Author: Silviu-Alin Bacanu

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 7,155
  • In genetics: 357
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Genome-wide association study of suicide death and polygenic prediction of clinical antecedents

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  • In genomics: 906
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QCAT: testing causality of variants using only summary association statistics

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  • Site-wide: 25,930
  • In genetics: 1,320
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  • Site-wide: 43,591
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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 31,333
  • In genetics: 1,580
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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

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  • Site-wide: 33,197
  • In genetics: 1,674
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Proof of concept: Molecular prediction of schizophrenia risk

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  • In genomics: 3,079
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Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

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  • In genetics: 1,834
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  • Site-wide: 76,833

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • In genetics: 1,983
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TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders

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  • In bioinformatics: 5,070
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FIQT: a simple, powerful method to accurately estimate effect sizes in genome scans

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  • In genetics: 2,576
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Pathway-based polygenic risk implicates GO: 17144 drug metabolism in recurrent depressive disorder

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  • In genetics: 3,069
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Method to estimate the approximate samples size that yield a certain number of significant GWAS signals in polygenic traits

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  • Site-wide: 92,685

JEPEGMIX2: improved gene-level joint analysis of eQTLs in cosmopolitan cohorts.

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  • In bioinformatics: 6,903
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The Impact on Estimations of Genetic Correlations of the Use, in Genome Wide Case-Control Studies, of Super-Normal, Unscreened and Family-History Screened Controls

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Increasing the resolution and precision of psychiatric GWAS by re-imputing summary statistics using a large, diverse reference panel

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  • Site-wide: 74,892
  • In bioinformatics: 6,969
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Assessing the role of long-noncoding RNA in nucleus accumbens in subjects with alcohol dependence

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  • In neuroscience: 13,076
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Host genome analysis of structural variations by Optical Genome Mapping provides clinically valuable insights into genes implicated in critical immune, viral infection, and viral replication pathways in patients with severe COVID-19.

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  • Site-wide: 94,130
  • In infectious diseases: 3,133
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  • Site-wide: 320
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Network Preservation Reveals Shared and Unique Biological Processes Associated with Chronic Alcohol Abuse in NAc and PFC.

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  • Site-wide: 115,621
  • In genomics: 6,411
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  • Site-wide: 57,205