Author: Peter Van Loo

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Preprints

The evolutionary history of 2,658 cancers

• Downloaded 9,680 times
• Download rankings, all-time:
  • Site-wide: 1,197
  • In cancer biology: 8
• Year to date:
  • Site-wide: 46,637
• Since beginning of last month:
  • Site-wide: 37,896

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

• Downloaded 6,361 times
• Download rankings, all-time:
  • Site-wide: 2,043
  • In cancer biology: 20
• Year to date:
  • Site-wide: 16,487
• Since beginning of last month:
  • Site-wide: 23,536

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours

• Downloaded 3,771 times
• Download rankings, all-time:
  • Site-wide: 4,180
  • In genomics: 404
• Year to date:
  • Site-wide: 98,777
• Since beginning of last month:
  • Site-wide: 33,670

Mutational signatures associated with tobacco smoking in human cancer

• Downloaded 3,626 times
• Download rankings, all-time:
  • Site-wide: 4,408
  • In cancer biology: 59
• Year to date:
  • Site-wide: 77,133
• Since beginning of last month:
  • Site-wide: 103,760

Universal Patterns Of Selection In Cancer And Somatic Tissues

• Downloaded 3,388 times
• Download rankings, all-time:
  • Site-wide: 4,856
  • In genomics: 468
• Year to date:
  • Site-wide: 99,936
• Since beginning of last month:
  • Site-wide: 123,798

Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

• Downloaded 2,527 times
• Download rankings, all-time:
  • Site-wide: 7,406
  • In genomics: 743
• Year to date:
  • Site-wide: 36,017
• Since beginning of last month:
  • Site-wide: 71,476

Neutral tumor evolution?

• Downloaded 2,152 times
• Download rankings, all-time:
  • Site-wide: 9,347
  • In cancer biology: 157
• Year to date:
  • Site-wide: 102,413
• Since beginning of last month:
  • Site-wide: 160,159

Creating Standards for Evaluating Tumour Subclonal Reconstruction

• Downloaded 2,132 times
• Download rankings, all-time:
  • Site-wide: 9,472
  • In bioinformatics: 1,026
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 61,272

Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer

• Downloaded 1,364 times
• Download rankings, all-time:
  • Site-wide: 18,584
  • In genomics: 1,740
• Year to date:
  • Site-wide: 12,545
• Since beginning of last month:
  • Site-wide: 15,596

Copy number-aware deconvolution of tumor-normal DNA methylation profiles

• Downloaded 1,254 times
• Download rankings, all-time:
  • Site-wide: 21,070
  • In genomics: 1,934
• Year to date:
  • Site-wide: 63,391
• Since beginning of last month:
  • Site-wide: 35,566

Signatures of copy number alterations in human cancer

• Downloaded 1,186 times
• Download rankings, all-time:
  • Site-wide: 22,997
  • In cancer biology: 554
• Year to date:
  • Site-wide: 2,822
• Since beginning of last month:
  • Site-wide: 4,057

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

• Downloaded 1,064 times
• Download rankings, all-time:
  • Site-wide: 27,160
  • In bioinformatics: 2,980
• Year to date:
  • Site-wide: 153,114
• Since beginning of last month:
  • Site-wide: 8,892

Biallelic mutations in cancer genomes reveal local mutational determinants

• Downloaded 863 times
• Download rankings, all-time:
  • Site-wide: 36,925
  • In cancer biology: 988
• Year to date:
  • Site-wide: 13,406
• Since beginning of last month:
  • Site-wide: 48,784

Allele-specific multi-sample copy number segmentation

• Downloaded 851 times
• Download rankings, all-time:
  • Site-wide: 37,642
  • In bioinformatics: 3,996
• Year to date:
  • Site-wide: 141,136
• Since beginning of last month:
  • Site-wide: 82,598

An Integrative Analysis of the Age-Associated Genomic, Transcriptomic and Epigenetic Landscape across Cancers

• Downloaded 691 times
• Download rankings, all-time:
  • Site-wide: 50,664
  • In cancer biology: 1,420
• Year to date:
  • Site-wide: 89,683
• Since beginning of last month:
  • Site-wide: 129,739

A pan-cancer landscape of somatic substitutions in non-unique regions of the human genome

• Downloaded 620 times
• Download rankings, all-time:
  • Site-wide: 58,561
  • In genomics: 4,239
• Year to date:
  • Site-wide: 31,377
• Since beginning of last month:
  • Site-wide: 88,850

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 74,701
  • In cancer biology: 2,172
• Year to date:
  • Site-wide: 95,352
• Since beginning of last month:
  • Site-wide: 26,319

Copy number motifs expose genome instability type and predict driver events and disease outcome in breast cancer

• Downloaded 440 times
• Download rankings, all-time:
  • Site-wide: 87,434
  • In bioinformatics: 7,795
• Year to date:
  • Site-wide: 146,450
• Since beginning of last month:
  • Site-wide: 138,006

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 88,148
  • In genomics: 5,598
• Year to date:
  • Site-wide: 116,810
• Since beginning of last month:
  • Site-wide: 74,327

Drivers underpinning the malignant transformation of giant cell tumour of bone

• Downloaded 240 times
• Download rankings, all-time:
  • Site-wide: 137,071
  • In genetic and genomic medicine: 823
• Year to date:
  • Site-wide: 90,037
• Since beginning of last month:
  • Site-wide: 56,988

A Genetic Model for Central Chondrosarcoma Evolution Correlates with Patient Outcome

• Downloaded 100 times
• Download rankings, all-time:
  • Site-wide: 166,553
  • In genetic and genomic medicine: 1,137
• Year to date:
  • Site-wide: 97,509
• Since beginning of last month:
  • Site-wide: 22,962