Author: Kresten Lindorff-Larsen
- ORCiD: http://orcid.org/0000-0002-4750-6039
- Most recently observed institution: University of Copenhagen
Rankings
- All-time downloads: 60,775 (rank: 4,116 )
- Categories:
- biochemistry: 5,935 (rank: 819 )
- bioengineering: 1,132 (rank: 6,110 (tie) )
- bioinformatics: 3,167 (rank: 6,788 )
- biophysics: 47,373 (rank: 4 )
- cell biology: 531 (rank: 32,902 (tie) )
- genetics: 745 (rank: 26,934 (tie) )
- immunology: 182 (rank: 51,887 (tie) )
- molecular biology: 391 (rank: 28,545 (tie) )
Downloads per author, site-wide
Preprints
FRETpredict: A Python package for FRET efficiency predictions using rotamer libraries
biophysics more details view paperNo download data for this paper yet.
A structural biology community assessment of AlphaFold 2 applications
biophysics more details view paper- Downloaded 11,347 times
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- Site-wide: 1,179
- In biophysics: 8
- Year to date:
- Site-wide: 11,497
- Since beginning of last month:
- Site-wide: 1,181
Computing, analyzing and comparing the radius of gyration and hydrodynamic radius in conformational ensembles of intrinsically disordered proteins
biophysics more details view paper- Downloaded 2,228 times
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- Site-wide: 11,424
- In biophysics: 241
- Year to date:
- Site-wide: 12,252
- Since beginning of last month:
- Site-wide: 26,363
Rapid protein stability prediction using deep learning representations
biophysics more details view paper- Downloaded 2,095 times
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- Site-wide: 12,539
- In biophysics: 374
- Year to date:
- Site-wide: 580
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- Site-wide: 507
Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach
biophysics more details view paper- Downloaded 2,013 times
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- Site-wide: 13,324
- In biophysics: 294
- Year to date:
- Site-wide: 57,559
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Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
biophysics more details view paper- Downloaded 1,514 times
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- Site-wide: 20,781
- In biophysics: 518
- Year to date:
- Site-wide: 62,868
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Accurate model of liquid-liquid phase behaviour of intrinsically-disordered proteins from data-driven optimization of single-chain properties
biophysics more details view paper- Downloaded 1,513 times
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- Site-wide: 20,801
- In biophysics: 525
- Year to date:
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Predicting and interpreting large scale mutagenesis data using analyses of protein stability and conservation
biophysics more details view paper- Downloaded 1,342 times
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- Site-wide: 25,234
- In biophysics: 648
- Year to date:
- Site-wide: 85,162
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Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations
biophysics more details view paper- Downloaded 1,240 times
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- Site-wide: 28,648
- In biophysics: 791
- Year to date:
- Site-wide: 77,873
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Barnaba: Software for Analysis of Nucleic Acids Structures and Trajectories
bioinformatics more details view paper- Downloaded 1,199 times
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- Site-wide: 30,147
- In bioinformatics: 3,203
- Year to date:
- Site-wide: 100,154
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How well do force fields capture the strength of salt bridges in proteins?
biophysics more details view paper- Downloaded 1,165 times
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- Site-wide: 31,583
- In biophysics: 897
- Year to date:
- Site-wide: 165,775
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- Site-wide: 118,886
Architecture and subunit dynamics of the mitochondrial TIM9·10·12 chaperone
biophysics more details view paper- Downloaded 1,164 times
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- Site-wide: 31,595
- In biophysics: 904
- Year to date:
- Site-wide: 130,235
- Since beginning of last month:
- Site-wide: 160,733
Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance
biophysics more details view paper- Downloaded 1,162 times
- Download rankings, all-time:
- Site-wide: 31,713
- In biophysics: 910
- Year to date:
- Site-wide: 74,847
- Since beginning of last month:
- Site-wide: 130,737
Deep mutational scanning by FACS-sorting of encapsulated E. coli micro-colonies
bioengineering more details view paper- Downloaded 1,143 times
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- Site-wide: 32,561
- In bioengineering: 624
- Year to date:
- Site-wide: 57,336
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- Site-wide: 145,357
Integrating NMR and Simulations Reveals Motions in the UUCG Tetraloop
biophysics more details view paper- Downloaded 1,070 times
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- Site-wide: 35,975
- In biophysics: 1,062
- Year to date:
- Site-wide: 106,963
- Since beginning of last month:
- Site-wide: 144,742
Global analysis of protein stability by temperature and chemical denaturation
biophysics more details view paper- Downloaded 1,005 times
- Download rankings, all-time:
- Site-wide: 39,658
- In biophysics: 1,226
- Year to date:
- Site-wide: 53,200
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- Site-wide: 39,699
Conformational Ensembles of Non-Coding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations
biophysics more details view paper- Downloaded 974 times
- Download rankings, all-time:
- Site-wide: 41,682
- In biophysics: 1,280
- Year to date:
- Site-wide: 132,860
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- Site-wide: 102,894
Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts
bioinformatics more details view paper- Downloaded 954 times
- Download rankings, all-time:
- Site-wide: 42,950
- In bioinformatics: 4,397
- Year to date:
- Site-wide: 161,952
- Since beginning of last month:
- Site-wide: 205,462
Improving Martini 3 for disordered and multidomain proteins
biophysics more details view paper- Downloaded 951 times
- Download rankings, all-time:
- Site-wide: 43,165
- In biophysics: 1,329
- Year to date:
- Site-wide: 142,906
- Since beginning of last month:
- Site-wide: 35,631
Global analysis of multi-mutants to improveprotein function
biophysics more details view paper- Downloaded 934 times
- Download rankings, all-time:
- Site-wide: 44,452
- In biophysics: 1,379
- Year to date:
- Site-wide: 63,193
- Since beginning of last month:
- Site-wide: 23,039
Classifying disease-associated variants using measures of protein activity and stability
biophysics more details view paper- Downloaded 933 times
- Download rankings, all-time:
- Site-wide: 44,476
- In biophysics: 1,358
- Year to date:
- Site-wide: 179,358
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Discovering functionally important sites in proteins
biophysics more details view paper- Downloaded 892 times
- Download rankings, all-time:
- Site-wide: 47,717
- In biophysics: 1,568
- Year to date:
- Site-wide: 21,451
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- Site-wide: 10,539
A dual-reporter system for investigating and optimizing protein translation and folding in E. coli
biochemistry more details view paper- Downloaded 890 times
- Download rankings, all-time:
- Site-wide: 47,907
- In biochemistry: 1,196
- Year to date:
- Site-wide: 92,962
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- Site-wide: 130,873
Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity
biochemistry more details view paper- Downloaded 851 times
- Download rankings, all-time:
- Site-wide: 51,275
- In biochemistry: 1,288
- Year to date:
- Site-wide: None
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- Site-wide: 68,662
Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome
biochemistry more details view paper- Downloaded 850 times
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- Site-wide: 51,347
- In biochemistry: 1,315
- Year to date:
- Site-wide: 99,497
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- Site-wide: 91,243
Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs
biophysics more details view paper- Downloaded 832 times
- Download rankings, all-time:
- Site-wide: 53,016
- In biophysics: 1,706
- Year to date:
- Site-wide: 178,862
- Since beginning of last month:
- Site-wide: 177,734
Computational Studies of Substrate Transport and Specificity in a Phospholipid Flippase
biophysics more details view paper- Downloaded 805 times
- Download rankings, all-time:
- Site-wide: 55,687
- In biophysics: 1,880
- Year to date:
- Site-wide: 18,286
- Since beginning of last month:
- Site-wide: 64,854
HSP70-binding motifs function as protein quality control degrons
biochemistry more details view paper- Downloaded 786 times
- Download rankings, all-time:
- Site-wide: 57,723
- In biochemistry: 1,596
- Year to date:
- Site-wide: 9,557
- Since beginning of last month:
- Site-wide: 31,185
A comprehensive map of human glucokinase variant activity
genetics more details view paper- Downloaded 775 times
- Download rankings, all-time:
- Site-wide: 58,978
- In genetics: 2,391
- Year to date:
- Site-wide: 25,418
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- Site-wide: 18,053
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor
biophysics more details view paper- Downloaded 771 times
- Download rankings, all-time:
- Site-wide: 59,389
- In biophysics: 1,941
- Year to date:
- Site-wide: 177,462
- Since beginning of last month:
- Site-wide: 208,356
PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates
biophysics more details view paper- Downloaded 757 times
- Download rankings, all-time:
- Site-wide: 60,997
- In biophysics: 2,033
- Year to date:
- Site-wide: 58,856
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- Site-wide: 204,253
Fitting side-chain NMR relaxation data using molecular simulations
biophysics more details view paper- Downloaded 752 times
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- Site-wide: 61,649
- In biophysics: 2,064
- Year to date:
- Site-wide: 156,794
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- Site-wide: 34,775
Order and disorder - an integrative structure of the full-length human growth hormone receptor
biophysics more details view paper- Downloaded 750 times
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- Site-wide: 61,904
- In biophysics: 2,036
- Year to date:
- Site-wide: 181,093
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- Site-wide: 164,288
Refinement of α-synuclein ensembles against SAXS data: Comparison of force fields and methods
biophysics more details view paper- Downloaded 733 times
- Download rankings, all-time:
- Site-wide: 64,072
- In biophysics: 2,120
- Year to date:
- Site-wide: 188,018
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- Site-wide: 170,320
Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins
biophysics more details view paper- Downloaded 720 times
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- Site-wide: 65,717
- In biophysics: 2,503
- Year to date:
- Site-wide: 3,934
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- Site-wide: 12,052
Charge Interactions in a Highly Charge-depleted Protein
biochemistry more details view paper- Downloaded 719 times
- Download rankings, all-time:
- Site-wide: 65,829
- In biochemistry: 1,753
- Year to date:
- Site-wide: 113,518
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Structural basis of client specificity in mitochondrial membrane-protein chaperones
biophysics more details view paper- Downloaded 704 times
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- Site-wide: 67,869
- In biophysics: 2,269
- Year to date:
- Site-wide: 156,471
- Since beginning of last month:
- Site-wide: 129,232
Refining conformational ensembles of flexible proteins against small-angle X-ray scattering data
biophysics more details view paper- Downloaded 655 times
- Download rankings, all-time:
- Site-wide: 74,917
- In biophysics: 2,614
- Year to date:
- Site-wide: 47,991
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- Site-wide: 104,054
Interpreting the molecular mechanisms of disease variants in human membrane proteins
biophysics more details view paper- Downloaded 642 times
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- Site-wide: 76,994
- In biophysics: 3,047
- Year to date:
- Site-wide: 14,630
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- Site-wide: 6,817
Transient exposure of a buried phosphorylation site in an autoinhibited protein
biophysics more details view paper- Downloaded 637 times
- Download rankings, all-time:
- Site-wide: 77,729
- In biophysics: 2,742
- Year to date:
- Site-wide: 142,164
- Since beginning of last month:
- Site-wide: 47,679
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks
bioinformatics more details view paper- Downloaded 637 times
- Download rankings, all-time:
- Site-wide: 77,751
- In bioinformatics: 7,143
- Year to date:
- Site-wide: 189,103
- Since beginning of last month:
- Site-wide: 112,952
Protein dynamics enables phosphorylation of buried residues in Cdk2/Cyclin A-bound p27
biophysics more details view paper- Downloaded 623 times
- Download rankings, all-time:
- Site-wide: 79,933
- In biophysics: 2,800
- Year to date:
- Site-wide: 130,278
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- Site-wide: 193,952
Monte Carlo Sampling of Protein Folding by Combining an All-Atom Physics-Based Model with a Native State Bias
biophysics more details view paper- Downloaded 615 times
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- Site-wide: 81,165
- In biophysics: 2,863
- Year to date:
- Site-wide: 135,662
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- Site-wide: 143,995
Improved Predictions of Phase Behaviour of Intrinsically Disordered Proteins by Tuning the Interaction Range
biophysics more details view paper- Downloaded 583 times
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- Site-wide: 86,969
- In biophysics: 3,162
- Year to date:
- Site-wide: 125,819
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Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution
biophysics more details view paper- Downloaded 556 times
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- Site-wide: 92,203
- In biophysics: 3,311
- Year to date:
- Site-wide: 153,927
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- Site-wide: 162,479
Conserved degronome features governing quality control-associated proteolysis
cell biology more details view paper- Downloaded 543 times
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- Site-wide: 95,062
- In cell biology: 4,416
- Year to date:
- Site-wide: 55,768
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Mg2+-dependent conformational equilibria in CorA: an integrated view on transport regulation
biophysics more details view paper- Downloaded 503 times
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- Site-wide: 103,822
- In biophysics: 3,793
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Bayesian-Maximum-Entropy reweighting of IDP ensembles based on NMR chemical shifts
biophysics more details view paper- Downloaded 485 times
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- Site-wide: 107,922
- In biophysics: 3,975
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- Site-wide: 179,530
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Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein
biochemistry more details view paper- Downloaded 441 times
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- Site-wide: 118,886
- In biochemistry: 3,531
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Accurate protein stability predictions from homology models
biophysics more details view paper- Downloaded 430 times
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- Site-wide: 121,915
- In biophysics: 4,696
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- Site-wide: 69,720
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Conformational Ensemble of RNA Oligonucleotides from Reweighted Molecular Simulations
biophysics more details view paper- Downloaded 404 times
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- Site-wide: 128,999
- In biophysics: 4,819
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Prediction of quality-control degradation signals in yeast proteins
bioinformatics more details view paper- Downloaded 404 times
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- Site-wide: 128,927
- In bioinformatics: 10,623
- Year to date:
- Site-wide: 125,485
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DEER-PREdict: Software for Efficient Calculation of Spin-Labeling EPR and NMR Data from Conformational Ensembles
biophysics more details view paper- Downloaded 394 times
- Download rankings, all-time:
- Site-wide: 132,014
- In biophysics: 4,937
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- Site-wide: 157,594
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- Site-wide: 214,141
Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation
molecular biology more details view paper- Downloaded 393 times
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- Site-wide: 132,516
- In molecular biology: 3,870
- Year to date:
- Site-wide: 185,821
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Increasing protein stability by inferring substitution effects from high-throughput experiments
biochemistry more details view paper- Downloaded 357 times
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- Site-wide: 143,101
- In biochemistry: 4,343
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Computational and experimental assessment of backbone templates for computational protein design
biochemistry more details view paper- Downloaded 354 times
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- Site-wide: 143,742
- In biochemistry: 4,357
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- Site-wide: 84,973
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Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations
biophysics more details view paper- Downloaded 351 times
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- Site-wide: 144,924
- In biophysics: 5,718
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- Site-wide: 69,509
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NMR structures and functional roles of two related chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus
biochemistry more details view paper- Downloaded 349 times
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- Site-wide: 145,467
- In biochemistry: 4,426
- Year to date:
- Site-wide: 80,814
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- Site-wide: 107,573
Deciphering the alphabet of disorder -- Glu and Asp act differently on local but not global properties
biophysics more details view paper- Downloaded 313 times
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- Site-wide: 156,303
- In biophysics: 6,128
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- Site-wide: 96,096
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- Site-wide: 21,926
Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant
biochemistry more details view paper- Downloaded 304 times
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- Site-wide: 158,966
- In biochemistry: 4,909
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Synergistic stabilization of a double mutant in CI2 from an in-cell library screen
biophysics more details view paper- Downloaded 262 times
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- Site-wide: 171,730
- In biophysics: 6,637
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Double mutant of chymotrypsin inhibitor 2 stabilized through increased conformational entropy
biophysics more details view paper- Downloaded 238 times
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- Site-wide: 178,347
- In biophysics: 6,840
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Properdin oligomers adopt rigid extended conformations supporting function
immunology more details view paper- Downloaded 182 times
- Download rankings, all-time:
- Site-wide: 192,018
- In immunology: 6,141
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- Site-wide: 201,040
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The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
biophysics more details view paper- Downloaded 143 times
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- Site-wide: 199,924
- In biophysics: 7,740
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Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components
biochemistry more details view paper- Downloaded 135 times
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- Site-wide: 201,398
- In biochemistry: 6,273
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WASCO: A Wasserstein-based statistical tool to compare conformational ensembles of intrinsically disordered proteins
bioinformatics more details view paper- Downloaded 100 times
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- Site-wide: 207,829
- In bioinformatics: None
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Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: comparison of experiments and computation.
biophysics more details view paper- Downloaded 88 times
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- Site-wide: 209,892
- In biophysics: 8,027
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Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2
biophysics more details view paper- Downloaded 61 times
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- Site-wide: 214,842
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- Site-wide: 42,013
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Rare catechol-O-methyltransferase (COMT) missense variants are structurally unstable proteasome targets
biochemistry more details view paper- Downloaded 60 times
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