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Author: Markku Laakso

  • Most recently observed institution: Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Rankings

  • All-time downloads: 64,302 (rank: 2,540 )
  • Categories:
    • bioinformatics: 1,729 (rank: 9,477 (tie) )
    • cell biology: 168 (rank: 39,224 (tie) )
    • epidemiology: 423 (rank: 19,830 (tie) )
    • genetic and genomic medicine: 5,198 (rank: 247 )
    • genetics: 29,711 (rank: 218 )
    • genomics: 26,870 (rank: 444 )
    • microbiology: 203 (rank: 54,944 (tie) )

Downloads per author, site-wide

Preprints

Analysis of protein-coding genetic variation in 60,706 humans

genomics more details view paper
  • Downloaded 22,118 times
  • Download rankings, all-time:
    • Site-wide: 361
    • In genomics: 13
  • Year to date:
    • Site-wide: 31,720
  • Since beginning of last month:
    • Site-wide: 105,541

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,277 times
  • Download rankings, all-time:
    • Site-wide: 4,357
    • In genomics: 444
  • Year to date:
    • Site-wide: 90,473
  • Since beginning of last month:
    • Site-wide: 105,456

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,216 times
  • Download rankings, all-time:
    • Site-wide: 4,487
    • In genetics: 171
  • Year to date:
    • Site-wide: 37,499
  • Since beginning of last month:
    • Site-wide: 105,638

Integrative approaches for large-scale transcriptome-wide association studies

genetics more details view paper
  • Downloaded 2,950 times
  • Download rankings, all-time:
    • Site-wide: 5,061
    • In genetics: 209
  • Year to date:
    • Site-wide: 62,741
  • Since beginning of last month:
    • Site-wide: 26,139

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

genetics more details view paper
  • Downloaded 2,582 times
  • Download rankings, all-time:
    • Site-wide: 6,126
    • In genetics: 256
  • Year to date:
    • Site-wide: 25,924
  • Since beginning of last month:
    • Site-wide: None

Large-scale association analyses identify host factors influencing human gut microbiome composition

genetics more details view paper
  • Downloaded 2,416 times
  • Download rankings, all-time:
    • Site-wide: 6,769
    • In genetics: 296
  • Year to date:
    • Site-wide: 5,264
  • Since beginning of last month:
    • Site-wide: 30,281

Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes

genetics more details view paper
  • Downloaded 2,075 times
  • Download rankings, all-time:
    • Site-wide: 8,436
    • In genetics: 368
  • Year to date:
    • Site-wide: 63,641
  • Since beginning of last month:
    • Site-wide: 70,827

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,896 times
  • Download rankings, all-time:
    • Site-wide: 9,670
    • In genetics: 418
  • Year to date:
    • Site-wide: 93,046
  • Since beginning of last month:
    • Site-wide: 37,028

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,750 times
  • Download rankings, all-time:
    • Site-wide: 10,869
    • In genetics: 479
  • Year to date:
    • Site-wide: 54,888
  • Since beginning of last month:
    • Site-wide: 23,151

Association Analysis and Meta-Analysis of Multi-allelic Variants for Large Scale Sequence Data

bioinformatics more details view paper
  • Downloaded 1,729 times
  • Download rankings, all-time:
    • Site-wide: 11,066
    • In bioinformatics: 1,272
  • Year to date:
    • Site-wide: 51,729
  • Since beginning of last month:
    • Site-wide: 63,480

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

genetics more details view paper
  • Downloaded 1,690 times
  • Download rankings, all-time:
    • Site-wide: 11,407
    • In genetics: 505
  • Year to date:
    • Site-wide: 93,581
  • Since beginning of last month:
    • Site-wide: 87,293

Reverse GWAS: Using Genetics to Identify and Model Phenotypic Subtypes

genetics more details view paper
  • Downloaded 1,670 times
  • Download rankings, all-time:
    • Site-wide: 11,637
    • In genetics: 521
  • Year to date:
    • Site-wide: 104,764
  • Since beginning of last month:
    • Site-wide: 46,519

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 1,478 times
  • Download rankings, all-time:
    • Site-wide: 13,921
    • In genetic and genomic medicine: 62
  • Year to date:
    • Site-wide: 6,357
  • Since beginning of last month:
    • Site-wide: 11,338

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

genomics more details view paper
  • Downloaded 1,475 times
  • Download rankings, all-time:
    • Site-wide: 13,948
    • In genomics: 1,421
  • Year to date:
    • Site-wide: 83,910
  • Since beginning of last month:
    • Site-wide: 70,809

Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study.

genetic and genomic medicine more details view paper
  • Downloaded 1,274 times
  • Download rankings, all-time:
    • Site-wide: 17,445
    • In genetic and genomic medicine: 76
  • Year to date:
    • Site-wide: 2,434
  • Since beginning of last month:
    • Site-wide: 1,413

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

genetics more details view paper
  • Downloaded 1,256 times
  • Download rankings, all-time:
    • Site-wide: 17,807
    • In genetics: 822
  • Year to date:
    • Site-wide: 66,151
  • Since beginning of last month:
    • Site-wide: 27,174

Efficient estimation and applications of cross-validated genetic predictions

genetics more details view paper
  • Downloaded 1,156 times
  • Download rankings, all-time:
    • Site-wide: 20,164
    • In genetics: 924
  • Year to date:
    • Site-wide: 40,698
  • Since beginning of last month:
    • Site-wide: 50,192

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

genetics more details view paper
  • Downloaded 1,138 times
  • Download rankings, all-time:
    • Site-wide: 20,632
    • In genetics: 943
  • Year to date:
    • Site-wide: 9,164
  • Since beginning of last month:
    • Site-wide: 7,119

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 993 times
  • Download rankings, all-time:
    • Site-wide: 25,192
    • In genetics: 1,144
  • Year to date:
    • Site-wide: 25,875
  • Since beginning of last month:
    • Site-wide: 114,557

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

genetic and genomic medicine more details view paper
  • Downloaded 924 times
  • Download rankings, all-time:
    • Site-wide: 27,971
    • In genetic and genomic medicine: 112
  • Year to date:
    • Site-wide: 31,515
  • Since beginning of last month:
    • Site-wide: 52,046

Epigenome-wide association in adipose tissue from the METSIM cohort

genetics more details view paper
  • Downloaded 883 times
  • Download rankings, all-time:
    • Site-wide: 29,817
    • In genetics: 1,356
  • Year to date:
    • Site-wide: 82,629
  • Since beginning of last month:
    • Site-wide: None

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 848 times
  • Download rankings, all-time:
    • Site-wide: 31,570
    • In genetics: 1,450
  • Year to date:
    • Site-wide: 7,607
  • Since beginning of last month:
    • Site-wide: 5,168

Heterozygous RFX6 protein truncating variants cause Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance

genetics more details view paper
  • Downloaded 828 times
  • Download rankings, all-time:
    • Site-wide: 32,573
    • In genetics: 1,497
  • Year to date:
    • Site-wide: 137,411
  • Since beginning of last month:
    • Site-wide: None

ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

genetic and genomic medicine more details view paper
  • Downloaded 807 times
  • Download rankings, all-time:
    • Site-wide: 33,806
    • In genetic and genomic medicine: 136
  • Year to date:
    • Site-wide: 20,543
  • Since beginning of last month:
    • Site-wide: 25,068

Interactions between genetic variation and cellular environment in skeletal muscle gene expression

genetics more details view paper
  • Downloaded 605 times
  • Download rankings, all-time:
    • Site-wide: 49,678
    • In genetics: 2,194
  • Year to date:
    • Site-wide: 137,344
  • Since beginning of last month:
    • Site-wide: 70,255

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

genetics more details view paper
  • Downloaded 589 times
  • Download rankings, all-time:
    • Site-wide: 51,386
    • In genetics: 2,260
  • Year to date:
    • Site-wide: 145,326
  • Since beginning of last month:
    • Site-wide: None

A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context

genetics more details view paper
  • Downloaded 522 times
  • Download rankings, all-time:
    • Site-wide: 59,479
    • In genetics: 2,623
  • Year to date:
    • Site-wide: 148,338
  • Since beginning of last month:
    • Site-wide: None

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

genetic and genomic medicine more details view paper
  • Downloaded 471 times
  • Download rankings, all-time:
    • Site-wide: 66,766
    • In genetic and genomic medicine: 276
  • Year to date:
    • Site-wide: 78,854
  • Since beginning of last month:
    • Site-wide: 64,693

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

epidemiology more details view paper
  • Downloaded 371 times
  • Download rankings, all-time:
    • Site-wide: 84,339
    • In epidemiology: 3,596
  • Year to date:
    • Site-wide: 111,444
  • Since beginning of last month:
    • Site-wide: 41,030

Association of Structural Variation with Cardiometabolic Traits in Finns

genetics more details view paper
  • Downloaded 368 times
  • Download rankings, all-time:
    • Site-wide: 85,009
    • In genetics: 3,694
  • Year to date:
    • Site-wide: 30,030
  • Since beginning of last month:
    • Site-wide: 101,092

Proper Conditional Analysis in the Presence of Missing Data Identified Novel Independently Associated Low Frequency Variants in Nicotine Dependence Genes

genetics more details view paper
  • Downloaded 280 times
  • Download rankings, all-time:
    • Site-wide: 104,674
    • In genetics: 4,421
  • Year to date:
    • Site-wide: 148,465
  • Since beginning of last month:
    • Site-wide: None

Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

genetic and genomic medicine more details view paper
  • Downloaded 244 times
  • Download rankings, all-time:
    • Site-wide: 113,281
    • In genetic and genomic medicine: 580
  • Year to date:
    • Site-wide: 48,089
  • Since beginning of last month:
    • Site-wide: 66,005

Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation

microbiology more details view paper
  • Downloaded 203 times
  • Download rankings, all-time:
    • Site-wide: 123,638
    • In microbiology: 9,119
  • Year to date:
    • Site-wide: 80,775
  • Since beginning of last month:
    • Site-wide: 20,540

Multiparametric profiling of cellular lipid metabolism in hypercholesterolemia

cell biology more details view paper
  • Downloaded 168 times
  • Download rankings, all-time:
    • Site-wide: 131,989
    • In cell biology: 6,086
  • Year to date:
    • Site-wide: 40,772
  • Since beginning of last month:
    • Site-wide: None

Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study

epidemiology more details view paper
  • Downloaded 52 times
  • Download rankings, all-time:
    • Site-wide: 152,281
    • In epidemiology: 6,268
  • Year to date:
    • Site-wide: 112,247
  • Since beginning of last month:
    • Site-wide: 9,286

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