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Author: Tom R Gaunt

Rankings

  • All-time downloads: 51,989 (rank: 4,895 )
  • Categories:
    • bioinformatics: 9,726 (rank: 1,296 )
    • cancer biology: 856 (rank: 17,734 (tie) )
    • cardiovascular medicine: 671 (rank: 1,777 (tie) )
    • epidemiology: 10,774 (rank: 2,086 )
    • genetic and genomic medicine: 6,666 (rank: 417 )
    • genetics: 12,415 (rank: 1,533 )
    • genomics: 3,932 (rank: 8,144 )
    • health informatics: 586 (rank: 2,632 )
    • neurology: 2,162 (rank: 1,039 (tie) )
    • oncology: 130 (rank: 8,570 (tie) )
    • pharmacology and therapeutics: 781 (rank: 593 (tie) )

Downloads per author, site-wide

Preprints

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

bioinformatics more details view paper
  • Downloaded 7,568 times
  • Download rankings, all-time:
    • Site-wide: 1,942
    • In bioinformatics: 99
  • Year to date:
    • Site-wide: 84,782
  • Since beginning of last month:
    • Site-wide: None

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

epidemiology more details view paper
  • Downloaded 4,525 times
  • Download rankings, all-time:
    • Site-wide: 3,900
    • In epidemiology: 419
  • Year to date:
    • Site-wide: 8,062
  • Since beginning of last month:
    • Site-wide: 4,824

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
  • Downloaded 4,470 times
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    • Site-wide: 3,960
    • In genetics: 112
  • Year to date:
    • Site-wide: 24,304
  • Since beginning of last month:
    • Site-wide: 12,118

Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases

genomics more details view paper
  • Downloaded 3,205 times
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    • Site-wide: 6,470
    • In genomics: 716
  • Year to date:
    • Site-wide: 2,552
  • Since beginning of last month:
    • Site-wide: 1,916

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

genetic and genomic medicine more details view paper
  • Downloaded 2,543 times
  • Download rankings, all-time:
    • Site-wide: 9,063
    • In genetic and genomic medicine: 58
  • Year to date:
    • Site-wide: 828
  • Since beginning of last month:
    • Site-wide: 5,732

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

neurology more details view paper
  • Downloaded 2,214 times
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    • Site-wide: 11,184
    • In neurology: 33
  • Year to date:
    • Site-wide: 17,352
  • Since beginning of last month:
    • Site-wide: 52,393

Using genetic variation to disentangle the complex relationship between food intake and health outcomes.

genetics more details view paper
  • Downloaded 1,782 times
  • Download rankings, all-time:
    • Site-wide: 15,573
    • In genetics: 621
  • Year to date:
    • Site-wide: 47,899
  • Since beginning of last month:
    • Site-wide: 47,536

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

genetics more details view paper
  • Downloaded 1,720 times
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    • Site-wide: 16,387
    • In genetics: 644
  • Year to date:
    • Site-wide: 159,903
  • Since beginning of last month:
    • Site-wide: 101,921

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

epidemiology more details view paper
  • Downloaded 1,487 times
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    • Site-wide: 20,656
    • In epidemiology: 1,328
  • Year to date:
    • Site-wide: 75,611
  • Since beginning of last month:
    • Site-wide: 31,364

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

genetic and genomic medicine more details view paper
  • Downloaded 1,459 times
  • Download rankings, all-time:
    • Site-wide: 21,275
    • In genetic and genomic medicine: 121
  • Year to date:
    • Site-wide: 55,185
  • Since beginning of last month:
    • Site-wide: 156,693

Searching for the causal effects of BMI in over 300 000 individuals, using Mendelian randomization

epidemiology more details view paper
  • Downloaded 1,439 times
  • Download rankings, all-time:
    • Site-wide: 21,733
    • In epidemiology: 1,354
  • Year to date:
    • Site-wide: 189,735
  • Since beginning of last month:
    • Site-wide: 48,957

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

bioinformatics more details view paper
  • Downloaded 1,229 times
  • Download rankings, all-time:
    • Site-wide: 27,954
    • In bioinformatics: 2,983
  • Year to date:
    • Site-wide: 107,948
  • Since beginning of last month:
    • Site-wide: 13,571

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

genetics more details view paper
  • Downloaded 1,106 times
  • Download rankings, all-time:
    • Site-wide: 32,967
    • In genetics: 1,306
  • Year to date:
    • Site-wide: 50,841
  • Since beginning of last month:
    • Site-wide: 86,853

The variant call format provides efficient and robust storage of GWAS summary statistics

genetics more details view paper
  • Downloaded 999 times
  • Download rankings, all-time:
    • Site-wide: 38,514
    • In genetics: 1,542
  • Year to date:
    • Site-wide: 71,417
  • Since beginning of last month:
    • Site-wide: None

An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkers

genetic and genomic medicine more details view paper
  • Downloaded 967 times
  • Download rankings, all-time:
    • Site-wide: 40,492
    • In genetic and genomic medicine: 297
  • Year to date:
    • Site-wide: 14,607
  • Since beginning of last month:
    • Site-wide: 30,180

The network of SARS-CoV-2-cancer molecular interactions and pathways

cancer biology more details view paper
  • Downloaded 920 times
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    • Site-wide: 43,703
    • In cancer biology: 1,271
  • Year to date:
    • Site-wide: 3,963
  • Since beginning of last month:
    • Site-wide: 87,125

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

pharmacology and therapeutics more details view paper
  • Downloaded 813 times
  • Download rankings, all-time:
    • Site-wide: 52,714
    • In pharmacology and therapeutics: 69
  • Year to date:
    • Site-wide: 37,273
  • Since beginning of last month:
    • Site-wide: 96,376

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

genetics more details view paper
  • Downloaded 808 times
  • Download rankings, all-time:
    • Site-wide: 53,217
    • In genetics: 2,058
  • Year to date:
    • Site-wide: 153,369
  • Since beginning of last month:
    • Site-wide: 79,403

Appraising the causal relevance of DNA methylation for risk of lung cancer

epidemiology more details view paper
  • Downloaded 762 times
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    • Site-wide: 57,990
    • In epidemiology: 2,759
  • Year to date:
    • Site-wide: 122,829
  • Since beginning of last month:
    • Site-wide: 39,590

A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular disease

genetic and genomic medicine more details view paper
  • Downloaded 687 times
  • Download rankings, all-time:
    • Site-wide: 67,279
    • In genetic and genomic medicine: 412
  • Year to date:
    • Site-wide: 76,173
  • Since beginning of last month:
    • Site-wide: 41,190

Epigenome-wide change and variation in DNA methylation from birth to late adolescence

genomics more details view paper
  • Downloaded 646 times
  • Download rankings, all-time:
    • Site-wide: 73,225
    • In genomics: 4,821
  • Year to date:
    • Site-wide: 174,158
  • Since beginning of last month:
    • Site-wide: 111,553

Epigenome-Wide Association Study Of Asthma And Wheeze In Childhood And Adolescence

epidemiology more details view paper
  • Downloaded 582 times
  • Download rankings, all-time:
    • Site-wide: 83,619
    • In epidemiology: 3,665
  • Year to date:
    • Site-wide: 189,421
  • Since beginning of last month:
    • Site-wide: 80,121

Cholesteryl Ester Transfer Protein as a Drug Target

cardiovascular medicine more details view paper
  • Downloaded 580 times
  • Download rankings, all-time:
    • Site-wide: 83,966
    • In cardiovascular medicine: 185
  • Year to date:
    • Site-wide: 139,761
  • Since beginning of last month:
    • Site-wide: 110,023

Navigating sample overlap, winner's curse and weak instrument bias in Mendelian randomization studies using the UK Biobank

epidemiology more details view paper
  • Downloaded 575 times
  • Download rankings, all-time:
    • Site-wide: 85,017
    • In epidemiology: 4,350
  • Year to date:
    • Site-wide: 15,361
  • Since beginning of last month:
    • Site-wide: 14,103

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

genomics more details view paper
  • Downloaded 535 times
  • Download rankings, all-time:
    • Site-wide: 92,795
    • In genomics: 5,580
  • Year to date:
    • Site-wide: 201,890
  • Since beginning of last month:
    • Site-wide: 78,786

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

genetics more details view paper
  • Downloaded 507 times
  • Download rankings, all-time:
    • Site-wide: 98,735
    • In genetics: 3,660
  • Year to date:
    • Site-wide: 199,575
  • Since beginning of last month:
    • Site-wide: 181,217

Triangulating molecular evidence to prioritise candidate causal genes at established atopic dermatitis loci

genetic and genomic medicine more details view paper
  • Downloaded 490 times
  • Download rankings, all-time:
    • Site-wide: 102,547
    • In genetic and genomic medicine: 636
  • Year to date:
    • Site-wide: 112,069
  • Since beginning of last month:
    • Site-wide: 112,884

Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships

genetic and genomic medicine more details view paper
  • Downloaded 484 times
  • Download rankings, all-time:
    • Site-wide: 104,058
    • In genetic and genomic medicine: 642
  • Year to date:
    • Site-wide: 135,496
  • Since beginning of last month:
    • Site-wide: 89,248

Diagnosis of coronary heart diseases using gene expression profiling; stable coronary artery disease, cardiac ischemia with and without myocardial necrosis

bioinformatics more details view paper
  • Downloaded 484 times
  • Download rankings, all-time:
    • Site-wide: 104,126
    • In bioinformatics: 8,556
  • Year to date:
    • Site-wide: 206,565
  • Since beginning of last month:
    • Site-wide: 173,760

Association of changing physical activity intensity and bout length with mortality: a study of 79,507 participants in UK Biobank

epidemiology more details view paper
  • Downloaded 465 times
  • Download rankings, all-time:
    • Site-wide: 108,551
    • In epidemiology: 4,534
  • Year to date:
    • Site-wide: 151,737
  • Since beginning of last month:
    • Site-wide: None

Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation

genetic and genomic medicine more details view paper
  • Downloaded 452 times
  • Download rankings, all-time:
    • Site-wide: 111,465
    • In genetic and genomic medicine: 811
  • Year to date:
    • Site-wide: 12,793
  • Since beginning of last month:
    • Site-wide: 22,417

The effect of circulating zinc, selenium, copper and vitamin K1 on COVID-19 outcomes: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 399 times
  • Download rankings, all-time:
    • Site-wide: 125,558
    • In epidemiology: 5,434
  • Year to date:
    • Site-wide: 54,325
  • Since beginning of last month:
    • Site-wide: 117,137

An Informatics Consult approach for generating clinical evidence for treatment decisions

health informatics more details view paper
  • Downloaded 357 times
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    • Site-wide: 137,718
    • In health informatics: 615
  • Year to date:
    • Site-wide: 163,763
  • Since beginning of last month:
    • Site-wide: None

Characterizing the human methylome across the life course: findings from eight UK-based studies

genetics more details view paper
  • Downloaded 341 times
  • Download rankings, all-time:
    • Site-wide: 142,458
    • In genetics: 5,505
  • Year to date:
    • Site-wide: 84,026
  • Since beginning of last month:
    • Site-wide: 30,047

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimers disease risk in the general population: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 337 times
  • Download rankings, all-time:
    • Site-wide: 143,671
    • In epidemiology: 6,205
  • Year to date:
    • Site-wide: 20,836
  • Since beginning of last month:
    • Site-wide: 52,593

Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases

epidemiology more details view paper
  • Downloaded 326 times
  • Download rankings, all-time:
    • Site-wide: 146,858
    • In epidemiology: 6,597
  • Year to date:
    • Site-wide: 21,900
  • Since beginning of last month:
    • Site-wide: 26,407

EpiGraphDB: a database and data mining platform for health data science

bioinformatics more details view paper
  • Downloaded 323 times
  • Download rankings, all-time:
    • Site-wide: 147,850
    • In bioinformatics: 11,266
  • Year to date:
    • Site-wide: 184,456
  • Since beginning of last month:
    • Site-wide: 114,781

Evidence of positive and negative selection associated with DNA methylation

genetics more details view paper
  • Downloaded 317 times
  • Download rankings, all-time:
    • Site-wide: 149,776
    • In genetics: 5,625
  • Year to date:
    • Site-wide: 82,152
  • Since beginning of last month:
    • Site-wide: 169,616

An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo)

bioinformatics more details view paper
  • Downloaded 295 times
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    • Site-wide: 156,320
    • In bioinformatics: 14,288
  • Year to date:
    • Site-wide: 25,783
  • Since beginning of last month:
    • Site-wide: 173,157

Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease status

genetics more details view paper
  • Downloaded 274 times
  • Download rankings, all-time:
    • Site-wide: 162,249
    • In genetics: 6,059
  • Year to date:
    • Site-wide: 61,651
  • Since beginning of last month:
    • Site-wide: 18,824

Exploring the variance in complex traits captured by DNA methylation assays

genetics more details view paper
  • Downloaded 273 times
  • Download rankings, all-time:
    • Site-wide: 162,607
    • In genetics: 6,065
  • Year to date:
    • Site-wide: 135,354
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    • Site-wide: 42,357

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples

genetic and genomic medicine more details view paper
  • Downloaded 270 times
  • Download rankings, all-time:
    • Site-wide: 163,612
    • In genetic and genomic medicine: 1,192
  • Year to date:
    • Site-wide: 43,814
  • Since beginning of last month:
    • Site-wide: 44,274

Evaluating the potential benefits and pitfalls of combining protein and expression quantitative trait loci in evidencing drug targets

genetics more details view paper
  • Downloaded 261 times
  • Download rankings, all-time:
    • Site-wide: 166,216
    • In genetics: 6,247
  • Year to date:
    • Site-wide: 31,076
  • Since beginning of last month:
    • Site-wide: 85,955

DNA co-methylation has a stable structure and is related to specific aspects of genome regulation

bioinformatics more details view paper
  • Downloaded 251 times
  • Download rankings, all-time:
    • Site-wide: 168,863
    • In bioinformatics: 12,764
  • Year to date:
    • Site-wide: 32,754
  • Since beginning of last month:
    • Site-wide: 71,398

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study

epidemiology more details view paper
  • Downloaded 197 times
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    • Site-wide: 182,732
    • In epidemiology: 7,443
  • Year to date:
    • Site-wide: 46,361
  • Since beginning of last month:
    • Site-wide: 19,118

Triangulating evidence in health sciences with Annotated Semantic Queries

health informatics more details view paper
  • Downloaded 177 times
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    • Site-wide: 187,303
    • In health informatics: 882
  • Year to date:
    • Site-wide: 53,791
  • Since beginning of last month:
    • Site-wide: 71,575

A comparison of the genes and genesets identified by EWAS and GWAS of fourteen complex traits

epidemiology more details view paper
  • Downloaded 175 times
  • Download rankings, all-time:
    • Site-wide: 187,752
    • In epidemiology: 7,415
  • Year to date:
    • Site-wide: 54,544
  • Since beginning of last month:
    • Site-wide: 26,906

Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

epidemiology more details view paper
  • Downloaded 167 times
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    • Site-wide: 189,493
    • In epidemiology: 7,412
  • Year to date:
    • Site-wide: 152,918
  • Since beginning of last month:
    • Site-wide: 150,778

Genetically proxied PCSK9 inhibition provides indication of lower prostate cancer risk: a Mendelian randomization study

oncology more details view paper
  • Downloaded 161 times
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    • Site-wide: 190,619
    • In oncology: 729
  • Year to date:
    • Site-wide: 60,209
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    • Site-wide: None

Integrating Mendelian randomization and literature-mined evidence for breast cancer risk factors

epidemiology more details view paper
  • Downloaded 144 times
  • Download rankings, all-time:
    • Site-wide: 193,770
    • In epidemiology: 7,901
  • Year to date:
    • Site-wide: 68,093
  • Since beginning of last month:
    • Site-wide: 15,532

Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins

cardiovascular medicine more details view paper
  • Downloaded 140 times
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    • Site-wide: 194,522
    • In cardiovascular medicine: 694
  • Year to date:
    • Site-wide: 69,533
  • Since beginning of last month:
    • Site-wide: 137,336

Automated development of clinical prediction models enables real-time risk stratification with exemplar application to hypoxic-ischaemic encephalopathy

health informatics more details view paper
  • Downloaded 133 times
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    • Site-wide: 195,838
    • In health informatics: 928
  • Year to date:
    • Site-wide: 73,410
  • Since beginning of last month:
    • Site-wide: 17,139

Using language models and ontology topology to perform semantic mapping of traits between biomedical datasets

bioinformatics more details view paper
  • Downloaded 110 times
  • Download rankings, all-time:
    • Site-wide: 199,706
    • In bioinformatics: None
  • Year to date:
    • Site-wide: 87,228
  • Since beginning of last month:
    • Site-wide: 22,733

Examining the evidence for Mendelian randomization homogeneity assumption violation using instrument association with exposure variance

epidemiology more details view paper
  • Downloaded 58 times
  • Download rankings, all-time:
    • Site-wide: 207,535
    • In epidemiology: None
  • Year to date:
    • Site-wide: 151,349
  • Since beginning of last month:
    • Site-wide: 121,827

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