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Author: L. Adrienne Cupples

  • ORCiD: http://orcid.org/0000-0003-0273-7965
  • Most recently observed institution: Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts; Data Management, Framingham Heart Study, Framingham, Massachusetts

Rankings

  • All-time downloads: 38,241 (rank: 3,813 )
  • Categories:
    • bioinformatics: 1,332 (rank: 11,054 (tie) )
    • epidemiology: 301 (rank: 20,004 (tie) )
    • genetic and genomic medicine: 852 (rank: 2,312 )
    • genetics: 19,727 (rank: 501 )
    • genomics: 16,029 (rank: 839 )

Downloads per author, site-wide

Preprints

Recovery of trait heritability from whole genome sequence data

genetics more details view paper
  • Downloaded 11,519 times
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    • Site-wide: 662
    • In genetics: 17
  • Year to date:
    • Site-wide: 3,000
  • Since beginning of last month:
    • Site-wide: 5,248

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

genomics more details view paper
  • Downloaded 8,181 times
  • Download rankings, all-time:
    • Site-wide: 1,042
    • In genomics: 94
  • Year to date:
    • Site-wide: 2,193
  • Since beginning of last month:
    • Site-wide: 4,808

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

genomics more details view paper
  • Downloaded 2,882 times
  • Download rankings, all-time:
    • Site-wide: 4,361
    • In genomics: 489
  • Year to date:
    • Site-wide: 7,793
  • Since beginning of last month:
    • Site-wide: 10,076

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

genomics more details view paper
  • Downloaded 2,092 times
  • Download rankings, all-time:
    • Site-wide: 6,976
    • In genomics: 771
  • Year to date:
    • Site-wide: 127,239
  • Since beginning of last month:
    • Site-wide: 110,850

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,660 times
  • Download rankings, all-time:
    • Site-wide: 9,872
    • In genetics: 469
  • Year to date:
    • Site-wide: 64,880
  • Since beginning of last month:
    • Site-wide: 45,358

Hardy Weinberg Exact Test In Large Scale Variant Calling Quality Control

bioinformatics more details view paper
  • Downloaded 1,011 times
  • Download rankings, all-time:
    • Site-wide: 20,650
    • In bioinformatics: 2,464
  • Year to date:
    • Site-wide: 45,231
  • Since beginning of last month:
    • Site-wide: 45,144

Personalized genetic assessment of age associated Alzheimers disease risk

genetics more details view paper
  • Downloaded 976 times
  • Download rankings, all-time:
    • Site-wide: 21,637
    • In genetics: 1,040
  • Year to date:
    • Site-wide: 76,703
  • Since beginning of last month:
    • Site-wide: 55,298

A Fully-Adjusted Two-Stage Procedure for Rank Normalization in Genetic Association Studies

genetics more details view paper
  • Downloaded 896 times
  • Download rankings, all-time:
    • Site-wide: 24,574
    • In genetics: 1,185
  • Year to date:
    • Site-wide: 68,908
  • Since beginning of last month:
    • Site-wide: 60,877

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

genetics more details view paper
  • Downloaded 840 times
  • Download rankings, all-time:
    • Site-wide: 26,897
    • In genetics: 1,302
  • Year to date:
    • Site-wide: 93,077
  • Since beginning of last month:
    • Site-wide: 96,645

Quality Control and Integration of Genotypes from Two Calling Pipelines for Whole Genome Sequence Data in the Alzheimer's Disease Sequencing Project

genetics more details view paper
  • Downloaded 833 times
  • Download rankings, all-time:
    • Site-wide: 27,181
    • In genetics: 1,316
  • Year to date:
    • Site-wide: 36,285
  • Since beginning of last month:
    • Site-wide: 38,022

Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure

genetics more details view paper
  • Downloaded 823 times
  • Download rankings, all-time:
    • Site-wide: 27,692
    • In genetics: 1,340
  • Year to date:
    • Site-wide: 37,203
  • Since beginning of last month:
    • Site-wide: 45,568

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

genomics more details view paper
  • Downloaded 747 times
  • Download rankings, all-time:
    • Site-wide: 31,712
    • In genomics: 2,824
  • Year to date:
    • Site-wide: 71,386
  • Since beginning of last month:
    • Site-wide: 85,686

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

genomics more details view paper
  • Downloaded 667 times
  • Download rankings, all-time:
    • Site-wide: 36,971
    • In genomics: 3,149
  • Year to date:
    • Site-wide: 75,090
  • Since beginning of last month:
    • Site-wide: 107,864

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 617 times
  • Download rankings, all-time:
    • Site-wide: 40,892
    • In genetics: 1,943
  • Year to date:
    • Site-wide: 5,002
  • Since beginning of last month:
    • Site-wide: 15,504

Genome Sequencing Unveils a New Regulatory Landscape of Platelet Reactivity

genomics more details view paper
  • Downloaded 545 times
  • Download rankings, all-time:
    • Site-wide: 47,691
    • In genomics: 3,792
  • Year to date:
    • Site-wide: 35,460
  • Since beginning of last month:
    • Site-wide: 28,439

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 506 times
  • Download rankings, all-time:
    • Site-wide: 52,036
    • In genomics: 4,036
  • Year to date:
    • Site-wide: 120,060
  • Since beginning of last month:
    • Site-wide: 116,900

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

genetics more details view paper
  • Downloaded 437 times
  • Download rankings, all-time:
    • Site-wide: 61,053
    • In genetics: 2,840
  • Year to date:
    • Site-wide: 76,917
  • Since beginning of last month:
    • Site-wide: 78,447

Methylome-Wide Association Study Of Central Adiposity Implicates Genes Involved In Immune And Endocrine Systems

genomics more details view paper
  • Downloaded 409 times
  • Download rankings, all-time:
    • Site-wide: 65,379
    • In genomics: 4,666
  • Year to date:
    • Site-wide: 72,987
  • Since beginning of last month:
    • Site-wide: 57,910

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

genetics more details view paper
  • Downloaded 396 times
  • Download rankings, all-time:
    • Site-wide: 67,467
    • In genetics: 3,098
  • Year to date:
    • Site-wide: 61,364
  • Since beginning of last month:
    • Site-wide: 70,581

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

bioinformatics more details view paper
  • Downloaded 321 times
  • Download rankings, all-time:
    • Site-wide: 80,797
    • In bioinformatics: 7,397
  • Year to date:
    • Site-wide: 55,841
  • Since beginning of last month:
    • Site-wide: 39,077

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

genetic and genomic medicine more details view paper
  • Downloaded 320 times
  • Download rankings, all-time:
    • Site-wide: 81,123
    • In genetic and genomic medicine: 285
  • Year to date:
    • Site-wide: 23,642
  • Since beginning of last month:
    • Site-wide: 20,822

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

epidemiology more details view paper
  • Downloaded 301 times
  • Download rankings, all-time:
    • Site-wide: 84,910
    • In epidemiology: 3,494
  • Year to date:
    • Site-wide: 77,391
  • Since beginning of last month:
    • Site-wide: 79,547

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

genetics more details view paper
  • Downloaded 292 times
  • Download rankings, all-time:
    • Site-wide: 86,914
    • In genetics: 3,933
  • Year to date:
    • Site-wide: 49,549
  • Since beginning of last month:
    • Site-wide: None

Population Stratification at the Phenotypic Variance level and Implication for the Analysis of Whole Genome Sequencing Data from Multiple Studies

genetics more details view paper
  • Downloaded 207 times
  • Download rankings, all-time:
    • Site-wide: 105,459
    • In genetics: 4,643
  • Year to date:
    • Site-wide: 89,066
  • Since beginning of last month:
    • Site-wide: 58,848

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

genetic and genomic medicine more details view paper
  • Downloaded 183 times
  • Download rankings, all-time:
    • Site-wide: 110,865
    • In genetic and genomic medicine: 484
  • Year to date:
    • Site-wide: 12,207
  • Since beginning of last month:
    • Site-wide: 3,437

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

genetic and genomic medicine more details view paper
  • Downloaded 178 times
  • Download rankings, all-time:
    • Site-wide: 111,777
    • In genetic and genomic medicine: 497
  • Year to date:
    • Site-wide: 12,724
  • Since beginning of last month:
    • Site-wide: 37,309

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

genetic and genomic medicine more details view paper
  • Downloaded 171 times
  • Download rankings, all-time:
    • Site-wide: 113,402
    • In genetic and genomic medicine: 512
  • Year to date:
    • Site-wide: 13,305
  • Since beginning of last month:
    • Site-wide: 41,735

Presence and Transmission of Mitochondrial Heteroplasmic Mutations in Human Populations of European and African Ancestry

genetics more details view paper
  • Downloaded 123 times
  • Download rankings, all-time:
    • Site-wide: 123,044
    • In genetics: 5,214
  • Year to date:
    • Site-wide: 99,550
  • Since beginning of last month:
    • Site-wide: 103,252

Lifestyle Risk Score for aggregating multiple lifestyle factors: Handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

genetics more details view paper
  • Downloaded 108 times
  • Download rankings, all-time:
    • Site-wide: 125,776
    • In genetics: 5,292
  • Year to date:
    • Site-wide: 124,899
  • Since beginning of last month:
    • Site-wide: 132,829

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