Author: Sarah E Harris

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Preprints

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 4,200
  • In genetics: 154
• Year to date:
  • Site-wide: 44,104
• Since beginning of last month:
  • Site-wide: 19,358

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,477
  • In genetics: 171
• Year to date:
  • Site-wide: 37,030
• Since beginning of last month:
  • Site-wide: 103,743

Molecular genetic contributions to self-rated health

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  • Site-wide: 7,481
  • In genetics: 329
• Year to date:
  • Site-wide: 96,898
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  • Site-wide: 105,698

GWAS on family history of Alzheimer's disease

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  • Site-wide: 8,832
  • In genetics: 381
• Year to date:
  • Site-wide: 101,701
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  • Site-wide: None

Genetic Prediction of Male Pattern Baldness

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  • Site-wide: 9,770
  • In genetics: 426
• Year to date:
  • Site-wide: 56,035
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  • Site-wide: 12,153

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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  • Site-wide: 11,770
  • In genetics: 531
• Year to date:
  • Site-wide: 101,209
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  • Site-wide: 105,665

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,641 times
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  • Site-wide: 11,935
  • In genomics: 1,226
• Year to date:
  • Site-wide: 72,915
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  • Site-wide: 33,505

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,492 times
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  • Site-wide: 13,666
  • In genetics: 624
• Year to date:
  • Site-wide: 42,701
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  • Site-wide: 16,890

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 14,421
  • In genetics: 657
• Year to date:
  • Site-wide: 7,515
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  • Site-wide: 127,674

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 15,594
  • In bioinformatics: 1,808
• Year to date:
  • Site-wide: 65,345
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  • Site-wide: 102,696

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

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  • Site-wide: 20,720
  • In genetics: 950
• Year to date:
  • Site-wide: 25,095
• Since beginning of last month:
  • Site-wide: 59,733

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 22,223
  • In genomics: 2,110
• Year to date:
  • Site-wide: 104,644
• Since beginning of last month:
  • Site-wide: 36,119

An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 24,365
  • In genetics: 1,114
• Year to date:
  • Site-wide: 107,977
• Since beginning of last month:
  • Site-wide: 103,555

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

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  • Site-wide: 31,465
  • In cell biology: 1,192
• Year to date:
  • Site-wide: 4,303
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  • Site-wide: 1,465

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 35,625
  • In genomics: 2,997
• Year to date:
  • Site-wide: 117,854
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  • Site-wide: 104,866

Genetic contributions to self-reported tiredness

• Downloaded 720 times
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  • Site-wide: 39,477
  • In genetics: 1,775
• Year to date:
  • Site-wide: 115,432
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  • Site-wide: 105,692

Epigenetic scores for the circulating proteome as tools for disease prediction

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  • Site-wide: 44,052
  • In genomics: 3,507
• Year to date:
  • Site-wide: 8,160
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  • Site-wide: 5,626

Cognitive ability and physical health: a Mendelian randomization study

• Downloaded 617 times
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  • Site-wide: 48,302
  • In genetics: 2,152
• Year to date:
  • Site-wide: 147,238
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  • Site-wide: None

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

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  • Site-wide: 50,043
  • In neuroscience: 7,048
• Year to date:
  • Site-wide: 85,027
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  • Site-wide: None

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 581 times
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  • Site-wide: 52,101
  • In genetics: 2,305
• Year to date:
  • Site-wide: 142,075
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  • Site-wide: None

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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  • Site-wide: 58,821
  • In genomics: 4,330
• Year to date:
  • Site-wide: 149,816
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  • Site-wide: None

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

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  • Site-wide: 61,955
  • In genomics: 4,473
• Year to date:
  • Site-wide: 138,855
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  • Site-wide: 120,423

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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  • Site-wide: 62,151
  • In genomics: 4,477
• Year to date:
  • Site-wide: 96,449
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  • Site-wide: 34,950

Polygenic predictors of age-related decline in cognitive ability

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  • Site-wide: 62,889
  • In genomics: 4,518
• Year to date:
  • Site-wide: 147,344
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  • Site-wide: None

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 490 times
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  • Site-wide: 63,739
  • In genetics: 2,806
• Year to date:
  • Site-wide: 124,274
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  • Site-wide: None

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 483 times
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  • Site-wide: 64,639
  • In genetics: 2,851
• Year to date:
  • Site-wide: 150,090
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  • Site-wide: None

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 77,737
  • In neuroscience: 11,522
• Year to date:
  • Site-wide: 143,050
• Since beginning of last month:
  • Site-wide: 88,909

An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

• Downloaded 403 times
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  • Site-wide: 77,870
  • In neurology: 215
• Year to date:
  • Site-wide: 31,894
• Since beginning of last month:
  • Site-wide: 69,051

An epigenetic predictor of death captures multi-modal measures of brain health

• Downloaded 390 times
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  • Site-wide: 80,276
  • In neuroscience: 11,942
• Year to date:
  • Site-wide: 140,907
• Since beginning of last month:
  • Site-wide: 56,140

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 354 times
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  • Site-wide: 87,469
  • In genetics: 3,805
• Year to date:
  • Site-wide: 151,131
• Since beginning of last month:
  • Site-wide: 105,906

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 312 times
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  • Site-wide: 96,699
  • In epidemiology: 4,087
• Year to date:
  • Site-wide: 132,494
• Since beginning of last month:
  • Site-wide: 41,184

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 304 times
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  • Site-wide: 98,555
  • In genetic and genomic medicine: 465
• Year to date:
  • Site-wide: 60,769
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  • Site-wide: 47,761

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

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  • Site-wide: 100,263
  • In cell biology: 4,605
• Year to date:
  • Site-wide: 120,912
• Since beginning of last month:
  • Site-wide: 101,402

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 289 times
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  • Site-wide: 102,059
  • In genomics: 6,123
• Year to date:
  • Site-wide: 68,458
• Since beginning of last month:
  • Site-wide: 81,376

Pulmonary function and risk of Alzheimer dementia: two-sample Mendelian randomization study

• Downloaded 242 times
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  • Site-wide: 113,426
  • In epidemiology: 4,766
• Year to date:
  • Site-wide: 79,753
• Since beginning of last month:
  • Site-wide: 97,837

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

• Downloaded 239 times
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  • Site-wide: 114,352
  • In neuroscience: 17,297
• Year to date:
  • Site-wide: 149,894
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  • Site-wide: None

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 202 times
• Download rankings, all-time:
  • Site-wide: 123,626
  • In neuroscience: 18,675
• Year to date:
  • Site-wide: 68,488
• Since beginning of last month:
  • Site-wide: 20,370

Blood-based epigenome-wide analyses of cognitive abilities

• Downloaded 199 times
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  • Site-wide: 124,253
  • In genetic and genomic medicine: 666
• Year to date:
  • Site-wide: 32,902
• Since beginning of last month:
  • Site-wide: 91,826

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

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  • Site-wide: 124,532
  • In neuroscience: 18,809
• Year to date:
  • Site-wide: 72,979
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  • Site-wide: None

Epigenetic predictors of lifestyle traits applied to the blood and brain

• Downloaded 176 times
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  • Site-wide: 129,987
  • In genetic and genomic medicine: 704
• Year to date:
  • Site-wide: 77,239
• Since beginning of last month:
  • Site-wide: 42,305

Local CpG density affects the trajectory of age-associated epigenetic changes

• Downloaded 154 times
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  • Site-wide: 134,868
  • In genetics: 5,453
• Year to date:
  • Site-wide: 44,306
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  • Site-wide: 76,842

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

• Downloaded 114 times
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  • Site-wide: 143,320
  • In psychiatry and clinical psychology: 826
• Year to date:
  • Site-wide: 60,658
• Since beginning of last month:
  • Site-wide: 9,826