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Author: Howard Y. Chang

  • Most recently observed institution: Howard Hughes Medical Institute, Stanford University

Rankings

  • All-time downloads: 80,356 (rank: 407 out of 361,837)
  • Categories:
    • bioinformatics: 1,742 (rank: 6,057 (tie) out of 31,329)
    • cancer biology: 1,136 (rank: 3,852 (tie) out of 24,618)
    • cell biology: 9,999 (rank: 235 out of 26,529)
    • evolutionary biology: 1,570 (rank: 2,468 (tie) out of 18,769)
    • genetics: 918 (rank: 13,167 (tie) out of 33,979)
    • genomics: 49,771 (rank: 122 out of 39,126)
    • immunology: 7,467 (rank: 184 out of 18,768)
    • molecular biology: 6,458 (rank: 229 out of 18,469)
    • neuroscience: 1,295 (rank: 11,629 (tie) out of 60,801)

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Preprints

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

genomics more details view paper
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    • Site-wide: 462 out of 84,043
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Atlas of Subcellular RNA Localization Revealed by APEX-seq

cell biology more details view paper
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    • In cell biology: 7 out of 4,278
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Clonal replacement of tumor-specific T cells following PD-1 blockade

immunology more details view paper
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    • In immunology: 9 out of 2,353
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Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiation

genomics more details view paper
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    • In genomics: 125 out of 5,425
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Genetic determinants of co-accessible chromatin regions in T cell activation across humans

genomics more details view paper
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    • In genomics: 151 out of 5,425
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A single cell framework for multi-omic analysis of disease identifies malignant regulatory signatures in mixed phenotype acute leukemia

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    • In genomics: 179 out of 5,425
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    • Site-wide: 1,293 out of 84,043
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Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

genomics more details view paper
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    • In genomics: 205 out of 5,425
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An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

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    • In genomics: 221 out of 5,425
  • Year to date:
    • Site-wide: 7,673 out of 84,043
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    • Site-wide: 6,592 out of 84,043

Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease

genomics more details view paper
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    • In genomics: 318 out of 5,425
  • Year to date:
    • Site-wide: 239 out of 84,043
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    • Site-wide: 901 out of 84,043

Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin

molecular biology more details view paper
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    • Site-wide: 1,656 out of 84,043
    • In molecular biology: 45 out of 2,822
  • Year to date:
    • Site-wide: 2,655 out of 84,043
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    • Site-wide: 5,454 out of 84,043

Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements

genomics more details view paper
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    • Site-wide: 1,685 out of 84,043
    • In genomics: 350 out of 5,425
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    • Site-wide: 29,914 out of 84,043
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    • Site-wide: 39,348 out of 84,043

HiChIP: Efficient and sensitive analysis of protein-directed genome architecture

genomics more details view paper
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    • Site-wide: 2,219 out of 84,043
    • In genomics: 434 out of 5,425
  • Year to date:
    • Site-wide: 59,155 out of 84,043
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    • Site-wide: 45,718 out of 84,043

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

genomics more details view paper
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    • Site-wide: 2,668 out of 84,043
    • In genomics: 520 out of 5,425
  • Year to date:
    • Site-wide: 15,322 out of 84,043
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    • Site-wide: 16,512 out of 84,043

ArchR: An integrative and scalable software package for single-cell chromatin accessibility analysis

genomics more details view paper
  • Downloaded 1,993 times
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    • Site-wide: 3,405 out of 84,043
    • In genomics: 635 out of 5,425
  • Year to date:
    • Site-wide: 394 out of 84,043
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    • Site-wide: 224 out of 84,043

Dynamic Regulation of RNA Structure in Mammalian Cells

molecular biology more details view paper
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    • Site-wide: 3,636 out of 84,043
    • In molecular biology: 114 out of 2,822
  • Year to date:
    • Site-wide: 17,126 out of 84,043
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    • Site-wide: 13,509 out of 84,043

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

genomics more details view paper
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    • Site-wide: 4,141 out of 84,043
    • In genomics: 722 out of 5,425
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    • Site-wide: 26,985 out of 84,043
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    • Site-wide: 25,784 out of 84,043

Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

immunology more details view paper
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    • In immunology: 109 out of 2,353
  • Year to date:
    • Site-wide: 495 out of 84,043
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    • Site-wide: 1,463 out of 84,043

Evolutionary dynamics of roX lncRNA function and genomic occupancy

evolutionary biology more details view paper
  • Downloaded 1,570 times
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    • Site-wide: 5,061 out of 84,043
    • In evolutionary biology: 241 out of 5,215
  • Year to date:
    • Site-wide: 77,613 out of 84,043
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    • Site-wide: 58,772 out of 84,043

Frequent extrachromosomal oncogene amplification drives aggressive tumors

cancer biology more details view paper
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    • Site-wide: 8,709 out of 84,043
    • In cancer biology: 237 out of 2,937
  • Year to date:
    • Site-wide: 2,645 out of 84,043
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    • Site-wide: 5,567 out of 84,043

Functional classification of noncoding RNAs associated with distinct histone modifications by PIRCh-seq

cell biology more details view paper
  • Downloaded 881 times
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    • In cell biology: 534 out of 4,278
  • Year to date:
    • Site-wide: 17,684 out of 84,043
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    • Site-wide: 17,497 out of 84,043

Structural modularity of the XIST ribonucleoprotein complex

molecular biology more details view paper
  • Downloaded 840 times
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    • In molecular biology: 445 out of 2,822
  • Year to date:
    • Site-wide: 7,830 out of 84,043
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    • Site-wide: 9,930 out of 84,043

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

neuroscience more details view paper
  • Downloaded 818 times
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    • Site-wide: 14,578 out of 84,043
    • In neuroscience: 2,379 out of 14,962
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    • Site-wide: 18,027 out of 84,043

Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment

cell biology more details view paper
  • Downloaded 711 times
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    • In cell biology: 765 out of 4,278
  • Year to date:
    • Site-wide: 43,284 out of 84,043
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    • Site-wide: 59,239 out of 84,043

CRISPRpic: Fast and precise analysis for CRISPR-induced mutations via prefixed index counting

bioinformatics more details view paper
  • Downloaded 680 times
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    • Site-wide: 19,237 out of 84,043
    • In bioinformatics: 2,843 out of 8,055
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    • Site-wide: 42,991 out of 84,043
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    • Site-wide: 48,311 out of 84,043

Satb1 integrates DNA sequence, shape, motif density and torsional stress to differentially bind targets in nucleosome-dense regions.

molecular biology more details view paper
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    • In molecular biology: 622 out of 2,822
  • Year to date:
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    • Site-wide: 31,044 out of 84,043

Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations

bioinformatics more details view paper
  • Downloaded 633 times
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    • Site-wide: 21,413 out of 84,043
    • In bioinformatics: 3,092 out of 8,055
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    • Site-wide: 46,140 out of 84,043

Exploring the role of Polycomb recruitment in Xist-mediated silencing of the X chromosome in ES cells

genetics more details view paper
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    • In genetics: 1,472 out of 4,416
  • Year to date:
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    • Site-wide: 23,225 out of 84,043

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

genomics more details view paper
  • Downloaded 568 times
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    • In genomics: 2,716 out of 5,425
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    • Site-wide: 9,076 out of 84,043

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

neuroscience more details view paper
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    • In neuroscience: 5,294 out of 14,962
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  • Since beginning of last month:
    • Site-wide: 67,319 out of 84,043

RNA-GPS Predicts SARS-CoV-2 RNA Localization to Host Mitochondria and Nucleolus

bioinformatics more details view paper
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    • Site-wide: 35,104 out of 84,043
    • In bioinformatics: 4,409 out of 8,055
  • Year to date:
    • Site-wide: 3,432 out of 84,043
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    • Site-wide: 1,202 out of 84,043

Morphogen-Lineage Selector Interactions During Surface Epithelial Commitment

genetics more details view paper
  • Downloaded 323 times
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    • Site-wide: 46,729 out of 84,043
    • In genetics: 2,706 out of 4,416
  • Year to date:
    • Site-wide: 74,472 out of 84,043
  • Since beginning of last month:
    • Site-wide: 81,663 out of 84,043

Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detection.

immunology more details view paper
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    • Site-wide: 78,972 out of 84,043
    • In immunology: 2,166 out of 2,353
  • Year to date:
    • Site-wide: 28,746 out of 84,043
  • Since beginning of last month:
    • Site-wide: 8,156 out of 84,043

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