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Author: Kresten Lindorff-Larsen

Rankings

  • All-time downloads: 60,775 (rank: 4,116 )
  • Categories:
    • biochemistry: 5,935 (rank: 819 )
    • bioengineering: 1,132 (rank: 6,110 (tie) )
    • bioinformatics: 3,167 (rank: 6,788 )
    • biophysics: 47,373 (rank: 4 )
    • cell biology: 531 (rank: 32,902 (tie) )
    • genetics: 745 (rank: 26,934 (tie) )
    • immunology: 182 (rank: 51,887 (tie) )
    • molecular biology: 391 (rank: 28,545 (tie) )

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Preprints

FRETpredict: A Python package for FRET efficiency predictions using rotamer libraries

biophysics more details view paper

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A structural biology community assessment of AlphaFold 2 applications

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Computing, analyzing and comparing the radius of gyration and hydrodynamic radius in conformational ensembles of intrinsically disordered proteins

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    • Site-wide: 11,424
    • In biophysics: 241
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Rapid protein stability prediction using deep learning representations

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Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach

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Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

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Accurate model of liquid-liquid phase behaviour of intrinsically-disordered proteins from data-driven optimization of single-chain properties

biophysics more details view paper
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Predicting and interpreting large scale mutagenesis data using analyses of protein stability and conservation

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    • Site-wide: 25,234
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Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

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Barnaba: Software for Analysis of Nucleic Acids Structures and Trajectories

bioinformatics more details view paper
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How well do force fields capture the strength of salt bridges in proteins?

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    • Site-wide: 31,583
    • In biophysics: 897
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Architecture and subunit dynamics of the mitochondrial TIM9·10·12 chaperone

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    • In biophysics: 904
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Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance

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  • Downloaded 1,162 times
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    • Site-wide: 31,713
    • In biophysics: 910
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Deep mutational scanning by FACS-sorting of encapsulated E. coli micro-colonies

bioengineering more details view paper
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    • In bioengineering: 624
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Integrating NMR and Simulations Reveals Motions in the UUCG Tetraloop

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    • In biophysics: 1,062
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Global analysis of protein stability by temperature and chemical denaturation

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    • Site-wide: 39,658
    • In biophysics: 1,226
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Conformational Ensembles of Non-Coding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations

biophysics more details view paper
  • Downloaded 974 times
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    • Site-wide: 41,682
    • In biophysics: 1,280
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    • Site-wide: 132,860
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Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts

bioinformatics more details view paper
  • Downloaded 954 times
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    • Site-wide: 42,950
    • In bioinformatics: 4,397
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Improving Martini 3 for disordered and multidomain proteins

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  • Downloaded 951 times
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    • In biophysics: 1,329
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Global analysis of multi-mutants to improveprotein function

biophysics more details view paper
  • Downloaded 934 times
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    • Site-wide: 44,452
    • In biophysics: 1,379
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Classifying disease-associated variants using measures of protein activity and stability

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  • Downloaded 933 times
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    • Site-wide: 44,476
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Discovering functionally important sites in proteins

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  • Downloaded 892 times
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    • Site-wide: 47,717
    • In biophysics: 1,568
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A dual-reporter system for investigating and optimizing protein translation and folding in E. coli

biochemistry more details view paper
  • Downloaded 890 times
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    • Site-wide: 47,907
    • In biochemistry: 1,196
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Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

biochemistry more details view paper
  • Downloaded 851 times
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    • In biochemistry: 1,288
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Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

biochemistry more details view paper
  • Downloaded 850 times
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    • Site-wide: 51,347
    • In biochemistry: 1,315
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Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

biophysics more details view paper
  • Downloaded 832 times
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    • Site-wide: 53,016
    • In biophysics: 1,706
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Computational Studies of Substrate Transport and Specificity in a Phospholipid Flippase

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  • Downloaded 805 times
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    • Site-wide: 55,687
    • In biophysics: 1,880
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    • Site-wide: 18,286
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    • Site-wide: 64,854

HSP70-binding motifs function as protein quality control degrons

biochemistry more details view paper
  • Downloaded 786 times
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    • Site-wide: 57,723
    • In biochemistry: 1,596
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    • Site-wide: 9,557
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A comprehensive map of human glucokinase variant activity

genetics more details view paper
  • Downloaded 775 times
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    • Site-wide: 58,978
    • In genetics: 2,391
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Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor

biophysics more details view paper
  • Downloaded 771 times
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    • Site-wide: 59,389
    • In biophysics: 1,941
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PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates

biophysics more details view paper
  • Downloaded 757 times
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    • Site-wide: 60,997
    • In biophysics: 2,033
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Fitting side-chain NMR relaxation data using molecular simulations

biophysics more details view paper
  • Downloaded 752 times
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    • Site-wide: 61,649
    • In biophysics: 2,064
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Order and disorder - an integrative structure of the full-length human growth hormone receptor

biophysics more details view paper
  • Downloaded 750 times
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    • In biophysics: 2,036
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Refinement of α-synuclein ensembles against SAXS data: Comparison of force fields and methods

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  • Downloaded 733 times
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    • Site-wide: 64,072
    • In biophysics: 2,120
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    • Site-wide: 188,018
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Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

biophysics more details view paper
  • Downloaded 720 times
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    • Site-wide: 65,717
    • In biophysics: 2,503
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    • Site-wide: 3,934
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Charge Interactions in a Highly Charge-depleted Protein

biochemistry more details view paper
  • Downloaded 719 times
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    • Site-wide: 65,829
    • In biochemistry: 1,753
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Structural basis of client specificity in mitochondrial membrane-protein chaperones

biophysics more details view paper
  • Downloaded 704 times
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    • Site-wide: 67,869
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Refining conformational ensembles of flexible proteins against small-angle X-ray scattering data

biophysics more details view paper
  • Downloaded 655 times
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    • Site-wide: 74,917
    • In biophysics: 2,614
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    • Site-wide: 47,991
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Interpreting the molecular mechanisms of disease variants in human membrane proteins

biophysics more details view paper
  • Downloaded 642 times
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    • Site-wide: 76,994
    • In biophysics: 3,047
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    • Site-wide: 14,630
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Transient exposure of a buried phosphorylation site in an autoinhibited protein

biophysics more details view paper
  • Downloaded 637 times
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Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

bioinformatics more details view paper
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    • Site-wide: 77,751
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Protein dynamics enables phosphorylation of buried residues in Cdk2/Cyclin A-bound p27

biophysics more details view paper
  • Downloaded 623 times
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    • Site-wide: 79,933
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Monte Carlo Sampling of Protein Folding by Combining an All-Atom Physics-Based Model with a Native State Bias

biophysics more details view paper
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    • Site-wide: 81,165
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Improved Predictions of Phase Behaviour of Intrinsically Disordered Proteins by Tuning the Interaction Range

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  • Downloaded 583 times
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    • Site-wide: 86,969
    • In biophysics: 3,162
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Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

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    • Site-wide: 92,203
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Conserved degronome features governing quality control-associated proteolysis

cell biology more details view paper
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    • Site-wide: 95,062
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Mg2+-dependent conformational equilibria in CorA: an integrated view on transport regulation

biophysics more details view paper
  • Downloaded 503 times
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    • Site-wide: 103,822
    • In biophysics: 3,793
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Bayesian-Maximum-Entropy reweighting of IDP ensembles based on NMR chemical shifts

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  • Downloaded 485 times
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    • Site-wide: 107,922
    • In biophysics: 3,975
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Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein

biochemistry more details view paper
  • Downloaded 441 times
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    • Site-wide: 118,886
    • In biochemistry: 3,531
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Accurate protein stability predictions from homology models

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Conformational Ensemble of RNA Oligonucleotides from Reweighted Molecular Simulations

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  • Downloaded 404 times
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    • Site-wide: 128,999
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Prediction of quality-control degradation signals in yeast proteins

bioinformatics more details view paper
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DEER-PREdict: Software for Efficient Calculation of Spin-Labeling EPR and NMR Data from Conformational Ensembles

biophysics more details view paper
  • Downloaded 394 times
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Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation

molecular biology more details view paper
  • Downloaded 393 times
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    • Site-wide: 132,516
    • In molecular biology: 3,870
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Increasing protein stability by inferring substitution effects from high-throughput experiments

biochemistry more details view paper
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Computational and experimental assessment of backbone templates for computational protein design

biochemistry more details view paper
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Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

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NMR structures and functional roles of two related chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus

biochemistry more details view paper
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    • Site-wide: 145,467
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Deciphering the alphabet of disorder -- Glu and Asp act differently on local but not global properties

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Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant

biochemistry more details view paper
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    • Site-wide: 158,966
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Synergistic stabilization of a double mutant in CI2 from an in-cell library screen

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Double mutant of chymotrypsin inhibitor 2 stabilized through increased conformational entropy

biophysics more details view paper
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Properdin oligomers adopt rigid extended conformations supporting function

immunology more details view paper
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The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

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Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components

biochemistry more details view paper
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WASCO: A Wasserstein-based statistical tool to compare conformational ensembles of intrinsically disordered proteins

bioinformatics more details view paper
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Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: comparison of experiments and computation.

biophysics more details view paper
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Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2

biophysics more details view paper
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Rare catechol-O-methyltransferase (COMT) missense variants are structurally unstable proteasome targets

biochemistry more details view paper
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