Author: Yang Wu

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Preprints

The Repertoire of Mutational Signatures in Human Cancer

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  • Site-wide: 363
  • In cancer biology: 2
• Year to date:
  • Site-wide: 2,063
• Since beginning of last month:
  • Site-wide: 2,117

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 902
  • In genetics: 26
• Year to date:
  • Site-wide: 33,676
• Since beginning of last month:
  • Site-wide: 36,682

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

• Downloaded 7,978 times
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  • Site-wide: 1,108
  • In infectious diseases: 313
• Year to date:
  • Site-wide: 5,073
• Since beginning of last month:
  • Site-wide: 20,101

Stability of the COVID-19 virus under wet, dry and acidic conditions

• Downloaded 5,197 times
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  • Site-wide: 1,966
  • In infectious diseases: 469
• Year to date:
  • Site-wide: 746
• Since beginning of last month:
  • Site-wide: 467

Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control

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  • Site-wide: 3,284
  • In genomics: 365
• Year to date:
  • Site-wide: 42,993
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  • Site-wide: 36,492

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

• Downloaded 3,555 times
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  • Site-wide: 3,386
  • In genetics: 127
• Year to date:
  • Site-wide: 35,236
• Since beginning of last month:
  • Site-wide: 32,689

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 2,362 times
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  • Site-wide: 6,089
  • In genetics: 283
• Year to date:
  • Site-wide: 7,745
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  • Site-wide: 10,775

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,261 times
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  • Site-wide: 6,489
  • In genetics: 306
• Year to date:
  • Site-wide: 48,215
• Since beginning of last month:
  • Site-wide: 36,780

Causal associations between risk factors and common diseases inferred from GWAS summary data

• Downloaded 1,788 times
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  • Site-wide: 9,186
  • In genetics: 430
• Year to date:
  • Site-wide: 83,989
• Since beginning of last month:
  • Site-wide: 57,557

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

• Downloaded 1,591 times
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  • Site-wide: 10,936
  • In microbiology: 619
• Year to date:
  • Site-wide: 31,772
• Since beginning of last month:
  • Site-wide: 29,945

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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  • Site-wide: 11,607
  • In genetics: 557
• Year to date:
  • Site-wide: 41,597
• Since beginning of last month:
  • Site-wide: 36,404

Protoporphyrin IX and verteporfin prevent SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

• Downloaded 1,459 times
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  • Site-wide: 12,374
  • In microbiology: 703
• Year to date:
  • Site-wide: 13,415
• Since beginning of last month:
  • Site-wide: 54,495

Cross-disorder analysis of schizophrenia and 19 immune diseases reveals genetic correlation

• Downloaded 1,445 times
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  • Site-wide: 12,561
  • In genetics: 608
• Year to date:
  • Site-wide: 71,461
• Since beginning of last month:
  • Site-wide: 110,248

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,331 times
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  • Site-wide: 14,244
  • In genetics: 691
• Year to date:
  • Site-wide: 29,168
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  • Site-wide: 44,497

Highly efficient and super-bright neurocircuit tracing using vector mixing-based virus cocktail

• Downloaded 1,307 times
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  • Site-wide: 14,635
  • In neuroscience: 1,717
• Year to date:
  • Site-wide: 43,036
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  • Site-wide: 47,589

Drosophila female-specific brain neuron elicits persistent position- and direction-selective male-like social behaviors

• Downloaded 1,156 times
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  • Site-wide: 17,605
  • In neuroscience: 2,164
• Year to date:
  • Site-wide: 46,315
• Since beginning of last month:
  • Site-wide: 47,368

Landscape and dynamics of the transcriptional regulatory network during natural killer cell differentiation

• Downloaded 1,055 times
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  • Site-wide: 20,143
  • In bioinformatics: 2,376
• Year to date:
  • Site-wide: 29,556
• Since beginning of last month:
  • Site-wide: 18,927

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 884 times
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  • Site-wide: 25,990
  • In genetics: 1,243
• Year to date:
  • Site-wide: 84,572
• Since beginning of last month:
  • Site-wide: 56,040

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

• Downloaded 838 times
• Download rankings, all-time:
  • Site-wide: 28,018
  • In immunology: 836
• Year to date:
  • Site-wide: 10,470
• Since beginning of last month:
  • Site-wide: 12,336

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 806 times
• Download rankings, all-time:
  • Site-wide: 29,584
  • In genetics: 1,416
• Year to date:
  • Site-wide: 91,852
• Since beginning of last month:
  • Site-wide: 74,777

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 767 times
• Download rankings, all-time:
  • Site-wide: 31,718
  • In genomics: 2,824
• Year to date:
  • Site-wide: 106,369
• Since beginning of last month:
  • Site-wide: 108,406

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

• Downloaded 728 times
• Download rankings, all-time:
  • Site-wide: 34,111
  • In genetics: 1,624
• Year to date:
  • Site-wide: 24,915
• Since beginning of last month:
  • Site-wide: 15,068

Improving the Efficiency of Genomic Selection in Chinese Simmental beef cattle

• Downloaded 657 times
• Download rankings, all-time:
  • Site-wide: 39,146
  • In genomics: 3,268
• Year to date:
  • Site-wide: 110,405
• Since beginning of last month:
  • Site-wide: 108,815

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

• Downloaded 598 times
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  • Site-wide: 44,047
  • In bioinformatics: 4,670
• Year to date:
  • Site-wide: 5,717
• Since beginning of last month:
  • Site-wide: 5,080

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 584 times
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  • Site-wide: 45,390
  • In genetics: 2,107
• Year to date:
  • Site-wide: 113,471
• Since beginning of last month:
  • Site-wide: 102,611

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

• Downloaded 546 times
• Download rankings, all-time:
  • Site-wide: 49,330
  • In microbiology: 3,094
• Year to date:
  • Site-wide: 18,574
• Since beginning of last month:
  • Site-wide: 45,590

Protein ubiquitylation is essential for the schizont to merozoite transition in Plasmodium falciparum blood-stage development

• Downloaded 510 times
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  • Site-wide: 53,531
  • In microbiology: 3,392
• Year to date:
  • Site-wide: 67,214
• Since beginning of last month:
  • Site-wide: 88,209

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 61,796
  • In immunology: 1,761
• Year to date:
  • Site-wide: 30,598
• Since beginning of last month:
  • Site-wide: 62,510

Aspiration-assisted Freeform Bioprinting of Tissue Spheroids in a Yield-stress Gel

• Downloaded 342 times
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  • Site-wide: 79,565
  • In bioengineering: 1,486
• Year to date:
  • Site-wide: 73,705
• Since beginning of last month:
  • Site-wide: 77,852

In Vitro Activities of Daptomycin Combined with Fosfomycin or Rifampin on Planktonic and Adherent Linezolid-resistant Enterococcus faecalis

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 104,703
  • In microbiology: 7,655
• Year to date:
  • Site-wide: 130,314
• Since beginning of last month:
  • Site-wide: 119,423

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 106,423
  • In cancer biology: 3,231
• Year to date:
  • Site-wide: 18,227
• Since beginning of last month:
  • Site-wide: 25,086

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 110,805
  • In immunology: 3,192
• Year to date:
  • Site-wide: 15,329
• Since beginning of last month:
  • Site-wide: 2,632

Widening the bottleneck: Heterologous expression, purification, and characterization of the Ktedonobacter racemifer minimal type II polyketide synthase in Escherichia coli

• Downloaded 185 times
• Download rankings, all-time:
  • Site-wide: 113,875
  • In biochemistry: 3,395
• Year to date:
  • Site-wide: 130,646
• Since beginning of last month:
  • Site-wide: 88,519

Recovery of high-qualitied Genomes from a deep-inland Salt Lake Using BASALT

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 114,514
  • In bioinformatics: 9,453
• Year to date:
  • Site-wide: 17,227
• Since beginning of last month:
  • Site-wide: 10,906

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

• Downloaded 173 times
• Download rankings, all-time:
  • Site-wide: 116,567
  • In cancer biology: 3,568
• Year to date:
  • Site-wide: 18,391
• Since beginning of last month:
  • Site-wide: 14,107

Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

• Downloaded 93 times
• Download rankings, all-time:
  • Site-wide: 132,538
  • In pharmacology and toxicology: 1,157
• Year to date:
  • Site-wide: 98,434
• Since beginning of last month:
  • Site-wide: 89,138