Author: Yang Wu

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Preprints

The Repertoire of Mutational Signatures in Human Cancer

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  • Site-wide: 436
  • In cancer biology: 2
• Year to date:
  • Site-wide: 2,244
• Since beginning of last month:
  • Site-wide: 6,956

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,107
  • In genetics: 26
• Year to date:
  • Site-wide: 44,043
• Since beginning of last month:
  • Site-wide: 31,968

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

• Downloaded 8,263 times
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  • Site-wide: 1,320
  • In infectious diseases: 388
• Year to date:
  • Site-wide: 6,913
• Since beginning of last month:
  • Site-wide: 19,992

Stability of the COVID-19 virus under wet, dry and acidic conditions

• Downloaded 6,382 times
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  • Site-wide: 1,839
  • In infectious diseases: 494
• Year to date:
  • Site-wide: 1,009
• Since beginning of last month:
  • Site-wide: 2,237

Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control

• Downloaded 3,710 times
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  • Site-wide: 3,856
  • In genomics: 385
• Year to date:
  • Site-wide: 54,891
• Since beginning of last month:
  • Site-wide: 38,439

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

• Downloaded 3,631 times
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  • Site-wide: 3,973
  • In genetics: 136
• Year to date:
  • Site-wide: 49,845
• Since beginning of last month:
  • Site-wide: 114,652

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 2,615 times
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  • Site-wide: 6,361
  • In genetics: 263
• Year to date:
  • Site-wide: 9,564
• Since beginning of last month:
  • Site-wide: 15,137

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,358 times
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  • Site-wide: 7,383
  • In genetics: 317
• Year to date:
  • Site-wide: 52,222
• Since beginning of last month:
  • Site-wide: 65,161

Causal associations between risk factors and common diseases inferred from GWAS summary data

• Downloaded 1,825 times
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  • Site-wide: 10,757
  • In genetics: 464
• Year to date:
  • Site-wide: 108,590
• Since beginning of last month:
  • Site-wide: 124,432

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

• Downloaded 1,673 times
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  • Site-wide: 12,215
  • In microbiology: 714
• Year to date:
  • Site-wide: 44,917
• Since beginning of last month:
  • Site-wide: 68,698

Protoporphyrin IX and verteporfin prevent SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

• Downloaded 1,621 times
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  • Site-wide: 12,785
  • In microbiology: 743
• Year to date:
  • Site-wide: 17,739
• Since beginning of last month:
  • Site-wide: 39,955

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 1,601 times
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  • Site-wide: 13,005
  • In genetics: 576
• Year to date:
  • Site-wide: 53,864
• Since beginning of last month:
  • Site-wide: 102,369

Cross-disorder analysis of schizophrenia and 19 immune diseases reveals genetic correlation

• Downloaded 1,509 times
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  • Site-wide: 14,217
  • In genetics: 634
• Year to date:
  • Site-wide: 80,669
• Since beginning of last month:
  • Site-wide: 58,992

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,454 times
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  • Site-wide: 15,097
  • In genetics: 678
• Year to date:
  • Site-wide: 33,912
• Since beginning of last month:
  • Site-wide: 25,092

Highly efficient and super-bright neurocircuit tracing using vector mixing-based virus cocktail

• Downloaded 1,448 times
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  • Site-wide: 15,161
  • In neuroscience: 1,702
• Year to date:
  • Site-wide: 37,601
• Since beginning of last month:
  • Site-wide: 86,025

Drosophila female-specific brain neuron elicits persistent position- and direction-selective male-like social behaviors

• Downloaded 1,227 times
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  • Site-wide: 19,448
  • In neuroscience: 2,339
• Year to date:
  • Site-wide: 60,819
• Since beginning of last month:
  • Site-wide: 101,583

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

• Downloaded 1,215 times
• Download rankings, all-time:
  • Site-wide: 19,742
  • In bioinformatics: 2,252
• Year to date:
  • Site-wide: 4,124
• Since beginning of last month:
  • Site-wide: 6,897

Landscape and dynamics of the transcriptional regulatory network during natural killer cell differentiation

• Downloaded 1,172 times
• Download rankings, all-time:
  • Site-wide: 20,860
  • In bioinformatics: 2,396
• Year to date:
  • Site-wide: 35,195
• Since beginning of last month:
  • Site-wide: 78,265

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

• Downloaded 1,153 times
• Download rankings, all-time:
  • Site-wide: 21,341
  • In genetics: 961
• Year to date:
  • Site-wide: 10,088
• Since beginning of last month:
  • Site-wide: 12,565

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

• Downloaded 1,091 times
• Download rankings, all-time:
  • Site-wide: 23,165
  • In immunology: 787
• Year to date:
  • Site-wide: 11,398
• Since beginning of last month:
  • Site-wide: 20,182

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19

• Downloaded 1,028 times
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  • Site-wide: 25,309
  • In intensive care and critical care medicine: 85
• Year to date:
  • Site-wide: 4,088
• Since beginning of last month:
  • Site-wide: 295

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 911 times
• Download rankings, all-time:
  • Site-wide: 30,146
  • In genetics: 1,352
• Year to date:
  • Site-wide: 119,779
• Since beginning of last month:
  • Site-wide: 152,320

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 831 times
• Download rankings, all-time:
  • Site-wide: 34,262
  • In genetics: 1,537
• Year to date:
  • Site-wide: 126,795
• Since beginning of last month:
  • Site-wide: 120,099

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 782 times
• Download rankings, all-time:
  • Site-wide: 37,427
  • In genomics: 3,093
• Year to date:
  • Site-wide: 146,322
• Since beginning of last month:
  • Site-wide: 155,938

Improving the Efficiency of Genomic Selection in Chinese Simmental beef cattle

• Downloaded 691 times
• Download rankings, all-time:
  • Site-wide: 44,276
  • In genomics: 3,502
• Year to date:
  • Site-wide: 126,816
• Since beginning of last month:
  • Site-wide: 112,620

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

• Downloaded 621 times
• Download rankings, all-time:
  • Site-wide: 50,967
  • In microbiology: 3,146
• Year to date:
  • Site-wide: 32,814
• Since beginning of last month:
  • Site-wide: 82,834

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 614 times
• Download rankings, all-time:
  • Site-wide: 51,757
  • In genetics: 2,254
• Year to date:
  • Site-wide: 132,680
• Since beginning of last month:
  • Site-wide: 103,473

Protein ubiquitylation is essential for the schizont to merozoite transition in Plasmodium falciparum blood-stage development

• Downloaded 575 times
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  • Site-wide: 56,193
  • In microbiology: 3,528
• Year to date:
  • Site-wide: 77,160
• Since beginning of last month:
  • Site-wide: 89,021

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 61,736
  • In immunology: 1,884
• Year to date:
  • Site-wide: 42,898
• Since beginning of last month:
  • Site-wide: 53,721

Recovery of high-qualitied Genomes from a deep-inland Salt Lake Using BASALT

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 79,263
  • In bioinformatics: 7,285
• Year to date:
  • Site-wide: 15,369
• Since beginning of last month:
  • Site-wide: 10,353

Aspiration-assisted Freeform Bioprinting of Tissue Spheroids in a Yield-stress Gel

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 89,699
  • In bioengineering: 1,708
• Year to date:
  • Site-wide: 111,032
• Since beginning of last month:
  • Site-wide: 107,899

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 96,067
  • In immunology: 2,875
• Year to date:
  • Site-wide: 21,064
• Since beginning of last month:
  • Site-wide: 41,339

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

• Downloaded 304 times
• Download rankings, all-time:
  • Site-wide: 105,003
  • In cancer biology: 3,155
• Year to date:
  • Site-wide: 24,763
• Since beginning of last month:
  • Site-wide: 22,461

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

• Downloaded 297 times
• Download rankings, all-time:
  • Site-wide: 106,757
  • In cancer biology: 3,216
• Year to date:
  • Site-wide: 31,789
• Since beginning of last month:
  • Site-wide: 87,521

In Vitro Activities of Daptomycin Combined with Fosfomycin or Rifampin on Planktonic and Adherent Linezolid-resistant Enterococcus faecalis

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 117,020
  • In microbiology: 8,437
• Year to date:
  • Site-wide: 138,058
• Since beginning of last month:
  • Site-wide: 141,142

Widening the bottleneck: Heterologous expression, purification, and characterization of the Ktedonobacter racemifer minimal type II polyketide synthase in Escherichia coli

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 127,944
  • In biochemistry: 3,858
• Year to date:
  • Site-wide: 140,928
• Since beginning of last month:
  • Site-wide: 147,077

Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 129,050
  • In pharmacology and toxicology: 1,024
• Year to date:
  • Site-wide: 60,982
• Since beginning of last month:
  • Site-wide: 27,258