Author: Zhe Zhang

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Preprints

Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial

• Downloaded 11,250 times
• Download rankings, all-time:
  • Site-wide: 1,105
  • In infectious diseases: 355
• Year to date:
  • Site-wide: 9,203
• Since beginning of last month:
  • Site-wide: 8,773

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

• Downloaded 4,558 times
• Download rankings, all-time:
  • Site-wide: 3,601
  • In biochemistry: 57
• Year to date:
  • Site-wide: 64,565
• Since beginning of last month:
  • Site-wide: 95,121

RNA-Seq 2G: Online Analysis Of Differential Gene Expression With Comprehensive Options Of Statistical Methods

• Downloaded 3,375 times
• Download rankings, all-time:
  • Site-wide: 5,489
  • In bioinformatics: 497
• Year to date:
  • Site-wide: 17,538
• Since beginning of last month:
  • Site-wide: 18,390

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry

• Downloaded 3,007 times
• Download rankings, all-time:
  • Site-wide: 6,502
  • In microbiology: 393
• Year to date:
  • Site-wide: 75,698
• Since beginning of last month:
  • Site-wide: 102,715

Aerosolized Ad5-nCoV booster vaccination elicited potent immune response against the SARS-CoV-2 Omicron variant after inactivated COVID-19 vaccine priming

• Downloaded 1,764 times
• Download rankings, all-time:
  • Site-wide: 14,300
  • In infectious diseases: None
• Year to date:
  • Site-wide: 761
• Since beginning of last month:
  • Site-wide: 924

The Chronic Kidney Disease and Acute Kidney Injury Involvement in COVID-19 Pandemic: A Systematic Review and Meta-analysis

• Downloaded 1,139 times
• Download rankings, all-time:
  • Site-wide: 27,964
  • In nephrology: 16
• Year to date:
  • Site-wide: 101,037
• Since beginning of last month:
  • Site-wide: 88,261

Tertiary Lymphoid Structure and CD8 T Cell Exclusion in Minimally Invasive Adenocarcinoma

• Downloaded 1,060 times
• Download rankings, all-time:
  • Site-wide: 31,157
  • In genetic and genomic medicine: 163
• Year to date:
  • Site-wide: 46,331
• Since beginning of last month:
  • Site-wide: 47,895

CTCF blocks anti-sense transcription initiation at divergent gene promoters

• Downloaded 1,010 times
• Download rankings, all-time:
  • Site-wide: 33,486
  • In molecular biology: 1,087
• Year to date:
  • Site-wide: 11,244
• Since beginning of last month:
  • Site-wide: 6,805

Generating Templates and Growth Charts for School-Aged Brain Development

• Downloaded 1,006 times
• Download rankings, all-time:
  • Site-wide: 33,702
  • In neuroscience: 4,078
• Year to date:
  • Site-wide: 96,519
• Since beginning of last month:
  • Site-wide: 140,631

Age-dependent sexual dimorphism in the adult human gut microbiota

• Downloaded 902 times
• Download rankings, all-time:
  • Site-wide: 39,582
  • In genomics: 3,002
• Year to date:
  • Site-wide: 118,365
• Since beginning of last month:
  • Site-wide: 116,167

An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

• Downloaded 877 times
• Download rankings, all-time:
  • Site-wide: 41,185
  • In systems biology: 793
• Year to date:
  • Site-wide: 102,207
• Since beginning of last month:
  • Site-wide: 76,208

Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

• Downloaded 780 times
• Download rankings, all-time:
  • Site-wide: 49,066
  • In genetics: 2,117
• Year to date:
  • Site-wide: 20,720
• Since beginning of last month:
  • Site-wide: 29,696

ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression

• Downloaded 778 times
• Download rankings, all-time:
  • Site-wide: 49,234
  • In molecular biology: 1,328
• Year to date:
  • Site-wide: 86,694
• Since beginning of last month:
  • Site-wide: 53,520

Genome sequencing analysis identifies high-risk Epstein-Barr virus subtypes for nasopharyngeal carcinoma

• Downloaded 696 times
• Download rankings, all-time:
  • Site-wide: 57,616
  • In genetics: 2,224
• Year to date:
  • Site-wide: 124,599
• Since beginning of last month:
  • Site-wide: 129,388

NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Data

• Downloaded 688 times
• Download rankings, all-time:
  • Site-wide: 58,525
  • In bioinformatics: 5,483
• Year to date:
  • Site-wide: 112,332
• Since beginning of last month:
  • Site-wide: 135,739

The female urinary microbiota in relation to the reproductive tract microbiota

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 58,793
  • In microbiology: 3,638
• Year to date:
  • Site-wide: 69,071
• Since beginning of last month:
  • Site-wide: 50,494

An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

• Downloaded 666 times
• Download rankings, all-time:
  • Site-wide: 61,276
  • In immunology: 1,820
• Year to date:
  • Site-wide: 132,141
• Since beginning of last month:
  • Site-wide: 151,649

A novel viral protein translation mechanism reveals mitochondria as a target for antiviral drug development

• Downloaded 648 times
• Download rankings, all-time:
  • Site-wide: 63,470
  • In microbiology: 3,808
• Year to date:
  • Site-wide: 86,654
• Since beginning of last month:
  • Site-wide: 135,462

The conserved ER-transmembrane protein TMEM39 coordinates with COPII to promote collagen secretion and prevent ER stress

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 70,232
  • In cell biology: 2,940
• Year to date:
  • Site-wide: 113,111
• Since beginning of last month:
  • Site-wide: 107,545

Sub-species niche specialization in the oral microbiome is associated with nasopharyngeal carcinoma risk

• Downloaded 568 times
• Download rankings, all-time:
  • Site-wide: 75,087
  • In microbiology: 4,456
• Year to date:
  • Site-wide: 151,542
• Since beginning of last month:
  • Site-wide: 151,154

Temporal and spatial dynamics mapping reveals follicle development regulated by different stromal cell populations

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 81,254
  • In developmental biology: None
• Year to date:
  • Site-wide: 4,482
• Since beginning of last month:
  • Site-wide: 4,899

PHARP: A pig haplotype reference panel for genotype imputation

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 89,664
  • In genomics: 6,098
• Year to date:
  • Site-wide: 41,488
• Since beginning of last month:
  • Site-wide: 42,636

Polyvinyl Chloride Degradation by Intestinal Klebsiella of Pest larvae

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 93,843
  • In microbiology: 8,354
• Year to date:
  • Site-wide: 13,569
• Since beginning of last month:
  • Site-wide: 14,565

Broadly Conserved Roles of TMEM-131 Family Proteins in Intracellular Collagen Assembly and Secretory Cargo Trafficking

• Downloaded 467 times
• Download rankings, all-time:
  • Site-wide: 94,450
  • In cell biology: 4,147
• Year to date:
  • Site-wide: 113,024
• Since beginning of last month:
  • Site-wide: 88,582

GSA-Genie: a web application for gene set analysis

• Downloaded 465 times
• Download rankings, all-time:
  • Site-wide: 94,993
  • In bioinformatics: 7,918
• Year to date:
  • Site-wide: 154,262
• Since beginning of last month:
  • Site-wide: 139,927

Changes of the Commensal Microbiome during Treatment are Associated with Clinical Response in Nasopharyngeal Carcinoma Patients

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 106,195
  • In oncology: 232
• Year to date:
  • Site-wide: 141,350
• Since beginning of last month:
  • Site-wide: 127,513

Accurate inference of the full base-pairing structure of RNA by deep mutational scanning and covariation-induced deviation of activity

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 108,388
  • In molecular biology: 2,959
• Year to date:
  • Site-wide: 188,124
• Since beginning of last month:
  • Site-wide: 187,064

High-quality genome assembly and high-density genetic map of asparagus bean

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 116,474
  • In genomics: 6,388
• Year to date:
  • Site-wide: 174,573
• Since beginning of last month:
  • Site-wide: 131,182

Resurrecting self-cleaving mini-ribozymes from 40-million-year-old LINE-1 elements in human genome

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 123,129
  • In molecular biology: 3,791
• Year to date:
  • Site-wide: 63,176
• Since beginning of last month:
  • Site-wide: 75,462

Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 127,014
  • In neuroscience: 19,698
• Year to date:
  • Site-wide: 51,555
• Since beginning of last month:
  • Site-wide: 122,808

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 164,416
  • In immunology: None
• Year to date:
  • Site-wide: 18,307
• Since beginning of last month:
  • Site-wide: 2,435

KIF2C regulates synaptic plasticity and cognition by mediating dynamic microtubule invasion of dendritic spines

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 172,127
  • In neuroscience: 24,685
• Year to date:
  • Site-wide: 53,209
• Since beginning of last month:
  • Site-wide: 83,373

Sex differences in the nasal microbiome of healthy young adults

• Downloaded 94 times
• Download rankings, all-time:
  • Site-wide: 186,430
  • In microbiology: None
• Year to date:
  • Site-wide: 49,341
• Since beginning of last month:
  • Site-wide: 8,860