Author: John Danesh

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • Site-wide: 271
  • In genomics: 10
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 61,826

Consequences Of Natural Perturbations In The Human Plasma Proteome

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  • Site-wide: 2,146
  • In genomics: 257
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• Since beginning of last month:
  • Site-wide: 100,970

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention

• Downloaded 4,048 times
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  • Site-wide: 2,285
  • In genetics: 97
• Year to date:
  • Site-wide: 18,430
• Since beginning of last month:
  • Site-wide: 10,432

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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  • Site-wide: 2,673
  • In genetics: 111
• Year to date:
  • Site-wide: 5,741
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  • Site-wide: 7,899

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,027 times
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  • Site-wide: 3,519
  • In genetics: 165
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  • Site-wide: None
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  • Site-wide: 59,760

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

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  • Site-wide: 5,181
  • In genomics: 622
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  • Site-wide: 67,597

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

• Downloaded 2,180 times
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  • Site-wide: 5,664
  • In genetics: 286
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  • Site-wide: None
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  • Site-wide: 6,614

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

• Downloaded 2,091 times
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  • Site-wide: 6,013
  • In genetics: 305
• Year to date:
  • Site-wide: 3,901
• Since beginning of last month:
  • Site-wide: 8,814

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 1,995 times
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  • Site-wide: 6,428
  • In genetics: 324
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  • Site-wide: 12,412

The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • Site-wide: 6,935
  • In genetic and genomic medicine: 17
• Year to date:
  • Site-wide: 30,855
• Since beginning of last month:
  • Site-wide: 10,645

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 7,310
  • In genetics: 365
• Year to date:
  • Site-wide: 28,248
• Since beginning of last month:
  • Site-wide: 78,121

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,627 times
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  • Site-wide: 8,742
  • In genetics: 450
• Year to date:
  • Site-wide: 40,216
• Since beginning of last month:
  • Site-wide: 28,708

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

• Downloaded 1,618 times
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  • Site-wide: 8,821
  • In genetic and genomic medicine: 22
• Year to date:
  • Site-wide: 22,746
• Since beginning of last month:
  • Site-wide: 19,445

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,540 times
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  • Site-wide: 9,510
  • In genomics: 1,082
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  • Site-wide: None
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  • Site-wide: 59,231

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

• Downloaded 1,489 times
• Download rankings, all-time:
  • Site-wide: 9,967
  • In genetic and genomic medicine: 28
• Year to date:
  • Site-wide: 52,497
• Since beginning of last month:
  • Site-wide: 24,329

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

• Downloaded 1,453 times
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  • Site-wide: 10,332
  • In genetics: 531
• Year to date:
  • Site-wide: 12,973
• Since beginning of last month:
  • Site-wide: 16,767

Learning polygenic scores for human blood cell traits

• Downloaded 1,369 times
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  • Site-wide: 11,353
  • In genetics: 593
• Year to date:
  • Site-wide: 44,870
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  • Site-wide: 17,040

Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

• Downloaded 1,098 times
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  • Site-wide: 15,804
  • In genetics: 826
• Year to date:
  • Site-wide: 10,268
• Since beginning of last month:
  • Site-wide: 47,176

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

• Downloaded 1,053 times
• Download rankings, all-time:
  • Site-wide: 16,812
  • In genetic and genomic medicine: 46
• Year to date:
  • Site-wide: 10,768
• Since beginning of last month:
  • Site-wide: 6,596

Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: Prospective cohort study and modelling analysis

• Downloaded 1,008 times
• Download rankings, all-time:
  • Site-wide: 17,970
  • In genomics: 1,898
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 87,857

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

• Downloaded 995 times
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  • Site-wide: 18,337
  • In genomics: 1,926
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 101,538

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

• Downloaded 981 times
• Download rankings, all-time:
  • Site-wide: 18,698
  • In genomics: 1,958
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 97,396

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

• Downloaded 774 times
• Download rankings, all-time:
  • Site-wide: 26,237
  • In genomics: 2,507
• Year to date:
  • Site-wide: 57,380
• Since beginning of last month:
  • Site-wide: 70,074

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 764 times
• Download rankings, all-time:
  • Site-wide: 26,665
  • In genetics: 1,356
• Year to date:
  • Site-wide: 11,688
• Since beginning of last month:
  • Site-wide: 18,141

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

• Downloaded 747 times
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  • Site-wide: 27,581
  • In genetics: 1,409
• Year to date:
  • Site-wide: 72,028
• Since beginning of last month:
  • Site-wide: 86,019

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 639 times
• Download rankings, all-time:
  • Site-wide: 34,040
  • In epidemiology: 1,611
• Year to date:
  • Site-wide: 75,219
• Since beginning of last month:
  • Site-wide: 84,794

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

• Downloaded 628 times
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  • Site-wide: 34,805
  • In genetics: 1,757
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 59,698

South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine

• Downloaded 597 times
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  • Site-wide: 37,129
  • In genomics: 3,198
• Year to date:
  • Site-wide: 15,423
• Since beginning of last month:
  • Site-wide: 8,052

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 462 times
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  • Site-wide: 50,511
  • In genetics: 2,466
• Year to date:
  • Site-wide: 405
• Since beginning of last month:
  • Site-wide: 1,009

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

• Downloaded 436 times
• Download rankings, all-time:
  • Site-wide: 53,761
  • In genetic and genomic medicine: 144
• Year to date:
  • Site-wide: 73,604
• Since beginning of last month:
  • Site-wide: 52,622

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 59,793
  • In genetics: 2,886
• Year to date:
  • Site-wide: 31,397
• Since beginning of last month:
  • Site-wide: 81,810

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 62,267
  • In genetics: 2,994
• Year to date:
  • Site-wide: 44,681
• Since beginning of last month:
  • Site-wide: 58,828

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 351 times
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  • Site-wide: 66,395
  • In genetics: 3,168
• Year to date:
  • Site-wide: 51,091
• Since beginning of last month:
  • Site-wide: 96,568

Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 69,643
  • In genetic and genomic medicine: 194
• Year to date:
  • Site-wide: 9,174
• Since beginning of last month:
  • Site-wide: 11,822

The influence of rare variants in circulating metabolic biomarkers

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 73,708
  • In genetics: 3,494
• Year to date:
  • Site-wide: 64,867
• Since beginning of last month:
  • Site-wide: 83,568

The 4C Initiative (Clinical Care for Cardiovascular disease in the COVID-19 pandemic): monitoring the indirect impact of the coronavirus pandemic on services for cardiovascular diseases in the UK

• Downloaded 253 times
• Download rankings, all-time:
  • Site-wide: 84,923
  • In public and global health: 834
• Year to date:
  • Site-wide: 34,767
• Since beginning of last month:
  • Site-wide: 48,293

Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 97,126
  • In epidemiology: 3,908
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 10,837

Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

• Downloaded 183 times
• Download rankings, all-time:
  • Site-wide: 99,357
  • In hematology: 57
• Year to date:
  • Site-wide: 8,814
• Since beginning of last month:
  • Site-wide: 7,777

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

• Downloaded 135 times
• Download rankings, all-time:
  • Site-wide: 108,588
  • In epidemiology: 4,350
• Year to date:
  • Site-wide: None
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  • Site-wide: None