Author: Pradeep Natarajan

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • Site-wide: 341
  • In genomics: 13
• Year to date:
  • Site-wide: 30,726
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  • Site-wide: 44,328

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 1,144
  • In genomics: 95
• Year to date:
  • Site-wide: 3,314
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  • Site-wide: 8,666

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease

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  • Site-wide: 2,333
  • In genomics: 230
• Year to date:
  • Site-wide: 48,155
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  • Site-wide: 39,801

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

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  • Site-wide: 2,389
  • In cell biology: 41
• Year to date:
  • Site-wide: 5,442
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  • Site-wide: 6,777

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,563
  • In genomics: 482
• Year to date:
  • Site-wide: 8,958
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  • Site-wide: 16,759

A statistical framework for cross-tissue transcriptome-wide association analysis

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  • Site-wide: 5,136
  • In genetics: 214
• Year to date:
  • Site-wide: 51,274
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  • Site-wide: 28,453

Human knockouts in a cohort with a high rate of consanguinity

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  • Site-wide: 5,968
  • In genomics: 636
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  • Site-wide: 100,304
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  • Site-wide: 87,422

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 6,829
  • In genetics: 306
• Year to date:
  • Site-wide: 103,205
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  • Site-wide: 73,764

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,103 times
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  • Site-wide: 7,914
  • In genomics: 835
• Year to date:
  • Site-wide: 138,264
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  • Site-wide: 141,676

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

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  • Site-wide: 16,195
  • In genetics: 760
• Year to date:
  • Site-wide: 32,872
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  • Site-wide: 34,240

Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19

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  • Site-wide: 16,307
  • In infectious diseases: 1,695
• Year to date:
  • Site-wide: 25,093
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  • Site-wide: 27,611

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 1,062 times
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  • Site-wide: 21,773
  • In genetic and genomic medicine: 83
• Year to date:
  • Site-wide: 6,115
• Since beginning of last month:
  • Site-wide: 8,433

Heart Rate Variability with Photoplethysmography in 8 Million Individuals: Results and Scaling Relations with Age, Gender, and Time of Day

• Downloaded 1,047 times
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  • Site-wide: 22,250
  • In physiology: 75
• Year to date:
  • Site-wide: 22,704
• Since beginning of last month:
  • Site-wide: 38,347

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 775 times
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  • Site-wide: 34,088
  • In genomics: 2,919
• Year to date:
  • Site-wide: 84,156
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  • Site-wide: 139,601

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 770 times
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  • Site-wide: 34,388
  • In genetics: 1,583
• Year to date:
  • Site-wide: 141,096
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  • Site-wide: 138,678

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 748 times
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  • Site-wide: 35,800
  • In genetics: 1,656
• Year to date:
  • Site-wide: 8,066
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  • Site-wide: 19,554

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 742 times
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  • Site-wide: 36,254
  • In genomics: 3,050
• Year to date:
  • Site-wide: 144,374
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  • Site-wide: 146,483

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 639 times
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  • Site-wide: 44,095
  • In genetic and genomic medicine: 170
• Year to date:
  • Site-wide: 58,178
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  • Site-wide: 48,153

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 548 times
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  • Site-wide: 53,425
  • In bioinformatics: 5,429
• Year to date:
  • Site-wide: 92,069
• Since beginning of last month:
  • Site-wide: 102,660

Increased CHIP Prevalence Amongst People Living with HIV

• Downloaded 537 times
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  • Site-wide: 54,724
  • In genetic and genomic medicine: 212
• Year to date:
  • Site-wide: 20,600
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  • Site-wide: 18,532

Clonal hematopoiesis in sickle cell disease

• Downloaded 514 times
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  • Site-wide: 57,610
  • In hematology: 43
• Year to date:
  • Site-wide: 7,266
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  • Site-wide: 828

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 481 times
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  • Site-wide: 62,111
  • In genetics: 2,781
• Year to date:
  • Site-wide: 21,008
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  • Site-wide: 52,173

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 433 times
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  • Site-wide: 69,476
  • In genetics: 3,106
• Year to date:
  • Site-wide: 100,874
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  • Site-wide: 107,972

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

• Downloaded 422 times
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  • Site-wide: 71,307
  • In genomics: 4,908
• Year to date:
  • Site-wide: 30,493
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  • Site-wide: 16,715

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 315 times
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  • Site-wide: 91,780
  • In cardiovascular medicine: 179
• Year to date:
  • Site-wide: 88,247
• Since beginning of last month:
  • Site-wide: 77,377

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 94,978
  • In genetic and genomic medicine: 421
• Year to date:
  • Site-wide: 15,551
• Since beginning of last month:
  • Site-wide: 19,606

Assessment and Utilization of Patient-Reported Outcomes Measures to Improve Cardiovascular Disease Prevention

• Downloaded 287 times
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  • Site-wide: 98,258
  • In cardiovascular medicine: 197
• Year to date:
  • Site-wide: 63,514
• Since beginning of last month:
  • Site-wide: 42,841

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 253 times
• Download rankings, all-time:
  • Site-wide: 106,085
  • In cardiovascular medicine: 223
• Year to date:
  • Site-wide: 66,622
• Since beginning of last month:
  • Site-wide: 60,756

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

• Downloaded 242 times
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  • Site-wide: 108,961
  • In genetic and genomic medicine: 527
• Year to date:
  • Site-wide: 20,891
• Since beginning of last month:
  • Site-wide: 9,917

Prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test

• Downloaded 231 times
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  • Site-wide: 111,536
  • In genetic and genomic medicine: 548
• Year to date:
  • Site-wide: 58,585
• Since beginning of last month:
  • Site-wide: 46,357

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 116,778
  • In cardiovascular medicine: 268
• Year to date:
  • Site-wide: 78,283
• Since beginning of last month:
  • Site-wide: 72,106

OUTCOMES OF A SMARTPHONE-BASED APPLICATION WITH LIVE HEALTH-COACHING POST-PERCUTANEOUS CORONARY INTERVENTION

• Downloaded 152 times
• Download rankings, all-time:
  • Site-wide: 130,366
  • In cardiovascular medicine: 357
• Year to date:
  • Site-wide: 83,895
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  • Site-wide: 92,975

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways

• Downloaded 134 times
• Download rankings, all-time:
  • Site-wide: 134,204
  • In genetic and genomic medicine: 727
• Year to date:
  • Site-wide: 42,318
• Since beginning of last month:
  • Site-wide: 5,748