Author: Yi Yang

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Preprints

REAP: A platform to identify autoantibodies that target the human exoproteome

• Downloaded 4,551 times
• Download rankings, all-time:
  • Site-wide: 3,881
  • In immunology: 158
• Year to date:
  • Site-wide: 2,152
• Since beginning of last month:
  • Site-wide: 4,626

Effect of continuous renal replacement therapy on all-cause mortality in COVID-19 patients undergoing invasive mechanical ventilation: a retrospective cohort study

• Downloaded 4,384 times
• Download rankings, all-time:
  • Site-wide: 4,078
  • In infectious diseases: 901
• Year to date:
  • Site-wide: 28,909
• Since beginning of last month:
  • Site-wide: 28,582

Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models

• Downloaded 2,291 times
• Download rankings, all-time:
  • Site-wide: 10,603
  • In bioinformatics: 1,088
• Year to date:
  • Site-wide: 66,544
• Since beginning of last month:
  • Site-wide: 175,565

The origin of domestication genes in goats

• Downloaded 1,252 times
• Download rankings, all-time:
  • Site-wide: 27,172
  • In genomics: 2,294
• Year to date:
  • Site-wide: 72,921
• Since beginning of last month:
  • Site-wide: 180,840

A Sparse Additive Model for High-Dimensional Interactions with an Exposure Variable

• Downloaded 1,248 times
• Download rankings, all-time:
  • Site-wide: 27,298
  • In bioinformatics: 3,092
• Year to date:
  • Site-wide: 42,466
• Since beginning of last month:
  • Site-wide: 14,763

Deep Unfolded Robust PCA with Application to Clutter Suppression in Ultrasound

• Downloaded 1,177 times
• Download rankings, all-time:
  • Site-wide: 29,915
  • In bioengineering: 580
• Year to date:
  • Site-wide: 39,635
• Since beginning of last month:
  • Site-wide: 14,743

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropy

• Downloaded 1,163 times
• Download rankings, all-time:
  • Site-wide: 30,477
  • In genetics: 1,200
• Year to date:
  • Site-wide: 150,873
• Since beginning of last month:
  • Site-wide: None

Joint dimension reduction and clustering analysis for single-cell RNA-seq and spatial transcriptomics data

• Downloaded 1,128 times
• Download rankings, all-time:
  • Site-wide: 32,013
  • In genomics: 2,683
• Year to date:
  • Site-wide: 4,148
• Since beginning of last month:
  • Site-wide: 44,485

A high-quality de novo genome assembly from a single parasitoid wasp

• Downloaded 1,084 times
• Download rankings, all-time:
  • Site-wide: 34,000
  • In genomics: 2,719
• Year to date:
  • Site-wide: 62,271
• Since beginning of last month:
  • Site-wide: None

Children Developing Celiac Disease Have a Distinct and Proinflammatory Gut Microbiota in the First 5 Years of Life

• Downloaded 996 times
• Download rankings, all-time:
  • Site-wide: 38,664
  • In microbiology: 2,430
• Year to date:
  • Site-wide: 13,030
• Since beginning of last month:
  • Site-wide: 10,674

An analytic approach for interpretable predictive models in high dimensional data, in the presence of interactions with exposures

• Downloaded 948 times
• Download rankings, all-time:
  • Site-wide: 41,730
  • In genomics: 3,128
• Year to date:
  • Site-wide: 196,279
• Since beginning of last month:
  • Site-wide: None

Age differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multi-center cohort study

• Downloaded 897 times
• Download rankings, all-time:
  • Site-wide: 45,360
  • In infectious diseases: 3,618
• Year to date:
  • Site-wide: 52,211
• Since beginning of last month:
  • Site-wide: 65,080

SC-MEB: spatial clustering with hidden Markov random field using empirical Bayes

• Downloaded 871 times
• Download rankings, all-time:
  • Site-wide: 47,492
  • In genomics: 3,676
• Year to date:
  • Site-wide: 26,459
• Since beginning of last month:
  • Site-wide: 34,823

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

• Downloaded 778 times
• Download rankings, all-time:
  • Site-wide: 56,204
  • In immunology: 1,830
• Year to date:
  • Site-wide: 109,000
• Since beginning of last month:
  • Site-wide: 53,920

CoMM-S2: a collaborative mixed model using summary statistics in transcriptome-wide association studies

• Downloaded 707 times
• Download rankings, all-time:
  • Site-wide: 64,606
  • In bioinformatics: 6,181
• Year to date:
  • Site-wide: 71,490
• Since beginning of last month:
  • Site-wide: 51,386

A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies

• Downloaded 675 times
• Download rankings, all-time:
  • Site-wide: 68,977
  • In bioinformatics: 6,323
• Year to date:
  • Site-wide: 158,757
• Since beginning of last month:
  • Site-wide: 76,263

Tripartite holobiont system in a vent snail broadens the concept of chemosymbiosis

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 86,031
  • In ecology: 2,142
• Year to date:
  • Site-wide: 76,936
• Since beginning of last month:
  • Site-wide: 142,227

A dynamic regulatory interface on SARS-CoV-2 RNA polymerase

• Downloaded 568 times
• Download rankings, all-time:
  • Site-wide: 86,273
  • In molecular biology: 2,402
• Year to date:
  • Site-wide: 130,497
• Since beginning of last month:
  • Site-wide: 114,617

PTRNAmark: an all-atomic distance-dependent knowledge-based potential for 3D RNA structure evaluation

• Downloaded 558 times
• Download rankings, all-time:
  • Site-wide: 88,133
  • In bioinformatics: 7,744
• Year to date:
  • Site-wide: 169,168
• Since beginning of last month:
  • Site-wide: 39,427

β-lactam Antibiotics Stimulate the Pathogenicity of Methicillin-resistant Staphylococcus aureus Via SarA-controlled Tandem Lipoprotein Expression

• Downloaded 556 times
• Download rankings, all-time:
  • Site-wide: 88,637
  • In pathology: 395
• Year to date:
  • Site-wide: 143,976
• Since beginning of last month:
  • Site-wide: 80,404

Dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis revealed by its hologenome

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 93,071
  • In genomics: 5,864
• Year to date:
  • Site-wide: 80,481
• Since beginning of last month:
  • Site-wide: 28,404

GproDIA enables data-independent acquisition glycoproteomics with comprehensive statistical control

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 93,915
  • In bioinformatics: 7,964
• Year to date:
  • Site-wide: 65,533
• Since beginning of last month:
  • Site-wide: 168,919

Pan-genome analysis reveals the molecular basis of niche adaptation of Staphylococcus epidermidis strains

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 96,314
  • In microbiology: 5,961
• Year to date:
  • Site-wide: 175,229
• Since beginning of last month:
  • Site-wide: 154,126

Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8+ T cell responses in HLA-A transgenic mice

• Downloaded 476 times
• Download rankings, all-time:
  • Site-wide: 106,014
  • In immunology: 3,323
• Year to date:
  • Site-wide: 76,019
• Since beginning of last month:
  • Site-wide: 43,686

Probabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 107,227
  • In genomics: 7,890
• Year to date:
  • Site-wide: 11,948
• Since beginning of last month:
  • Site-wide: 13,127

Crystal structure of chromo barrel domain of RBBP1

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 134,025
  • In biochemistry: 3,879
• Year to date:
  • Site-wide: 181,957
• Since beginning of last month:
  • Site-wide: 77,611

hFUT1-based live cell assay to profile α1-2-fucosides enhanced influenza A virus infection

• Downloaded 355 times
• Download rankings, all-time:
  • Site-wide: 138,343
  • In biochemistry: 3,989
• Year to date:
  • Site-wide: 202,517
• Since beginning of last month:
  • Site-wide: 109,911

An Unexpected Single-step Glycosylation Enables the Construction of Antibody-Biomacromolecule Conjugates as Therapeutics

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 140,916
  • In biochemistry: None
• Year to date:
  • Site-wide: 19,984
• Since beginning of last month:
  • Site-wide: 2,592

Computationally reconstructed interactome of Bradyrhizobium diazoefficiens USDA110 reveals novel functional modules and protein hubs for symbiotic nitrogen fixation

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 154,774
  • In systems biology: 3,069
• Year to date:
  • Site-wide: 62,570
• Since beginning of last month:
  • Site-wide: 171,798

Emergent vulnerability to intensive coastal anthropogenic disturbances in mangrove forests

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 169,910
  • In ecology: 5,676
• Year to date:
  • Site-wide: 96,184
• Since beginning of last month:
  • Site-wide: 51,512

Recombinant HcGAPDH Protein Expressed on Probiotic Bacillus subtilis Spores Protects Sheep from Haemonchus contortus Infection by Inducing both Humoral and Cell-mediated Responses

• Downloaded 245 times
• Download rankings, all-time:
  • Site-wide: 170,609
  • In microbiology: 12,121
• Year to date:
  • Site-wide: 155,025
• Since beginning of last month:
  • Site-wide: 185,038

SpatialDEG: Identification of differentially expressed genes by leveraging spatial information in spatially resolved transcriptomic studies

• Downloaded 228 times
• Download rankings, all-time:
  • Site-wide: 175,256
  • In genetics: 6,404
• Year to date:
  • Site-wide: 37,874
• Since beginning of last month:
  • Site-wide: 86,411

Regulating AMPK and insulin level by Vinegar, Swimming and Refeeding on High-Fat Diet Rats to Rebuild Lipid Homeostasis

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 176,191
  • In molecular biology: 5,164
• Year to date:
  • Site-wide: 191,229
• Since beginning of last month:
  • Site-wide: 108,015

The synergistic effects of plants and nitrogen on microbial hitchhiking

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 177,284
  • In microbiology: 14,152
• Year to date:
  • Site-wide: 39,845
• Since beginning of last month:
  • Site-wide: None

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 178,538
  • In immunology: 5,523
• Year to date:
  • Site-wide: 118,595
• Since beginning of last month:
  • Site-wide: 116,816

Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 180,032
  • In microbiology: 13,016
• Year to date:
  • Site-wide: 177,540
• Since beginning of last month:
  • Site-wide: 158,848

MINE is a method for detecting spatial density of regulatory chromatin interactions based on a MultI-modal NEtwork

• Downloaded 132 times
• Download rankings, all-time:
  • Site-wide: 195,995
  • In bioinformatics: 13,954
• Year to date:
  • Site-wide: 74,100
• Since beginning of last month:
  • Site-wide: 186,108

Characterization of the gene expression profile in younger and older low-grade glioma patients

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 198,276
  • In neurology: 1,366
• Year to date:
  • Site-wide: 81,282
• Since beginning of last month:
  • Site-wide: None

Phosphorylation of the Smooth Muscle Master Splicing Regulator RBPMS Regulates its Splicing Activity

• Downloaded 85 times
• Download rankings, all-time:
  • Site-wide: 203,562
  • In molecular biology: None
• Year to date:
  • Site-wide: 110,193
• Since beginning of last month:
  • Site-wide: 72,556