Author: Sarah E. Harris

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Preprints

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,975
  • In genetics: 168
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  • Site-wide: 54,308
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Molecular genetic contributions to self-rated health

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  • Site-wide: 6,342
  • In genetics: 305
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  • Site-wide: 55,609
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GWAS on family history of Alzheimer's disease

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  • Site-wide: 7,516
  • In genetics: 353
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  • Site-wide: 62,410
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  • Site-wide: 48,518

Genetic Prediction of Male Pattern Baldness

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  • Site-wide: 8,805
  • In genetics: 413
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  • Site-wide: 61,324
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Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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  • Site-wide: 10,227
  • In genetics: 494
• Year to date:
  • Site-wide: 85,831
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  • Site-wide: 94,714

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • Site-wide: 10,607
  • In genomics: 1,152
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  • Site-wide: 74,515
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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 13,149
  • In genetics: 647
• Year to date:
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Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 14,042
  • In bioinformatics: 1,714
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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 16,765
  • In genetics: 821
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Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 19,762
  • In genomics: 1,993
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  • Site-wide: 96,732
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  • Site-wide: 110,854

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

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  • Site-wide: 20,225
  • In genetics: 971
• Year to date:
  • Site-wide: 17,170
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  • Site-wide: 50,238

An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 21,077
  • In genetics: 1,012
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  • Site-wide: 62,438
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  • Site-wide: 61,290

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 31,472
  • In genomics: 2,814
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  • Site-wide: 94,111
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  • Site-wide: 108,316

Genetic contributions to self-reported tiredness

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  • Site-wide: 33,698
  • In genetics: 1,632
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  • Site-wide: 57,634
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  • Site-wide: 128,064

Cognitive ability and physical health: a Mendelian randomization study

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  • Site-wide: 41,546
  • In genetics: 1,966
• Year to date:
  • Site-wide: 111,574
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  • Site-wide: 111,158

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

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  • Site-wide: 44,485
  • In neuroscience: 6,431
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  • Site-wide: 48,129
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  • Site-wide: 47,134

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

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  • Site-wide: 45,154
  • In genetics: 2,118
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  • Site-wide: 106,626
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  • Site-wide: 104,571

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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  • Site-wide: 50,480
  • In genomics: 3,953
• Year to date:
  • Site-wide: 115,843
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  • Site-wide: 96,925

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

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  • Site-wide: 54,417
  • In genomics: 4,168
• Year to date:
  • Site-wide: 113,547
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  • Site-wide: 122,077

Polygenic predictors of age-related decline in cognitive ability

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  • Site-wide: 54,758
  • In genomics: 4,180
• Year to date:
  • Site-wide: 123,740
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  • Site-wide: 117,690

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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  • Site-wide: 55,735
  • In genetics: 2,588
• Year to date:
  • Site-wide: 118,304
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  • Site-wide: 130,812

Genetic contributions to trail making test performance in UK Biobank

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  • Site-wide: 56,830
  • In genetics: 2,651
• Year to date:
  • Site-wide: 101,537
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  • Site-wide: 65,735

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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  • Site-wide: 57,969
  • In genomics: 4,333
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  • Site-wide: 76,145

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 68,916
  • In neuroscience: 10,441
• Year to date:
  • Site-wide: 126,294
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  • Site-wide: 109,641

An epigenetic predictor of death captures multi-modal measures of brain health

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  • Site-wide: 71,917
  • In neuroscience: 10,954
• Year to date:
  • Site-wide: 129,856
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  • Site-wide: 117,839

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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  • Site-wide: 76,396
  • In genetics: 3,494
• Year to date:
  • Site-wide: 127,963
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  • Site-wide: 119,409

An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

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  • Site-wide: 79,650
  • In neurology: 193
• Year to date:
  • Site-wide: 19,366
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  • Site-wide: 15,007

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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  • Site-wide: 87,806
  • In epidemiology: 3,605
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  • Site-wide: 123,570
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  • Site-wide: 131,411

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

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  • Site-wide: 89,587
  • In cell biology: 4,152
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  • Site-wide: 75,837

Creating and validating a DNA methylation-based proxy for Interleukin-6

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  • Site-wide: 98,055
  • In genetic and genomic medicine: 385
• Year to date:
  • Site-wide: 50,797
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  • Site-wide: 66,532

DNA methylation proxies for 16 plasma proteins predict the incidence of 7 leading causes of morbidity

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  • Site-wide: 99,857
  • In genomics: 5,985
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  • Site-wide: 22,479
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  • Site-wide: 24,179

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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  • Site-wide: 100,934
  • In neuroscience: 15,673
• Year to date:
  • Site-wide: 128,592
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  • Site-wide: 107,825

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 104,866
  • In genomics: 6,130
• Year to date:
  • Site-wide: 98,746
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  • Site-wide: 75,307

Pulmonary function and risk of Alzheimer dementia: two-sample Mendelian randomization study

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  • Site-wide: 108,875
  • In epidemiology: 4,472
• Year to date:
  • Site-wide: 70,363
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  • Site-wide: 56,553

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

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  • Site-wide: 117,828
  • In neuroscience: 18,169
• Year to date:
  • Site-wide: 55,339
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  • Site-wide: 42,117

Epigenetic predictors of lifestyle traits applied to the blood and brain

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  • Site-wide: 122,656
  • In genetic and genomic medicine: 580
• Year to date:
  • Site-wide: 66,431
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  • Site-wide: 51,264

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

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  • Site-wide: 123,283
  • In neuroscience: 18,950
• Year to date:
  • Site-wide: 100,297
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  • Site-wide: 74,723