-wide: 73,012

2-amino-1,3-benzothiazole-6-carboxamide Preferentially Binds the Tandem Mismatch Motif r(UY:GA)

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 156,327
  • In biochemistry: 4,595
• Year to date:
  • Site-wide: 127,418
• Since beginning of last month:
  • Site-wide: 95,913

Ovipositor and mouthparts in a fossil insect support a novel ecological role for early orthopterans in Pennsylvanian forests

• Downloaded 233 times
• Download rankings, all-time:
  • Site-wide: 157,897
  • In evolutionary biology: 7,038
• Year to date:
  • Site-wide: 131,334
• Since beginning of last month:
  • Site-wide: 169,114

INCIDENCE OF VENOUS THROMBOTIC EVENTS AND EVENTS OF SPECIAL INTEREST IN A RETROSPECTIVE COHORT OF COMMERCIALLY-INSURED US PATIENTS

• Downloaded 216 times
• Download rankings, all-time:
  • Site-wide: 162,373
  • In epidemiology: 6,550
• Year to date:
  • Site-wide: 75,415
• Since beginning of last month:
  • Site-wide: 97,626

Coordinated regulation of ribosomes and proteasomes by PRMT1 in the maintenance of neural stemness of cancer cells and neural stem cells

• Downloaded 213 times
• Download rankings, all-time:
  • Site-wide: 163,129
  • In cell biology: 7,004
• Year to date:
  • Site-wide: 188,782
• Since beginning of last month:
  • Site-wide: 186,374

New insights into colorectal cancer liver metastasis carcinogenesis and its effect with moxibustion

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 168,586
  • In cancer biology: 4,919
• Year to date:
  • Site-wide: 52,487
• Since beginning of last month:
  • Site-wide: 139,020

mTOR Inhibition Overcomes RSK3-mediated Resistance to BET Inhibitors in Small Cell Lung Cancer

• Downloaded 183 times
• Download rankings, all-time:
  • Site-wide: 170,697
  • In cancer biology: 5,127
• Year to date:
  • Site-wide: 45,683
• Since beginning of last month:
  • Site-wide: 51,656

Dynamic Spatial-Temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in Mammals

• Downloaded 146 times
• Download rankings, all-time:
  • Site-wide: 178,650
  • In evolutionary biology: 7,881
• Year to date:
  • Site-wide: 102,722
• Since beginning of last month:
  • Site-wide: 139,128

ISG15 Monomer Promotes IFNα-mediated Antiviral Activity against Pseudorabies Virus by Facilitating phosphorylation of STAT1/STAT2

• Downloaded 88 times
• Download rankings, all-time:
  • Site-wide: 187,013
  • In molecular biology: None
• Year to date:
  • Site-wide: 52,732
• Since beginning of last month:
  • Site-wide: 9,898

Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity

• Downloaded 78 times
• Download rankings, all-time:
  • Site-wide: 187,973
  • In neuroscience: None
• Year to date:
  • Site-wide: 59,184
• Since beginning of last month:
  • Site-wide: 12,063

Portrait of a genus: genome sequencing reveals evidence of adaptive variation in Zea

• Downloaded 63 times
• Download rankings, all-time:
  • Site-wide: 189,127
  • In genetics: None
• Year to date:
  • Site-wide: 72,036
• Since beginning of last month:
  • Site-wide: 17,038