Author: Michael P. Snyder

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Preprints

Index Switching Causes “Spreading-Of-Signal” Among Multiplexed Samples In Illumina HiSeq 4000 DNA Sequencing

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  • Site-wide: 268
  • In molecular biology: 3
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A Quantitative Proteome Map of the Human Body

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  • Site-wide: 3,078
  • In systems biology: 42
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  • Site-wide: 15,796

Molecular Choreography of Acute Exercise

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  • Site-wide: 4,559
  • In systems biology: 75
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A genome-wide almanac of co-essential modules assigns function to uncharacterized genes

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  • Site-wide: 5,412
  • In genomics: 633
• Year to date:
  • Site-wide: 10,989
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  • Site-wide: 10,989

Identification and mitigation of pervasive off-target activity in CRISPR-Cas9 screens for essential non-coding elements

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  • Site-wide: 6,551
  • In genomics: 752
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Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

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  • Site-wide: 7,409
  • In cell biology: 173
• Year to date:
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High Frequency Actionable Pathogenic Exome Mutations in an Average-Risk Cohort

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  • Site-wide: 8,072
  • In genomics: 909
• Year to date:
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  • Site-wide: 60,265

Static And Dynamic DNA Loops Form AP-1 Bound Activation Hubs During Macrophage Development

• Downloaded 1,660 times
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  • Site-wide: 9,163
  • In genomics: 1,035
• Year to date:
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Integrative analysis of RNA, translation and protein levels reveals distinct regulatory variation across humans

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  • Site-wide: 11,376
  • In genomics: 1,271
• Year to date:
  • Site-wide: 60,980
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Cross-species blastocyst chimerism between nonhuman primates using iPSCs

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  • Site-wide: 15,814
  • In developmental biology: 261
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The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation

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  • In genomics: 1,814
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  • Site-wide: 7,497
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A limited set of transcriptional programs define major cell types

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  • Site-wide: 21,888
  • In genomics: 2,184
• Year to date:
  • Site-wide: 59,285
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  • Site-wide: 59,285

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis

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  • Site-wide: 29,562
  • In genomics: 2,708
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  • Site-wide: 18,164
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NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells

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  • Site-wide: 32,350
  • In genetics: 1,612
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Chromosome-level de novo assembly of the pig-tailed macaque genome using linked-read sequencing and HiC proximity scaffolding

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  • In genomics: 3,077
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A Common Class of Transcripts with 5'-Intron Depletion, Distinct Early Coding Sequence Features, and N1-Methyladenosine Modification

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  • Site-wide: 38,350
  • In bioinformatics: 4,236
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Benchmarking workflows to assess performance and suitability of germline variant calling pipelines in clinical diagnostic assays.

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  • Site-wide: 51,240
  • In bioinformatics: 5,294
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KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear Stress

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  • Site-wide: 60,800
  • In molecular biology: 1,759
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Deep learning-based detection of COVID-19 using wearables data

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  • Site-wide: 63,659
  • In infectious diseases: 2,769
• Year to date:
  • Site-wide: 1,495
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  • Site-wide: 1,495

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

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  • Site-wide: 69,114
  • In systems biology: 1,690
• Year to date:
  • Site-wide: 55,408
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  • Site-wide: 55,408

RobNorm: model-based robust normalization methodfor labeled quantitative mass spectrometry proteomics data

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  • In bioinformatics: 6,806
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HAT1 drives a gene-metabolite circuit that links nutrient metabolism to histone production

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  • Site-wide: 78,632
  • In molecular biology: 2,319
• Year to date:
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  • Site-wide: 112,743

AdaTiSS: A Novel Data-Adaptive Robust Method for Quantifying Tissue Specificity Scores

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  • Site-wide: 94,512
  • In bioinformatics: 8,221
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Age-related decline in metabolite heavy isotope content in rodent organs

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  • Site-wide: 95,034
  • In systems biology: 2,246
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AdaReg: Data Adaptive Robust Estimation in Linear Regression with Application in GTEx Gene Expressions

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  • Site-wide: 98,777
  • In bioinformatics: 8,500
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  • Site-wide: 63,070
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  • Site-wide: 63,070

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from mendelian randomisation, transcriptomics and risk genotypes

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  • Site-wide: 112,087
  • In neurology: 398
• Year to date:
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  • Site-wide: 20,061