Author: Pradeep Natarajan

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • Site-wide: 392
  • In genomics: 13
• Year to date:
  • Site-wide: 30,149
• Since beginning of last month:
  • Site-wide: 64,254

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 8,630 times
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  • Site-wide: 1,266
  • In genomics: 97
• Year to date:
  • Site-wide: 4,117
• Since beginning of last month:
  • Site-wide: 12,786

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

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  • Site-wide: 2,447
  • In cell biology: 37
• Year to date:
  • Site-wide: 5,017
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  • Site-wide: 4,876

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease

• Downloaded 4,998 times
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  • Site-wide: 2,582
  • In genomics: 241
• Year to date:
  • Site-wide: 49,264
• Since beginning of last month:
  • Site-wide: 56,340

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,827
  • In genomics: 485
• Year to date:
  • Site-wide: 10,841
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  • Site-wide: 20,974

A statistical framework for cross-tissue transcriptome-wide association analysis

• Downloaded 2,880 times
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  • Site-wide: 5,602
  • In genetics: 226
• Year to date:
  • Site-wide: 57,733
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  • Site-wide: 56,709

Human knockouts in a cohort with a high rate of consanguinity

• Downloaded 2,588 times
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  • Site-wide: 6,526
  • In genomics: 667
• Year to date:
  • Site-wide: 102,712
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  • Site-wide: 128,109

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,351 times
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  • Site-wide: 7,506
  • In genetics: 320
• Year to date:
  • Site-wide: 118,519
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  • Site-wide: 112,655

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,118 times
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  • Site-wide: 8,750
  • In genomics: 875
• Year to date:
  • Site-wide: 151,219
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  • Site-wide: 153,165

Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19

• Downloaded 1,390 times
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  • Site-wide: 16,412
  • In infectious diseases: 1,830
• Year to date:
  • Site-wide: 26,108
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  • Site-wide: 27,594

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

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  • Site-wide: 16,922
  • In genetics: 758
• Year to date:
  • Site-wide: 38,160
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  • Site-wide: 46,890

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 1,307 times
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  • Site-wide: 17,971
  • In genetic and genomic medicine: 82
• Year to date:
  • Site-wide: 6,102
• Since beginning of last month:
  • Site-wide: 14,222

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 1,191 times
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  • Site-wide: 20,630
  • In genetics: 924
• Year to date:
  • Site-wide: 5,157
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  • Site-wide: 2,589

Heart Rate Variability with Photoplethysmography in 8 Million Individuals: Results and Scaling Relations with Age, Gender, and Time of Day

• Downloaded 1,113 times
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  • Site-wide: 22,784
  • In physiology: 71
• Year to date:
  • Site-wide: 28,003
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  • Site-wide: 42,382

Clonal hematopoiesis in sickle cell disease

• Downloaded 906 times
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  • Site-wide: 30,804
  • In hematology: 25
• Year to date:
  • Site-wide: 5,264
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  • Site-wide: 4,857

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 806 times
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  • Site-wide: 36,427
  • In genomics: 3,022
• Year to date:
  • Site-wide: 96,511
• Since beginning of last month:
  • Site-wide: 109,578

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 782 times
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  • Site-wide: 38,009
  • In genetics: 1,673
• Year to date:
  • Site-wide: 155,871
• Since beginning of last month:
  • Site-wide: 150,089

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 754 times
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  • Site-wide: 40,029
  • In genomics: 3,231
• Year to date:
  • Site-wide: 157,348
• Since beginning of last month:
  • Site-wide: 158,384

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 45,286
  • In genetic and genomic medicine: 197
• Year to date:
  • Site-wide: 63,558
• Since beginning of last month:
  • Site-wide: 100,371

Increased CHIP Prevalence Amongst People Living with HIV

• Downloaded 642 times
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  • Site-wide: 49,621
  • In genetic and genomic medicine: 215
• Year to date:
  • Site-wide: 21,881
• Since beginning of last month:
  • Site-wide: 29,097

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 57,933
  • In bioinformatics: 5,748
• Year to date:
  • Site-wide: 111,188
• Since beginning of last month:
  • Site-wide: 135,875

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 537 times
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  • Site-wide: 62,062
  • In genetics: 2,674
• Year to date:
  • Site-wide: 27,508
• Since beginning of last month:
  • Site-wide: 67,608

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

• Downloaded 536 times
• Download rankings, all-time:
  • Site-wide: 62,255
  • In genomics: 4,489
• Year to date:
  • Site-wide: 27,962
• Since beginning of last month:
  • Site-wide: 26,606

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 472 times
• Download rankings, all-time:
  • Site-wide: 71,920
  • In genetics: 3,096
• Year to date:
  • Site-wide: 101,025
• Since beginning of last month:
  • Site-wide: 76,484

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 81,971
  • In genetic and genomic medicine: 372
• Year to date:
  • Site-wide: 16,909
• Since beginning of last month:
  • Site-wide: 17,489

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 339 times
• Download rankings, all-time:
  • Site-wide: 98,307
  • In cardiovascular medicine: 203
• Year to date:
  • Site-wide: 105,744
• Since beginning of last month:
  • Site-wide: 123,738

Assessment and Utilization of Patient-Reported Outcomes Measures to Improve Cardiovascular Disease Prevention

• Downloaded 333 times
• Download rankings, all-time:
  • Site-wide: 99,726
  • In cardiovascular medicine: 209
• Year to date:
  • Site-wide: 69,892
• Since beginning of last month:
  • Site-wide: 77,091

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 107,795
  • In cardiovascular medicine: 236
• Year to date:
  • Site-wide: 71,533
• Since beginning of last month:
  • Site-wide: 85,736

Prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 107,810
  • In genetic and genomic medicine: 564
• Year to date:
  • Site-wide: 56,059
• Since beginning of last month:
  • Site-wide: 33,206

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 111,146
  • In genetics: 4,599
• Year to date:
  • Site-wide: 28,820
• Since beginning of last month:
  • Site-wide: 2,370

TP53-mediated clonal hematopoiesis confers increased risk for incident peripheral artery disease

• Downloaded 269 times
• Download rankings, all-time:
  • Site-wide: 115,902
  • In genetic and genomic medicine: 628
• Year to date:
  • Site-wide: 31,442
• Since beginning of last month:
  • Site-wide: 11,469

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 117,861
  • In genetic and genomic medicine: 650
• Year to date:
  • Site-wide: 32,575
• Since beginning of last month:
  • Site-wide: None

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 120,979
  • In cardiovascular medicine: 298
• Year to date:
  • Site-wide: 86,059
• Since beginning of last month:
  • Site-wide: 99,631

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 122,624
  • In genetic and genomic medicine: 684
• Year to date:
  • Site-wide: 35,685
• Since beginning of last month:
  • Site-wide: 34,926

OUTCOMES OF A SMARTPHONE-BASED APPLICATION WITH LIVE HEALTH-COACHING POST-PERCUTANEOUS CORONARY INTERVENTION

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 133,741
  • In cardiovascular medicine: 369
• Year to date:
  • Site-wide: 83,886
• Since beginning of last month:
  • Site-wide: 64,379

Photoreceptor layer thinning is an early biomarker for age-related macular degeneration development: Epidemiological and genetic evidence from UK Biobank optical coherence tomography data

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 152,421
  • In ophthalmology: 165
• Year to date:
  • Site-wide: 80,403
• Since beginning of last month:
  • Site-wide: 25,434

A MUC5B gene polymorphism, rs35705950-T, confers protective effects in COVID-19 infection

• Downloaded 63 times
• Download rankings, all-time:
  • Site-wide: 158,794
  • In infectious diseases: 6,308
• Year to date:
  • Site-wide: 122,982
• Since beginning of last month:
  • Site-wide: 23,195