Author: Zhenghong Yuan

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Preprints

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2

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The S1/S2 boundary of SARS-CoV-2 spike protein modulates cell entry pathways and transmission

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• Year to date:
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Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids

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  • In cell biology: 128
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Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

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Protoporphyrin IX and verteporfin prevent SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

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Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity.

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A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2

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Extracellular HBV RNAs are heterogeneous in length and circulate as virions and capsid-antibody-complexes in chronic hepatitis B patients

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A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

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Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

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Functional mapping of B-cell linear epitopes 1 of SARS-CoV-2 in COVID-19 convalescent population

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Hepatitis C virus NS5A inhibitor daclatasvir allosterically impairs NS4B-involved protein-protein interactions within the viral replicase and disrupts the replicase quaternary structure in a replicase assembly surrogate system

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Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

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  • In immunology: 2,890
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Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

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  • In cell biology: 4,985
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Susceptibilities of human ACE2 genetic variants in coronavirus infection

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Spatial and functional links between cellular virological state and progression of liver fibrosis in chronic hepatitis B

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  • In microbiology: 9,846
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Single-cell transcriptome profiling simulation reveals the impact of sequencing parameters and algorithms on clustering

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  • In bioinformatics: 10,683
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