Author: John Danesh

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Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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Analysis of protein-coding genetic variation in 60,706 humans

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Consequences Of Natural Perturbations In The Human Plasma Proteome

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Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

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Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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The Polygenic and Monogenic Basis of Blood Traits and Diseases

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

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ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

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Learning polygenic scores for human blood cell traits

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The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

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Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

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Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: Prospective cohort study and modelling analysis

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Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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Genetic effects on promoter usage are highly context-specific and contribute to complex traits

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

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Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

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Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

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South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine

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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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Accuracy of four lateral flow immunoassays for anti SARS-CoV-2 antibodies: a head-to-head comparative study

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Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

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Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

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Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

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Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

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Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

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The influence of rare variants in circulating metabolic biomarkers

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The 4C Initiative (Clinical Care for Cardiovascular disease in the COVID-19 pandemic): monitoring the indirect impact of the coronavirus pandemic on services for cardiovascular diseases in the UK

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Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

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