Author: Tom R Gaunt

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Preprints

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,341 times
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  • Site-wide: 1,307
  • In bioinformatics: 80
• Year to date:
  • Site-wide: 32,680
• Since beginning of last month:
  • Site-wide: 45,287

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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  • Site-wide: 3,057
  • In genetics: 112
• Year to date:
  • Site-wide: 9,875
• Since beginning of last month:
  • Site-wide: 11,253

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,570 times
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  • Site-wide: 3,554
  • In epidemiology: 345
• Year to date:
  • Site-wide: 11,024
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  • Site-wide: 13,571

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,631 times
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  • Site-wide: 11,079
  • In genetics: 515
• Year to date:
  • Site-wide: 125,254
• Since beginning of last month:
  • Site-wide: 114,049

Using genetic variation to disentangle the complex relationship between food intake and health outcomes.

• Downloaded 1,372 times
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  • Site-wide: 14,357
  • In genetics: 676
• Year to date:
  • Site-wide: 24,655
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  • Site-wide: 47,754

Searching for the causal effects of BMI in over 300 000 individuals, using Mendelian randomization

• Downloaded 1,334 times
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  • Site-wide: 14,960
  • In epidemiology: 991
• Year to date:
  • Site-wide: 118,985
• Since beginning of last month:
  • Site-wide: 114,083

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,212 times
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  • Site-wide: 17,294
  • In epidemiology: 1,094
• Year to date:
  • Site-wide: 25,352
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  • Site-wide: 20,758

Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases

• Downloaded 1,129 times
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  • Site-wide: 19,195
  • In genomics: 1,897
• Year to date:
  • Site-wide: 1,842
• Since beginning of last month:
  • Site-wide: 2,245

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

• Downloaded 1,081 times
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  • Site-wide: 20,467
  • In bioinformatics: 2,383
• Year to date:
  • Site-wide: 70,876
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  • Site-wide: 80,989

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 1,025 times
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  • Site-wide: 22,115
  • In neurology: 44
• Year to date:
  • Site-wide: 2,140
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  • Site-wide: 2,603

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 874 times
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  • Site-wide: 27,799
  • In genetic and genomic medicine: 100
• Year to date:
  • Site-wide: 8,185
• Since beginning of last month:
  • Site-wide: 7,634

The variant call format provides efficient and robust storage of GWAS summary statistics

• Downloaded 723 times
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  • Site-wide: 36,190
  • In genetics: 1,692
• Year to date:
  • Site-wide: 23,010
• Since beginning of last month:
  • Site-wide: 23,549

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 684 times
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  • Site-wide: 38,994
  • In genetics: 1,803
• Year to date:
  • Site-wide: 130,458
• Since beginning of last month:
  • Site-wide: 113,631

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 656 times
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  • Site-wide: 41,216
  • In epidemiology: 1,989
• Year to date:
  • Site-wide: 101,755
• Since beginning of last month:
  • Site-wide: 98,108

Epigenome-wide change and variation in DNA methylation from birth to late adolescence

• Downloaded 529 times
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  • Site-wide: 53,643
  • In genomics: 4,113
• Year to date:
  • Site-wide: 62,044
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  • Site-wide: 71,777

Epigenome-Wide Association Study Of Asthma And Wheeze In Childhood And Adolescence

• Downloaded 514 times
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  • Site-wide: 55,597
  • In epidemiology: 2,469
• Year to date:
  • Site-wide: 117,350
• Since beginning of last month:
  • Site-wide: 107,300

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

• Downloaded 497 times
• Download rankings, all-time:
  • Site-wide: 57,696
  • In genetics: 2,617
• Year to date:
  • Site-wide: 6,039
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  • Site-wide: 7,221

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

• Downloaded 455 times
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  • Site-wide: 63,558
  • In genomics: 4,569
• Year to date:
  • Site-wide: 135,522
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  • Site-wide: 121,002

Diagnosis of coronary heart diseases using gene expression profiling; stable coronary artery disease, cardiac ischemia with and without myocardial necrosis

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 68,515
  • In bioinformatics: 6,524
• Year to date:
  • Site-wide: 141,516
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  • Site-wide: 128,757

A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular disease

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 71,263
  • In genetic and genomic medicine: 269
• Year to date:
  • Site-wide: 67,535
• Since beginning of last month:
  • Site-wide: 53,468

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 78,251
  • In genetics: 3,503
• Year to date:
  • Site-wide: 39,507
• Since beginning of last month:
  • Site-wide: 62,084

Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships

• Downloaded 364 times
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  • Site-wide: 78,849
  • In genetic and genomic medicine: 315
• Year to date:
  • Site-wide: 105,752
• Since beginning of last month:
  • Site-wide: 102,266

Cholesteryl Ester Transfer Protein as a Drug Target

• Downloaded 344 times
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  • Site-wide: 82,688
  • In cardiovascular medicine: 143
• Year to date:
  • Site-wide: 55,256
• Since beginning of last month:
  • Site-wide: 39,165

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

• Downloaded 305 times
• Download rankings, all-time:
  • Site-wide: 90,867
  • In pharmacology and therapeutics: 88
• Year to date:
  • Site-wide: 12,123
• Since beginning of last month:
  • Site-wide: 12,699

Association of changing physical activity intensity and bout length with mortality: a study of 79,507 participants in UK Biobank

• Downloaded 301 times
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  • Site-wide: 91,827
  • In epidemiology: 3,816
• Year to date:
  • Site-wide: 79,484
• Since beginning of last month:
  • Site-wide: 74,717

Triangulating molecular evidence to prioritise candidate causal genes at established atopic dermatitis loci

• Downloaded 260 times
• Download rankings, all-time:
  • Site-wide: 101,030
  • In genetic and genomic medicine: 451
• Year to date:
  • Site-wide: 26,861
• Since beginning of last month:
  • Site-wide: 30,480

EpiGraphDB: a database and data mining platform for health data science

• Downloaded 251 times
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  • Site-wide: 103,299
  • In bioinformatics: 8,778
• Year to date:
  • Site-wide: 105,284
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  • Site-wide: 86,113

An Informatics Consult approach for generating clinical evidence for treatment decisions

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 115,595
  • In health informatics: 436
• Year to date:
  • Site-wide: 21,750
• Since beginning of last month:
  • Site-wide: 24,067

Exploring the variance in complex traits captured by DNA methylation assays

• Downloaded 120 times
• Download rankings, all-time:
  • Site-wide: 132,749
  • In genetics: 5,452
• Year to date:
  • Site-wide: 114,120
• Since beginning of last month:
  • Site-wide: 131,299