Author: Pradeep Natarajan

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • Site-wide: 307
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• Year to date:
  • Site-wide: 21,278
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  • Site-wide: 16,278

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 1,050
  • In genomics: 95
• Year to date:
  • Site-wide: 2,402
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  • Site-wide: 6,002

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease

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  • Site-wide: 2,076
  • In genomics: 214
• Year to date:
  • Site-wide: 45,519
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  • Site-wide: 46,528

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

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  • Site-wide: 2,264
  • In cell biology: 40
• Year to date:
  • Site-wide: 5,590
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  • Site-wide: 5,555

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,324
  • In genomics: 478
• Year to date:
  • Site-wide: 7,112
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  • Site-wide: 7,873

A statistical framework for cross-tissue transcriptome-wide association analysis

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  • Site-wide: 4,667
  • In genetics: 205
• Year to date:
  • Site-wide: 55,258
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  • Site-wide: 63,773

Human knockouts in a cohort with a high rate of consanguinity

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  • Site-wide: 5,304
  • In genomics: 594
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  • Site-wide: 82,140
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  • Site-wide: 104,294

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 6,142
  • In genetics: 289
• Year to date:
  • Site-wide: 108,591
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  • Site-wide: 94,809

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,092 times
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  • Site-wide: 7,041
  • In genomics: 773
• Year to date:
  • Site-wide: 127,464
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  • Site-wide: 114,224

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

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  • Site-wide: 15,635
  • In genetics: 768
• Year to date:
  • Site-wide: 28,968
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  • Site-wide: 32,664

Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19

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  • Site-wide: 16,028
  • In infectious diseases: 1,540
• Year to date:
  • Site-wide: 21,378
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  • Site-wide: 28,020

Heart Rate Variability with Photoplethysmography in 8 Million Individuals: Results and Scaling Relations with Age, Gender, and Time of Day

• Downloaded 953 times
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  • Site-wide: 22,652
  • In physiology: 80
• Year to date:
  • Site-wide: 19,941
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  • Site-wide: 18,989

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 846 times
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  • Site-wide: 26,849
  • In genetic and genomic medicine: 87
• Year to date:
  • Site-wide: 5,200
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  • Site-wide: 6,043

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 757 times
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  • Site-wide: 31,391
  • In genetics: 1,510
• Year to date:
  • Site-wide: 133,746
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  • Site-wide: 130,858

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 747 times
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  • Site-wide: 31,942
  • In genomics: 2,833
• Year to date:
  • Site-wide: 74,760
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  • Site-wide: 90,892

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 740 times
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  • Site-wide: 32,392
  • In genomics: 2,862
• Year to date:
  • Site-wide: 117,651
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  • Site-wide: 133,243

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 631 times
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  • Site-wide: 40,034
  • In genetics: 1,895
• Year to date:
  • Site-wide: 5,177
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  • Site-wide: 14,748

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 593 times
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  • Site-wide: 43,247
  • In genetic and genomic medicine: 138
• Year to date:
  • Site-wide: 53,055
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  • Site-wide: 35,842

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 536 times
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  • Site-wide: 49,049
  • In bioinformatics: 5,092
• Year to date:
  • Site-wide: 61,726
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  • Site-wide: 78,572

Increased CHIP Prevalence Amongst People Living with HIV

• Downloaded 439 times
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  • Site-wide: 61,231
  • In genetic and genomic medicine: 203
• Year to date:
  • Site-wide: 17,742
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  • Site-wide: 20,843

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 418 times
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  • Site-wide: 64,421
  • In genetics: 2,976
• Year to date:
  • Site-wide: 13,841
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  • Site-wide: 7,223

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 410 times
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  • Site-wide: 65,610
  • In genetics: 3,022
• Year to date:
  • Site-wide: 94,202
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  • Site-wide: 108,150

Genome-Wide Screening Reveals CSDE1 as a Novel Regulator of the LDL Receptor

• Downloaded 301 times
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  • Site-wide: 85,649
  • In genomics: 5,469
• Year to date:
  • Site-wide: 47,130
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  • Site-wide: 38,615

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 290 times
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  • Site-wide: 87,930
  • In cardiovascular medicine: 147
• Year to date:
  • Site-wide: 77,578
• Since beginning of last month:
  • Site-wide: 99,333

Assessment and Utilization of Patient-Reported Outcomes Measures to Improve Cardiovascular Disease Prevention

• Downloaded 249 times
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  • Site-wide: 96,855
  • In cardiovascular medicine: 184
• Year to date:
  • Site-wide: 54,226
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  • Site-wide: 52,962

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 215 times
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  • Site-wide: 104,388
  • In cardiovascular medicine: 212
• Year to date:
  • Site-wide: 59,237
• Since beginning of last month:
  • Site-wide: 38,190

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

• Downloaded 198 times
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  • Site-wide: 108,388
  • In genetic and genomic medicine: 475
• Year to date:
  • Site-wide: 12,044
• Since beginning of last month:
  • Site-wide: 3,873

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 111,692
  • In cardiovascular medicine: 250
• Year to date:
  • Site-wide: 66,629
• Since beginning of last month:
  • Site-wide: 59,964

Prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test

• Downloaded 155 times
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  • Site-wide: 117,435
  • In genetic and genomic medicine: 552
• Year to date:
  • Site-wide: 102,015
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  • Site-wide: 88,236

OUTCOMES OF A SMARTPHONE-BASED APPLICATION WITH LIVE HEALTH-COACHING POST-PERCUTANEOUS CORONARY INTERVENTION

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• Download rankings, all-time:
  • Site-wide: 122,273
  • In cardiovascular medicine: 313
• Year to date:
  • Site-wide: 62,762
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  • Site-wide: 56,115