Author: Michael P. Snyder

Downloads per author, site-wide

Preprints

Index Switching Causes “Spreading-Of-Signal” Among Multiplexed Samples In Illumina HiSeq 4000 DNA Sequencing

• Downloaded 23,453 times
• Download rankings, all-time:
  • Site-wide: 231 out of 118,294
  • In molecular biology: 3 out of 3,618
• Year to date:
  • Site-wide: 4,195 out of 118,294
• Since beginning of last month:
  • Site-wide: 4,913 out of 118,294

A Quantitative Proteome Map of the Human Body

• Downloaded 3,347 times
• Download rankings, all-time:
  • Site-wide: 2,846 out of 118,294
  • In systems biology: 41 out of 2,636
• Year to date:
  • Site-wide: 3,165 out of 118,294
• Since beginning of last month:
  • Site-wide: 2,237 out of 118,294

Molecular Choreography of Acute Exercise

• Downloaded 2,411 times
• Download rankings, all-time:
  • Site-wide: 4,591 out of 118,294
  • In systems biology: 81 out of 2,636
• Year to date:
  • Site-wide: 2,148 out of 118,294
• Since beginning of last month:
  • Site-wide: 5,432 out of 118,294

A genome-wide almanac of co-essential modules assigns function to uncharacterized genes

• Downloaded 2,201 times
• Download rankings, all-time:
  • Site-wide: 5,246 out of 118,294
  • In genomics: 654 out of 6,435
• Year to date:
  • Site-wide: 4,048 out of 118,294
• Since beginning of last month:
  • Site-wide: 7,403 out of 118,294

Identification and mitigation of pervasive off-target activity in CRISPR-Cas9 screens for essential non-coding elements

• Downloaded 2,029 times
• Download rankings, all-time:
  • Site-wide: 5,899 out of 118,294
  • In genomics: 721 out of 6,435
• Year to date:
  • Site-wide: 23,071 out of 118,294
• Since beginning of last month:
  • Site-wide: 43,077 out of 118,294

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

• Downloaded 1,813 times
• Download rankings, all-time:
  • Site-wide: 6,999 out of 118,294
  • In cell biology: 162 out of 5,422
• Year to date:
  • Site-wide: 21,496 out of 118,294
• Since beginning of last month:
  • Site-wide: 20,567 out of 118,294

High Frequency Actionable Pathogenic Exome Mutations in an Average-Risk Cohort

• Downloaded 1,756 times
• Download rankings, all-time:
  • Site-wide: 7,298 out of 118,294
  • In genomics: 862 out of 6,435
• Year to date:
  • Site-wide: 33,160 out of 118,294
• Since beginning of last month:
  • Site-wide: 47,964 out of 118,294

Static And Dynamic DNA Loops Form AP-1 Bound Activation Hubs During Macrophage Development

• Downloaded 1,626 times
• Download rankings, all-time:
  • Site-wide: 8,234 out of 118,294
  • In genomics: 976 out of 6,435
• Year to date:
  • Site-wide: 66,993 out of 118,294
• Since beginning of last month:
  • Site-wide: 74,598 out of 118,294

Integrative analysis of RNA, translation and protein levels reveals distinct regulatory variation across humans

• Downloaded 1,403 times
• Download rankings, all-time:
  • Site-wide: 10,218 out of 118,294
  • In genomics: 1,197 out of 6,435
• Year to date:
  • Site-wide: 101,490 out of 118,294
• Since beginning of last month:
  • Site-wide: 84,493 out of 118,294

Cross-species blastocyst chimerism between nonhuman primates using iPSCs

• Downloaded 1,094 times
• Download rankings, all-time:
  • Site-wide: 14,915 out of 118,294
  • In developmental biology: 251 out of 3,118
• Year to date:
  • Site-wide: 22,209 out of 118,294
• Since beginning of last month:
  • Site-wide: 25,267 out of 118,294

MOBN: an interactive database of multi-omics biological networks

• Downloaded 914 times
• Download rankings, all-time:
  • Site-wide: 19,467 out of 118,294
  • In bioinformatics: 2,445 out of 9,577
• Year to date:
  • Site-wide: 45,319 out of 118,294
• Since beginning of last month:
  • Site-wide: 40,439 out of 118,294

A limited set of transcriptional programs define major cell types

• Downloaded 898 times
• Download rankings, all-time:
  • Site-wide: 19,944 out of 118,294
  • In genomics: 2,076 out of 6,435
• Year to date:
  • Site-wide: 11,486 out of 118,294
• Since beginning of last month:
  • Site-wide: 65,592 out of 118,294

The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation

• Downloaded 780 times
• Download rankings, all-time:
  • Site-wide: 24,374 out of 118,294
  • In genomics: 2,399 out of 6,435
• Year to date:
  • Site-wide: 8,064 out of 118,294
• Since beginning of last month:
  • Site-wide: 760 out of 118,294

NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells

• Downloaded 662 times
• Download rankings, all-time:
  • Site-wide: 30,607 out of 118,294
  • In genetics: 1,569 out of 5,135
• Year to date:
  • Site-wide: 67,039 out of 118,294
• Since beginning of last month:
  • Site-wide: 75,032 out of 118,294

Chromosome-level de novo assembly of the pig-tailed macaque genome using linked-read sequencing and HiC proximity scaffolding

• Downloaded 632 times
• Download rankings, all-time:
  • Site-wide: 32,541 out of 118,294
  • In genomics: 2,939 out of 6,435
• Year to date:
  • Site-wide: 48,554 out of 118,294
• Since beginning of last month:
  • Site-wide: 106,886 out of 118,294

A Common Class of Transcripts with 5'-Intron Depletion, Distinct Early Coding Sequence Features, and N1-Methyladenosine Modification

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 34,867 out of 118,294
  • In bioinformatics: 3,962 out of 9,577
• Year to date:
  • Site-wide: 93,921 out of 118,294
• Since beginning of last month:
  • Site-wide: 77,459 out of 118,294

Benchmarking workflows to assess performance and suitability of germline variant calling pipelines in clinical diagnostic assays.

• Downloaded 454 times
• Download rankings, all-time:
  • Site-wide: 48,399 out of 118,294
  • In bioinformatics: 5,127 out of 9,577
• Year to date:
  • Site-wide: 52,854 out of 118,294
• Since beginning of last month:
  • Site-wide: 91,959 out of 118,294

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 65,606 out of 118,294
  • In genomics: 4,683 out of 6,435
• Year to date:
  • Site-wide: 23,313 out of 118,294
• Since beginning of last month:
  • Site-wide: 2,399 out of 118,294

KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear Stress

• Downloaded 319 times
• Download rankings, all-time:
  • Site-wide: 67,873 out of 118,294
  • In molecular biology: 2,011 out of 3,618
• Year to date:
  • Site-wide: 24,457 out of 118,294
• Since beginning of last month:
  • Site-wide: 18,726 out of 118,294

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 72,850 out of 118,294
  • In systems biology: 1,836 out of 2,636
• Year to date:
  • Site-wide: 27,417 out of 118,294
• Since beginning of last month:
  • Site-wide: 64,696 out of 118,294

HAT1 drives a gene-metabolite circuit that links nutrient metabolism to histone production

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 73,398 out of 118,294
  • In molecular biology: 2,187 out of 3,618
• Year to date:
  • Site-wide: 75,791 out of 118,294
• Since beginning of last month:
  • Site-wide: 94,723 out of 118,294

RobNorm: Model-Based Robust Normalization for High-Throughput Proteomics from Mass Spectrometry Platform

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 74,630 out of 118,294
  • In bioinformatics: 6,980 out of 9,577
• Year to date:
  • Site-wide: 46,279 out of 118,294
• Since beginning of last month:
  • Site-wide: 20,986 out of 118,294

AdaTiSS: A Novel Data-Adaptive Robust Method for Quantifying Tissue Specificity Scores

• Downloaded 202 times
• Download rankings, all-time:
  • Site-wide: 90,581 out of 118,294
  • In bioinformatics: 7,999 out of 9,577
• Year to date:
  • Site-wide: 61,045 out of 118,294
• Since beginning of last month:
  • Site-wide: 27,263 out of 118,294

Age-related decline in metabolite heavy isotope content in rodent organs

• Downloaded 196 times
• Download rankings, all-time:
  • Site-wide: 91,659 out of 118,294
  • In systems biology: 2,215 out of 2,636
• Year to date:
  • Site-wide: 87,502 out of 118,294
• Since beginning of last month:
  • Site-wide: 85,203 out of 118,294

AdaReg: Data Adaptive Robust Estimation in Linear Regression with Application in GTEx Gene Expressions

• Downloaded 180 times
• Download rankings, all-time:
  • Site-wide: 94,869 out of 118,294
  • In bioinformatics: 8,225 out of 9,577
• Year to date:
  • Site-wide: 89,001 out of 118,294
• Since beginning of last month:
  • Site-wide: 87,893 out of 118,294