Author: Fang Chen

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Preprints

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

• Downloaded 13,181 times
• Download rankings, all-time:
  • Site-wide: 900
  • In immunology: 40
• Year to date:
  • Site-wide: 10,584
• Since beginning of last month:
  • Site-wide: 7,777

Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2

• Downloaded 9,232 times
• Download rankings, all-time:
  • Site-wide: 1,407
  • In allergy and immunology: 10
• Year to date:
  • Site-wide: 36,626
• Since beginning of last month:
  • Site-wide: 61,722

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

• Downloaded 3,906 times
• Download rankings, all-time:
  • Site-wide: 4,431
  • In microbiology: 290
• Year to date:
  • Site-wide: 51,654
• Since beginning of last month:
  • Site-wide: 61,841

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

• Downloaded 3,056 times
• Download rankings, all-time:
  • Site-wide: 6,359
  • In genomics: 579
• Year to date:
  • Site-wide: 86,911
• Since beginning of last month:
  • Site-wide: 84,084

Advanced Whole Genome Sequencing Using an Entirely PCR-free Massively Parallel Sequencing Workflow

• Downloaded 2,984 times
• Download rankings, all-time:
  • Site-wide: 6,570
  • In genomics: 643
• Year to date:
  • Site-wide: 15,450
• Since beginning of last month:
  • Site-wide: 6,985

Resequencing the Escherichia coli genome by GenoCare single molecule sequencing platform

• Downloaded 2,969 times
• Download rankings, all-time:
  • Site-wide: 6,610
  • In genomics: 595
• Year to date:
  • Site-wide: 113,842
• Since beginning of last month:
  • Site-wide: 130,176

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

• Downloaded 2,683 times
• Download rankings, all-time:
  • Site-wide: 7,665
  • In cell biology: 159
• Year to date:
  • Site-wide: 22,635
• Since beginning of last month:
  • Site-wide: 26,240

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

• Downloaded 2,620 times
• Download rankings, all-time:
  • Site-wide: 7,965
  • In genomics: 727
• Year to date:
  • Site-wide: 144,110
• Since beginning of last month:
  • Site-wide: 119,113

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

• Downloaded 2,207 times
• Download rankings, all-time:
  • Site-wide: 10,196
  • In cell biology: 225
• Year to date:
  • Site-wide: 41,207
• Since beginning of last month:
  • Site-wide: 47,051

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

• Downloaded 1,933 times
• Download rankings, all-time:
  • Site-wide: 12,466
  • In genomics: 1,121
• Year to date:
  • Site-wide: 81,869
• Since beginning of last month:
  • Site-wide: 95,172

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

• Downloaded 1,740 times
• Download rankings, all-time:
  • Site-wide: 14,588
  • In developmental biology: 194
• Year to date:
  • Site-wide: 46,185
• Since beginning of last month:
  • Site-wide: 66,658

How many COVID-19 PCR positive individuals do weexpect to see on the Diamond Princess cruise ship?

• Downloaded 1,721 times
• Download rankings, all-time:
  • Site-wide: 14,818
  • In infectious diseases: 1,848
• Year to date:
  • Site-wide: 125,797
• Since beginning of last month:
  • Site-wide: 106,446

One-Step Rapid Quantification of SARS-CoV-2 Virus Particles via Low-Cost Nanoplasmonic Sensors in Generic Microplate Reader and Point-of-Care Device

• Downloaded 1,665 times
• Download rankings, all-time:
  • Site-wide: 15,557
  • In bioengineering: 255
• Year to date:
  • Site-wide: 83,420
• Since beginning of last month:
  • Site-wide: 62,053

The Trans-omics Landscape of COVID-19

• Downloaded 1,531 times
• Download rankings, all-time:
  • Site-wide: 17,718
  • In infectious diseases: 2,036
• Year to date:
  • Site-wide: 93,464
• Since beginning of last month:
  • Site-wide: 83,670

An ATAC-seq atlas of chromatin accessibility in mouse tissues

• Downloaded 1,389 times
• Download rankings, all-time:
  • Site-wide: 20,587
  • In genomics: 1,756
• Year to date:
  • Site-wide: 163,558
• Since beginning of last month:
  • Site-wide: 188,373

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 1,338 times
• Download rankings, all-time:
  • Site-wide: 21,795
  • In developmental biology: 350
• Year to date:
  • Site-wide: 54,624
• Since beginning of last month:
  • Site-wide: 58,161

Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

• Downloaded 1,196 times
• Download rankings, all-time:
  • Site-wide: 26,016
  • In bioinformatics: 2,776
• Year to date:
  • Site-wide: 64,087
• Since beginning of last month:
  • Site-wide: 57,442

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

• Downloaded 1,191 times
• Download rankings, all-time:
  • Site-wide: 26,171
  • In cell biology: 851
• Year to date:
  • Site-wide: 80,200
• Since beginning of last month:
  • Site-wide: 79,572

PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

• Downloaded 1,047 times
• Download rankings, all-time:
  • Site-wide: 31,725
  • In molecular biology: 929
• Year to date:
  • Site-wide: 22,448
• Since beginning of last month:
  • Site-wide: 33,605

Impaired cellular immunity to SARS-CoV-2 in severe COVID-19 patients

• Downloaded 1,034 times
• Download rankings, all-time:
  • Site-wide: 32,372
  • In allergy and immunology: 99
• Year to date:
  • Site-wide: 104,940
• Since beginning of last month:
  • Site-wide: 100,009

Assessment of the gene expression profiles of leukocytes from different isolations

• Downloaded 920 times
• Download rankings, all-time:
  • Site-wide: 38,531
  • In molecular biology: 1,114
• Year to date:
  • Site-wide: 36,322
• Since beginning of last month:
  • Site-wide: 42,260

The mitochondrial DNA content can not predict the embryo viability

• Downloaded 894 times
• Download rankings, all-time:
  • Site-wide: 40,137
  • In ecology: 774
• Year to date:
  • Site-wide: 138,001
• Since beginning of last month:
  • Site-wide: 104,439

Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients

• Downloaded 882 times
• Download rankings, all-time:
  • Site-wide: 40,947
  • In epidemiology: 2,059
• Year to date:
  • Site-wide: 92,984
• Since beginning of last month:
  • Site-wide: 85,233

SLR-superscaffolder: a de novo scaffolding tool for synthetic long reads using a top-to-bottom scheme

• Downloaded 856 times
• Download rankings, all-time:
  • Site-wide: 42,801
  • In bioinformatics: 4,236
• Year to date:
  • Site-wide: 116,869
• Since beginning of last month:
  • Site-wide: 159,418

Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

• Downloaded 839 times
• Download rankings, all-time:
  • Site-wide: 44,135
  • In cancer biology: 1,125
• Year to date:
  • Site-wide: 121,566
• Since beginning of last month:
  • Site-wide: 146,941

Single cell chromatin accessibility of the developmental cephalochordate

• Downloaded 824 times
• Download rankings, all-time:
  • Site-wide: 45,297
  • In developmental biology: 937
• Year to date:
  • Site-wide: 81,593
• Since beginning of last month:
  • Site-wide: 90,932

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

• Downloaded 820 times
• Download rankings, all-time:
  • Site-wide: 45,644
  • In cell biology: 1,836
• Year to date:
  • Site-wide: 69,556
• Since beginning of last month:
  • Site-wide: 79,542

Detection and characterization of copy number variants based on whole-genome sequencing by DNBSEQ platforms

• Downloaded 809 times
• Download rankings, all-time:
  • Site-wide: 46,552
  • In bioinformatics: 4,661
• Year to date:
  • Site-wide: 83,127
• Since beginning of last month:
  • Site-wide: 59,433

Single cell atlas of trisomy 21 cerebral cortex

• Downloaded 741 times
• Download rankings, all-time:
  • Site-wide: 52,860
  • In neuroscience: 7,189
• Year to date:
  • Site-wide: 84,610
• Since beginning of last month:
  • Site-wide: 103,150

Advanced whole genome sequencing and analysis of fetal genomes from amniotic fluid

• Downloaded 716 times
• Download rankings, all-time:
  • Site-wide: 55,406
  • In genomics: 3,927
• Year to date:
  • Site-wide: 125,003
• Since beginning of last month:
  • Site-wide: 94,432

Evaluation of five cell-free DNA isolation kits for plasma

• Downloaded 712 times
• Download rankings, all-time:
  • Site-wide: 55,849
  • In molecular biology: 1,593
• Year to date:
  • Site-wide: 72,395
• Since beginning of last month:
  • Site-wide: 51,659

Robust Benchmark Structural Variant Calls of An Asian Using the State-of-Art Long Fragment Sequencing Technologies

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 56,613
  • In genomics: 4,020
• Year to date:
  • Site-wide: 81,381
• Since beginning of last month:
  • Site-wide: 112,837

An integrated Asian human SNV and indel benchmark combining multiple sequencing methods

• Downloaded 675 times
• Download rankings, all-time:
  • Site-wide: 60,232
  • In genomics: 4,141
• Year to date:
  • Site-wide: 101,050
• Since beginning of last month:
  • Site-wide: 153,739

Noninvasive prenatal detection of fetal trisomy and single gene disease by shotgun sequencing of placenta originated exosome DNA: a proof-of-concept validation

• Downloaded 666 times
• Download rankings, all-time:
  • Site-wide: 61,401
  • In genetics: 2,359
• Year to date:
  • Site-wide: 163,696
• Since beginning of last month:
  • Site-wide: 161,050

Development of a Genomic DNA Reference Material Panel for Thalassemia Genetic Testing

• Downloaded 620 times
• Download rankings, all-time:
  • Site-wide: 67,318
  • In genetics: 2,749
• Year to date:
  • Site-wide: 71,151
• Since beginning of last month:
  • Site-wide: 66,520

Genomic epidemiology of SARS-CoV-2 in the United Arab Emirates reveals novel virus mutation, patterns of co-infection and tissue specific host innate immune response

• Downloaded 597 times
• Download rankings, all-time:
  • Site-wide: 70,857
  • In epidemiology: 4,017
• Year to date:
  • Site-wide: 21,358
• Since beginning of last month:
  • Site-wide: 4,748

High-resolution Cell Atlas of Pig Lung and Online Platform Exploring for Lung Single Cell

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 84,227
  • In cell biology: 4,024
• Year to date:
  • Site-wide: 58,263
• Since beginning of last month:
  • Site-wide: 52,612

FabriEVEs: A dedicated platform for endogenous viral elements in fishes, amphibians, birds, reptiles and invertebrates

• Downloaded 516 times
• Download rankings, all-time:
  • Site-wide: 84,575
  • In evolutionary biology: 3,848
• Year to date:
  • Site-wide: 152,976
• Since beginning of last month:
  • Site-wide: 130,484

Two Color Single Molecule Sequencing on GenoCare 1600 Platform to Facilitate Clinical Applications

• Downloaded 504 times
• Download rankings, all-time:
  • Site-wide: 86,932
  • In genetic and genomic medicine: 487
• Year to date:
  • Site-wide: 52,295
• Since beginning of last month:
  • Site-wide: 52,619

Noninvasive prenatal diagnosis for Haemophilia A by a haplotype-based approach using cell-free fetal DNA in maternal plasma

• Downloaded 481 times
• Download rankings, all-time:
  • Site-wide: 91,524
  • In molecular biology: 2,558
• Year to date:
  • Site-wide: 134,153
• Since beginning of last month:
  • Site-wide: 117,779

Clp protease and antisense RNA jointly regulate the global regulator CarD to mediate mycobacterial starvation response

• Downloaded 449 times
• Download rankings, all-time:
  • Site-wide: 98,810
  • In microbiology: 6,498
• Year to date:
  • Site-wide: 30,502
• Since beginning of last month:
  • Site-wide: 87,738

Compensatory replacement of the BigH1 variant histone by canonical H1 supports normal embryonic development in Drosophila

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 101,135
  • In developmental biology: 2,550
• Year to date:
  • Site-wide: 93,477
• Since beginning of last month:
  • Site-wide: 65,988

Clinical and molecular diagnostic study of 320 Chinese children with epilepsy by Genome Sequencing

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 110,101
  • In genetic and genomic medicine: 596
• Year to date:
  • Site-wide: 109,810
• Since beginning of last month:
  • Site-wide: 168,706

Genome sequencing combining prenatal ultrasound in the evaluation of fetal CNS structural anomalies

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 112,055
  • In genetic and genomic medicine: 644
• Year to date:
  • Site-wide: 103,884
• Since beginning of last month:
  • Site-wide: 121,147

AsmMix: A pipeline for high quality diploid denovo assembly

• Downloaded 388 times
• Download rankings, all-time:
  • Site-wide: 113,335
  • In genomics: 6,450
• Year to date:
  • Site-wide: 90,172
• Since beginning of last month:
  • Site-wide: 99,540

Effect of storage conditions on peripheral leukocytes transcriptome

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 118,768
  • In molecular biology: 3,417
• Year to date:
  • Site-wide: 119,880
• Since beginning of last month:
  • Site-wide: 80,873

Impact of blood storage conditions on the transcript profile of plasma cell-free RNA

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 122,803
  • In molecular biology: 3,707
• Year to date:
  • Site-wide: 65,982
• Since beginning of last month:
  • Site-wide: 52,892

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 123,934
  • In cancer biology: 3,862
• Year to date:
  • Site-wide: 47,945
• Since beginning of last month:
  • Site-wide: 69,984

Combined use of Candida Utilis and Idesia polycarpa var. Vestita Fruit Improve the Production Performance of Laying Quail

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 126,205
  • In microbiology: 8,619
• Year to date:
  • Site-wide: 107,045
• Since beginning of last month:
  • Site-wide: 129,775

A phenotype-specific framework for identifying the eye abnormalities causative nonsynonymous-variants

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 154,253
  • In bioinformatics: 11,311
• Year to date:
  • Site-wide: 157,077
• Since beginning of last month:
  • Site-wide: 153,650

Tissue-specific accumulation profiles of phorbol esters in Jatropha curcas and gene induction in response to abiotic and biotic stresses

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 161,010
  • In plant biology: 4,294
• Year to date:
  • Site-wide: 130,902
• Since beginning of last month:
  • Site-wide: 83,664

BDdb: a comprehensive platform for exploration and utilization of birth defect multi-omics data

• Downloaded 217 times
• Download rankings, all-time:
  • Site-wide: 162,515
  • In bioinformatics: 11,717
• Year to date:
  • Site-wide: 168,208
• Since beginning of last month:
  • Site-wide: 127,720

Elevated transcriptional pausing of RNA polymerase II underlies acquired resistance to radiotherapy

• Downloaded 132 times
• Download rankings, all-time:
  • Site-wide: 181,271
  • In cancer biology: 5,310
• Year to date:
  • Site-wide: 84,429
• Since beginning of last month:
  • Site-wide: 155,104

Whole-exome Sequencing Study of Hypospadias

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 182,690
  • In genetic and genomic medicine: 1,238
• Year to date:
  • Site-wide: 37,193
• Since beginning of last month:
  • Site-wide: 100,703