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Author: Stephen Burgess

Rankings

  • All-time downloads: 46,356 (rank: 3,159 )
  • Categories:
    • bioinformatics: 546 (rank: 24,104 (tie) )
    • cardiovascular medicine: 1,192 (rank: 342 (tie) )
    • epidemiology: 12,379 (rank: 1,069 )
    • genetic and genomic medicine: 4,184 (rank: 210 )
    • genetics: 20,662 (rank: 467 )
    • genomics: 5,350 (rank: 4,341 (tie) )
    • neurology: 251 (rank: 3,902 (tie) )
    • oncology: 629 (rank: 923 (tie) )
    • psychiatry and clinical psychology: 475 (rank: 2,039 (tie) )
    • sexual and reproductive health: 688 (rank: 178 (tie) )

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Preprints

Cross-fitted instrument: a blueprint for one-sample Mendelian Randomization

bioinformatics more details view paper

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Consequences Of Natural Perturbations In The Human Plasma Proteome

genomics more details view paper
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    • Site-wide: 2,603
    • In genomics: 283
  • Year to date:
    • Site-wide: 94,819
  • Since beginning of last month:
    • Site-wide: 93,591

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

epidemiology more details view paper
  • Downloaded 4,043 times
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    • Site-wide: 2,804
    • In epidemiology: 298
  • Year to date:
    • Site-wide: 25,186
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A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

genetics more details view paper
  • Downloaded 3,932 times
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    • Site-wide: 2,928
    • In genetics: 108
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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
  • Downloaded 3,884 times
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    • Site-wide: 2,981
    • In genetics: 112
  • Year to date:
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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

genetics more details view paper
  • Downloaded 2,615 times
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    • Site-wide: 5,225
    • In genetics: 234
  • Year to date:
    • Site-wide: 6,202
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    • Site-wide: 9,529

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

genetics more details view paper
  • Downloaded 1,890 times
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    • Site-wide: 8,481
    • In genetics: 388
  • Year to date:
    • Site-wide: 4,946
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    • Site-wide: 6,063

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

genetic and genomic medicine more details view paper
  • Downloaded 1,678 times
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    • Site-wide: 10,121
    • In genetic and genomic medicine: 37
  • Year to date:
    • Site-wide: 50,190
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    • Site-wide: 91,932

Selecting causal risk factors from high-throughput experiments using multivariable Mendelian randomization

genetics more details view paper
  • Downloaded 1,555 times
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    • Site-wide: 11,313
    • In genetics: 537
  • Year to date:
    • Site-wide: 52,581
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    • Site-wide: 70,162

A Comparison Of Robust Mendelian Randomization Methods Using Summary Data

epidemiology more details view paper
  • Downloaded 1,349 times
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    • Site-wide: 13,992
    • In epidemiology: 933
  • Year to date:
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Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: Prospective cohort study and modelling analysis

genomics more details view paper
  • Downloaded 1,088 times
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    • Site-wide: 19,264
    • In genomics: 1,928
  • Year to date:
    • Site-wide: 54,572
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    • Site-wide: 58,137

A robust and efficient method for Mendelian randomization with hundreds of genetic variants: unravelling mechanisms linking HDL-cholesterol and coronary heart disease

genetics more details view paper
  • Downloaded 1,022 times
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    • Site-wide: 21,142
    • In genetics: 1,010
  • Year to date:
    • Site-wide: 75,484
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    • Site-wide: 69,846

Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases

genetic and genomic medicine more details view paper
  • Downloaded 983 times
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    • Site-wide: 22,316
    • In genetic and genomic medicine: 77
  • Year to date:
    • Site-wide: 14,737
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High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

epidemiology more details view paper
  • Downloaded 897 times
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    • Site-wide: 25,555
    • In epidemiology: 1,418
  • Year to date:
    • Site-wide: 17,579
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    • Site-wide: 7,346

Cardiometabolic traits, sepsis and severe covid-19 with respiratory failure: a Mendelian randomization investigation

epidemiology more details view paper
  • Downloaded 884 times
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    • Site-wide: 26,030
    • In epidemiology: 1,437
  • Year to date:
    • Site-wide: 23,106
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    • Site-wide: 34,475

Shared risk alleles with discordant polygenic effects: Disentangling the genetic overlap between ASD and ADHD

genetics more details view paper
  • Downloaded 842 times
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    • Site-wide: 27,864
    • In genetics: 1,340
  • Year to date:
    • Site-wide: 65,240
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    • Site-wide: 40,193

Power calculator for instrumental variable analysis in pharmacoepidemiology

epidemiology more details view paper
  • Downloaded 822 times
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    • Site-wide: 28,840
    • In epidemiology: 1,514
  • Year to date:
    • Site-wide: 121,096
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    • Site-wide: 131,247

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

genetics more details view paper
  • Downloaded 802 times
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    • Site-wide: 29,905
    • In genetics: 1,435
  • Year to date:
    • Site-wide: 22,378
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    • Site-wide: 33,204

Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization

genetics more details view paper
  • Downloaded 757 times
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    • Site-wide: 32,357
    • In genetics: 1,541
  • Year to date:
    • Site-wide: 102,660
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    • Site-wide: 88,265

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

genetics more details view paper
  • Downloaded 736 times
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    • Site-wide: 33,648
    • In genetics: 1,608
  • Year to date:
    • Site-wide: 96,043
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    • Site-wide: 128,758

Genetically predicted serum urate, blood pressure and cardiovascular disease: an updated Mendelian randomization investigation

cardiovascular medicine more details view paper
  • Downloaded 692 times
  • Download rankings, all-time:
    • Site-wide: 36,550
    • In cardiovascular medicine: 55
  • Year to date:
    • Site-wide: 48,969
  • Since beginning of last month:
    • Site-wide: 54,557

Genetic insights into the biological mechanisms governing human ovarian ageing

sexual and reproductive health more details view paper
  • Downloaded 688 times
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    • Site-wide: 36,836
    • In sexual and reproductive health: 17
  • Year to date:
    • Site-wide: 2,665
  • Since beginning of last month:
    • Site-wide: 6,186

Factorial Mendelian randomization: using genetic variants to assess interactions

epidemiology more details view paper
  • Downloaded 681 times
  • Download rankings, all-time:
    • Site-wide: 37,375
    • In epidemiology: 1,832
  • Year to date:
    • Site-wide: 101,085
  • Since beginning of last month:
    • Site-wide: 77,784

Dissecting causal pathways using Mendelian randomization with summarized genetic data: application to age at menarche and risk of breast cancer

epidemiology more details view paper
  • Downloaded 657 times
  • Download rankings, all-time:
    • Site-wide: 39,175
    • In epidemiology: 1,885
  • Year to date:
    • Site-wide: 114,003
  • Since beginning of last month:
    • Site-wide: 86,926

Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation

epidemiology more details view paper
  • Downloaded 649 times
  • Download rankings, all-time:
    • Site-wide: 39,884
    • In epidemiology: 1,911
  • Year to date:
    • Site-wide: 54,650
  • Since beginning of last month:
    • Site-wide: 40,371

Predicting the effect of statins on cancer risk using genetic variants: a Mendelian randomization study in UK Biobank

oncology more details view paper
  • Downloaded 629 times
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    • Site-wide: 41,412
    • In oncology: 48
  • Year to date:
    • Site-wide: 75,033
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    • Site-wide: 66,054

MR-Clust: Clustering of genetic variants in Mendelian randomization with similar causal estimates

bioinformatics more details view paper
  • Downloaded 546 times
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    • Site-wide: 49,432
    • In bioinformatics: 5,126
  • Year to date:
    • Site-wide: 99,125
  • Since beginning of last month:
    • Site-wide: 126,317

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

genetic and genomic medicine more details view paper
  • Downloaded 510 times
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    • Site-wide: 53,624
    • In genetic and genomic medicine: 183
  • Year to date:
    • Site-wide: 46,377
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    • Site-wide: 36,635

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

epidemiology more details view paper
  • Downloaded 506 times
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    • Site-wide: 54,066
    • In epidemiology: 2,393
  • Year to date:
    • Site-wide: 129,411
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    • Site-wide: 131,201

Improving on a modal-based estimation method: model averaging for consistent and efficient estimation in Mendelian randomization when a plurality of candidate instruments are valid

genetics more details view paper
  • Downloaded 506 times
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    • Site-wide: 54,072
    • In genetics: 2,485
  • Year to date:
    • Site-wide: 90,307
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    • Site-wide: 88,234

Polygenic modelling of treatment effect heterogeneity

genetic and genomic medicine more details view paper
  • Downloaded 505 times
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    • Site-wide: 54,150
    • In genetic and genomic medicine: 185
  • Year to date:
    • Site-wide: 77,343
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    • Site-wide: 91,769

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

epidemiology more details view paper
  • Downloaded 475 times
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    • Site-wide: 58,017
    • In epidemiology: 2,526
  • Year to date:
    • Site-wide: 31,220
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    • Site-wide: 37,567

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort

genetics more details view paper
  • Downloaded 462 times
  • Download rankings, all-time:
    • Site-wide: 59,715
    • In genetics: 2,741
  • Year to date:
    • Site-wide: 124,340
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    • Site-wide: 77,753

Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

epidemiology more details view paper
  • Downloaded 451 times
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    • Site-wide: 61,239
    • In epidemiology: 2,656
  • Year to date:
    • Site-wide: 15,313
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    • Site-wide: 18,784

Bayesian variable selection with a pleiotropic loss function in Mendelian randomization

genetics more details view paper
  • Downloaded 420 times
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    • Site-wide: 65,912
    • In genetics: 3,021
  • Year to date:
    • Site-wide: 96,717
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    • Site-wide: 58,451

Semiparametric methods for estimation of a non-linear exposure-outcome relationship using instrumental variables with application to Mendelian randomization

genetics more details view paper
  • Downloaded 377 times
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    • Site-wide: 73,224
    • In genetics: 3,308
  • Year to date:
    • Site-wide: 105,350
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    • Site-wide: 113,178

Urinary biomarkers and cardiovascular outcomes in the UK Biobank: observational and Mendelian randomization analyses

epidemiology more details view paper
  • Downloaded 373 times
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    • Site-wide: 73,952
    • In epidemiology: 3,100
  • Year to date:
    • Site-wide: 122,460
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    • Site-wide: 89,164

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

genetics more details view paper
  • Downloaded 372 times
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    • Site-wide: 74,116
    • In genetics: 3,336
  • Year to date:
    • Site-wide: 35,534
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    • Site-wide: 41,649

Body size and composition and site-specific cancers in UK Biobank: a Mendelian randomisation study

genetics more details view paper
  • Downloaded 343 times
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    • Site-wide: 79,441
    • In genetics: 3,583
  • Year to date:
    • Site-wide: 69,180
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Leveraging genetic data to elucidate the relationship between Covid-19 and ischemic stroke

cardiovascular medicine more details view paper
  • Downloaded 301 times
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    • Site-wide: 87,933
    • In cardiovascular medicine: 148
  • Year to date:
    • Site-wide: 8,894
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    • Site-wide: 8,599

Genetically proxied inhibition of interleukin-6 signaling: opposing associations with susceptibility to COVID-19 and pneumonia

genetic and genomic medicine more details view paper
  • Downloaded 273 times
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    • Site-wide: 94,088
    • In genetic and genomic medicine: 377
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    • Site-wide: 63,395
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    • Site-wide: 62,352

Association of Inflammation with Depression and Anxiety: Evidence for Symptom-Specificity and Potential Causality from UK Biobank and NESDA Cohorts

psychiatry and clinical psychology more details view paper
  • Downloaded 251 times
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    • Site-wide: 99,115
    • In psychiatry and clinical psychology: 378
  • Year to date:
    • Site-wide: 11,473
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    • Site-wide: 28,795

Predicting the efficacy of exenatide in Parkinson's disease using genetics - a Mendelian randomization study

neurology more details view paper
  • Downloaded 251 times
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    • Site-wide: 99,086
    • In neurology: 294
  • Year to date:
    • Site-wide: 54,410
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    • Site-wide: 62,642

Genome-wide association study of skin and soft tissue infection susceptibility

genetic and genomic medicine more details view paper
  • Downloaded 235 times
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    • Site-wide: 102,606
    • In genetic and genomic medicine: 442
  • Year to date:
    • Site-wide: 38,683
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    • Site-wide: 75,061

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

psychiatry and clinical psychology more details view paper
  • Downloaded 224 times
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    • Site-wide: 105,282
    • In psychiatry and clinical psychology: 422
  • Year to date:
    • Site-wide: 13,390
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    • Site-wide: 26,118

The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

epidemiology more details view paper
  • Downloaded 215 times
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    • Site-wide: 107,332
    • In epidemiology: 4,441
  • Year to date:
    • Site-wide: 125,957
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    • Site-wide: 106,368

Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease

cardiovascular medicine more details view paper
  • Downloaded 199 times
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    • Site-wide: 110,801
    • In cardiovascular medicine: 241
  • Year to date:
    • Site-wide: 15,532
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    • Site-wide: 45,458

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

epidemiology more details view paper
  • Downloaded 198 times
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    • Site-wide: 111,035
    • In epidemiology: 4,587
  • Year to date:
    • Site-wide: 129,655
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    • Site-wide: 119,691

Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank

epidemiology more details view paper
  • Downloaded 179 times
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    • Site-wide: 115,477
    • In epidemiology: 4,760
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    • Site-wide: 17,865
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    • Site-wide: 45,566

Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity

genetics more details view paper
  • Downloaded 147 times
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    • Site-wide: 122,324
    • In genetics: 5,171
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