Author: Mihai G Netea

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Preprints

The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses

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  • Site-wide: 73
  • In infectious diseases: 26
• Year to date:
  • Site-wide: 132
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  • Site-wide: 162

The effect of influenza vaccination on trained immunity: impact on COVID-19

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  • Site-wide: 1,176
  • In infectious diseases: 385
• Year to date:
  • Site-wide: 8,837
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  • Site-wide: 14,485

COVID-19: A model correlating BCG vaccination to protection from mortality implicates trained immunity

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  • Site-wide: 2,947
  • In infectious diseases: 756
• Year to date:
  • Site-wide: 7,029
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  • Site-wide: 10,459

Genomics of Mesolithic Scandinavia reveal colonization routes and high-latitude adaptation

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  • Site-wide: 3,898
  • In genomics: 354
• Year to date:
  • Site-wide: 25,358
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  • Site-wide: 43,275

Hydroxychloroquine inhibits trained immunity - implications for COVID-19

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  • Site-wide: 5,238
  • In allergy and immunology: 37
• Year to date:
  • Site-wide: 51,344
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  • Site-wide: 64,417

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

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  • Site-wide: 5,433
  • In infectious diseases: 1,096
• Year to date:
  • Site-wide: 39,000
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  • Site-wide: 45,334

ACTIVATE-2: A DOUBLE-BLIND RANDOMIZED TRIAL OF BCG VACCINATION AGAINST COVID19 IN INDIVIDUALS AT RISK

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  • Site-wide: 5,839
  • In infectious diseases: 1,153
• Year to date:
  • Site-wide: 16,337
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  • Site-wide: 41,825

Early Anakinra Treatment for COVID-19 Guided by Urokinase Plasminogen Receptor

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  • Site-wide: 8,949
  • In infectious diseases: 1,500
• Year to date:
  • Site-wide: 68,082
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  • Site-wide: 32,269

Swarm Learning as a privacy-preserving machine learning approach for disease classification

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  • Site-wide: 9,247
  • In bioinformatics: 972
• Year to date:
  • Site-wide: 80,171
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  • Site-wide: 24,753

A systems approach to inflammation identifies therapeutic targets in SARS-CoV-2 infection

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  • Site-wide: 12,317
  • In infectious diseases: 1,798
• Year to date:
  • Site-wide: 23,323
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  • Site-wide: 65,341

Comparative analysis of neutrophil and monocyte epigenomes

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  • Site-wide: 15,381
  • In genomics: 1,394
• Year to date:
  • Site-wide: 37,213
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  • Site-wide: 90,126

Heme induces innate immunity memory

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  • Site-wide: 21,736
  • In immunology: 810
• Year to date:
  • Site-wide: 83,937
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  • Site-wide: 101,558

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

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  • Site-wide: 22,418
  • In genomics: 1,934
• Year to date:
  • Site-wide: 132,400
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  • Site-wide: 201,096

Anakinra To Prevent Respiratory Failure In COVID-19

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  • Site-wide: 22,541
  • In infectious diseases: 2,464
• Year to date:
  • Site-wide: 19,881
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  • Site-wide: 35,581

Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes

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  • Site-wide: 27,135
  • In infectious diseases: 2,704
• Year to date:
  • Site-wide: 81,158
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  • Site-wide: 53,341

Increased plasma heparanase activity in COVID-19 patients

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  • Site-wide: 29,040
  • In infectious diseases: 2,792
• Year to date:
  • Site-wide: 185,526
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  • Site-wide: 130,070

Gut microbial structural variations as determinants of human bile acid metabolism

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  • Site-wide: 40,097
  • In microbiology: 2,332
• Year to date:
  • Site-wide: 66,951
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  • Site-wide: 72,481

Effect of anakinra on mortality in COVID-19: a patient level meta-analysis

• Downloaded 988 times
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  • Site-wide: 40,706
  • In infectious diseases: 3,403
• Year to date:
  • Site-wide: 53,289
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  • Site-wide: 36,669

Clone expansion of mutation-driven clonal hematopoiesis is associated with aging and metabolic dysfunction in individuals with obesity

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  • Site-wide: 42,843
  • In genomics: 3,380
• Year to date:
  • Site-wide: 28,401
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  • Site-wide: 21,467

ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically Ill COVID-19 Patients

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  • Site-wide: 48,337
  • In intensive care and critical care medicine: 141
• Year to date:
  • Site-wide: 29,602
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  • Site-wide: 50,025

COVID-19 as cause of viral sepsis: A Systematic Review and Meta-Analysis

• Downloaded 824 times
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  • Site-wide: 53,845
  • In infectious diseases: 3,920
• Year to date:
  • Site-wide: 145,673
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  • Site-wide: 87,548

IL-1 Mediates Tissue Specific Inflammation and Severe Respiratory Failure In Covid-19: Clinical And Experimental Evidence

• Downloaded 775 times
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  • Site-wide: 58,860
  • In infectious diseases: 4,100
• Year to date:
  • Site-wide: 122,470
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  • Site-wide: 28,252

The genetic risk for COVID-19 severity is associated with defective innate immune responses

• Downloaded 767 times
• Download rankings, all-time:
  • Site-wide: 59,898
  • In genetic and genomic medicine: 378
• Year to date:
  • Site-wide: 115,805
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  • Site-wide: 47,821

Impact of rare and common genetic variation in the Interleukin-1 pathway for human cytokine responses

• Downloaded 669 times
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  • Site-wide: 72,711
  • In systems biology: 1,456
• Year to date:
  • Site-wide: 151,995
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  • Site-wide: 192,926

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

• Downloaded 536 times
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  • Site-wide: 96,347
  • In immunology: 3,146
• Year to date:
  • Site-wide: 56,273
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  • Site-wide: 123,337

The right microbial stimulus can direct innate immune effector cells to specific organ sites to clear pathology

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 97,964
  • In immunology: 3,155
• Year to date:
  • Site-wide: 105,644
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  • Site-wide: 116,948

Discovery, diversity and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts

• Downloaded 502 times
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  • Site-wide: 103,917
  • In microbiology: 6,766
• Year to date:
  • Site-wide: 191,517
• Since beginning of last month:
  • Site-wide: 113,688

Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 116,384
  • In immunology: 3,954
• Year to date:
  • Site-wide: 24,172
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  • Site-wide: 13,971

Evolution of cytokine production capacity in ancient and modern European populations

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  • Site-wide: 129,244
  • In genomics: 7,135
• Year to date:
  • Site-wide: 160,010
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  • Site-wide: 111,986

Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: a retrospective cohort study

• Downloaded 398 times
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  • Site-wide: 130,706
  • In genetic and genomic medicine: 933
• Year to date:
  • Site-wide: 61,576
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  • Site-wide: 16,883

Distinct gene programs underpinning 'disease tolerance' and 'resistance' in influenza virus infection

• Downloaded 328 times
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  • Site-wide: 151,977
  • In systems biology: 3,147
• Year to date:
  • Site-wide: 27,945
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  • Site-wide: 14,856

Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control

• Downloaded 305 times
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  • Site-wide: 158,780
  • In immunology: 5,007
• Year to date:
  • Site-wide: 69,916
• Since beginning of last month:
  • Site-wide: 167,444

Genetic factors affecting immune phenotypes in type 1 diabetes

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  • Site-wide: 158,849
  • In endocrinology: 219
• Year to date:
  • Site-wide: 41,614
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  • Site-wide: 36,929

One vaccine to counter many diseases? Modelling the economics of oral polio vaccine against child mortality and COVID-19

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  • Site-wide: 159,096
  • In health economics: 251
• Year to date:
  • Site-wide: 68,670
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  • Site-wide: 115,878

A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis

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  • Site-wide: 168,768
  • In infectious diseases: 7,394
• Year to date:
  • Site-wide: 127,706
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  • Site-wide: 108,312

THE EFFECT OF THE MEASLES, MUMPS AND RUBELLA VACCINE ON INNATE AND ADAPTIVE IMMUNE RESPONSES IN PERSONS RECEIVING A SARS-COV-2 mRNA VACCINE.A SUB-STUDY OF THE CROWN CORONATION TRIAL

• Downloaded 206 times
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  • Site-wide: 186,458
  • In allergy and immunology: 342
• Year to date:
  • Site-wide: 74,911
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  • Site-wide: 56,872

Differential recognition and cytokine induction by the peptidorhamnomannan from Sporothrix brasiliensis and S. schenckii

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  • Site-wide: 191,422
  • In immunology: 6,235
• Year to date:
  • Site-wide: 35,103
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  • Site-wide: 116,084

TMAO and its precursors in relation to host genetics, gut microbial composition, diet, and clinical outcomes: Meta-analysis of 5 prospective population-based cohorts

• Downloaded 176 times
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  • Site-wide: 193,173
  • In epidemiology: 7,718
• Year to date:
  • Site-wide: 38,032
• Since beginning of last month:
  • Site-wide: 21,914

MMR vaccination induces a trained immunity program characterized by functional and metabolic reprogramming of γδ T cells

• Downloaded 172 times
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  • Site-wide: 194,024
  • In immunology: 6,342
• Year to date:
  • Site-wide: 33,861
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  • Site-wide: 5,191

BCG vaccination of healthcare workers does not reduce SARS-CoV-2 infections nor infection severity or duration: a randomised placebo-controlled trial

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  • Site-wide: 203,915
  • In infectious diseases: None
• Year to date:
  • Site-wide: 33,639
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  • Site-wide: 2,028

Bacillus Calmette-Guerin vaccine to reduce COVID-19 infections and hospitalisations in healthcare workers: a living systematic review and prospective ALL-IN meta-analysis of individual participant data from randomised controlled trials

• Downloaded 110 times
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  • Site-wide: 205,951
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• Year to date:
  • Site-wide: 9,248
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  • Site-wide: 3,237

Diversity and ecology of Caudoviricetes phages with genome terminal repeats in fecal metagenomes from four Dutch cohorts

• Downloaded 105 times
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  • Site-wide: 206,947
  • In microbiology: 15,796
• Year to date:
  • Site-wide: 129,595
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  • Site-wide: 157,405

Integration of Candida albicans-induced single-cell gene expression data and circulatory protein concentrations reveal genetic regulators of inflammation

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  • Site-wide: 207,160
  • In genomics: 9,432
• Year to date:
  • Site-wide: 108,684
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  • Site-wide: 157,775

Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

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  • Site-wide: 211,222
  • In immunology: 6,765
• Year to date:
  • Site-wide: 108,201
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  • Site-wide: 62,669

Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis

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  • Site-wide: 211,599
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  • Site-wide: 1,799
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