Author: Lu Chen

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Preprints

A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

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  • Site-wide: 5,355
  • In cell biology: 100
• Year to date:
  • Site-wide: 3,344
• Since beginning of last month:
  • Site-wide: 16,256

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

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  • Site-wide: 5,729
  • In microbiology: 360
• Year to date:
  • Site-wide: 16,243
• Since beginning of last month:
  • Site-wide: 90,660

Comparative analysis of neutrophil and monocyte epigenomes

• Downloaded 1,611 times
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  • Site-wide: 12,156
  • In genomics: 1,250
• Year to date:
  • Site-wide: 31,374
• Since beginning of last month:
  • Site-wide: 113,442

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 1,334 times
• Download rankings, all-time:
  • Site-wide: 16,145
  • In cell biology: 478
• Year to date:
  • Site-wide: 12,960
• Since beginning of last month:
  • Site-wide: 4,961

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,292 times
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  • Site-wide: 16,950
  • In microbiology: 987
• Year to date:
  • Site-wide: 8,154
• Since beginning of last month:
  • Site-wide: 22,316

Interpretable Artificial Intelligence for COVID-19 Diagnosis from Chest CT Reveals Specificity of Ground-Glass Opacities

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• Download rankings, all-time:
  • Site-wide: 17,857
  • In health informatics: 81
• Year to date:
  • Site-wide: 30,510
• Since beginning of last month:
  • Site-wide: 40,191

Genome-wide Analysis of Differential Transcriptional and Epigenetic Variability Across Human Immune Cell Types

• Downloaded 1,112 times
• Download rankings, all-time:
  • Site-wide: 21,143
  • In genomics: 2,019
• Year to date:
  • Site-wide: 133,029
• Since beginning of last month:
  • Site-wide: None

Transposons modulate transcriptomic and phenotypic variation via the formation of circular RNAs in maize

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  • Site-wide: 23,134
  • In genomics: 2,188
• Year to date:
  • Site-wide: 128,584
• Since beginning of last month:
  • Site-wide: None

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis

• Downloaded 879 times
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  • Site-wide: 29,706
  • In microbiology: 1,752
• Year to date:
  • Site-wide: 17,053
• Since beginning of last month:
  • Site-wide: 49,928

Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility

• Downloaded 876 times
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  • Site-wide: 29,826
  • In genetics: 1,361
• Year to date:
  • Site-wide: 51,842
• Since beginning of last month:
  • Site-wide: 38,488

Robust Antibacterial Activity of Tungsten Oxide (WO3-X) Nanodots

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  • Site-wide: 31,711
  • In pharmacology and toxicology: 176
• Year to date:
  • Site-wide: 30,865
• Since beginning of last month:
  • Site-wide: 112,138

The Ocular Glymphatic Clearance System

• Downloaded 754 times
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  • Site-wide: 36,840
  • In physiology: 169
• Year to date:
  • Site-wide: 28,466
• Since beginning of last month:
  • Site-wide: 32,473

ZEAMAP, a comprehensive database adapted to the maize multi-omics era

• Downloaded 690 times
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  • Site-wide: 41,450
  • In bioinformatics: 4,431
• Year to date:
  • Site-wide: 63,813
• Since beginning of last month:
  • Site-wide: 117,881

Human Identical Sequences of SARS-CoV-2 Promote Clinical Progression of COVID-19 by Upregulating Hyaluronan via NamiRNA-Enhancer Network

• Downloaded 575 times
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  • Site-wide: 52,393
  • In molecular biology: 1,475
• Year to date:
  • Site-wide: 29,203
• Since beginning of last month:
  • Site-wide: 24,857

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

• Downloaded 556 times
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  • Site-wide: 54,568
  • In pharmacology and toxicology: 326
• Year to date:
  • Site-wide: 87,648
• Since beginning of last month:
  • Site-wide: 43,464

Portrait of a genus: the genetic diversity of Zea

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  • Site-wide: 71,922
  • In evolutionary biology: 3,753
• Year to date:
  • Site-wide: 11,073
• Since beginning of last month:
  • Site-wide: 71,672

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 85,771
  • In bioengineering: 1,628
• Year to date:
  • Site-wide: 14,463
• Since beginning of last month:
  • Site-wide: 100,875

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 96,600
  • In plant biology: 2,572
• Year to date:
  • Site-wide: 70,019
• Since beginning of last month:
  • Site-wide: 48,962

Enriched G-quadruplexes on the Drosophila Male X Chromosome Function as Insulators of Dosage Compensation Complex

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 97,118
  • In evolutionary biology: 4,989
• Year to date:
  • Site-wide: 126,782
• Since beginning of last month:
  • Site-wide: 123,007

Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype

• Downloaded 271 times
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  • Site-wide: 105,680
  • In microbiology: 7,545
• Year to date:
  • Site-wide: 65,495
• Since beginning of last month:
  • Site-wide: 26,587

TGS1 controls snRNA 3' end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 112,807
  • In genetics: 4,747
• Year to date:
  • Site-wide: 67,984
• Since beginning of last month:
  • Site-wide: 97,902

Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating PPARγ-UCP2 cascade

• Downloaded 181 times
• Download rankings, all-time:
  • Site-wide: 128,008
  • In pathology: 739
• Year to date:
  • Site-wide: 98,304
• Since beginning of last month:
  • Site-wide: 58,384

Clonal inactivation of telomerase promotes accelerated stem cell differentiation

• Downloaded 177 times
• Download rankings, all-time:
  • Site-wide: 128,908
  • In developmental biology: 3,453
• Year to date:
  • Site-wide: 36,700
• Since beginning of last month:
  • Site-wide: None

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

• Downloaded 170 times
• Download rankings, all-time:
  • Site-wide: 130,551
  • In biochemistry: 3,921
• Year to date:
  • Site-wide: 96,020
• Since beginning of last month:
  • Site-wide: 102,740

Coordinated regulation of ribosomes and proteasomes by PRMT1 in the maintenance of neural stemness of cancer cells and neural stem cells

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 133,193
  • In cell biology: 6,123
• Year to date:
  • Site-wide: 75,851
• Since beginning of last month:
  • Site-wide: 34,436

2-amino-1,3-benzothiazole-6-carboxamide Preferentially Binds the Tandem Mismatch Motif r(UY:GA)

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 139,511
  • In biochemistry: 4,226
• Year to date:
  • Site-wide: 117,677
• Since beginning of last month:
  • Site-wide: 96,354

Ovipositor and mouthparts in a fossil insect support a novel ecological role for early orthopterans in Pennsylvanian forests

• Downloaded 88 times
• Download rankings, all-time:
  • Site-wide: 147,079
  • In evolutionary biology: 7,087
• Year to date:
  • Site-wide: 74,761
• Since beginning of last month:
  • Site-wide: None

INCIDENCE OF THROMBOTIC EVENTS IN A COMMERCIALLY-INSURED US POPULATION

• Downloaded 66 times
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  • Site-wide: 149,914
  • In epidemiology: 6,178
• Year to date:
  • Site-wide: 92,726
• Since beginning of last month:
  • Site-wide: 14,367

Dynamic Spatial-Temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in Mammals

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• Download rankings, all-time:
  • Site-wide: 155,239
  • In evolutionary biology: 7,398
• Year to date:
  • Site-wide: 155,193
• Since beginning of last month:
  • Site-wide: 126,519