Author: Tom R Gaunt

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Preprints

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,253 times
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  • Site-wide: 1,142
  • In bioinformatics: 71
• Year to date:
  • Site-wide: 24,526
• Since beginning of last month:
  • Site-wide: 14,312

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 3,737 times
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  • Site-wide: 2,821
  • In genetics: 112
• Year to date:
  • Site-wide: 8,559
• Since beginning of last month:
  • Site-wide: 6,381

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,359 times
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  • Site-wide: 3,297
  • In epidemiology: 324
• Year to date:
  • Site-wide: 9,851
• Since beginning of last month:
  • Site-wide: 7,588

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,619 times
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  • Site-wide: 9,608
  • In genetics: 477
• Year to date:
  • Site-wide: 92,792
• Since beginning of last month:
  • Site-wide: None

Searching for the causal effects of BMI in over 300 000 individuals, using Mendelian randomization

• Downloaded 1,317 times
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  • Site-wide: 13,020
  • In epidemiology: 865
• Year to date:
  • Site-wide: 99,137
• Since beginning of last month:
  • Site-wide: 78,018

Using genetic variation to disentangle the complex relationship between food intake and health outcomes.

• Downloaded 1,287 times
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  • Site-wide: 13,507
  • In genetics: 680
• Year to date:
  • Site-wide: 12,738
• Since beginning of last month:
  • Site-wide: 14,543

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,103 times
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  • Site-wide: 17,060
  • In epidemiology: 1,037
• Year to date:
  • Site-wide: 19,262
• Since beginning of last month:
  • Site-wide: 15,539

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

• Downloaded 1,035 times
• Download rankings, all-time:
  • Site-wide: 18,743
  • In bioinformatics: 2,263
• Year to date:
  • Site-wide: 74,400
• Since beginning of last month:
  • Site-wide: 73,462

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 673 times
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  • Site-wide: 34,366
  • In genetics: 1,679
• Year to date:
  • Site-wide: 100,781
• Since beginning of last month:
  • Site-wide: 89,082

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 628 times
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  • Site-wide: 37,612
  • In epidemiology: 1,804
• Year to date:
  • Site-wide: 106,946
• Since beginning of last month:
  • Site-wide: None

The variant call format provides efficient and robust storage of GWAS summary statistics

• Downloaded 609 times
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  • Site-wide: 39,105
  • In genetics: 1,898
• Year to date:
  • Site-wide: 16,354
• Since beginning of last month:
  • Site-wide: 24,135

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 39,633
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 8,328
• Since beginning of last month:
  • Site-wide: 12,888

Epigenome-Wide Association Study Of Asthma And Wheeze In Childhood And Adolescence

• Downloaded 498 times
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  • Site-wide: 49,994
  • In epidemiology: 2,206
• Year to date:
  • Site-wide: 91,156
• Since beginning of last month:
  • Site-wide: None

Epigenome-wide change and variation in DNA methylation from birth to late adolescence

• Downloaded 493 times
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  • Site-wide: 50,515
  • In genomics: 3,986
• Year to date:
  • Site-wide: 35,476
• Since beginning of last month:
  • Site-wide: 39,408

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

• Downloaded 444 times
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  • Site-wide: 56,731
  • In genomics: 4,302
• Year to date:
  • Site-wide: 113,277
• Since beginning of last month:
  • Site-wide: 77,281

Diagnosis of coronary heart diseases using gene expression profiling; stable coronary artery disease, cardiac ischemia with and without myocardial necrosis

• Downloaded 417 times
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  • Site-wide: 60,494
  • In bioinformatics: 5,997
• Year to date:
  • Site-wide: 113,956
• Since beginning of last month:
  • Site-wide: 103,181

A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular disease

• Downloaded 357 times
• Download rankings, all-time:
  • Site-wide: 70,111
  • In genetic and genomic medicine: 210
• Year to date:
  • Site-wide: 76,560
• Since beginning of last month:
  • Site-wide: 68,488

Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 73,814
  • In genetic and genomic medicine: 226
• Year to date:
  • Site-wide: 114,399
• Since beginning of last month:
  • Site-wide: 99,106

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 74,989
  • In genetics: 3,492
• Year to date:
  • Site-wide: 15,422
• Since beginning of last month:
  • Site-wide: 22,170

Cholesteryl Ester Transfer Protein as a Drug Target

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 83,567
  • In cardiovascular medicine: 128
• Year to date:
  • Site-wide: 50,041
• Since beginning of last month:
  • Site-wide: 54,450

Association of changing physical activity intensity and bout length with mortality: a study of 79,507 participants in UK Biobank

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 85,696
  • In epidemiology: 3,514
• Year to date:
  • Site-wide: 47,111
• Since beginning of last month:
  • Site-wide: 26,224

EpiGraphDB: a database and data mining platform for health data science

• Downloaded 230 times
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  • Site-wide: 95,365
  • In bioinformatics: 8,302
• Year to date:
  • Site-wide: 84,543
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  • Site-wide: 81,838

Triangulating molecular evidence to prioritise candidate causal genes at established atopic dermatitis loci

• Downloaded 134 times
• Download rankings, all-time:
  • Site-wide: 115,242
  • In genetic and genomic medicine: 509
• Year to date:
  • Site-wide: 32,530
• Since beginning of last month:
  • Site-wide: 18,285

Exploring the variance in complex traits captured by DNA methylation assays

• Downloaded 111 times
• Download rankings, all-time:
  • Site-wide: 119,519
  • In genetics: 5,137
• Year to date:
  • Site-wide: 59,811
• Since beginning of last month:
  • Site-wide: 38,374

An Informatics Consult approach for generating clinical evidence for treatment decisions

• Downloaded 99 times
• Download rankings, all-time:
  • Site-wide: 121,457
  • In health informatics: 460
• Year to date:
  • Site-wide: 12,138
• Since beginning of last month:
  • Site-wide: 14,933