Author: Sarah E Harris

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Preprints

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 5,518
  • In genetics: 183
• Year to date:
  • Site-wide: 74,168
• Since beginning of last month:
  • Site-wide: 26,134

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,393 times
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  • Site-wide: 5,776
  • In genetics: 194
• Year to date:
  • Site-wide: 83,347
• Since beginning of last month:
  • Site-wide: 131,206

Molecular genetic contributions to self-rated health

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  • Site-wide: 9,631
  • In genetics: 373
• Year to date:
  • Site-wide: 83,348
• Since beginning of last month:
  • Site-wide: 100,620

GWAS on family history of Alzheimer's disease

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  • Site-wide: 11,617
  • In genetics: 438
• Year to date:
  • Site-wide: 143,865
• Since beginning of last month:
  • Site-wide: 131,408

Genetic Prediction of Male Pattern Baldness

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  • Site-wide: 12,451
  • In genetics: 463
• Year to date:
  • Site-wide: 92,362
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  • Site-wide: None

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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  • Site-wide: 14,487
  • In genetics: 585
• Year to date:
  • Site-wide: 84,400
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  • Site-wide: 25,973

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,787 times
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  • Site-wide: 14,923
  • In genomics: 1,361
• Year to date:
  • Site-wide: 76,035
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  • Site-wide: 76,146

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,741 times
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  • Site-wide: 15,517
  • In genetics: 628
• Year to date:
  • Site-wide: 49,379
• Since beginning of last month:
  • Site-wide: 31,690

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,669 times
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  • Site-wide: 16,513
  • In genetics: 677
• Year to date:
  • Site-wide: 67,622
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  • Site-wide: 33,516

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 19,101
  • In bioinformatics: 2,062
• Year to date:
  • Site-wide: 95,244
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  • Site-wide: 99,643

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

• Downloaded 1,453 times
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  • Site-wide: 20,544
  • In cell biology: 639
• Year to date:
  • Site-wide: 16,399
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  • Site-wide: 67,203

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

• Downloaded 1,366 times
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  • Site-wide: 22,631
  • In genetics: 924
• Year to date:
  • Site-wide: 76,422
• Since beginning of last month:
  • Site-wide: 40,283

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 1,137 times
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  • Site-wide: 30,170
  • In genomics: 2,523
• Year to date:
  • Site-wide: 145,037
• Since beginning of last month:
  • Site-wide: 132,861

An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 32,475
  • In genetics: 1,303
• Year to date:
  • Site-wide: 173,045
• Since beginning of last month:
  • Site-wide: 95,633

Epigenetic scores for the circulating proteome as tools for disease prediction

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  • Site-wide: 34,449
  • In genomics: 2,822
• Year to date:
  • Site-wide: 39,194
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  • Site-wide: 85,528

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 859 times
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  • Site-wide: 46,208
  • In genomics: 3,491
• Year to date:
  • Site-wide: 121,407
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  • Site-wide: 47,670

Genetic contributions to self-reported tiredness

• Downloaded 789 times
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  • Site-wide: 52,498
  • In genetics: 2,065
• Year to date:
  • Site-wide: 138,152
• Since beginning of last month:
  • Site-wide: 170,827

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

• Downloaded 729 times
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  • Site-wide: 58,768
  • In neuroscience: 8,222
• Year to date:
  • Site-wide: 103,768
• Since beginning of last month:
  • Site-wide: 65,898

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 705 times
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  • Site-wide: 61,681
  • In genomics: 4,337
• Year to date:
  • Site-wide: 37,177
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  • Site-wide: None

An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

• Downloaded 694 times
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  • Site-wide: 63,025
  • In neurology: 219
• Year to date:
  • Site-wide: 63,646
• Since beginning of last month:
  • Site-wide: 24,080

Cognitive ability and physical health: a Mendelian randomization study

• Downloaded 669 times
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  • Site-wide: 66,455
  • In genetics: 2,558
• Year to date:
  • Site-wide: 188,968
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  • Site-wide: None

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 651 times
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  • Site-wide: 68,914
  • In genetics: 2,675
• Year to date:
  • Site-wide: 141,153
• Since beginning of last month:
  • Site-wide: 100,628

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

• Downloaded 589 times
• Download rankings, all-time:
  • Site-wide: 78,429
  • In genetic and genomic medicine: 527
• Year to date:
  • Site-wide: 6,445
• Since beginning of last month:
  • Site-wide: 22,096

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 576 times
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  • Site-wide: 80,593
  • In genomics: 5,208
• Year to date:
  • Site-wide: 155,484
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  • Site-wide: 141,378

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

• Downloaded 568 times
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  • Site-wide: 82,046
  • In genomics: 5,241
• Year to date:
  • Site-wide: 195,983
• Since beginning of last month:
  • Site-wide: 127,775

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 562 times
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  • Site-wide: 83,094
  • In genetics: 3,184
• Year to date:
  • Site-wide: 176,051
• Since beginning of last month:
  • Site-wide: 164,428

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

• Downloaded 557 times
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  • Site-wide: 84,063
  • In genomics: 5,354
• Year to date:
  • Site-wide: 152,840
• Since beginning of last month:
  • Site-wide: 129,005

Blood-based epigenome-wide analyses of cognitive abilities

• Downloaded 555 times
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  • Site-wide: 84,326
  • In genetic and genomic medicine: 532
• Year to date:
  • Site-wide: 80,864
• Since beginning of last month:
  • Site-wide: 25,638

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 545 times
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  • Site-wide: 86,210
  • In genomics: 5,409
• Year to date:
  • Site-wide: 182,280
• Since beginning of last month:
  • Site-wide: None

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 542 times
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  • Site-wide: 86,755
  • In genetics: 3,369
• Year to date:
  • Site-wide: 177,034
• Since beginning of last month:
  • Site-wide: 95,613

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 496 times
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  • Site-wide: 96,274
  • In neuroscience: 13,911
• Year to date:
  • Site-wide: 159,384
• Since beginning of last month:
  • Site-wide: 127,136

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 486 times
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  • Site-wide: 98,427
  • In genetic and genomic medicine: 607
• Year to date:
  • Site-wide: 96,965
• Since beginning of last month:
  • Site-wide: 112,722

An epigenetic predictor of death captures multi-modal measures of brain health

• Downloaded 435 times
• Download rankings, all-time:
  • Site-wide: 110,498
  • In neuroscience: 15,909
• Year to date:
  • Site-wide: 188,421
• Since beginning of last month:
  • Site-wide: 164,085

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 121,511
  • In genetics: 4,589
• Year to date:
  • Site-wide: 195,026
• Since beginning of last month:
  • Site-wide: 164,529

Pulmonary function and risk of Alzheimer dementia: two-sample Mendelian randomization study

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 125,833
  • In epidemiology: 5,277
• Year to date:
  • Site-wide: 148,036
• Since beginning of last month:
  • Site-wide: 112,752

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 377 times
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  • Site-wide: 125,608
  • In epidemiology: 5,231
• Year to date:
  • Site-wide: 172,842
• Since beginning of last month:
  • Site-wide: 124,926

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

• Downloaded 367 times
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  • Site-wide: 128,471
  • In cell biology: 5,971
• Year to date:
  • Site-wide: 163,114
• Since beginning of last month:
  • Site-wide: 80,667

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

• Downloaded 340 times
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  • Site-wide: 136,368
  • In neuroscience: 20,070
• Year to date:
  • Site-wide: 87,876
• Since beginning of last month:
  • Site-wide: 113,259

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

• Downloaded 327 times
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  • Site-wide: 140,299
  • In neuroscience: 20,560
• Year to date:
  • Site-wide: 162,002
• Since beginning of last month:
  • Site-wide: 171,227

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 297 times
• Download rankings, all-time:
  • Site-wide: 149,146
  • In neuroscience: 21,894
• Year to date:
  • Site-wide: 125,565
• Since beginning of last month:
  • Site-wide: 65,276

Local CpG density affects the trajectory of age-associated epigenetic changes

• Downloaded 292 times
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  • Site-wide: 150,593
  • In genetics: 5,683
• Year to date:
  • Site-wide: 105,413
• Since beginning of last month:
  • Site-wide: 151,754

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

• Downloaded 284 times
• Download rankings, all-time:
  • Site-wide: 152,909
  • In psychiatry and clinical psychology: 934
• Year to date:
  • Site-wide: 87,281
• Since beginning of last month:
  • Site-wide: 56,612

Refining epigenetic prediction of chronological and biological age

• Downloaded 270 times
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  • Site-wide: 156,939
  • In genomics: None
• Year to date:
  • Site-wide: 23,012
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  • Site-wide: 271

Epigenetic predictors of lifestyle traits applied to the blood and brain

• Downloaded 253 times
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  • Site-wide: 161,842
  • In genetic and genomic medicine: 1,115
• Year to date:
  • Site-wide: 156,721
• Since beginning of last month:
  • Site-wide: None

Association between plasma phospho-tau181 and cognitive change from age 73 to 82: Lothian Birth Cohort 1936

• Downloaded 252 times
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  • Site-wide: 162,140
  • In neuroscience: 24,007
• Year to date:
  • Site-wide: 48,831
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  • Site-wide: 44,570

Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors

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  • Site-wide: 181,374
  • In epidemiology: 7,320
• Year to date:
  • Site-wide: 42,750
• Since beginning of last month:
  • Site-wide: 21,971

Life-course exposure to air pollution and biological ageing in the Lothian Birth Cohort 1936

• Downloaded 141 times
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  • Site-wide: 188,362
  • In occupational and environmental health: 353
• Year to date:
  • Site-wide: 55,910
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  • Site-wide: 54,911