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Author: John Danesh

  • ORCiD: http://orcid.org/0000-0003-1158-6791
  • Most recently observed institution: The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge

Rankings

  • All-time downloads: 70,955 (rank: 1,775 )
  • Categories:
    • epidemiology: 968 (rank: 7,651 (tie) )
    • genetic and genomic medicine: 6,828 (rank: 88 )
    • genetics: 28,384 (rank: 204 )
    • genomics: 34,339 (rank: 236 )
    • hematology: 183 (rank: 684 (tie) )
    • public and global health: 253 (rank: 5,957 (tie) )

Downloads per author, site-wide

Preprints

Analysis of protein-coding genetic variation in 60,706 humans

genomics more details view paper
  • Downloaded 21,895 times
  • Download rankings, all-time:
    • Site-wide: 271
    • In genomics: 10
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 61,826

Consequences Of Natural Perturbations In The Human Plasma Proteome

genomics more details view paper
  • Downloaded 4,230 times
  • Download rankings, all-time:
    • Site-wide: 2,146
    • In genomics: 257
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 100,970

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention

genetics more details view paper
  • Downloaded 4,048 times
  • Download rankings, all-time:
    • Site-wide: 2,285
    • In genetics: 97
  • Year to date:
    • Site-wide: 18,430
  • Since beginning of last month:
    • Site-wide: 10,432

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
  • Downloaded 3,634 times
  • Download rankings, all-time:
    • Site-wide: 2,673
    • In genetics: 111
  • Year to date:
    • Site-wide: 5,741
  • Since beginning of last month:
    • Site-wide: 7,899

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,027 times
  • Download rankings, all-time:
    • Site-wide: 3,519
    • In genetics: 165
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 59,760

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

genomics more details view paper
  • Downloaded 2,319 times
  • Download rankings, all-time:
    • Site-wide: 5,181
    • In genomics: 622
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 67,597

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

genetics more details view paper
  • Downloaded 2,180 times
  • Download rankings, all-time:
    • Site-wide: 5,664
    • In genetics: 286
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 6,614

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

genetics more details view paper
  • Downloaded 2,091 times
  • Download rankings, all-time:
    • Site-wide: 6,013
    • In genetics: 305
  • Year to date:
    • Site-wide: 3,901
  • Since beginning of last month:
    • Site-wide: 8,814

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

genetics more details view paper
  • Downloaded 1,995 times
  • Download rankings, all-time:
    • Site-wide: 6,428
    • In genetics: 324
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 12,412

The Polygenic and Monogenic Basis of Blood Traits and Diseases

genetic and genomic medicine more details view paper
  • Downloaded 1,900 times
  • Download rankings, all-time:
    • Site-wide: 6,935
    • In genetic and genomic medicine: 17
  • Year to date:
    • Site-wide: 30,855
  • Since beginning of last month:
    • Site-wide: 10,645

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,833 times
  • Download rankings, all-time:
    • Site-wide: 7,310
    • In genetics: 365
  • Year to date:
    • Site-wide: 28,248
  • Since beginning of last month:
    • Site-wide: 78,121

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,627 times
  • Download rankings, all-time:
    • Site-wide: 8,742
    • In genetics: 450
  • Year to date:
    • Site-wide: 40,216
  • Since beginning of last month:
    • Site-wide: 28,708

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

genetic and genomic medicine more details view paper
  • Downloaded 1,618 times
  • Download rankings, all-time:
    • Site-wide: 8,821
    • In genetic and genomic medicine: 22
  • Year to date:
    • Site-wide: 22,746
  • Since beginning of last month:
    • Site-wide: 19,445

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

genomics more details view paper
  • Downloaded 1,540 times
  • Download rankings, all-time:
    • Site-wide: 9,510
    • In genomics: 1,082
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 59,231

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

genetic and genomic medicine more details view paper
  • Downloaded 1,489 times
  • Download rankings, all-time:
    • Site-wide: 9,967
    • In genetic and genomic medicine: 28
  • Year to date:
    • Site-wide: 52,497
  • Since beginning of last month:
    • Site-wide: 24,329

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

genetics more details view paper
  • Downloaded 1,453 times
  • Download rankings, all-time:
    • Site-wide: 10,332
    • In genetics: 531
  • Year to date:
    • Site-wide: 12,973
  • Since beginning of last month:
    • Site-wide: 16,767

Learning polygenic scores for human blood cell traits

genetics more details view paper
  • Downloaded 1,369 times
  • Download rankings, all-time:
    • Site-wide: 11,353
    • In genetics: 593
  • Year to date:
    • Site-wide: 44,870
  • Since beginning of last month:
    • Site-wide: 17,040

Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

genetics more details view paper
  • Downloaded 1,098 times
  • Download rankings, all-time:
    • Site-wide: 15,804
    • In genetics: 826
  • Year to date:
    • Site-wide: 10,268
  • Since beginning of last month:
    • Site-wide: 47,176

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

genetic and genomic medicine more details view paper
  • Downloaded 1,053 times
  • Download rankings, all-time:
    • Site-wide: 16,812
    • In genetic and genomic medicine: 46
  • Year to date:
    • Site-wide: 10,768
  • Since beginning of last month:
    • Site-wide: 6,596

Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: Prospective cohort study and modelling analysis

genomics more details view paper
  • Downloaded 1,008 times
  • Download rankings, all-time:
    • Site-wide: 17,970
    • In genomics: 1,898
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 87,857

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

genomics more details view paper
  • Downloaded 995 times
  • Download rankings, all-time:
    • Site-wide: 18,337
    • In genomics: 1,926
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 101,538

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

genomics more details view paper
  • Downloaded 981 times
  • Download rankings, all-time:
    • Site-wide: 18,698
    • In genomics: 1,958
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 97,396

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

genomics more details view paper
  • Downloaded 774 times
  • Download rankings, all-time:
    • Site-wide: 26,237
    • In genomics: 2,507
  • Year to date:
    • Site-wide: 57,380
  • Since beginning of last month:
    • Site-wide: 70,074

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 764 times
  • Download rankings, all-time:
    • Site-wide: 26,665
    • In genetics: 1,356
  • Year to date:
    • Site-wide: 11,688
  • Since beginning of last month:
    • Site-wide: 18,141

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

genetics more details view paper
  • Downloaded 747 times
  • Download rankings, all-time:
    • Site-wide: 27,581
    • In genetics: 1,409
  • Year to date:
    • Site-wide: 72,028
  • Since beginning of last month:
    • Site-wide: 86,019

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

epidemiology more details view paper
  • Downloaded 639 times
  • Download rankings, all-time:
    • Site-wide: 34,040
    • In epidemiology: 1,611
  • Year to date:
    • Site-wide: 75,219
  • Since beginning of last month:
    • Site-wide: 84,794

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

genetics more details view paper
  • Downloaded 628 times
  • Download rankings, all-time:
    • Site-wide: 34,805
    • In genetics: 1,757
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 59,698

South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine

genomics more details view paper
  • Downloaded 597 times
  • Download rankings, all-time:
    • Site-wide: 37,129
    • In genomics: 3,198
  • Year to date:
    • Site-wide: 15,423
  • Since beginning of last month:
    • Site-wide: 8,052

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 462 times
  • Download rankings, all-time:
    • Site-wide: 50,511
    • In genetics: 2,466
  • Year to date:
    • Site-wide: 405
  • Since beginning of last month:
    • Site-wide: 1,009

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

genetic and genomic medicine more details view paper
  • Downloaded 436 times
  • Download rankings, all-time:
    • Site-wide: 53,761
    • In genetic and genomic medicine: 144
  • Year to date:
    • Site-wide: 73,604
  • Since beginning of last month:
    • Site-wide: 52,622

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

genetics more details view paper
  • Downloaded 392 times
  • Download rankings, all-time:
    • Site-wide: 59,793
    • In genetics: 2,886
  • Year to date:
    • Site-wide: 31,397
  • Since beginning of last month:
    • Site-wide: 81,810

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

genetics more details view paper
  • Downloaded 376 times
  • Download rankings, all-time:
    • Site-wide: 62,267
    • In genetics: 2,994
  • Year to date:
    • Site-wide: 44,681
  • Since beginning of last month:
    • Site-wide: 58,828

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

genetics more details view paper
  • Downloaded 351 times
  • Download rankings, all-time:
    • Site-wide: 66,395
    • In genetics: 3,168
  • Year to date:
    • Site-wide: 51,091
  • Since beginning of last month:
    • Site-wide: 96,568

Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

genetic and genomic medicine more details view paper
  • Downloaded 332 times
  • Download rankings, all-time:
    • Site-wide: 69,643
    • In genetic and genomic medicine: 194
  • Year to date:
    • Site-wide: 9,174
  • Since beginning of last month:
    • Site-wide: 11,822

The influence of rare variants in circulating metabolic biomarkers

genetics more details view paper
  • Downloaded 309 times
  • Download rankings, all-time:
    • Site-wide: 73,708
    • In genetics: 3,494
  • Year to date:
    • Site-wide: 64,867
  • Since beginning of last month:
    • Site-wide: 83,568

The 4C Initiative (Clinical Care for Cardiovascular disease in the COVID-19 pandemic): monitoring the indirect impact of the coronavirus pandemic on services for cardiovascular diseases in the UK

public and global health more details view paper
  • Downloaded 253 times
  • Download rankings, all-time:
    • Site-wide: 84,923
    • In public and global health: 834
  • Year to date:
    • Site-wide: 34,767
  • Since beginning of last month:
    • Site-wide: 48,293

Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

epidemiology more details view paper
  • Downloaded 194 times
  • Download rankings, all-time:
    • Site-wide: 97,126
    • In epidemiology: 3,908
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 10,837

Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

hematology more details view paper
  • Downloaded 183 times
  • Download rankings, all-time:
    • Site-wide: 99,357
    • In hematology: 57
  • Year to date:
    • Site-wide: 8,814
  • Since beginning of last month:
    • Site-wide: 7,777

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

epidemiology more details view paper
  • Downloaded 135 times
  • Download rankings, all-time:
    • Site-wide: 108,588
    • In epidemiology: 4,350
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: None

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