Author: Fang Chen

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Preprints

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

• Downloaded 12,471 times
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  • Site-wide: 617
  • In immunology: 19
• Year to date:
  • Site-wide: 5,641
• Since beginning of last month:
  • Site-wide: 7,752

Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2

• Downloaded 8,771 times
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  • Site-wide: 992
  • In allergy and immunology: 6
• Year to date:
  • Site-wide: 11,304
• Since beginning of last month:
  • Site-wide: 12,005

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

• Downloaded 3,530 times
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  • Site-wide: 3,426
  • In microbiology: 232
• Year to date:
  • Site-wide: 9,001
• Since beginning of last month:
  • Site-wide: 11,408

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

• Downloaded 2,879 times
• Download rankings, all-time:
  • Site-wide: 4,544
  • In genomics: 503
• Year to date:
  • Site-wide: 24,993
• Since beginning of last month:
  • Site-wide: 45,506

Resequencing the Escherichia coli genome by GenoCare single molecule sequencing platform

• Downloaded 2,837 times
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  • Site-wide: 4,639
  • In genomics: 509
• Year to date:
  • Site-wide: 104,651
• Since beginning of last month:
  • Site-wide: 129,531

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

• Downloaded 2,522 times
• Download rankings, all-time:
  • Site-wide: 5,512
  • In genomics: 609
• Year to date:
  • Site-wide: 101,776
• Since beginning of last month:
  • Site-wide: 92,392

Advanced Whole Genome Sequencing Using an Entirely PCR-free Massively Parallel Sequencing Workflow

• Downloaded 2,235 times
• Download rankings, all-time:
  • Site-wide: 6,590
  • In genomics: 730
• Year to date:
  • Site-wide: 3,915
• Since beginning of last month:
  • Site-wide: 2,206

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

• Downloaded 2,151 times
• Download rankings, all-time:
  • Site-wide: 6,996
  • In cell biology: 154
• Year to date:
  • Site-wide: 14,792
• Since beginning of last month:
  • Site-wide: 15,336

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

• Downloaded 1,796 times
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  • Site-wide: 9,133
  • In genomics: 982
• Year to date:
  • Site-wide: 51,263
• Since beginning of last month:
  • Site-wide: 49,039

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

• Downloaded 1,776 times
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  • Site-wide: 9,289
  • In cell biology: 228
• Year to date:
  • Site-wide: 6,267
• Since beginning of last month:
  • Site-wide: 11,000

How many COVID-19 PCR positive individuals do weexpect to see on the Diamond Princess cruise ship?

• Downloaded 1,560 times
• Download rankings, all-time:
  • Site-wide: 11,249
  • In infectious diseases: 1,321
• Year to date:
  • Site-wide: 35,637
• Since beginning of last month:
  • Site-wide: 51,747

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

• Downloaded 1,505 times
• Download rankings, all-time:
  • Site-wide: 11,802
  • In developmental biology: 172
• Year to date:
  • Site-wide: 28,884
• Since beginning of last month:
  • Site-wide: 26,937

One-Step Rapid Quantification of SARS-CoV-2 Virus Particles via Low-Cost Nanoplasmonic Sensors in Generic Microplate Reader and Point-of-Care Device

• Downloaded 1,335 times
• Download rankings, all-time:
  • Site-wide: 14,194
  • In bioengineering: 234
• Year to date:
  • Site-wide: 9,704
• Since beginning of last month:
  • Site-wide: 15,374

An ATAC-seq atlas of chromatin accessibility in mouse tissues

• Downloaded 1,309 times
• Download rankings, all-time:
  • Site-wide: 14,622
  • In genomics: 1,524
• Year to date:
  • Site-wide: 87,278
• Since beginning of last month:
  • Site-wide: 68,448

The Trans-omics Landscape of COVID-19

• Downloaded 1,283 times
• Download rankings, all-time:
  • Site-wide: 15,076
  • In infectious diseases: 1,521
• Year to date:
  • Site-wide: 18,823
• Since beginning of last month:
  • Site-wide: 17,694

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

• Downloaded 1,010 times
• Download rankings, all-time:
  • Site-wide: 21,485
  • In cell biology: 737
• Year to date:
  • Site-wide: 39,252
• Since beginning of last month:
  • Site-wide: 22,804

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 992 times
• Download rankings, all-time:
  • Site-wide: 22,011
  • In developmental biology: 395
• Year to date:
  • Site-wide: 48,412
• Since beginning of last month:
  • Site-wide: 41,799

Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

• Downloaded 918 times
• Download rankings, all-time:
  • Site-wide: 24,723
  • In bioinformatics: 2,882
• Year to date:
  • Site-wide: 20,409
• Since beginning of last month:
  • Site-wide: 17,570

Impaired cellular immunity to SARS-CoV-2 in severe COVID-19 patients

• Downloaded 865 times
• Download rankings, all-time:
  • Site-wide: 26,846
  • In allergy and immunology: 57
• Year to date:
  • Site-wide: 38,702
• Since beginning of last month:
  • Site-wide: 53,893

The mitochondrial DNA content can not predict the embryo viability

• Downloaded 761 times
• Download rankings, all-time:
  • Site-wide: 32,098
  • In ecology: 708
• Year to date:
  • Site-wide: 56,899
• Since beginning of last month:
  • Site-wide: 69,706

Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

• Downloaded 727 times
• Download rankings, all-time:
  • Site-wide: 34,180
  • In cancer biology: 917
• Year to date:
  • Site-wide: 94,901
• Since beginning of last month:
  • Site-wide: 119,860

SLR-superscaffolder: a de novo scaffolding tool for synthetic long reads using a top-to-bottom scheme

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 35,620
  • In bioinformatics: 3,938
• Year to date:
  • Site-wide: 48,825
• Since beginning of last month:
  • Site-wide: 45,457

Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients

• Downloaded 693 times
• Download rankings, all-time:
  • Site-wide: 36,443
  • In epidemiology: 1,795
• Year to date:
  • Site-wide: 31,776
• Since beginning of last month:
  • Site-wide: 28,971

PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

• Downloaded 676 times
• Download rankings, all-time:
  • Site-wide: 37,716
  • In molecular biology: 1,059
• Year to date:
  • Site-wide: 56,565
• Since beginning of last month:
  • Site-wide: 49,033

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

• Downloaded 659 times
• Download rankings, all-time:
  • Site-wide: 38,990
  • In cell biology: 1,584
• Year to date:
  • Site-wide: 90,462
• Since beginning of last month:
  • Site-wide: 83,770

Advanced whole genome sequencing and analysis of fetal genomes from amniotic fluid

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 41,004
  • In genomics: 3,386
• Year to date:
  • Site-wide: 98,056
• Since beginning of last month:
  • Site-wide: 57,497

Single cell chromatin accessibility of the developmental cephalochordate

• Downloaded 620 times
• Download rankings, all-time:
  • Site-wide: 42,199
  • In developmental biology: 946
• Year to date:
  • Site-wide: 47,044
• Since beginning of last month:
  • Site-wide: 39,781

Detection and characterization of copy number variants based on whole-genome sequencing by DNBSEQ platforms

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 43,106
  • In bioinformatics: 4,601
• Year to date:
  • Site-wide: 58,717
• Since beginning of last month:
  • Site-wide: 63,789

Assessment of the gene expression profiles of leukocytes from different isolations

• Downloaded 604 times
• Download rankings, all-time:
  • Site-wide: 43,535
  • In molecular biology: 1,242
• Year to date:
  • Site-wide: 27,768
• Since beginning of last month:
  • Site-wide: 24,800

Noninvasive prenatal detection of fetal trisomy and single gene disease by shotgun sequencing of placenta originated exosome DNA: a proof-of-concept validation

• Downloaded 573 times
• Download rankings, all-time:
  • Site-wide: 46,525
  • In genetics: 2,167
• Year to date:
  • Site-wide: 95,101
• Since beginning of last month:
  • Site-wide: 95,967

Evaluation of five cell-free DNA isolation kits for plasma

• Downloaded 545 times
• Download rankings, all-time:
  • Site-wide: 49,426
  • In molecular biology: 1,394
• Year to date:
  • Site-wide: 75,412
• Since beginning of last month:
  • Site-wide: 48,113

An integrated Asian human SNV and indel benchmark combining multiple sequencing methods

• Downloaded 539 times
• Download rankings, all-time:
  • Site-wide: 50,105
  • In genomics: 3,920
• Year to date:
  • Site-wide: 90,781
• Since beginning of last month:
  • Site-wide: 71,476

Single cell atlas of trisomy 21 cerebral cortex

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 51,800
  • In neuroscience: 7,579
• Year to date:
  • Site-wide: 60,247
• Since beginning of last month:
  • Site-wide: 77,660

Robust Benchmark Structural Variant Calls of An Asian Using the State-of-Art Long Fragment Sequencing Technologies

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 54,609
  • In genomics: 4,165
• Year to date:
  • Site-wide: 19,047
• Since beginning of last month:
  • Site-wide: 16,495

FabriEVEs: A dedicated platform for endogenous viral elements in fishes, amphibians, birds, reptiles and invertebrates

• Downloaded 435 times
• Download rankings, all-time:
  • Site-wide: 63,554
  • In evolutionary biology: 3,441
• Year to date:
  • Site-wide: 100,662
• Since beginning of last month:
  • Site-wide: 130,934

Noninvasive prenatal diagnosis for Haemophilia A by a haplotype-based approach using cell-free fetal DNA in maternal plasma

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 71,439
  • In molecular biology: 2,086
• Year to date:
  • Site-wide: 107,489
• Since beginning of last month:
  • Site-wide: 105,636

Development of a Genomic DNA Reference Material Panel for Thalassemia Genetic Testing

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 73,280
  • In genetics: 3,308
• Year to date:
  • Site-wide: 31,925
• Since beginning of last month:
  • Site-wide: 20,096

Compensatory replacement of the BigH1 variant histone by canonical H1 supports normal embryonic development in Drosophila

• Downloaded 305 times
• Download rankings, all-time:
  • Site-wide: 87,147
  • In developmental biology: 2,345
• Year to date:
  • Site-wide: 99,702
• Since beginning of last month:
  • Site-wide: 72,387

High-resolution Cell Atlas of Pig Lung and Online Platform Exploring for Lung Single Cell

• Downloaded 254 times
• Download rankings, all-time:
  • Site-wide: 98,349
  • In cell biology: 4,566
• Year to date:
  • Site-wide: 19,884
• Since beginning of last month:
  • Site-wide: 20,007

Two Color Single Molecule Sequencing on GenoCare 1600 Platform to Facilitate Clinical Applications

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 99,693
  • In genetic and genomic medicine: 417
• Year to date:
  • Site-wide: 49,741
• Since beginning of last month:
  • Site-wide: 47,676

Genome sequencing combining prenatal ultrasound in the evaluation of fetal CNS structural anomalies

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 99,990
  • In genetic and genomic medicine: 421
• Year to date:
  • Site-wide: 88,458
• Since beginning of last month:
  • Site-wide: 65,229

Effect of storage conditions on peripheral leukocytes transcriptome

• Downloaded 233 times
• Download rankings, all-time:
  • Site-wide: 103,035
  • In molecular biology: 3,061
• Year to date:
  • Site-wide: 57,651
• Since beginning of last month:
  • Site-wide: 53,940

Clinical and molecular diagnostic study of 320 Chinese children with epilepsy by Genome Sequencing

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 105,370
  • In genetic and genomic medicine: 456
• Year to date:
  • Site-wide: 69,712
• Since beginning of last month:
  • Site-wide: 63,900

AsmMix: A pipeline for high quality diploid denovo assembly

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 105,897
  • In genomics: 6,174
• Year to date:
  • Site-wide: 13,612
• Since beginning of last month:
  • Site-wide: 61,098

Combined use of Candida Utilis and Idesia polycarpa var. Vestita Fruit Improve the Production Performance of Laying Quail

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 110,508
  • In microbiology: 8,166
• Year to date:
  • Site-wide: 121,578
• Since beginning of last month:
  • Site-wide: 94,438

Genomic epidemiology of SARS-CoV-2 in the United Arab Emirates reveals novel virus mutation, patterns of co-infection and tissue specific host innate immune response

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 114,631
  • In epidemiology: 4,720
• Year to date:
  • Site-wide: 17,276
• Since beginning of last month:
  • Site-wide: 11,064

A phenotype-specific framework for identifying the eye abnormalities causative nonsynonymous-variants

• Downloaded 154 times
• Download rankings, all-time:
  • Site-wide: 120,861
  • In bioinformatics: 9,788
• Year to date:
  • Site-wide: 120,525
• Since beginning of last month:
  • Site-wide: 113,233

Mycobacterial CarD defines a novel mechanism of response to starvation stress

• Downloaded 149 times
• Download rankings, all-time:
  • Site-wide: 121,893
  • In microbiology: 9,212
• Year to date:
  • Site-wide: 22,387
• Since beginning of last month:
  • Site-wide: 4,133

BDdb: a comprehensive platform for exploration and utilization of birth defect multi-omics data

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 127,141
  • In bioinformatics: 10,103
• Year to date:
  • Site-wide: 110,181
• Since beginning of last month:
  • Site-wide: 96,038

Tissue-specific accumulation profiles of phorbol esters in Jatropha curcas and gene induction in response to abiotic and biotic stresses

• Downloaded 108 times
• Download rankings, all-time:
  • Site-wide: 129,902
  • In plant biology: 3,684
• Year to date:
  • Site-wide: 69,324
• Since beginning of last month:
  • Site-wide: 41,308

Impact of blood storage conditions on the transcript profile of plasma cell-free RNA

• Downloaded 103 times
• Download rankings, all-time:
  • Site-wide: 130,801
  • In molecular biology: 3,920
• Year to date:
  • Site-wide: 34,010
• Since beginning of last month:
  • Site-wide: 12,473