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Author: Markku Laakso

  • Most recently observed institution: Institute of Clinical Medicine, University of Eastern Finland, and Kuopio University Hospital

Rankings

  • All-time downloads: 58,614 (rank: 2,246 )
  • Categories:
    • bioinformatics: 1,641 (rank: 8,371 (tie) )
    • epidemiology: 332 (rank: 17,640 (tie) )
    • genetic and genomic medicine: 2,884 (rank: 268 )
    • genetics: 27,034 (rank: 227 )
    • genomics: 26,584 (rank: 335 )
    • microbiology: 139 (rank: 50,694 (tie) )

Downloads per author, site-wide

Preprints

Analysis of protein-coding genetic variation in 60,706 humans

genomics more details view paper
  • Downloaded 21,936 times
  • Download rankings, all-time:
    • Site-wide: 290
    • In genomics: 11
  • Year to date:
    • Site-wide: 44,836
  • Since beginning of last month:
    • Site-wide: 44,836

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,223 times
  • Download rankings, all-time:
    • Site-wide: 3,484
    • In genomics: 397
  • Year to date:
    • Site-wide: 60,991
  • Since beginning of last month:
    • Site-wide: 60,991

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,069 times
  • Download rankings, all-time:
    • Site-wide: 3,724
    • In genetics: 166
  • Year to date:
    • Site-wide: 34,847
  • Since beginning of last month:
    • Site-wide: 34,847

Integrative approaches for large-scale transcriptome-wide association studies

genetics more details view paper
  • Downloaded 2,879 times
  • Download rankings, all-time:
    • Site-wide: 4,045
    • In genetics: 185
  • Year to date:
    • Site-wide: 28,540
  • Since beginning of last month:
    • Site-wide: 28,540

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

genetics more details view paper
  • Downloaded 2,418 times
  • Download rankings, all-time:
    • Site-wide: 5,266
    • In genetics: 248
  • Year to date:
    • Site-wide: 13,638
  • Since beginning of last month:
    • Site-wide: 13,638

Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes

genetics more details view paper
  • Downloaded 1,989 times
  • Download rankings, all-time:
    • Site-wide: 6,943
    • In genetics: 341
  • Year to date:
    • Site-wide: 47,466
  • Since beginning of last month:
    • Site-wide: 47,466

Large-scale association analyses identify host factors influencing human gut microbiome composition

genetics more details view paper
  • Downloaded 1,971 times
  • Download rankings, all-time:
    • Site-wide: 7,052
    • In genetics: 343
  • Year to date:
    • Site-wide: 2,314
  • Since beginning of last month:
    • Site-wide: 2,314

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,826 times
  • Download rankings, all-time:
    • Site-wide: 7,912
    • In genetics: 385
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: None

Association Analysis and Meta-Analysis of Multi-allelic Variants for Large Scale Sequence Data

bioinformatics more details view paper
  • Downloaded 1,641 times
  • Download rankings, all-time:
    • Site-wide: 9,344
    • In bioinformatics: 1,148
  • Year to date:
    • Site-wide: 23,914
  • Since beginning of last month:
    • Site-wide: 23,914

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,637 times
  • Download rankings, all-time:
    • Site-wide: 9,393
    • In genetics: 462
  • Year to date:
    • Site-wide: 70,723
  • Since beginning of last month:
    • Site-wide: 70,723

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

genetics more details view paper
  • Downloaded 1,637 times
  • Download rankings, all-time:
    • Site-wide: 9,396
    • In genetics: 463
  • Year to date:
    • Site-wide: 67,544
  • Since beginning of last month:
    • Site-wide: 67,544

Reverse GWAS: Using Genetics to Identify and Model Phenotypic Subtypes

genetics more details view paper
  • Downloaded 1,614 times
  • Download rankings, all-time:
    • Site-wide: 9,589
    • In genetics: 479
  • Year to date:
    • Site-wide: 120,637
  • Since beginning of last month:
    • Site-wide: 120,637

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

genomics more details view paper
  • Downloaded 1,425 times
  • Download rankings, all-time:
    • Site-wide: 11,489
    • In genomics: 1,282
  • Year to date:
    • Site-wide: 38,399
  • Since beginning of last month:
    • Site-wide: 38,399

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

genetics more details view paper
  • Downloaded 1,187 times
  • Download rankings, all-time:
    • Site-wide: 15,124
    • In genetics: 778
  • Year to date:
    • Site-wide: 30,883
  • Since beginning of last month:
    • Site-wide: 30,883

Efficient estimation and applications of cross-validated genetic predictions

genetics more details view paper
  • Downloaded 1,010 times
  • Download rankings, all-time:
    • Site-wide: 19,313
    • In genetics: 963
  • Year to date:
    • Site-wide: 50,492
  • Since beginning of last month:
    • Site-wide: 50,492

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 980 times
  • Download rankings, all-time:
    • Site-wide: 20,101
    • In genetic and genomic medicine: 60
  • Year to date:
    • Site-wide: 6,026
  • Since beginning of last month:
    • Site-wide: 6,026

Epigenome-wide association in adipose tissue from the METSIM cohort

genetics more details view paper
  • Downloaded 824 times
  • Download rankings, all-time:
    • Site-wide: 25,786
    • In genetics: 1,287
  • Year to date:
    • Site-wide: 50,984
  • Since beginning of last month:
    • Site-wide: 50,984

Heterozygous RFX6 protein truncating variants cause Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance

genetics more details view paper
  • Downloaded 810 times
  • Download rankings, all-time:
    • Site-wide: 26,365
    • In genetics: 1,318
  • Year to date:
    • Site-wide: 70,758
  • Since beginning of last month:
    • Site-wide: 70,758

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 794 times
  • Download rankings, all-time:
    • Site-wide: 27,112
    • In genetics: 1,351
  • Year to date:
    • Site-wide: 25,949
  • Since beginning of last month:
    • Site-wide: 25,949

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

genetic and genomic medicine more details view paper
  • Downloaded 765 times
  • Download rankings, all-time:
    • Site-wide: 28,550
    • In genetic and genomic medicine: 82
  • Year to date:
    • Site-wide: 23,058
  • Since beginning of last month:
    • Site-wide: 23,058

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

genetics more details view paper
  • Downloaded 711 times
  • Download rankings, all-time:
    • Site-wide: 31,667
    • In genetics: 1,574
  • Year to date:
    • Site-wide: 13,379
  • Since beginning of last month:
    • Site-wide: 13,379

ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

genetic and genomic medicine more details view paper
  • Downloaded 606 times
  • Download rankings, all-time:
    • Site-wide: 39,017
    • In genetic and genomic medicine: 111
  • Year to date:
    • Site-wide: 11,904
  • Since beginning of last month:
    • Site-wide: 11,904

Interactions between genetic variation and cellular environment in skeletal muscle gene expression

genetics more details view paper
  • Downloaded 585 times
  • Download rankings, all-time:
    • Site-wide: 40,803
    • In genetics: 1,967
  • Year to date:
    • Site-wide: 79,455
  • Since beginning of last month:
    • Site-wide: 79,455

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

genetics more details view paper
  • Downloaded 570 times
  • Download rankings, all-time:
    • Site-wide: 42,155
    • In genetics: 2,031
  • Year to date:
    • Site-wide: 104,883
  • Since beginning of last month:
    • Site-wide: 104,883

A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context

genetics more details view paper
  • Downloaded 511 times
  • Download rankings, all-time:
    • Site-wide: 48,153
    • In genetics: 2,305
  • Year to date:
    • Site-wide: 78,226
  • Since beginning of last month:
    • Site-wide: 78,226

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 504 times
  • Download rankings, all-time:
    • Site-wide: 48,957
    • In genetics: 2,342
  • Year to date:
    • Site-wide: 3,350
  • Since beginning of last month:
    • Site-wide: 3,350

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

genetic and genomic medicine more details view paper
  • Downloaded 398 times
  • Download rankings, all-time:
    • Site-wide: 63,044
    • In genetic and genomic medicine: 187
  • Year to date:
    • Site-wide: 81,510
  • Since beginning of last month:
    • Site-wide: 81,510

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

epidemiology more details view paper
  • Downloaded 332 times
  • Download rankings, all-time:
    • Site-wide: 73,947
    • In epidemiology: 3,060
  • Year to date:
    • Site-wide: 77,335
  • Since beginning of last month:
    • Site-wide: 77,335

Proper Conditional Analysis in the Presence of Missing Data Identified Novel Independently Associated Low Frequency Variants in Nicotine Dependence Genes

genetics more details view paper
  • Downloaded 263 times
  • Download rankings, all-time:
    • Site-wide: 87,744
    • In genetics: 4,025
  • Year to date:
    • Site-wide: 106,980
  • Since beginning of last month:
    • Site-wide: 106,980

Association of Structural Variation with Cardiometabolic Traits in Finns

genetics more details view paper
  • Downloaded 225 times
  • Download rankings, all-time:
    • Site-wide: 96,043
    • In genetics: 4,372
  • Year to date:
    • Site-wide: 14,970
  • Since beginning of last month:
    • Site-wide: 14,970

Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation

microbiology more details view paper
  • Downloaded 139 times
  • Download rankings, all-time:
    • Site-wide: 113,662
    • In microbiology: 8,603
  • Year to date:
    • Site-wide: 56,438
  • Since beginning of last month:
    • Site-wide: 56,438

Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

genetic and genomic medicine more details view paper
  • Downloaded 135 times
  • Download rankings, all-time:
    • Site-wide: 114,474
    • In genetic and genomic medicine: 501
  • Year to date:
    • Site-wide: 32,678
  • Since beginning of last month:
    • Site-wide: 32,678

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