Author: Gad Getz

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

• Downloaded 22,118 times
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  • Site-wide: 360
  • In genomics: 13
• Year to date:
  • Site-wide: 31,297
• Since beginning of last month:
  • Site-wide: 104,631

The Repertoire of Mutational Signatures in Human Cancer

• Downloaded 19,925 times
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  • Site-wide: 407
  • In cancer biology: 2
• Year to date:
  • Site-wide: 1,872
• Since beginning of last month:
  • Site-wide: 1,204

The evolutionary history of 2,658 cancers

• Downloaded 9,608 times
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  • Site-wide: 1,017
  • In cancer biology: 8
• Year to date:
  • Site-wide: 30,221
• Since beginning of last month:
  • Site-wide: 13,418

The GTEx Consortium atlas of genetic regulatory effects across human tissues

• Downloaded 8,565 times
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  • Site-wide: 1,188
  • In genetics: 29
• Year to date:
  • Site-wide: 5,573
• Since beginning of last month:
  • Site-wide: 61,411

Calling Somatic SNVs and Indels with Mutect2

• Downloaded 6,816 times
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  • Site-wide: 1,565
  • In bioinformatics: 95
• Year to date:
  • Site-wide: 915
• Since beginning of last month:
  • Site-wide: 566

The whole-genome panorama of cancer drivers

• Downloaded 6,810 times
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  • Site-wide: 1,570
  • In cancer biology: 15
• Year to date:
  • Site-wide: 14,968
• Since beginning of last month:
  • Site-wide: 116,903

Rapid and efficient analysis of 20,000 RNA-seq samples with Toil

• Downloaded 6,631 times
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  • Site-wide: 1,634
  • In bioinformatics: 101
• Year to date:
  • Site-wide: 24,526
• Since beginning of last month:
  • Site-wide: 100,654

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

• Downloaded 6,244 times
• Download rankings, all-time:
  • Site-wide: 1,778
  • In cancer biology: 19
• Year to date:
  • Site-wide: 4,290
• Since beginning of last month:
  • Site-wide: 6,186

Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes

• Downloaded 5,640 times
• Download rankings, all-time:
  • Site-wide: 2,043
  • In genomics: 179
• Year to date:
  • Site-wide: 19,144
• Since beginning of last month:
  • Site-wide: 12,717

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

• Downloaded 4,593 times
• Download rankings, all-time:
  • Site-wide: 2,709
  • In cancer biology: 34
• Year to date:
  • Site-wide: 1,963
• Since beginning of last month:
  • Site-wide: 1,190

Tumor mutational landscape is a record of the pre-malignant state

• Downloaded 3,702 times
• Download rankings, all-time:
  • Site-wide: 3,666
  • In genomics: 377
• Year to date:
  • Site-wide: 18,989
• Since beginning of last month:
  • Site-wide: 80,042

A comprehensive analysis of RNA sequences reveals macroscopic somatic clonal expansion across normal tissues

• Downloaded 3,397 times
• Download rankings, all-time:
  • Site-wide: 4,132
  • In genomics: 421
• Year to date:
  • Site-wide: 46,822
• Since beginning of last month:
  • Site-wide: 62,959

Scaling computational genomics to millions of individuals with GPUs

• Downloaded 3,344 times
• Download rankings, all-time:
  • Site-wide: 4,222
  • In genomics: 430
• Year to date:
  • Site-wide: 79,058
• Since beginning of last month:
  • Site-wide: 111,908

A deep learning system can accurately classify primary and metastatic cancers based on patterns of passenger mutations

• Downloaded 3,265 times
• Download rankings, all-time:
  • Site-wide: 4,366
  • In cancer biology: 60
• Year to date:
  • Site-wide: 57,432
• Since beginning of last month:
  • Site-wide: 31,784

Comprehensive analysis of tumour initiation, spatial and temporal progression under multiple lines of treatment

• Downloaded 3,206 times
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  • Site-wide: 4,509
  • In bioinformatics: 428
• Year to date:
  • Site-wide: 5,702
• Since beginning of last month:
  • Site-wide: 51,044

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

• Downloaded 2,926 times
• Download rankings, all-time:
  • Site-wide: 5,097
  • In cancer biology: 74
• Year to date:
  • Site-wide: 36,649
• Since beginning of last month:
  • Site-wide: 51,127

Cell type specific genetic regulation of gene expression across human tissues

• Downloaded 2,686 times
• Download rankings, all-time:
  • Site-wide: 5,745
  • In genomics: 596
• Year to date:
  • Site-wide: 18,976
• Since beginning of last month:
  • Site-wide: 40,466

Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

• Downloaded 2,405 times
• Download rankings, all-time:
  • Site-wide: 6,798
  • In genomics: 720
• Year to date:
  • Site-wide: 47,812
• Since beginning of last month:
  • Site-wide: 78,921

A comparative analysis of network mutation burdens across 21 tumor types augments discovery from cancer genomes

• Downloaded 2,160 times
• Download rankings, all-time:
  • Site-wide: 7,962
  • In cancer biology: 127
• Year to date:
  • Site-wide: 111,913
• Since beginning of last month:
  • Site-wide: 29,632

Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

• Downloaded 2,140 times
• Download rankings, all-time:
  • Site-wide: 8,073
  • In genomics: 836
• Year to date:
  • Site-wide: 64,517
• Since beginning of last month:
  • Site-wide: None

Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes

• Downloaded 2,075 times
• Download rankings, all-time:
  • Site-wide: 8,404
  • In genetics: 368
• Year to date:
  • Site-wide: 62,894
• Since beginning of last month:
  • Site-wide: 62,720

Passenger Hotspot Mutations in Cancer

• Downloaded 1,964 times
• Download rankings, all-time:
  • Site-wide: 9,160
  • In genomics: 931
• Year to date:
  • Site-wide: 62,799
• Since beginning of last month:
  • Site-wide: 22,497

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

• Downloaded 1,843 times
• Download rankings, all-time:
  • Site-wide: 10,027
  • In cell biology: 239
• Year to date:
  • Site-wide: 1,479
• Since beginning of last month:
  • Site-wide: 9,076

Pathway and network analysis of more than 2,500 whole cancer genomes

• Downloaded 1,614 times
• Download rankings, all-time:
  • Site-wide: 12,213
  • In cancer biology: 249
• Year to date:
  • Site-wide: 95,206
• Since beginning of last month:
  • Site-wide: 26,482

Framework For Quality Assessment Of Whole Genome, Cancer Sequences

• Downloaded 1,103 times
• Download rankings, all-time:
  • Site-wide: 21,528
  • In genomics: 2,051
• Year to date:
  • Site-wide: 132,008
• Since beginning of last month:
  • Site-wide: None

The Tangent copy-number inference pipeline for cancer genome analyses

• Downloaded 1,085 times
• Download rankings, all-time:
  • Site-wide: 22,062
  • In bioinformatics: 2,510
• Year to date:
  • Site-wide: 24,329
• Since beginning of last month:
  • Site-wide: 5,205

Expanding discovery from cancer genomes by integrating protein network analyses with in vivo tumorigenesis assays

• Downloaded 946 times
• Download rankings, all-time:
  • Site-wide: 26,939
  • In cancer biology: 667
• Year to date:
  • Site-wide: 149,681
• Since beginning of last month:
  • Site-wide: 116,890

Detecting cancer vulnerabilities through gene networks under purifying selection in 4,700 cancer genomes

• Downloaded 758 times
• Download rankings, all-time:
  • Site-wide: 36,821
  • In bioinformatics: 3,975
• Year to date:
  • Site-wide: 122,422
• Since beginning of last month:
  • Site-wide: None

Case-control analysis identifies shared properties of rare germline variation in cancer predisposing genes

• Downloaded 712 times
• Download rankings, all-time:
  • Site-wide: 40,097
  • In genetics: 1,806
• Year to date:
  • Site-wide: 137,962
• Since beginning of last month:
  • Site-wide: 49,382

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 63,850
  • In cancer biology: 1,837
• Year to date:
  • Site-wide: 62,454
• Since beginning of last month:
  • Site-wide: 42,596