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Author: Joseph Heitman

  • ORCiD: http://orcid.org/0000-0001-6369-5995
  • Most recently observed institution: Departments of Molecular Genetics and Microbiology, Medicine, and Pharmacology and Cancer Biology, Duke University Medical Center

Rankings

  • All-time downloads: 14,090 (rank: 13,501 )
  • Categories:
    • biochemistry: 208 (rank: 20,434 (tie) )
    • evolutionary biology: 999 (rank: 6,789 (tie) )
    • genetics: 5,235 (rank: 3,636 )
    • genomics: 2,739 (rank: 8,768 )
    • microbiology: 4,715 (rank: 2,935 )
    • molecular biology: 194 (rank: 23,356 (tie) )

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Preprints

An atlas of genetic variation for linking pathogen-induced cellular traits to human disease

genetics more details view paper
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Population Genomics Of Cryptococcus neoformans var. grubii Reveals New Biogeographic Relationships And Finely Maps Hybridization

genomics more details view paper
  • Downloaded 1,003 times
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Loss of centromere function drives karyotype evolution in closely related Malassezia species

genomics more details view paper
  • Downloaded 909 times
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Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

microbiology more details view paper
  • Downloaded 621 times
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Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions

genetics more details view paper
  • Downloaded 578 times
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A novel mycovirus evokes transcriptional rewiring in the fungus Malassezia and stimulates interferon-β production in macrophages

microbiology more details view paper
  • Downloaded 531 times
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Convergent evolution of linked mating-type loci in basidiomycete fungi

evolutionary biology more details view paper
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Hypermutation in Cryptococcus reveals a novel pathway to 5-fluorocytosine (5FC) resistance

microbiology more details view paper
  • Downloaded 498 times
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Population Genomics And The Evolution Of Virulence In The Fungal Pathogen Cryptococcus neoformans

genomics more details view paper
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Centromere scission drives chromosome shuffling and reproductive isolation

genetics more details view paper
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Genetic and genomic analyses reveal boundaries between species closely related to Cryptococcus pathogens

evolutionary biology more details view paper
  • Downloaded 475 times
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    • In evolutionary biology: 3,098
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Advancing functional genetics through Agrobacterium-mediated insertional mutagenesis and CRISPR/Cas9 in the commensal and pathogenic yeast Malassezia furfur

microbiology more details view paper
  • Downloaded 452 times
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Horizontal gene transfer in the human and skin commensal Malassezia: a bacterially-derived flavohemoglobin is required for NO resistance and host interaction

microbiology more details view paper
  • Downloaded 450 times
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Mating-type specific ribosomal proteins control aspects of sexual reproduction in Cryptococcus neoformans

genetics more details view paper
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The pheromone and pheromone receptor mating-type locus is involved in controlling uniparental mitochondrial inheritance in Cryptococcus

genetics more details view paper
  • Downloaded 354 times
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Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii

genomics more details view paper
  • Downloaded 337 times
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Whole genome analysis illustrates global clonal population structure of the ubiquitous dermatophyte pathogen Trichophyton rubrum

genetics more details view paper
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Pleiotropy and Epistasis Within and Between Signaling Pathways Defines the Genetic Architecture of Fungal Virulence

genetics more details view paper
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Early diverging fungus Mucor circinelloides lacks centromeric histone CENP-A and displays a mosaic of point and regional centromeres

genetics more details view paper
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Transposon mobilization in the human fungal pathogen Cryptococcus deneoformans is mutagenic during infection and promotes drug resistance in vitro

microbiology more details view paper
  • Downloaded 296 times
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    • In microbiology: 6,265
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Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans

microbiology more details view paper
  • Downloaded 278 times
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    • Site-wide: 92,582
    • In microbiology: 6,619
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A High Resolution Map of Meiotic Recombination in Cryptococcus Demonstrates Decreased Recombination in Unisexual Reproduction

genetics more details view paper
  • Downloaded 271 times
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Cryptococcus deuterogattii VGIIa infection associated with travel to the Pacific Northwest outbreak region in an anti-GM-CSF autoantibody positive patient in the United States

microbiology more details view paper
  • Downloaded 245 times
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A novel resistance pathway for calcineurin inhibitors in the human pathogenic Mucorales Mucor circinelloides

microbiology more details view paper
  • Downloaded 235 times
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Application of an optimized annotation pipeline to the Cryptococcus deuterogattii genome reveals dynamic primary metabolic gene clusters and genomic impact of RNAi loss

microbiology more details view paper
  • Downloaded 232 times
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Outbreak of invasive wound mucormycosis in a burn unit due to multiple strains of Mucor circinelloides f. circinelloides resolved by whole genome sequencing

microbiology more details view paper
  • Downloaded 228 times
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Cryptococcus neoformans recovered from olive trees (Olea europaea) in Turkey reveal allopatry with African and South American lineages

genetics more details view paper
  • Downloaded 227 times
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Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans

genetics more details view paper
  • Downloaded 221 times
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Designing Selective and Non-Immunosuppressive Antifungal FK506 Analogs: Structures, Biophysics and Dynamics of Fungal and Human Calcineurin-Inhibitor Complexes

biochemistry more details view paper
  • Downloaded 208 times
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Expression of a Malassezia codon optimized mCherry fluorescent protein in a bicistronic vector

molecular biology more details view paper
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    • In molecular biology: 3,321
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Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides

microbiology more details view paper
  • Downloaded 189 times
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Tornadic shear stress induces a transient, calcineurin-dependent hyper-virulent phenotype in Mucorales molds

microbiology more details view paper
  • Downloaded 174 times
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Drug-resistant epimutants exhibit organ-specific stability and induction during murine infections caused by the human fungal pathogen Mucor circinelloides

microbiology more details view paper
  • Downloaded 155 times
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Neocentromeres lack epigenetic memory and hallmarks of native centromeres in Cryptococcus deuterogattii

genetics more details view paper
  • Downloaded 152 times
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Multiple pathways to homothallism in closely related yeast lineages in the Basidiomycota

microbiology more details view paper
  • Downloaded 131 times
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Clonal evolution in serially passaged Cryptococcus neoformans x deneoformans hybrids reveals a heterogenous landscape of mitotic recombination

genetics more details view paper
  • Downloaded 94 times
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