Author: Wolf Reik

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Preprints

The Human Cell Atlas

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Accurate prediction of single-cell DNA methylation states using deep learning

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Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification

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SC3 - consensus clustering of single-cell RNA-Seq data

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scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

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Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data

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A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of zygotic genome activation

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Single-cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

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Tracking the embryonic stem cell transition from ground state pluripotency

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Establishment In Culture Of Expanded Potential Stem Cells

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Screening for genes that accelerate the epigenetic ageing clock in humans reveals a role for the H3K36 methyltransferase NSD1

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Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

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Epigenetic resetting of human pluripotency

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A non-catalytic role of TET3 promotes open chromatin and enhances global transcription

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5-Formylcytosine controls nucleosome positioning through covalent histone-DNA interaction

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Genome-scale oscillations in DNA methylation during exit from pluripotency

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The non-canonical SMC protein SmcHD1 antagonises TAD formation on the inactive X chromosome

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Dppa2 and Dppa4 directly regulate the Dux driven zygotic transcriptional programme

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Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in muscle stem cells

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Dppa2/4 target chromatin bivalency enabling multi-lineage commitment

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Multi-Tissue DNA Methylation Age Predictor In Mouse

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DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance

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Enhancer priming by H3K4 methylation safeguards germline competence

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Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons

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Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation

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Genome wide efficiency profiling reveals modulation of maintenance and de novo methylation by Tets

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