Author: James G Wilson

Downloads per author, site-wide

Preprints

Analysis of protein-coding genetic variation in 60,706 humans

• Downloaded 22,018 times
• Download rankings, all-time:
  • Site-wide: 307
  • In genomics: 11
• Year to date:
  • Site-wide: 24,954
• Since beginning of last month:
  • Site-wide: 21,889

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 8,181 times
• Download rankings, all-time:
  • Site-wide: 1,049
  • In genomics: 95
• Year to date:
  • Site-wide: 2,341
• Since beginning of last month:
  • Site-wide: 5,676

An epigenetic biomarker of aging for lifespan and healthspan

• Downloaded 2,937 times
• Download rankings, all-time:
  • Site-wide: 4,279
  • In epidemiology: 390
• Year to date:
  • Site-wide: 34,946
• Since beginning of last month:
  • Site-wide: 26,782

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 2,917 times
• Download rankings, all-time:
  • Site-wide: 4,318
  • In genomics: 478
• Year to date:
  • Site-wide: 6,926
• Since beginning of last month:
  • Site-wide: 7,421

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

• Downloaded 2,370 times
• Download rankings, all-time:
  • Site-wide: 5,854
  • In genomics: 660
• Year to date:
  • Site-wide: 60,914
• Since beginning of last month:
  • Site-wide: 88,772

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,092 times
• Download rankings, all-time:
  • Site-wide: 7,022
  • In genomics: 774
• Year to date:
  • Site-wide: 127,581
• Since beginning of last month:
  • Site-wide: 114,842

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,851 times
• Download rankings, all-time:
  • Site-wide: 8,446
  • In genetics: 396
• Year to date:
  • Site-wide: 90,476
• Since beginning of last month:
  • Site-wide: 94,685

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,660 times
• Download rankings, all-time:
  • Site-wide: 9,934
  • In genetics: 472
• Year to date:
  • Site-wide: 66,827
• Since beginning of last month:
  • Site-wide: 48,007

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

• Downloaded 1,655 times
• Download rankings, all-time:
  • Site-wide: 9,978
  • In genetics: 477
• Year to date:
  • Site-wide: 72,456
• Since beginning of last month:
  • Site-wide: 62,029

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,206 times
• Download rankings, all-time:
  • Site-wide: 16,004
  • In genetics: 790
• Year to date:
  • Site-wide: 5,543
• Since beginning of last month:
  • Site-wide: 4,874

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 1,180 times
• Download rankings, all-time:
  • Site-wide: 16,545
  • In hiv aids: 7
• Year to date:
  • Site-wide: 6,288
• Since beginning of last month:
  • Site-wide: 3,828

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,083 times
• Download rankings, all-time:
  • Site-wide: 18,761
  • In genetic and genomic medicine: 66
• Year to date:
  • Site-wide: 8,274
• Since beginning of last month:
  • Site-wide: 10,855

Genome-wide association study of asthma in individuals of African ancestry reveals novel asthma susceptibility loci

• Downloaded 948 times
• Download rankings, all-time:
  • Site-wide: 22,736
  • In bioinformatics: 2,690
• Year to date:
  • Site-wide: 85,509
• Since beginning of last month:
  • Site-wide: 87,821

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 877 times
• Download rankings, all-time:
  • Site-wide: 25,469
  • In genetics: 1,228
• Year to date:
  • Site-wide: 20,462
• Since beginning of last month:
  • Site-wide: 12,631

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

• Downloaded 840 times
• Download rankings, all-time:
  • Site-wide: 27,025
  • In genetics: 1,304
• Year to date:
  • Site-wide: 95,777
• Since beginning of last month:
  • Site-wide: 101,091

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

• Downloaded 811 times
• Download rankings, all-time:
  • Site-wide: 28,424
  • In genetic and genomic medicine: 91
• Year to date:
  • Site-wide: 28,450
• Since beginning of last month:
  • Site-wide: 25,000

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 31,883
  • In genomics: 2,829
• Year to date:
  • Site-wide: 73,959
• Since beginning of last month:
  • Site-wide: 88,720

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

• Downloaded 740 times
• Download rankings, all-time:
  • Site-wide: 32,321
  • In genomics: 2,859
• Year to date:
  • Site-wide: 116,782
• Since beginning of last month:
  • Site-wide: 133,371

De novo mutations across 1,465 diverse genomes reveal novel mutational insights and reductions in the Amish founder population.

• Downloaded 701 times
• Download rankings, all-time:
  • Site-wide: 34,809
  • In genetics: 1,666
• Year to date:
  • Site-wide: 68,036
• Since beginning of last month:
  • Site-wide: 54,114

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 37,169
  • In genomics: 3,160
• Year to date:
  • Site-wide: 78,307
• Since beginning of last month:
  • Site-wide: 108,702

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 617 times
• Download rankings, all-time:
  • Site-wide: 41,049
  • In genetics: 1,947
• Year to date:
  • Site-wide: 5,375
• Since beginning of last month:
  • Site-wide: 17,873

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 614 times
• Download rankings, all-time:
  • Site-wide: 41,382
  • In genetics: 1,956
• Year to date:
  • Site-wide: 92,178
• Since beginning of last month:
  • Site-wide: 62,327

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 476 times
• Download rankings, all-time:
  • Site-wide: 56,160
  • In genetics: 2,610
• Year to date:
  • Site-wide: 119,870
• Since beginning of last month:
  • Site-wide: 133,276

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 59,807
  • In genetics: 2,775
• Year to date:
  • Site-wide: 62,447
• Since beginning of last month:
  • Site-wide: 48,021

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 78,207
  • In genetic and genomic medicine: 275
• Year to date:
  • Site-wide: 21,269
• Since beginning of last month:
  • Site-wide: 16,985

Biological Pathways and Gene Networks Link Inflammation and Vascular Remodeling to Both Heart Failure with Preserved and Reduced Ejection Fraction in Women across Ethnicities

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 86,587
  • In genetics: 3,923
• Year to date:
  • Site-wide: 78,453
• Since beginning of last month:
  • Site-wide: 58,629

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 293 times
• Download rankings, all-time:
  • Site-wide: 87,102
  • In epidemiology: 3,573
• Year to date:
  • Site-wide: 41,556
• Since beginning of last month:
  • Site-wide: 57,120

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 112,370
  • In genetic and genomic medicine: 504
• Year to date:
  • Site-wide: 13,510
• Since beginning of last month:
  • Site-wide: 41,034