Author: Bin Li

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Preprints

Single-cell analysis of severe COVID-19 patients reveals a monocyte-driven inflammatory storm attenuated by Tocilizumab

• Downloaded 6,387 times
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  • Site-wide: 2,274
  • In genomics: 168
• Year to date:
  • Site-wide: 42,353
• Since beginning of last month:
  • Site-wide: 57,355

Preservation of Chromatin Organization after Acute Loss of CTCF in Mouse Embryonic Stem Cells

• Downloaded 5,356 times
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  • Site-wide: 2,891
  • In genomics: 234
• Year to date:
  • Site-wide: 87,862
• Since beginning of last month:
  • Site-wide: 85,824

Systematic mapping of chromatin state landscapes during mouse development

• Downloaded 5,038 times
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  • Site-wide: 3,128
  • In genomics: 271
• Year to date:
  • Site-wide: 37,872
• Since beginning of last month:
  • Site-wide: 29,728

An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum

• Downloaded 4,984 times
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  • Site-wide: 3,173
  • In neuroscience: 178
• Year to date:
  • Site-wide: 66,695
• Since beginning of last month:
  • Site-wide: 91,434

Discovering the Interactions between Circular RNAs and RNA-binding Proteins from CLIP-seq Data using circScan

• Downloaded 2,363 times
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  • Site-wide: 9,243
  • In molecular biology: 202
• Year to date:
  • Site-wide: 68,506
• Since beginning of last month:
  • Site-wide: 66,610

Spatiotemporal DNA Methylome Dynamics of the Developing Mammalian Fetus

• Downloaded 1,993 times
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  • Site-wide: 11,936
  • In genomics: 1,061
• Year to date:
  • Site-wide: 124,911
• Since beginning of last month:
  • Site-wide: 67,067

CTCF Promotes Long-range Enhancer-promoter Interactions and Lineage-specific Gene Expression in Mammalian Cells

• Downloaded 1,978 times
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  • Site-wide: 12,065
  • In genomics: 1,111
• Year to date:
  • Site-wide: 51,481
• Since beginning of last month:
  • Site-wide: 42,574

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

• Downloaded 1,933 times
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  • Site-wide: 12,466
  • In genomics: 1,121
• Year to date:
  • Site-wide: 81,869
• Since beginning of last month:
  • Site-wide: 95,172

APEC: an accesson-based method for single-cell chromatin accessibility analysis

• Downloaded 1,623 times
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  • Site-wide: 16,153
  • In bioinformatics: 1,749
• Year to date:
  • Site-wide: 60,900
• Since beginning of last month:
  • Site-wide: 72,381

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis

• Downloaded 1,262 times
• Download rankings, all-time:
  • Site-wide: 23,902
  • In microbiology: 1,426
• Year to date:
  • Site-wide: 30,956
• Since beginning of last month:
  • Site-wide: 51,059

Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath

• Downloaded 1,023 times
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  • Site-wide: 32,855
  • In genomics: 2,764
• Year to date:
  • Site-wide: 50,176
• Since beginning of last month:
  • Site-wide: 32,674

Phosphorothioate-modified DNA oligonucleotides inactivate CRISPR-Cpf1 mediated genome editing

• Downloaded 974 times
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  • Site-wide: 35,357
  • In bioengineering: 615
• Year to date:
  • Site-wide: 121,442
• Since beginning of last month:
  • Site-wide: 93,643

Discovery and Functional Characterization of Pro-growth Enhancers in Human Cancer Cells

• Downloaded 938 times
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  • Site-wide: 37,422
  • In cancer biology: 1,239
• Year to date:
  • Site-wide: 20,206
• Since beginning of last month:
  • Site-wide: 10,030

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation

• Downloaded 918 times
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  • Site-wide: 38,675
  • In genomics: 2,901
• Year to date:
  • Site-wide: 176,230
• Since beginning of last month:
  • Site-wide: 180,112

WEDGE: imputation of gene expression values from single-cell RNA-seq datasets using biased matrix decomposition

• Downloaded 826 times
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  • Site-wide: 45,100
  • In bioinformatics: 4,907
• Year to date:
  • Site-wide: 35,594
• Since beginning of last month:
  • Site-wide: 18,248

TCR repertoire analysis reveals effector memory T cells differentiation into Th17 cells in rheumatoid arthritis

• Downloaded 712 times
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  • Site-wide: 55,830
  • In immunology: 1,712
• Year to date:
  • Site-wide: 117,502
• Since beginning of last month:
  • Site-wide: 78,311

Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone

• Downloaded 709 times
• Download rankings, all-time:
  • Site-wide: 56,174
  • In neuroscience: 8,363
• Year to date:
  • Site-wide: 51,063
• Since beginning of last month:
  • Site-wide: 51,918

Impacts of Desulfobacterales and Chromatiales on sulfate reduction in the subtropical mangrove ecosystem as revealed by SMDB analysis

• Downloaded 659 times
• Download rankings, all-time:
  • Site-wide: 62,248
  • In bioinformatics: 6,330
• Year to date:
  • Site-wide: 36,700
• Since beginning of last month:
  • Site-wide: 54,226

TRAF6 directs Foxp3 localization and facilitates Treg function through K63-type ubiquitination

• Downloaded 635 times
• Download rankings, all-time:
  • Site-wide: 65,312
  • In immunology: 1,922
• Year to date:
  • Site-wide: 142,732
• Since beginning of last month:
  • Site-wide: 114,551

Bioinformatics of Potential Biomarkers in Patients with Repeated Implantation Failure

• Downloaded 583 times
• Download rankings, all-time:
  • Site-wide: 72,952
  • In sexual and reproductive health: 45
• Year to date:
  • Site-wide: 119,872
• Since beginning of last month:
  • Site-wide: 151,228

Profiling the microbial community structure and functional diversity of a dam-regulated river undergoing gravel bar restoration

• Downloaded 553 times
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  • Site-wide: 77,858
  • In microbiology: 4,735
• Year to date:
  • Site-wide: 132,005
• Since beginning of last month:
  • Site-wide: 137,638

The Telomerase Reverse Transcriptase (TERT) and p53 Regulate Mammalian PNS and CNS Axon Regeneration downstream of c-Myc

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 85,512
  • In neuroscience: 11,649
• Year to date:
  • Site-wide: 152,921
• Since beginning of last month:
  • Site-wide: 174,495

DIRC3 and close to NABP1 Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell Carcinoma

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 98,245
  • In plant biology: 2,369
• Year to date:
  • Site-wide: 178,843
• Since beginning of last month:
  • Site-wide: 143,285

Gating mechanism of human N-type voltage-gated calcium channel

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 100,194
  • In neuroscience: 15,831
• Year to date:
  • Site-wide: 49,606
• Since beginning of last month:
  • Site-wide: 55,733

Branching Networks Can Have Opposing Influences on Genetic Variation in Riverine Metapopulations

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 111,088
  • In ecology: 2,893
• Year to date:
  • Site-wide: 147,886
• Since beginning of last month:
  • Site-wide: 174,512

Detection of adaptive divergence in populations of the stream mayfly Ephemera strigata with machine learning

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 111,843
  • In evolutionary biology: 5,079
• Year to date:
  • Site-wide: 178,096
• Since beginning of last month:
  • Site-wide: 143,697

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways

• Downloaded 386 times
• Download rankings, all-time:
  • Site-wide: 113,913
  • In cell biology: 5,197
• Year to date:
  • Site-wide: 93,386
• Since beginning of last month:
  • Site-wide: 70,969

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 115,985
  • In developmental biology: 3,038
• Year to date:
  • Site-wide: 112,868
• Since beginning of last month:
  • Site-wide: 76,953

Dissecting the landscape of activated CMV-stimulated CD4+ T cells in human by linking single-cell RNA-seq with T-cell receptor sequencing

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 117,516
  • In immunology: 3,400
• Year to date:
  • Site-wide: 146,193
• Since beginning of last month:
  • Site-wide: 168,390

Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 119,789
  • In infectious diseases: 5,459
• Year to date:
  • Site-wide: 97,178
• Since beginning of last month:
  • Site-wide: 166,610

Reference genes for RT-qPCR normalisation in different tissues, developmental stages and stress conditions of Hypericum perforatum

• Downloaded 333 times
• Download rankings, all-time:
  • Site-wide: 128,510
  • In plant biology: 3,296
• Year to date:
  • Site-wide: 146,492
• Since beginning of last month:
  • Site-wide: 175,685

Effect of soybean molasses-adsorbents on in vitro ruminal fermentation characteristics, milk production performance in lactating dairy cows

• Downloaded 319 times
• Download rankings, all-time:
  • Site-wide: 132,631
  • In animal behavior and cognition: 1,445
• Year to date:
  • Site-wide: 163,379
• Since beginning of last month:
  • Site-wide: 162,058

Schistosoma Japonicum infection in Treg-specific USP21 knock-out mice

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 134,491
  • In immunology: 4,003
• Year to date:
  • Site-wide: 88,900
• Since beginning of last month:
  • Site-wide: 169,176

Performance Comparison of Computational Prediction Methods for the Function and Pathogenicity of Non-coding Variants

• Downloaded 297 times
• Download rankings, all-time:
  • Site-wide: 139,329
  • In bioinformatics: 10,794
• Year to date:
  • Site-wide: 65,043
• Since beginning of last month:
  • Site-wide: 167,708

Circular RNA circGTIC1 drives gastric TIC self-renewal to initiate gastric tumorigenesis and metastasis

• Downloaded 280 times
• Download rankings, all-time:
  • Site-wide: 144,278
  • In biochemistry: 4,020
• Year to date:
  • Site-wide: 173,548
• Since beginning of last month:
  • Site-wide: 185,528

NF-YA Transcriptionally Activates the Expression of SOX2 in Cervical Cancer Stem Cells

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 145,466
  • In cancer biology: 4,244
• Year to date:
  • Site-wide: 129,405
• Since beginning of last month:
  • Site-wide: 72,168

The RNA binding protein hnRNP-U is required for physiological hypertrophy of skeletal muscle

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 147,111
  • In cell biology: 6,460
• Year to date:
  • Site-wide: 160,746
• Since beginning of last month:
  • Site-wide: 102,879

TLR2 signaling pathway combats Streptococcus uberis infection by inducing production of mitochondrial reactive oxygen species

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 153,464
  • In pathology: 823
• Year to date:
  • Site-wide: 176,677
• Since beginning of last month:
  • Site-wide: 170,182

Genome assembly and transcriptome analysis provide insights into the anti-schistosome mechanism of Microtus fortis

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 160,526
  • In bioinformatics: 11,633
• Year to date:
  • Site-wide: 167,722
• Since beginning of last month:
  • Site-wide: 168,294

Inhibition of Pten activity promotes IB4 positive sensory neuronal axon growth

• Downloaded 177 times
• Download rankings, all-time:
  • Site-wide: 172,338
  • In neuroscience: 24,141
• Year to date:
  • Site-wide: 162,559
• Since beginning of last month:
  • Site-wide: 140,648

Safety assessment of insecticidal proteins: A case study utilizing His-tagged protein to determine the safety of Mpp75Aa1.1, a new ETX_MTX2 protein that controls western corn rootworm

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 172,893
  • In pharmacology and toxicology: None
• Year to date:
  • Site-wide: 23,717
• Since beginning of last month:
  • Site-wide: 10,362

Implications of taxonomic and numerical resolution on DNA metabarcoding-based inference of benthic macroinvertebrate responses to river restoration

• Downloaded 173 times
• Download rankings, all-time:
  • Site-wide: 173,329
  • In ecology: 5,733
• Year to date:
  • Site-wide: 122,027
• Since beginning of last month:
  • Site-wide: 133,515