Author: Yang Wu

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Preprints

The Repertoire of Mutational Signatures in Human Cancer

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  • Site-wide: 558
  • In cancer biology: 2
• Year to date:
  • Site-wide: 25,895
• Since beginning of last month:
  • Site-wide: 21,681

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,395
  • In genetics: 27
• Year to date:
  • Site-wide: 26,127
• Since beginning of last month:
  • Site-wide: 21,650

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

• Downloaded 8,632 times
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  • Site-wide: 1,670
  • In infectious diseases: 497
• Year to date:
  • Site-wide: 46,678
• Since beginning of last month:
  • Site-wide: 20,400

Stability of the COVID-19 virus under wet, dry and acidic conditions

• Downloaded 7,323 times
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  • Site-wide: 2,077
  • In infectious diseases: 584
• Year to date:
  • Site-wide: 21,989
• Since beginning of last month:
  • Site-wide: 39,037

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

• Downloaded 6,305 times
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  • Site-wide: 2,554
  • In genetics: 72
• Year to date:
  • Site-wide: 4,833
• Since beginning of last month:
  • Site-wide: 7,730

Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control

• Downloaded 3,963 times
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  • Site-wide: 4,864
  • In genomics: 446
• Year to date:
  • Site-wide: 19,344
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  • Site-wide: 61,315

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

• Downloaded 3,878 times
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  • Site-wide: 5,023
  • In genetics: 160
• Year to date:
  • Site-wide: 37,781
• Since beginning of last month:
  • Site-wide: 52,408

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

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  • Site-wide: 5,648
  • In bioinformatics: 532
• Year to date:
  • Site-wide: 6,657
• Since beginning of last month:
  • Site-wide: 7,812

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 3,325 times
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  • Site-wide: 6,322
  • In genetics: 215
• Year to date:
  • Site-wide: 8,064
• Since beginning of last month:
  • Site-wide: 11,162

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,517 times
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  • Site-wide: 9,471
  • In genetics: 364
• Year to date:
  • Site-wide: 102,787
• Since beginning of last month:
  • Site-wide: 142,590

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19

• Downloaded 2,322 times
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  • Site-wide: 10,724
  • In intensive care and critical care medicine: 47
• Year to date:
  • Site-wide: 21,685
• Since beginning of last month:
  • Site-wide: 27,849

Causal associations between risk factors and common diseases inferred from GWAS summary data

• Downloaded 1,883 times
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  • Site-wide: 14,749
  • In genetics: 579
• Year to date:
  • Site-wide: 104,621
• Since beginning of last month:
  • Site-wide: 207,912

Highly efficient and super-bright neurocircuit tracing using vector mixing-based virus cocktail

• Downloaded 1,821 times
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  • Site-wide: 15,563
  • In neuroscience: 1,657
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 43,054

Protoporphyrin IX and verteporfin prevent SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

• Downloaded 1,795 times
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  • Site-wide: 15,913
  • In microbiology: 903
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 100,960

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

• Downloaded 1,780 times
• Download rankings, all-time:
  • Site-wide: 16,109
  • In microbiology: 913
• Year to date:
  • Site-wide: 131,287
• Since beginning of last month:
  • Site-wide: 128,921

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 1,733 times
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  • Site-wide: 16,772
  • In genetics: 679
• Year to date:
  • Site-wide: 59,531
• Since beginning of last month:
  • Site-wide: 151,461

Cross-disorder analysis of schizophrenia and 19 immune diseases reveals genetic correlation

• Downloaded 1,669 times
• Download rankings, all-time:
  • Site-wide: 17,823
  • In genetics: 719
• Year to date:
  • Site-wide: 80,616
• Since beginning of last month:
  • Site-wide: 75,892

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,617 times
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  • Site-wide: 18,733
  • In genetics: 759
• Year to date:
  • Site-wide: 48,061
• Since beginning of last month:
  • Site-wide: 60,319

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

• Downloaded 1,433 times
• Download rankings, all-time:
  • Site-wide: 22,727
  • In genetics: 912
• Year to date:
  • Site-wide: 115,401
• Since beginning of last month:
  • Site-wide: 55,012

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

• Downloaded 1,430 times
• Download rankings, all-time:
  • Site-wide: 22,822
  • In immunology: 857
• Year to date:
  • Site-wide: 78,695
• Since beginning of last month:
  • Site-wide: 24,350

Drosophila female-specific brain neuron elicits persistent position- and direction-selective male-like social behaviors

• Downloaded 1,404 times
• Download rankings, all-time:
  • Site-wide: 23,515
  • In neuroscience: 2,785
• Year to date:
  • Site-wide: 80,299
• Since beginning of last month:
  • Site-wide: 59,709

Landscape and dynamics of the transcriptional regulatory network during natural killer cell differentiation

• Downloaded 1,286 times
• Download rankings, all-time:
  • Site-wide: 27,049
  • In bioinformatics: 2,910
• Year to date:
  • Site-wide: 175,227
• Since beginning of last month:
  • Site-wide: 149,159

Recovery of high-qualitied Genomes from a deep-inland Salt Lake Using BASALT

• Downloaded 1,154 times
• Download rankings, all-time:
  • Site-wide: 32,073
  • In bioinformatics: 3,517
• Year to date:
  • Site-wide: 29,327
• Since beginning of last month:
  • Site-wide: 35,954

AAV11 permits efficient retrograde targeting of projection neurons

• Downloaded 1,094 times
• Download rankings, all-time:
  • Site-wide: 34,801
  • In neuroscience: 4,519
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 19,914

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 1,027 times
• Download rankings, all-time:
  • Site-wide: 38,372
  • In genetics: 1,514
• Year to date:
  • Site-wide: 163,384
• Since beginning of last month:
  • Site-wide: 151,056

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 890 times
• Download rankings, all-time:
  • Site-wide: 47,844
  • In genetics: 1,863
• Year to date:
  • Site-wide: 174,833
• Since beginning of last month:
  • Site-wide: 200,069

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 830 times
• Download rankings, all-time:
  • Site-wide: 53,195
  • In genomics: 3,832
• Year to date:
  • Site-wide: 197,136
• Since beginning of last month:
  • Site-wide: 152,496

Improving the Efficiency of Genomic Selection in Chinese Simmental beef cattle

• Downloaded 800 times
• Download rankings, all-time:
  • Site-wide: 56,216
  • In genomics: 3,987
• Year to date:
  • Site-wide: 142,203
• Since beginning of last month:
  • Site-wide: 152,008

Nitric oxide signaling controls collective contractions in a colonial choanoflagellate

• Downloaded 751 times
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  • Site-wide: 61,757
  • In evolutionary biology: 2,668
• Year to date:
  • Site-wide: 55,649
• Since beginning of last month:
  • Site-wide: 72,933

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 62,791
  • In microbiology: 3,815
• Year to date:
  • Site-wide: 90,406
• Since beginning of last month:
  • Site-wide: 80,524

mSigHdp: hierarchical Dirichlet process mixture modeling for mutational signature discovery

• Downloaded 729 times
• Download rankings, all-time:
  • Site-wide: 64,599
  • In bioinformatics: 6,347
• Year to date:
  • Site-wide: 12,973
• Since beginning of last month:
  • Site-wide: 17,900

Protein ubiquitylation is essential for the schizont to merozoite transition in Plasmodium falciparum blood-stage development

• Downloaded 687 times
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  • Site-wide: 70,184
  • In microbiology: 4,216
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 187,101

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 679 times
• Download rankings, all-time:
  • Site-wide: 71,287
  • In genetics: 2,742
• Year to date:
  • Site-wide: 141,944
• Since beginning of last month:
  • Site-wide: 202,599

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

• Downloaded 631 times
• Download rankings, all-time:
  • Site-wide: 78,695
  • In cancer biology: 2,339
• Year to date:
  • Site-wide: 55,942
• Since beginning of last month:
  • Site-wide: 28,952

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

• Downloaded 622 times
• Download rankings, all-time:
  • Site-wide: 80,036
  • In immunology: 2,614
• Year to date:
  • Site-wide: 134,074
• Since beginning of last month:
  • Site-wide: 130,983

Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

• Downloaded 575 times
• Download rankings, all-time:
  • Site-wide: 88,576
  • In pharmacology and toxicology: 586
• Year to date:
  • Site-wide: 34,271
• Since beginning of last month:
  • Site-wide: 30,824

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 100,383
  • In immunology: 3,234
• Year to date:
  • Site-wide: 121,346
• Since beginning of last month:
  • Site-wide: 104,343

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 107,025
  • In cancer biology: 3,251
• Year to date:
  • Site-wide: 132,172
• Since beginning of last month:
  • Site-wide: 86,132

Aspiration-assisted Freeform Bioprinting of Tissue Spheroids in a Yield-stress Gel

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 118,269
  • In bioengineering: 2,414
• Year to date:
  • Site-wide: 45,753
• Since beginning of last month:
  • Site-wide: 190,397

In Vitro Activities of Daptomycin Combined with Fosfomycin or Rifampin on Planktonic and Adherent Linezolid-resistant Enterococcus faecalis

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 142,090
  • In microbiology: 9,788
• Year to date:
  • Site-wide: 172,996
• Since beginning of last month:
  • Site-wide: 116,512

Widening the bottleneck: Heterologous expression, purification, and characterization of the Ktedonobacter racemifer minimal type II polyketide synthase in Escherichia coli

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 152,745
  • In biochemistry: 4,698
• Year to date:
  • Site-wide: 113,476
• Since beginning of last month:
  • Site-wide: 122,812

A pangenome analysis pipeline (PSVCP) provides insights into rice functional gene identification

• Downloaded 317 times
• Download rankings, all-time:
  • Site-wide: 155,020
  • In genetics: 6,064
• Year to date:
  • Site-wide: 15,844
• Since beginning of last month:
  • Site-wide: 14,934

Topical anticholinergic medications for primary hyperhidrosis: A protocol for systematic review and meta-analysis

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 183,419
  • In dermatology: 86
• Year to date:
  • Site-wide: 6,093
• Since beginning of last month:
  • Site-wide: 34,166