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Author: Markku Laakso

  • Most recently observed institution: Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Rankings

  • All-time downloads: 61,225 (rank: 2,290 )
  • Categories:
    • bioinformatics: 1,684 (rank: 8,812 (tie) )
    • cell biology: 86 (rank: 38,844 (tie) )
    • epidemiology: 341 (rank: 19,102 (tie) )
    • genetic and genomic medicine: 3,958 (rank: 244 )
    • genetics: 28,259 (rank: 219 )
    • genomics: 26,746 (rank: 342 )
    • microbiology: 151 (rank: 53,599 (tie) )

Downloads per author, site-wide

Preprints

Analysis of protein-coding genetic variation in 60,706 humans

genomics more details view paper
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    • Site-wide: 310
    • In genomics: 11
  • Year to date:
    • Site-wide: 22,198
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    • Site-wide: 15,048

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,252 times
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    • Site-wide: 3,801
    • In genomics: 421
  • Year to date:
    • Site-wide: 64,475
  • Since beginning of last month:
    • Site-wide: 76,308

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,089 times
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    • Site-wide: 4,084
    • In genetics: 169
  • Year to date:
    • Site-wide: 58,385
  • Since beginning of last month:
    • Site-wide: 70,652

Integrative approaches for large-scale transcriptome-wide association studies

genetics more details view paper
  • Downloaded 2,908 times
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    • Site-wide: 4,428
    • In genetics: 192
  • Year to date:
    • Site-wide: 45,957
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    • Site-wide: 59,342

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

genetics more details view paper
  • Downloaded 2,506 times
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    • Site-wide: 5,527
    • In genetics: 251
  • Year to date:
    • Site-wide: 17,564
  • Since beginning of last month:
    • Site-wide: 20,803

Large-scale association analyses identify host factors influencing human gut microbiome composition

genetics more details view paper
  • Downloaded 2,241 times
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    • Site-wide: 6,508
    • In genetics: 310
  • Year to date:
    • Site-wide: 3,198
  • Since beginning of last month:
    • Site-wide: 4,977

Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes

genetics more details view paper
  • Downloaded 2,036 times
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    • Site-wide: 7,474
    • In genetics: 346
  • Year to date:
    • Site-wide: 45,218
  • Since beginning of last month:
    • Site-wide: 32,112

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,863 times
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    • Site-wide: 8,548
    • In genetics: 398
  • Year to date:
    • Site-wide: 77,493
  • Since beginning of last month:
    • Site-wide: 48,411

Association Analysis and Meta-Analysis of Multi-allelic Variants for Large Scale Sequence Data

bioinformatics more details view paper
  • Downloaded 1,684 times
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    • Site-wide: 9,941
    • In bioinformatics: 1,190
  • Year to date:
    • Site-wide: 35,764
  • Since beginning of last month:
    • Site-wide: 37,233

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,669 times
  • Download rankings, all-time:
    • Site-wide: 10,058
    • In genetics: 474
  • Year to date:
    • Site-wide: 64,515
  • Since beginning of last month:
    • Site-wide: 55,141

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

genetics more details view paper
  • Downloaded 1,662 times
  • Download rankings, all-time:
    • Site-wide: 10,120
    • In genetics: 477
  • Year to date:
    • Site-wide: 71,693
  • Since beginning of last month:
    • Site-wide: 53,150

Reverse GWAS: Using Genetics to Identify and Model Phenotypic Subtypes

genetics more details view paper
  • Downloaded 1,633 times
  • Download rankings, all-time:
    • Site-wide: 10,390
    • In genetics: 493
  • Year to date:
    • Site-wide: 107,849
  • Since beginning of last month:
    • Site-wide: 66,329

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

genomics more details view paper
  • Downloaded 1,444 times
  • Download rankings, all-time:
    • Site-wide: 12,443
    • In genomics: 1,337
  • Year to date:
    • Site-wide: 62,569
  • Since beginning of last month:
    • Site-wide: 70,017

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

genetics more details view paper
  • Downloaded 1,200 times
  • Download rankings, all-time:
    • Site-wide: 16,514
    • In genetics: 800
  • Year to date:
    • Site-wide: 61,320
  • Since beginning of last month:
    • Site-wide: 90,575

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 1,177 times
  • Download rankings, all-time:
    • Site-wide: 16,977
    • In genetic and genomic medicine: 59
  • Year to date:
    • Site-wide: 6,497
  • Since beginning of last month:
    • Site-wide: 4,910

Efficient estimation and applications of cross-validated genetic predictions

genetics more details view paper
  • Downloaded 1,088 times
  • Download rankings, all-time:
    • Site-wide: 19,040
    • In genetics: 920
  • Year to date:
    • Site-wide: 31,924
  • Since beginning of last month:
    • Site-wide: 18,854

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 908 times
  • Download rankings, all-time:
    • Site-wide: 24,821
    • In genetics: 1,188
  • Year to date:
    • Site-wide: 18,967
  • Since beginning of last month:
    • Site-wide: 9,474

Epigenome-wide association in adipose tissue from the METSIM cohort

genetics more details view paper
  • Downloaded 852 times
  • Download rankings, all-time:
    • Site-wide: 27,085
    • In genetics: 1,294
  • Year to date:
    • Site-wide: 59,708
  • Since beginning of last month:
    • Site-wide: 43,650

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

genetics more details view paper
  • Downloaded 838 times
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    • Site-wide: 27,734
    • In genetics: 1,332
  • Year to date:
    • Site-wide: 13,409
  • Since beginning of last month:
    • Site-wide: 8,417

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

genetic and genomic medicine more details view paper
  • Downloaded 824 times
  • Download rankings, all-time:
    • Site-wide: 28,379
    • In genetic and genomic medicine: 91
  • Year to date:
    • Site-wide: 29,384
  • Since beginning of last month:
    • Site-wide: 39,163

Heterozygous RFX6 protein truncating variants cause Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance

genetics more details view paper
  • Downloaded 816 times
  • Download rankings, all-time:
    • Site-wide: 28,771
    • In genetics: 1,389
  • Year to date:
    • Site-wide: 108,755
  • Since beginning of last month:
    • Site-wide: 126,132

ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

genetic and genomic medicine more details view paper
  • Downloaded 677 times
  • Download rankings, all-time:
    • Site-wide: 37,197
    • In genetic and genomic medicine: 122
  • Year to date:
    • Site-wide: 18,776
  • Since beginning of last month:
    • Site-wide: 20,222

Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study.

genetic and genomic medicine more details view paper
  • Downloaded 663 times
  • Download rankings, all-time:
    • Site-wide: 38,297
    • In genetic and genomic medicine: 127
  • Year to date:
    • Site-wide: 2,572
  • Since beginning of last month:
    • Site-wide: 814

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 658 times
  • Download rankings, all-time:
    • Site-wide: 38,640
    • In genetics: 1,824
  • Year to date:
    • Site-wide: 5,609
  • Since beginning of last month:
    • Site-wide: 14,114

Interactions between genetic variation and cellular environment in skeletal muscle gene expression

genetics more details view paper
  • Downloaded 592 times
  • Download rankings, all-time:
    • Site-wide: 44,171
    • In genetics: 2,056
  • Year to date:
    • Site-wide: 112,806
  • Since beginning of last month:
    • Site-wide: 118,250

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

genetics more details view paper
  • Downloaded 577 times
  • Download rankings, all-time:
    • Site-wide: 45,645
    • In genetics: 2,128
  • Year to date:
    • Site-wide: 124,286
  • Since beginning of last month:
    • Site-wide: 132,162

A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context

genetics more details view paper
  • Downloaded 520 times
  • Download rankings, all-time:
    • Site-wide: 51,765
    • In genetics: 2,393
  • Year to date:
    • Site-wide: 107,419
  • Since beginning of last month:
    • Site-wide: 91,402

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

genetic and genomic medicine more details view paper
  • Downloaded 428 times
  • Download rankings, all-time:
    • Site-wide: 63,987
    • In genetic and genomic medicine: 219
  • Year to date:
    • Site-wide: 68,848
  • Since beginning of last month:
    • Site-wide: 55,835

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

epidemiology more details view paper
  • Downloaded 341 times
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    • Site-wide: 78,995
    • In epidemiology: 3,288
  • Year to date:
    • Site-wide: 104,337
  • Since beginning of last month:
    • Site-wide: 95,104

Association of Structural Variation with Cardiometabolic Traits in Finns

genetics more details view paper
  • Downloaded 331 times
  • Download rankings, all-time:
    • Site-wide: 80,910
    • In genetics: 3,659
  • Year to date:
    • Site-wide: 16,133
  • Since beginning of last month:
    • Site-wide: 11,190

Proper Conditional Analysis in the Presence of Missing Data Identified Novel Independently Associated Low Frequency Variants in Nicotine Dependence Genes

genetics more details view paper
  • Downloaded 272 times
  • Download rankings, all-time:
    • Site-wide: 93,340
    • In genetics: 4,169
  • Year to date:
    • Site-wide: 121,956
  • Since beginning of last month:
    • Site-wide: 70,718

Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

genetic and genomic medicine more details view paper
  • Downloaded 189 times
  • Download rankings, all-time:
    • Site-wide: 112,045
    • In genetic and genomic medicine: 512
  • Year to date:
    • Site-wide: 36,046
  • Since beginning of last month:
    • Site-wide: 33,170

Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation

microbiology more details view paper
  • Downloaded 151 times
  • Download rankings, all-time:
    • Site-wide: 120,203
    • In microbiology: 9,080
  • Year to date:
    • Site-wide: 84,969
  • Since beginning of last month:
    • Site-wide: 108,966

Multiparametric assessment of cellular lipid metabolism in hypercholesterolemia

cell biology more details view paper
  • Downloaded 86 times
  • Download rankings, all-time:
    • Site-wide: 132,500
    • In cell biology: 6,056
  • Year to date:
    • Site-wide: 37,812
  • Since beginning of last month:
    • Site-wide: 5,883

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