Author: Pradeep Natarajan

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • Site-wide: 470
  • In genomics: 13
• Year to date:
  • Site-wide: 32,486
• Since beginning of last month:
  • Site-wide: 36,612

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 9,038 times
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  • Site-wide: 1,441
  • In genomics: 92
• Year to date:
  • Site-wide: 12,334
• Since beginning of last month:
  • Site-wide: 16,883

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

• Downloaded 5,544 times
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  • Site-wide: 2,757
  • In cell biology: 39
• Year to date:
  • Site-wide: 14,711
• Since beginning of last month:
  • Site-wide: 16,996

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease

• Downloaded 5,123 times
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  • Site-wide: 3,079
  • In genomics: 261
• Year to date:
  • Site-wide: 64,997
• Since beginning of last month:
  • Site-wide: 36,788

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 3,397 times
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  • Site-wide: 5,439
  • In genomics: 498
• Year to date:
  • Site-wide: 30,212
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  • Site-wide: 44,132

A statistical framework for cross-tissue transcriptome-wide association analysis

• Downloaded 2,987 times
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  • Site-wide: 6,550
  • In genetics: 233
• Year to date:
  • Site-wide: 76,462
• Since beginning of last month:
  • Site-wide: 76,414

Human knockouts in a cohort with a high rate of consanguinity

• Downloaded 2,654 times
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  • Site-wide: 7,787
  • In genomics: 706
• Year to date:
  • Site-wide: 139,371
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  • Site-wide: 129,445

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 8,947
  • In genetics: 343
• Year to date:
  • Site-wide: 133,085
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  • Site-wide: 132,590

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,145 times
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  • Site-wide: 10,642
  • In genomics: 953
• Year to date:
  • Site-wide: 176,741
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  • Site-wide: 177,398

Clonal hematopoiesis is driven by aberrant activation of TCL1A

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  • Site-wide: 14,455
  • In genetics: 913
• Year to date:
  • Site-wide: 1,440
• Since beginning of last month:
  • Site-wide: 1,899

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 1,697 times
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  • Site-wide: 15,117
  • In genetic and genomic medicine: 88
• Year to date:
  • Site-wide: 16,296
• Since beginning of last month:
  • Site-wide: 26,574

Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19

• Downloaded 1,570 times
• Download rankings, all-time:
  • Site-wide: 17,032
  • In infectious diseases: 2,019
• Year to date:
  • Site-wide: 46,772
• Since beginning of last month:
  • Site-wide: 42,794

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 1,513 times
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  • Site-wide: 18,031
  • In genetics: 781
• Year to date:
  • Site-wide: 27,584
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  • Site-wide: 21,983

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

• Downloaded 1,507 times
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  • Site-wide: 18,114
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 6,472
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  • Site-wide: 7,059

Clonal hematopoiesis is associated with protection from Alzheimer's disease

• Downloaded 1,482 times
• Download rankings, all-time:
  • Site-wide: 18,552
  • In hematology: 24
• Year to date:
  • Site-wide: 1,941
• Since beginning of last month:
  • Site-wide: 4,143

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

• Downloaded 1,465 times
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  • Site-wide: 18,910
  • In genetics: 795
• Year to date:
  • Site-wide: 61,948
• Since beginning of last month:
  • Site-wide: 49,364

Heart Rate Variability with Photoplethysmography in 8 Million Individuals: Results and Scaling Relations with Age, Gender, and Time of Day

• Downloaded 1,305 times
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  • Site-wide: 22,657
  • In physiology: 76
• Year to date:
  • Site-wide: 30,762
• Since beginning of last month:
  • Site-wide: 29,751

Clonal hematopoiesis in sickle cell disease

• Downloaded 1,249 times
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  • Site-wide: 24,269
  • In hematology: 21
• Year to date:
  • Site-wide: 26,573
• Since beginning of last month:
  • Site-wide: 34,858

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

• Downloaded 1,166 times
• Download rankings, all-time:
  • Site-wide: 26,951
  • In genomics: 2,592
• Year to date:
  • Site-wide: 9,612
• Since beginning of last month:
  • Site-wide: 36,447

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

• Downloaded 941 times
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  • Site-wide: 37,226
  • In genomics: 3,522
• Year to date:
  • Site-wide: 12,100
• Since beginning of last month:
  • Site-wide: 19,180

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 859 times
• Download rankings, all-time:
  • Site-wide: 42,543
  • In genomics: 3,180
• Year to date:
  • Site-wide: 160,440
• Since beginning of last month:
  • Site-wide: 173,478

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 816 times
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  • Site-wide: 45,841
  • In genetics: 1,794
• Year to date:
  • Site-wide: 154,468
• Since beginning of last month:
  • Site-wide: 114,807

Increased CHIP Prevalence Amongst People Living with HIV

• Downloaded 813 times
• Download rankings, all-time:
  • Site-wide: 46,056
  • In genetic and genomic medicine: 240
• Year to date:
  • Site-wide: 46,001
• Since beginning of last month:
  • Site-wide: 44,540

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 811 times
• Download rankings, all-time:
  • Site-wide: 46,297
  • In genetic and genomic medicine: 234
• Year to date:
  • Site-wide: 88,993
• Since beginning of last month:
  • Site-wide: 84,815

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 781 times
• Download rankings, all-time:
  • Site-wide: 48,937
  • In genomics: 3,512
• Year to date:
  • Site-wide: 170,725
• Since beginning of last month:
  • Site-wide: 140,826

Clonal hematopoiesis and risk of chronic liver disease

• Downloaded 772 times
• Download rankings, all-time:
  • Site-wide: 49,823
  • In hematology: 79
• Year to date:
  • Site-wide: 2,540
• Since beginning of last month:
  • Site-wide: 9,308

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

• Downloaded 664 times
• Download rankings, all-time:
  • Site-wide: 61,587
  • In genetic and genomic medicine: 353
• Year to date:
  • Site-wide: 28,197
• Since beginning of last month:
  • Site-wide: 42,611

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 65,510
  • In bioinformatics: 6,140
• Year to date:
  • Site-wide: 89,270
• Since beginning of last month:
  • Site-wide: 116,965

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 616 times
• Download rankings, all-time:
  • Site-wide: 67,787
  • In genetics: 2,695
• Year to date:
  • Site-wide: 113,066
• Since beginning of last month:
  • Site-wide: 84,734

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 71,917
  • In genetics: 3,422
• Year to date:
  • Site-wide: 23,826
• Since beginning of last month:
  • Site-wide: 21,528

TP53-mediated clonal hematopoiesis confers increased risk for incident peripheral artery disease

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 73,805
  • In genetic and genomic medicine: 509
• Year to date:
  • Site-wide: 18,558
• Since beginning of last month:
  • Site-wide: 27,332

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 73,810
  • In genetics: 3,779
• Year to date:
  • Site-wide: 15,368
• Since beginning of last month:
  • Site-wide: 20,380

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 558 times
• Download rankings, all-time:
  • Site-wide: 76,807
  • In genetics: 3,009
• Year to date:
  • Site-wide: 132,354
• Since beginning of last month:
  • Site-wide: 74,062

Photoreceptor layer thinning is an early biomarker for age-related macular degeneration development: Epidemiological and genetic evidence from UK Biobank optical coherence tomography data

• Downloaded 459 times
• Download rankings, all-time:
  • Site-wide: 96,118
  • In ophthalmology: 122
• Year to date:
  • Site-wide: 25,312
• Since beginning of last month:
  • Site-wide: 18,842

Cost effective sequencing enables longitudinal profiling of clonal hematopoiesis

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 103,475
  • In genetic and genomic medicine: 397
• Year to date:
  • Site-wide: 6,239
• Since beginning of last month:
  • Site-wide: 9,850

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 410 times
• Download rankings, all-time:
  • Site-wide: 107,745
  • In cardiovascular medicine: 231
• Year to date:
  • Site-wide: 158,798
• Since beginning of last month:
  • Site-wide: 136,388

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 108,999
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 6,794
• Since beginning of last month:
  • Site-wide: 12,860

Prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test

• Downloaded 404 times
• Download rankings, all-time:
  • Site-wide: 109,247
  • In genetic and genomic medicine: 617
• Year to date:
  • Site-wide: 102,387
• Since beginning of last month:
  • Site-wide: 122,707

Assessment and Utilization of Patient-Reported Outcomes Measures to Improve Cardiovascular Disease Prevention

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 110,058
  • In cardiovascular medicine: 250
• Year to date:
  • Site-wide: 110,005
• Since beginning of last month:
  • Site-wide: 84,485

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 348 times
• Download rankings, all-time:
  • Site-wide: 124,027
  • In cardiovascular medicine: 289
• Year to date:
  • Site-wide: 161,161
• Since beginning of last month:
  • Site-wide: 153,980

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways

• Downloaded 339 times
• Download rankings, all-time:
  • Site-wide: 126,493
  • In genetic and genomic medicine: 762
• Year to date:
  • Site-wide: 66,991
• Since beginning of last month:
  • Site-wide: 83,265

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

• Downloaded 321 times
• Download rankings, all-time:
  • Site-wide: 131,772
  • In cardiovascular medicine: 328
• Year to date:
  • Site-wide: 127,099
• Since beginning of last month:
  • Site-wide: 100,215

A MUC5B gene polymorphism, rs35705950-T, confers protective effects in COVID-19 infection

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 136,104
  • In infectious diseases: 6,191
• Year to date:
  • Site-wide: 47,473
• Since beginning of last month:
  • Site-wide: 44,687

OUTCOMES OF A SMARTPHONE-BASED APPLICATION WITH LIVE HEALTH-COACHING POST-PERCUTANEOUS CORONARY INTERVENTION

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 146,985
  • In cardiovascular medicine: 399
• Year to date:
  • Site-wide: 131,731
• Since beginning of last month:
  • Site-wide: 124,755

Genome-wide Discovery for Diabetes-Dependent Triglycerides-Associated Loci

• Downloaded 256 times
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  • Site-wide: 151,131
  • In genetic and genomic medicine: 1,129
• Year to date:
  • Site-wide: 13,615
• Since beginning of last month:
  • Site-wide: 58,330

Machine Learning for Sudden Cardiac Death Prediction in the Atherosclerosis Risk in Communities Study

• Downloaded 183 times
• Download rankings, all-time:
  • Site-wide: 170,885
  • In cardiovascular medicine: 592
• Year to date:
  • Site-wide: 22,027
• Since beginning of last month:
  • Site-wide: 86,733

Genetic Architecture And Clinical Outcomes Of The Fredrickson-Levy-Lees Dyslipoproteinemias

• Downloaded 180 times
• Download rankings, all-time:
  • Site-wide: 171,605
  • In cardiovascular medicine: None
• Year to date:
  • Site-wide: 22,534
• Since beginning of last month:
  • Site-wide: 3,061

Polygenic predisposition to venous thromboembolism is associated with increased COVID-19 positive testing rates

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 171,942
  • In hematology: 144
• Year to date:
  • Site-wide: 22,940
• Since beginning of last month:
  • Site-wide: 32,564