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Author: John Danesh

  • ORCiD: http://orcid.org/0000-0003-1158-6791
  • Most recently observed institution: British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Rankings

  • All-time downloads: 75,635 (rank: 1,839 )
  • Categories:
    • epidemiology: 1,928 (rank: 5,346 )
    • genetic and genomic medicine: 7,517 (rank: 93 )
    • genetics: 30,698 (rank: 187 )
    • genomics: 34,878 (rank: 244 )
    • hematology: 325 (rank: 679 (tie) )
    • public and global health: 289 (rank: 7,220 (tie) )

Downloads per author, site-wide

Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

infectious diseases more details view paper

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Analysis of protein-coding genetic variation in 60,706 humans

genomics more details view paper
  • Downloaded 22,018 times
  • Download rankings, all-time:
    • Site-wide: 307
    • In genomics: 11
  • Year to date:
    • Site-wide: 23,678
  • Since beginning of last month:
    • Site-wide: 18,975

Consequences Of Natural Perturbations In The Human Plasma Proteome

genomics more details view paper
  • Downloaded 4,257 times
  • Download rankings, all-time:
    • Site-wide: 2,489
    • In genomics: 275
  • Year to date:
    • Site-wide: 87,916
  • Since beginning of last month:
    • Site-wide: 96,647

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention

genetics more details view paper
  • Downloaded 4,098 times
  • Download rankings, all-time:
    • Site-wide: 2,632
    • In genetics: 101
  • Year to date:
    • Site-wide: 43,173
  • Since beginning of last month:
    • Site-wide: 61,110

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
  • Downloaded 3,834 times
  • Download rankings, all-time:
    • Site-wide: 2,908
    • In genetics: 113
  • Year to date:
    • Site-wide: 9,168
  • Since beginning of last month:
    • Site-wide: 8,930

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,082 times
  • Download rankings, all-time:
    • Site-wide: 3,975
    • In genetics: 168
  • Year to date:
    • Site-wide: 54,309
  • Since beginning of last month:
    • Site-wide: 72,291

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

genetics more details view paper
  • Downloaded 2,538 times
  • Download rankings, all-time:
    • Site-wide: 5,244
    • In genetics: 240
  • Year to date:
    • Site-wide: 5,832
  • Since beginning of last month:
    • Site-wide: 6,390

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

genetics more details view paper
  • Downloaded 2,408 times
  • Download rankings, all-time:
    • Site-wide: 5,681
    • In genetics: 266
  • Year to date:
    • Site-wide: 4,797
  • Since beginning of last month:
    • Site-wide: 4,669

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

genomics more details view paper
  • Downloaded 2,370 times
  • Download rankings, all-time:
    • Site-wide: 5,816
    • In genomics: 659
  • Year to date:
    • Site-wide: 59,143
  • Since beginning of last month:
    • Site-wide: 85,991

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

genetics more details view paper
  • Downloaded 2,292 times
  • Download rankings, all-time:
    • Site-wide: 6,127
    • In genetics: 290
  • Year to date:
    • Site-wide: 7,670
  • Since beginning of last month:
    • Site-wide: 10,567

The Polygenic and Monogenic Basis of Blood Traits and Diseases

genetic and genomic medicine more details view paper
  • Downloaded 2,006 times
  • Download rankings, all-time:
    • Site-wide: 7,410
    • In genetic and genomic medicine: 25
  • Year to date:
    • Site-wide: 22,651
  • Since beginning of last month:
    • Site-wide: 20,029

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,851 times
  • Download rankings, all-time:
    • Site-wide: 8,388
    • In genetics: 393
  • Year to date:
    • Site-wide: 87,764
  • Since beginning of last month:
    • Site-wide: 88,900

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

genetics more details view paper
  • Downloaded 1,806 times
  • Download rankings, all-time:
    • Site-wide: 8,717
    • In genetics: 408
  • Year to date:
    • Site-wide: 4,539
  • Since beginning of last month:
    • Site-wide: 2,732

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

genetic and genomic medicine more details view paper
  • Downloaded 1,672 times
  • Download rankings, all-time:
    • Site-wide: 9,782
    • In genetic and genomic medicine: 35
  • Year to date:
    • Site-wide: 41,580
  • Since beginning of last month:
    • Site-wide: 34,761

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,660 times
  • Download rankings, all-time:
    • Site-wide: 9,872
    • In genetics: 469
  • Year to date:
    • Site-wide: 64,880
  • Since beginning of last month:
    • Site-wide: 45,358

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

genomics more details view paper
  • Downloaded 1,580 times
  • Download rankings, all-time:
    • Site-wide: 10,607
    • In genomics: 1,152
  • Year to date:
    • Site-wide: 74,515
  • Since beginning of last month:
    • Site-wide: 89,263

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

genetic and genomic medicine more details view paper
  • Downloaded 1,570 times
  • Download rankings, all-time:
    • Site-wide: 10,714
    • In genetic and genomic medicine: 40
  • Year to date:
    • Site-wide: 31,232
  • Since beginning of last month:
    • Site-wide: 26,945

Learning polygenic scores for human blood cell traits

genetics more details view paper
  • Downloaded 1,491 times
  • Download rankings, all-time:
    • Site-wide: 11,504
    • In genetics: 557
  • Year to date:
    • Site-wide: 19,764
  • Since beginning of last month:
    • Site-wide: 20,547

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

genetic and genomic medicine more details view paper
  • Downloaded 1,366 times
  • Download rankings, all-time:
    • Site-wide: 13,167
    • In genetic and genomic medicine: 46
  • Year to date:
    • Site-wide: 5,368
  • Since beginning of last month:
    • Site-wide: 6,007

Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

genetics more details view paper
  • Downloaded 1,132 times
  • Download rankings, all-time:
    • Site-wide: 17,470
    • In genetics: 852
  • Year to date:
    • Site-wide: 50,019
  • Since beginning of last month:
    • Site-wide: 72,686

Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: Prospective cohort study and modelling analysis

genomics more details view paper
  • Downloaded 1,076 times
  • Download rankings, all-time:
    • Site-wide: 18,845
    • In genomics: 1,911
  • Year to date:
    • Site-wide: 49,951
  • Since beginning of last month:
    • Site-wide: 52,271

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

genomics more details view paper
  • Downloaded 1,023 times
  • Download rankings, all-time:
    • Site-wide: 20,284
    • In genomics: 2,030
  • Year to date:
    • Site-wide: 90,487
  • Since beginning of last month:
    • Site-wide: 87,336

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

genomics more details view paper
  • Downloaded 1,022 times
  • Download rankings, all-time:
    • Site-wide: 20,333
    • In genomics: 2,035
  • Year to date:
    • Site-wide: 69,750
  • Since beginning of last month:
    • Site-wide: 108,346

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 877 times
  • Download rankings, all-time:
    • Site-wide: 25,360
    • In genetics: 1,223
  • Year to date:
    • Site-wide: 19,255
  • Since beginning of last month:
    • Site-wide: 10,875

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

genomics more details view paper
  • Downloaded 788 times
  • Download rankings, all-time:
    • Site-wide: 29,417
    • In genomics: 2,678
  • Year to date:
    • Site-wide: 110,236
  • Since beginning of last month:
    • Site-wide: 107,862

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

genetics more details view paper
  • Downloaded 776 times
  • Download rankings, all-time:
    • Site-wide: 30,045
    • In genetics: 1,463
  • Year to date:
    • Site-wide: 20,085
  • Since beginning of last month:
    • Site-wide: 17,822

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

genetics more details view paper
  • Downloaded 754 times
  • Download rankings, all-time:
    • Site-wide: 31,262
    • In genetics: 1,511
  • Year to date:
    • Site-wide: 132,062
  • Since beginning of last month:
    • Site-wide: 127,052

South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine

genomics more details view paper
  • Downloaded 744 times
  • Download rankings, all-time:
    • Site-wide: 31,932
    • In genomics: 2,837
  • Year to date:
    • Site-wide: 14,664
  • Since beginning of last month:
    • Site-wide: 21,303

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

epidemiology more details view paper
  • Downloaded 652 times
  • Download rankings, all-time:
    • Site-wide: 38,088
    • In epidemiology: 1,836
  • Year to date:
    • Site-wide: 120,770
  • Since beginning of last month:
    • Site-wide: 129,293

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 617 times
  • Download rankings, all-time:
    • Site-wide: 40,891
    • In genetics: 1,943
  • Year to date:
    • Site-wide: 5,001
  • Since beginning of last month:
    • Site-wide: 15,525

Accuracy of four lateral flow immunoassays for anti SARS-CoV-2 antibodies: a head-to-head comparative study

epidemiology more details view paper
  • Downloaded 608 times
  • Download rankings, all-time:
    • Site-wide: 41,686
    • In epidemiology: 1,977
  • Year to date:
    • Site-wide: 2,229
  • Since beginning of last month:
    • Site-wide: 12,830

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

genetic and genomic medicine more details view paper
  • Downloaded 488 times
  • Download rankings, all-time:
    • Site-wide: 54,261
    • In genetic and genomic medicine: 174
  • Year to date:
    • Site-wide: 48,371
  • Since beginning of last month:
    • Site-wide: 58,177

Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

epidemiology more details view paper
  • Downloaded 423 times
  • Download rankings, all-time:
    • Site-wide: 63,105
    • In epidemiology: 2,711
  • Year to date:
    • Site-wide: 13,060
  • Since beginning of last month:
    • Site-wide: 12,308

Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

genetic and genomic medicine more details view paper
  • Downloaded 415 times
  • Download rankings, all-time:
    • Site-wide: 64,291
    • In genetic and genomic medicine: 204
  • Year to date:
    • Site-wide: 25,611
  • Since beginning of last month:
    • Site-wide: 19,442

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

genetics more details view paper
  • Downloaded 410 times
  • Download rankings, all-time:
    • Site-wide: 65,212
    • In genetics: 3,004
  • Year to date:
    • Site-wide: 91,171
  • Since beginning of last month:
    • Site-wide: 101,098

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

genetics more details view paper
  • Downloaded 386 times
  • Download rankings, all-time:
    • Site-wide: 68,992
    • In genetics: 3,168
  • Year to date:
    • Site-wide: 119,288
  • Since beginning of last month:
    • Site-wide: 95,950

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

genetics more details view paper
  • Downloaded 367 times
  • Download rankings, all-time:
    • Site-wide: 72,194
    • In genetics: 3,295
  • Year to date:
    • Site-wide: 103,164
  • Since beginning of last month:
    • Site-wide: 89,148

Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

hematology more details view paper
  • Downloaded 325 times
  • Download rankings, all-time:
    • Site-wide: 79,964
    • In hematology: 53
  • Year to date:
    • Site-wide: 14,409
  • Since beginning of last month:
    • Site-wide: 16,541

The influence of rare variants in circulating metabolic biomarkers

genetics more details view paper
  • Downloaded 319 times
  • Download rankings, all-time:
    • Site-wide: 81,236
    • In genetics: 3,698
  • Year to date:
    • Site-wide: 123,013
  • Since beginning of last month:
    • Site-wide: 106,199

The 4C Initiative (Clinical Care for Cardiovascular disease in the COVID-19 pandemic): monitoring the indirect impact of the coronavirus pandemic on services for cardiovascular diseases in the UK

public and global health more details view paper
  • Downloaded 289 times
  • Download rankings, all-time:
    • Site-wide: 87,570
    • In public and global health: 972
  • Year to date:
    • Site-wide: 59,717
  • Since beginning of last month:
    • Site-wide: 57,742

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

epidemiology more details view paper
  • Downloaded 245 times
  • Download rankings, all-time:
    • Site-wide: 97,098
    • In epidemiology: 3,978
  • Year to date:
    • Site-wide: 32,517
  • Since beginning of last month:
    • Site-wide: 46,884

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