Author: Wolf Reik

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Preprints

The Human Cell Atlas

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Accurate prediction of single-cell DNA methylation states using deep learning

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  • Site-wide: 1,342
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Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification

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  • In developmental biology: 7
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SC3 - consensus clustering of single-cell RNA-Seq data

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  • Site-wide: 1,717
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scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

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  • In genomics: 203
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Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data

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  • Site-wide: 3,892
  • In genomics: 456
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Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis

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  • In developmental biology: 39
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A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of zygotic genome activation

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  • Site-wide: 4,184
  • In developmental biology: 43
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Single-cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

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Tracking the embryonic stem cell transition from ground state pluripotency

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  • Site-wide: 7,698
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  • Site-wide: 18,941
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Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

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  • In molecular biology: 199
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Establishment In Culture Of Expanded Potential Stem Cells

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  • Site-wide: 8,855
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  • Site-wide: 54,575
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Screening for genes that accelerate the epigenetic ageing clock in humans reveals a role for the H3K36 methyltransferase NSD1

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  • Site-wide: 11,796
  • In genomics: 1,311
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  • Site-wide: 96,997
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Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

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  • Site-wide: 12,064
  • In bioinformatics: 1,489
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Epigenetic resetting of human pluripotency

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  • Site-wide: 12,422
  • In developmental biology: 188
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A non-catalytic role of TET3 promotes open chromatin and enhances global transcription

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  • Site-wide: 14,134
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• Year to date:
  • Site-wide: 37,792
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5-Formylcytosine controls nucleosome positioning through covalent histone-DNA interaction

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  • Site-wide: 17,840
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Genome-scale oscillations in DNA methylation during exit from pluripotency

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  • Site-wide: 18,217
  • In genomics: 1,885
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  • Site-wide: 111,802
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The non-canonical SMC protein SmcHD1 antagonises TAD formation on the inactive X chromosome

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  • Site-wide: 18,580
  • In molecular biology: 510
• Year to date:
  • Site-wide: 98,606
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  • Site-wide: 98,606

Dppa2 and Dppa4 directly regulate the Dux driven zygotic transcriptional programme

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  • Site-wide: 20,474
  • In molecular biology: 552
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  • Site-wide: 68,548
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  • Site-wide: 68,548

Enhancer-associated H3K4 methylation safeguards in vitro germlinecompetence

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  • Site-wide: 24,218
  • In genomics: 2,349
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  • Site-wide: 6,857
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  • Site-wide: 6,857

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in muscle stem cells

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  • In genomics: 2,438
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Dppa2/4 target chromatin bivalency enabling multi-lineage commitment

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  • Site-wide: 29,376
  • In molecular biology: 823
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Multi-Tissue DNA Methylation Age Predictor In Mouse

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  • Site-wide: 36,206
  • In genomics: 3,141
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DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance

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  • Site-wide: 37,221
  • In genomics: 3,197
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  • Site-wide: 34,890

Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons

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  • Site-wide: 45,283
  • In genomics: 3,670
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Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates

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  • Site-wide: 50,629
  • In genomics: 3,982
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  • Site-wide: 1,208
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Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation

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  • Site-wide: 64,045
  • In molecular biology: 1,871
• Year to date:
  • Site-wide: 41,946
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  • Site-wide: 41,946

Genome wide efficiency profiling reveals modulation of maintenance and de novo methylation by Tets

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  • Site-wide: 92,414
  • In genomics: 5,725
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  • Site-wide: 57,633
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  • Site-wide: 57,633

Histone modifications form a cell-type-specific chromosomal bar code that modulates and maintains patterns of gene expression through the cell cycle

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  • Site-wide: 104,474
  • In genomics: 6,096
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