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Author: Kresten Lindorff-Larsen

Rankings

  • All-time downloads: 38,471 (rank: 5,278 )
  • Categories:
    • biochemistry: 3,456 (rank: 1,167 (tie) )
    • bioengineering: 1,021 (rank: 4,598 (tie) )
    • bioinformatics: 2,449 (rank: 7,135 (tie) )
    • biophysics: 31,095 (rank: 8 )
    • immunology: 139 (rank: 40,555 (tie) )
    • molecular biology: 311 (rank: 24,229 (tie) )

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Preprints

Double mutant of chymotrypsin inhibitor 2 stabilized through increased conformational entropy

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A structural biology community assessment of AlphaFold 2 applications

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    • Site-wide: 1,792
    • In biophysics: 18
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Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach

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    • Site-wide: 12,841
    • In biophysics: 290
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Computing, analyzing and comparing the radius of gyration and hydrodynamic radius in conformational ensembles of intrinsically disordered proteins

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    • Site-wide: 14,176
    • In biophysics: 333
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Accurate model of liquid-liquid phase behaviour of intrinsically-disordered proteins from data-driven optimization of single-chain properties

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    • In biophysics: 598
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Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

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  • Downloaded 1,130 times
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    • Site-wide: 23,602
    • In biophysics: 622
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How well do force fields capture the strength of salt bridges in proteins?

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  • Downloaded 1,085 times
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    • Site-wide: 25,157
    • In biophysics: 690
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Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

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    • Site-wide: 25,642
    • In biophysics: 704
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Barnaba: Software for Analysis of Nucleic Acids Structures and Trajectories

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    • In bioinformatics: 3,015
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Deep mutational scanning by FACS-sorting of encapsulated E. coli micro-colonies

bioengineering more details view paper
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    • Site-wide: 27,584
    • In bioengineering: 490
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Predicting and interpreting large scale mutagenesis data using analyses of protein stability and conservation

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    • Site-wide: 28,391
    • In biophysics: 806
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    • Site-wide: 5,301
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Integrating NMR and Simulations Reveals Motions in the UUCG Tetraloop

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  • Downloaded 988 times
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    • Site-wide: 28,956
    • In biophysics: 830
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Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance

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  • Downloaded 961 times
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    • Site-wide: 30,117
    • In biophysics: 881
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Architecture and subunit dynamics of the mitochondrial TIM9·10·12 chaperone

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  • Downloaded 937 times
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    • Site-wide: 31,251
    • In biophysics: 919
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    • Site-wide: 22,735
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Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts

bioinformatics more details view paper
  • Downloaded 909 times
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    • Site-wide: 32,716
    • In bioinformatics: 3,574
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    • Site-wide: 164,356
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Classifying disease-associated variants using measures of protein activity and stability

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  • Downloaded 847 times
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    • Site-wide: 36,216
    • In biophysics: 1,104
  • Year to date:
    • Site-wide: 69,164
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Global analysis of protein stability by temperature and chemical denaturation

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  • Downloaded 835 times
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    • Site-wide: 36,994
    • In biophysics: 1,130
  • Year to date:
    • Site-wide: 28,889
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    • Site-wide: 17,925

Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

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  • Downloaded 787 times
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    • Site-wide: 40,296
    • In biophysics: 1,264
  • Year to date:
    • Site-wide: 69,748
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A dual-reporter system for investigating and optimizing protein translation and folding in E. coli

biochemistry more details view paper
  • Downloaded 783 times
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    • Site-wide: 40,588
    • In biochemistry: 1,001
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    • Site-wide: 20,533
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Conformational Ensembles of Non-Coding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations

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  • Downloaded 771 times
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    • Site-wide: 41,511
    • In biophysics: 1,315
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    • Site-wide: 18,241
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Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

biochemistry more details view paper
  • Downloaded 751 times
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    • Site-wide: 43,128
    • In biochemistry: 1,081
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    • Site-wide: 83,598
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Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor

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  • Downloaded 701 times
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    • Site-wide: 47,459
    • In biophysics: 1,546
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    • Site-wide: 129,406
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    • Site-wide: 137,444

Order and disorder - an integrative structure of the full-length human growth hormone receptor

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  • Downloaded 687 times
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    • Site-wide: 48,821
    • In biophysics: 1,600
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    • Site-wide: 53,841
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PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates

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  • Downloaded 643 times
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    • Site-wide: 53,445
    • In biophysics: 1,759
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    • Site-wide: 70,515
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    • Site-wide: 23,329

Fitting side-chain NMR relaxation data using molecular simulations

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  • Downloaded 635 times
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    • Site-wide: 54,287
    • In biophysics: 1,798
  • Year to date:
    • Site-wide: 28,540
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    • Site-wide: 55,627

Structural basis of client specificity in mitochondrial membrane-protein chaperones

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  • Downloaded 627 times
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    • Site-wide: 55,297
    • In biophysics: 1,844
  • Year to date:
    • Site-wide: 104,360
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Refinement of α-synuclein ensembles against SAXS data: Comparison of force fields and methods

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  • Downloaded 608 times
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    • Site-wide: 57,596
    • In biophysics: 1,925
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    • Site-wide: 11,621
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    • Site-wide: 28,903

Charge Interactions in a Highly Charge-depleted Protein

biochemistry more details view paper
  • Downloaded 608 times
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    • Site-wide: 57,511
    • In biochemistry: 1,510
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    • Site-wide: 57,841
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Computational Studies of Substrate Transport and Specificity in a Phospholipid Flippase

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  • Downloaded 580 times
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    • Site-wide: 60,987
    • In biophysics: 2,086
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Monte Carlo Sampling of Protein Folding by Combining an All-Atom Physics-Based Model with a Native State Bias

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  • Downloaded 549 times
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    • Site-wide: 65,184
    • In biophysics: 2,254
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    • Site-wide: 37,780

Protein dynamics enables phosphorylation of buried residues in Cdk2/Cyclin A-bound p27

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  • Downloaded 545 times
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    • Site-wide: 65,800
    • In biophysics: 2,295
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    • Site-wide: 57,866
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Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

bioinformatics more details view paper
  • Downloaded 510 times
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    • Site-wide: 71,212
    • In bioinformatics: 6,690
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    • Site-wide: 15,212
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Refining conformational ensembles of flexible proteins against small-angle X-ray scattering data

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  • Downloaded 505 times
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    • Site-wide: 71,912
    • In biophysics: 2,569
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Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

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  • Downloaded 505 times
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    • Site-wide: 71,965
    • In biophysics: 2,562
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    • Site-wide: 142,950
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Global analysis of multi-mutants to discover stabilizing amino acid substitutions

biophysics more details view paper
  • Downloaded 485 times
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    • Site-wide: 75,433
    • In biophysics: 2,704
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    • Site-wide: 32,252
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Transient exposure of a buried phosphorylation site in an autoinhibited protein

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  • Downloaded 464 times
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    • Site-wide: 79,147
    • In biophysics: 2,868
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Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

biochemistry more details view paper
  • Downloaded 430 times
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    • Site-wide: 85,624
    • In biochemistry: 2,426
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Mg2+-dependent conformational equilibria in CorA: an integrated view on transport regulation

biophysics more details view paper
  • Downloaded 407 times
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    • Site-wide: 90,504
    • In biophysics: 3,347
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    • Site-wide: 21,627
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Bayesian-Maximum-Entropy reweighting of IDP ensembles based on NMR chemical shifts

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  • Downloaded 399 times
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    • Site-wide: 92,108
    • In biophysics: 3,435
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Improving the global dimensions of intrinsically disordered proteins in Martini 3

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    • In biophysics: 3,631
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Conformational Ensemble of RNA Oligonucleotides from Reweighted Molecular Simulations

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  • Downloaded 355 times
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    • In biophysics: 3,873
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DEER-PREdict: Software for Efficient Calculation of Spin-Labeling EPR and NMR Data from Conformational Ensembles

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  • Downloaded 318 times
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    • Site-wide: 111,460
    • In biophysics: 4,268
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Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation

molecular biology more details view paper
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    • Site-wide: 113,136
    • In molecular biology: 3,371
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Computational and experimental assessment of backbone templates for computational protein design

biochemistry more details view paper
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    • In biochemistry: 3,737
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Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant

biochemistry more details view paper
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    • In biochemistry: 3,981
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NMR structures and functional roles of two related chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus

biochemistry more details view paper
  • Downloaded 230 times
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    • Site-wide: 134,505
    • In biochemistry: 4,064
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Synergistic stabilization of a double mutant in CI2 from an in-cell library screen

biophysics more details view paper
  • Downloaded 199 times
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    • Site-wide: 142,024
    • In biophysics: 5,445
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    • Site-wide: 89,728
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Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein

biochemistry more details view paper
  • Downloaded 147 times
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    • Site-wide: 153,126
    • In biochemistry: 4,671
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Properdin oligomers adopt rigid extended conformations supporting function

immunology more details view paper
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    • In immunology: 4,716
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