Author: Tom R Gaunt

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Preprints

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,376 times
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  • Site-wide: 1,396
  • In bioinformatics: 84
• Year to date:
  • Site-wide: 35,232
• Since beginning of last month:
  • Site-wide: 31,505

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 4,030 times
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  • Site-wide: 3,207
  • In genetics: 109
• Year to date:
  • Site-wide: 10,910
• Since beginning of last month:
  • Site-wide: 23,444

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,671 times
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  • Site-wide: 3,638
  • In epidemiology: 359
• Year to date:
  • Site-wide: 10,680
• Since beginning of last month:
  • Site-wide: 59,155

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,641 times
• Download rankings, all-time:
  • Site-wide: 11,730
  • In genetics: 533
• Year to date:
  • Site-wide: 128,787
• Since beginning of last month:
  • Site-wide: 84,094

Using genetic variation to disentangle the complex relationship between food intake and health outcomes.

• Downloaded 1,424 times
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  • Site-wide: 14,438
  • In genetics: 667
• Year to date:
  • Site-wide: 25,019
• Since beginning of last month:
  • Site-wide: 91,873

Searching for the causal effects of BMI in over 300 000 individuals, using Mendelian randomization

• Downloaded 1,350 times
• Download rankings, all-time:
  • Site-wide: 15,657
  • In epidemiology: 1,046
• Year to date:
  • Site-wide: 115,472
• Since beginning of last month:
  • Site-wide: 75,354

Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases

• Downloaded 1,326 times
• Download rankings, all-time:
  • Site-wide: 16,096
  • In genomics: 1,599
• Year to date:
  • Site-wide: 2,118
• Since beginning of last month:
  • Site-wide: 19,940

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,242 times
• Download rankings, all-time:
  • Site-wide: 17,718
  • In epidemiology: 1,139
• Year to date:
  • Site-wide: 29,166
• Since beginning of last month:
  • Site-wide: 82,613

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 1,166 times
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  • Site-wide: 19,471
  • In neurology: 39
• Year to date:
  • Site-wide: 2,499
• Since beginning of last month:
  • Site-wide: 10,626

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

• Downloaded 1,089 times
• Download rankings, all-time:
  • Site-wide: 21,529
  • In bioinformatics: 2,485
• Year to date:
  • Site-wide: 84,546
• Since beginning of last month:
  • Site-wide: None

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 970 times
• Download rankings, all-time:
  • Site-wide: 25,542
  • In genetic and genomic medicine: 102
• Year to date:
  • Site-wide: 8,558
• Since beginning of last month:
  • Site-wide: 28,478

The variant call format provides efficient and robust storage of GWAS summary statistics

• Downloaded 768 times
• Download rankings, all-time:
  • Site-wide: 35,409
  • In genetics: 1,616
• Year to date:
  • Site-wide: 24,437
• Since beginning of last month:
  • Site-wide: 12,596

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 688 times
• Download rankings, all-time:
  • Site-wide: 41,136
  • In genetics: 1,846
• Year to date:
  • Site-wide: 141,522
• Since beginning of last month:
  • Site-wide: 72,911

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 663 times
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  • Site-wide: 43,236
  • In epidemiology: 2,101
• Year to date:
  • Site-wide: 115,127
• Since beginning of last month:
  • Site-wide: 75,315

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 50,539
  • In genetics: 2,242
• Year to date:
  • Site-wide: 6,782
• Since beginning of last month:
  • Site-wide: 19,866

Epigenome-wide change and variation in DNA methylation from birth to late adolescence

• Downloaded 548 times
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  • Site-wide: 54,883
  • In genomics: 4,133
• Year to date:
  • Site-wide: 67,995
• Since beginning of last month:
  • Site-wide: 36,282

Epigenome-Wide Association Study Of Asthma And Wheeze In Childhood And Adolescence

• Downloaded 516 times
• Download rankings, all-time:
  • Site-wide: 58,933
  • In epidemiology: 2,639
• Year to date:
  • Site-wide: 133,932
• Since beginning of last month:
  • Site-wide: None

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

• Downloaded 458 times
• Download rankings, all-time:
  • Site-wide: 67,242
  • In genomics: 4,741
• Year to date:
  • Site-wide: 146,558
• Since beginning of last month:
  • Site-wide: 70,942

A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular disease

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 69,858
  • In genetic and genomic medicine: 282
• Year to date:
  • Site-wide: 63,212
• Since beginning of last month:
  • Site-wide: 105,285

Diagnosis of coronary heart diseases using gene expression profiling; stable coronary artery disease, cardiac ischemia with and without myocardial necrosis

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 71,096
  • In bioinformatics: 6,740
• Year to date:
  • Site-wide: 142,575
• Since beginning of last month:
  • Site-wide: None

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

• Downloaded 421 times
• Download rankings, all-time:
  • Site-wide: 73,239
  • In pharmacology and therapeutics: 76
• Year to date:
  • Site-wide: 10,968
• Since beginning of last month:
  • Site-wide: 42,196

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

• Downloaded 395 times
• Download rankings, all-time:
  • Site-wide: 77,859
  • In genetics: 3,395
• Year to date:
  • Site-wide: 43,170
• Since beginning of last month:
  • Site-wide: None

Cholesteryl Ester Transfer Protein as a Drug Target

• Downloaded 395 times
• Download rankings, all-time:
  • Site-wide: 77,792
  • In cardiovascular medicine: 141
• Year to date:
  • Site-wide: 47,195
• Since beginning of last month:
  • Site-wide: 28,549

Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 81,495
  • In genetic and genomic medicine: 349
• Year to date:
  • Site-wide: 111,926
• Since beginning of last month:
  • Site-wide: 106,166

Association of changing physical activity intensity and bout length with mortality: a study of 79,507 participants in UK Biobank

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 93,508
  • In epidemiology: 3,927
• Year to date:
  • Site-wide: 83,577
• Since beginning of last month:
  • Site-wide: 103,338

Triangulating molecular evidence to prioritise candidate causal genes at established atopic dermatitis loci

• Downloaded 298 times
• Download rankings, all-time:
  • Site-wide: 98,094
  • In genetic and genomic medicine: 455
• Year to date:
  • Site-wide: 29,302
• Since beginning of last month:
  • Site-wide: 49,660

EpiGraphDB: a database and data mining platform for health data science

• Downloaded 254 times
• Download rankings, all-time:
  • Site-wide: 108,497
  • In bioinformatics: 9,160
• Year to date:
  • Site-wide: 122,586
• Since beginning of last month:
  • Site-wide: 100,166

An Informatics Consult approach for generating clinical evidence for treatment decisions

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 116,564
  • In health informatics: 450
• Year to date:
  • Site-wide: 26,482
• Since beginning of last month:
  • Site-wide: 40,346

Exploring the variance in complex traits captured by DNA methylation assays

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 136,330
  • In genetics: 5,496
• Year to date:
  • Site-wide: 109,586
• Since beginning of last month:
  • Site-wide: 44,740

Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

• Downloaded 48 times
• Download rankings, all-time:
  • Site-wide: 150,286
  • In epidemiology: 6,186
• Year to date:
  • Site-wide: 108,612
• Since beginning of last month:
  • Site-wide: 17,966

Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

• Downloaded 0 times
• Download rankings, all-time:
  • Site-wide: 154,739
  • In epidemiology: 6,376
• Year to date:
  • Site-wide: 154,689
• Since beginning of last month:
  • Site-wide: 104,348