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Author: Howard Y. Chang

Rankings

  • All-time downloads: 108,837 (rank: 825 )
  • Categories:
    • bioinformatics: 2,859 (rank: 4,374 )
    • cancer biology: 3,213 (rank: 1,174 )
    • cell biology: 11,038 (rank: 250 )
    • evolutionary biology: 1,616 (rank: 3,279 (tie) )
    • genetics: 2,141 (rank: 8,322 (tie) )
    • genomics: 61,860 (rank: 121 )
    • immunology: 10,508 (rank: 572 )
    • microbiology: 2,293 (rank: 5,312 (tie) )
    • molecular biology: 7,769 (rank: 284 )
    • neuroscience: 5,540 (rank: 2,883 (tie) )

Downloads per author, site-wide

Preprints

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

genomics more details view paper
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    • Site-wide: 520
    • In genomics: 35
  • Year to date:
    • Site-wide: 3,221
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    • Site-wide: 3,221

Atlas of Subcellular RNA Localization Revealed by APEX-seq

cell biology more details view paper
  • Downloaded 9,011 times
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    • Site-wide: 850
    • In cell biology: 8
  • Year to date:
    • Site-wide: 24,114
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    • Site-wide: 24,114

Clonal replacement of tumor-specific T cells following PD-1 blockade

immunology more details view paper
  • Downloaded 6,234 times
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    • Site-wide: 1,358
    • In immunology: 30
  • Year to date:
    • Site-wide: 38,387
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    • Site-wide: 38,387

ArchR: An integrative and scalable software package for single-cell chromatin accessibility analysis

genomics more details view paper
  • Downloaded 5,695 times
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    • Site-wide: 1,553
    • In genomics: 148
  • Year to date:
    • Site-wide: 1,037
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    • Site-wide: 1,037

Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiation

genomics more details view paper
  • Downloaded 5,587 times
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    • Site-wide: 1,607
    • In genomics: 159
  • Year to date:
    • Site-wide: 42,544
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    • Site-wide: 42,544

A single cell framework for multi-omic analysis of disease identifies malignant regulatory signatures in mixed phenotype acute leukemia

genomics more details view paper
  • Downloaded 5,316 times
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    • Site-wide: 1,706
    • In genomics: 170
  • Year to date:
    • Site-wide: 8,423
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    • Site-wide: 8,423

Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease

genomics more details view paper
  • Downloaded 5,299 times
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    • Site-wide: 1,710
    • In genomics: 171
  • Year to date:
    • Site-wide: 2,933
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    • Site-wide: 2,933

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

genomics more details view paper
  • Downloaded 5,011 times
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    • Site-wide: 1,839
    • In genomics: 191
  • Year to date:
    • Site-wide: 40,056
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    • Site-wide: 40,056

Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

genomics more details view paper
  • Downloaded 4,501 times
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    • Site-wide: 2,141
    • In genomics: 234
  • Year to date:
    • Site-wide: 29,435
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    • Site-wide: 29,435

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

genomics more details view paper
  • Downloaded 4,372 times
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    • Site-wide: 2,235
    • In genomics: 254
  • Year to date:
    • Site-wide: 25,881
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    • Site-wide: 25,881

Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin

molecular biology more details view paper
  • Downloaded 3,408 times
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    • Site-wide: 3,212
    • In molecular biology: 69
  • Year to date:
    • Site-wide: 22,696
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    • Site-wide: 22,696

Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements

genomics more details view paper
  • Downloaded 3,138 times
  • Download rankings, all-time:
    • Site-wide: 3,626
    • In genomics: 418
  • Year to date:
    • Site-wide: 52,934
  • Since beginning of last month:
    • Site-wide: 52,934

Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

immunology more details view paper
  • Downloaded 2,645 times
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    • Site-wide: 4,615
    • In immunology: 127
  • Year to date:
    • Site-wide: 4,747
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    • Site-wide: 4,747

HiChIP: Efficient and sensitive analysis of protein-directed genome architecture

genomics more details view paper
  • Downloaded 2,640 times
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    • Site-wide: 4,636
    • In genomics: 538
  • Year to date:
    • Site-wide: 95,893
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    • Site-wide: 95,893

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

genomics more details view paper
  • Downloaded 2,525 times
  • Download rankings, all-time:
    • Site-wide: 4,909
    • In genomics: 575
  • Year to date:
    • Site-wide: 37,976
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    • Site-wide: 37,976

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

microbiology more details view paper
  • Downloaded 2,293 times
  • Download rankings, all-time:
    • Site-wide: 5,698
    • In microbiology: 321
  • Year to date:
    • Site-wide: 1,737
  • Since beginning of last month:
    • Site-wide: 1,737

Dynamic Regulation of RNA Structure in Mammalian Cells

molecular biology more details view paper
  • Downloaded 2,054 times
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    • Site-wide: 6,656
    • In molecular biology: 155
  • Year to date:
    • Site-wide: 44,290
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    • Site-wide: 44,290

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

genomics more details view paper
  • Downloaded 1,880 times
  • Download rankings, all-time:
    • Site-wide: 7,577
    • In genomics: 843
  • Year to date:
    • Site-wide: 62,913
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    • Site-wide: 62,913

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set

neuroscience more details view paper
  • Downloaded 1,843 times
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    • Site-wide: 7,816
    • In neuroscience: 820
  • Year to date:
    • Site-wide: 11,714
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    • Site-wide: 11,714

Frequent extrachromosomal oncogene amplification drives aggressive tumors

cancer biology more details view paper
  • Downloaded 1,677 times
  • Download rankings, all-time:
    • Site-wide: 9,078
    • In cancer biology: 167
  • Year to date:
    • Site-wide: 15,943
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    • Site-wide: 15,943

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

neuroscience more details view paper
  • Downloaded 1,639 times
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    • Site-wide: 9,377
    • In neuroscience: 1,009
  • Year to date:
    • Site-wide: 322
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    • Site-wide: 322

Evolutionary dynamics of roX lncRNA function and genomic occupancy

evolutionary biology more details view paper
  • Downloaded 1,616 times
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    • Site-wide: 9,578
    • In evolutionary biology: 317
  • Year to date:
    • Site-wide: 83,744
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    • Site-wide: 83,744

EcDNA hubs drive cooperative intermolecular oncogene expression

cancer biology more details view paper
  • Downloaded 1,536 times
  • Download rankings, all-time:
    • Site-wide: 10,296
    • In cancer biology: 202
  • Year to date:
    • Site-wide: 1,354
  • Since beginning of last month:
    • Site-wide: 1,354

RNA-GPS Predicts SARS-CoV-2 RNA Localization to Host Mitochondria and Nucleolus

bioinformatics more details view paper
  • Downloaded 1,391 times
  • Download rankings, all-time:
    • Site-wide: 11,940
    • In bioinformatics: 1,476
  • Year to date:
    • Site-wide: 16,061
  • Since beginning of last month:
    • Site-wide: 16,061

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

immunology more details view paper
  • Downloaded 1,238 times
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    • Site-wide: 14,182
    • In immunology: 395
  • Year to date:
    • Site-wide: 7,971
  • Since beginning of last month:
    • Site-wide: 7,971

Structural modularity of the XIST ribonucleoprotein complex

molecular biology more details view paper
  • Downloaded 1,156 times
  • Download rankings, all-time:
    • Site-wide: 15,765
    • In molecular biology: 445
  • Year to date:
    • Site-wide: 51,720
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    • Site-wide: 51,720

The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation

genomics more details view paper
  • Downloaded 1,080 times
  • Download rankings, all-time:
    • Site-wide: 17,457
    • In genomics: 1,816
  • Year to date:
    • Site-wide: 7,974
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    • Site-wide: 7,974

Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylation

genetics more details view paper
  • Downloaded 1,067 times
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    • Site-wide: 17,784
    • In genetics: 897
  • Year to date:
    • Site-wide: 7,236
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    • Site-wide: 7,236

Functional classification of noncoding RNAs associated with distinct histone modifications by PIRCh-seq

cell biology more details view paper
  • Downloaded 1,010 times
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    • Site-wide: 19,307
    • In cell biology: 659
  • Year to date:
    • Site-wide: 47,384
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    • Site-wide: 47,384

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

neuroscience more details view paper
  • Downloaded 982 times
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    • Site-wide: 20,063
    • In neuroscience: 2,571
  • Year to date:
    • Site-wide: 96,622
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    • Site-wide: 96,622

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells

genomics more details view paper
  • Downloaded 980 times
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    • Site-wide: 20,112
    • In genomics: 2,038
  • Year to date:
    • Site-wide: 471
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    • Site-wide: 471

Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment

cell biology more details view paper
  • Downloaded 820 times
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    • Site-wide: 25,952
    • In cell biology: 968
  • Year to date:
    • Site-wide: 57,072
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    • Site-wide: 57,072

CRISPRpic: Fast and precise analysis for CRISPR-induced mutations via prefixed index counting

bioinformatics more details view paper
  • Downloaded 772 times
  • Download rankings, all-time:
    • Site-wide: 28,198
    • In bioinformatics: 3,262
  • Year to date:
    • Site-wide: 71,033
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    • Site-wide: 71,033

Satb1 integrates DNA sequence, shape, motif density and torsional stress to differentially bind targets in nucleosome-dense regions.

molecular biology more details view paper
  • Downloaded 731 times
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    • Site-wide: 30,461
    • In molecular biology: 857
  • Year to date:
    • Site-wide: 104,259
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    • Site-wide: 104,259

Exploring the role of Polycomb recruitment in Xist-mediated silencing of the X chromosome in ES cells

genetics more details view paper
  • Downloaded 705 times
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    • Site-wide: 32,009
    • In genetics: 1,598
  • Year to date:
    • Site-wide: 36,280
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    • Site-wide: 36,280

Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations

bioinformatics more details view paper
  • Downloaded 696 times
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    • Site-wide: 32,580
    • In bioinformatics: 3,693
  • Year to date:
    • Site-wide: 105,349
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    • Site-wide: 105,349

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

genomics more details view paper
  • Downloaded 679 times
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    • Site-wide: 33,699
    • In genomics: 2,984
  • Year to date:
    • Site-wide: 79,708
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    • Site-wide: 79,708

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

neuroscience more details view paper
  • Downloaded 558 times
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    • Site-wide: 43,348
    • In neuroscience: 6,302
  • Year to date:
    • Site-wide: 75,162
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    • Site-wide: 75,162

A primed immune transcriptional program is activated in oligodendroglia in multiple sclerosis

neuroscience more details view paper
  • Downloaded 518 times
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    • Site-wide: 47,412
    • In neuroscience: 6,975
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    • Site-wide: 14,363
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KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear Stress

molecular biology more details view paper
  • Downloaded 420 times
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    • Site-wide: 59,743
    • In molecular biology: 1,725
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    • Site-wide: 18,196
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Morphogen-Lineage Selector Interactions During Surface Epithelial Commitment

genetics more details view paper
  • Downloaded 369 times
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    • Site-wide: 67,626
    • In genetics: 3,167
  • Year to date:
    • Site-wide: 113,295
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    • Site-wide: 113,295

PEPATAC: An optimized ATAC-seq pipeline with serial alignments

genomics more details view paper
  • Downloaded 242 times
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    • Site-wide: 92,400
    • In genomics: 5,720
  • Year to date:
    • Site-wide: 26,117
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    • Site-wide: 26,117

Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detection.

immunology more details view paper
  • Downloaded 228 times
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    • Site-wide: 95,447
    • In immunology: 2,634
  • Year to date:
    • Site-wide: 57,508
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    • Site-wide: 57,508

The Autism Risk Factor CHD8 Is a Chromatin Activator and Functionally Dependent on the ERK-MAPK Pathway Effector ELK1

cell biology more details view paper
  • Downloaded 197 times
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    • Site-wide: 102,225
    • In cell biology: 4,741
  • Year to date:
    • Site-wide: 26,227
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Distinct T cell chromatin landscapes in scleroderma subtypes

immunology more details view paper
  • Downloaded 163 times
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    • Site-wide: 109,125
    • In immunology: 3,043
  • Year to date:
    • Site-wide: 5,556
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