Author: Markku Laakso

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Integrative approaches for large-scale transcriptome-wide association studies

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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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Reverse GWAS: Using Genetics to Identify and Model Phenotypic Subtypes

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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Association Analysis and Meta-Analysis of Multi-allelic Variants for Large Scale Sequence Data

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Genetics of human gut microbiome composition

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Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Efficient estimation and applications of cross-validated genetic predictions

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Epigenome-wide association in adipose tissue from the METSIM cohort

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Heterozygous RFX6 protein truncating variants cause Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

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Interactions between genetic variation and cellular environment in skeletal muscle gene expression

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Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context

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ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

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Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

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Proper Conditional Analysis in the Presence of Missing Data Identified Novel Independently Associated Low Frequency Variants in Nicotine Dependence Genes

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Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation

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Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

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